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Auteur Eugene KRONBERG |
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Transient and steady-state auditory gamma-band responses in first-degree relatives of people with autism spectrum disorder / Donald C. ROJAS in Molecular Autism, (July 2011)
[article]
Titre : Transient and steady-state auditory gamma-band responses in first-degree relatives of people with autism spectrum disorder Type de document : Texte imprimé et/ou numérique Auteurs : Donald C. ROJAS, Auteur ; Peter D. TEALE, Auteur ; Keeran MAHARAJH, Auteur ; Eugene KRONBERG, Auteur ; Katie YOUNGPETER, Auteur ; Lisa B. WILSON, Auteur ; Alissa WALLACE, Auteur ; Susan HEPBURN, Auteur Année de publication : 2011 Article en page(s) : 13 p. Langues : Anglais (eng) Index. décimale : PER Périodiques Résumé : Background
Stimulus-related γ-band oscillations, which may be related to perceptual binding, are reduced in people with autism spectrum disorders (ASD). The purpose of this study was to examine auditory transient and steady-state γ-band findings in first-degree relatives of people with ASD to assess the potential familiality of these findings in ASD.
Methods
Magnetoencephalography (MEG) recordings in 21 parents who had a child with an autism spectrum disorder (pASD) and 20 healthy adult control subjects (HC) were obtained. Gamma-band phase locking factor (PLF), and evoked and induced power to 32, 40 and 48 Hz amplitude-modulated sounds were measured for transient and steady-state responses. Participants were also tested on a number of behavioral and cognitive assessments related to the broad autism phenotype (BAP).
Results
Reliable group differences were seen primarily for steady-state responses. In the left hemisphere, pASD subjects exhibited lower phase-locked steady-state power in all three conditions. Total γ-band power, including the non-phase-locked component, was also reduced in the pASD group. In addition, pASD subjects had significantly lower PLF than the HC group. Correlations were seen between MEG measures and BAP measures.
Conclusions
The reduction in steady-state γ-band responses in the pASD group is consistent with previous results for children with ASD. Steady-state responses may be more sensitive than transient responses to phase-locking errors in ASD. Together with the lower PLF and phase-locked power in first-degree relatives, correlations between γ-band measures and behavioral measures relevant to the BAP highlight the potential of γ-band deficits as a potential new autism endophenotype.En ligne : http://dx.doi.org/10.1186/2040-2392-2-11 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=141
in Molecular Autism > (July 2011) . - 13 p.[article] Transient and steady-state auditory gamma-band responses in first-degree relatives of people with autism spectrum disorder [Texte imprimé et/ou numérique] / Donald C. ROJAS, Auteur ; Peter D. TEALE, Auteur ; Keeran MAHARAJH, Auteur ; Eugene KRONBERG, Auteur ; Katie YOUNGPETER, Auteur ; Lisa B. WILSON, Auteur ; Alissa WALLACE, Auteur ; Susan HEPBURN, Auteur . - 2011 . - 13 p.
Langues : Anglais (eng)
in Molecular Autism > (July 2011) . - 13 p.
Index. décimale : PER Périodiques Résumé : Background
Stimulus-related γ-band oscillations, which may be related to perceptual binding, are reduced in people with autism spectrum disorders (ASD). The purpose of this study was to examine auditory transient and steady-state γ-band findings in first-degree relatives of people with ASD to assess the potential familiality of these findings in ASD.
Methods
Magnetoencephalography (MEG) recordings in 21 parents who had a child with an autism spectrum disorder (pASD) and 20 healthy adult control subjects (HC) were obtained. Gamma-band phase locking factor (PLF), and evoked and induced power to 32, 40 and 48 Hz amplitude-modulated sounds were measured for transient and steady-state responses. Participants were also tested on a number of behavioral and cognitive assessments related to the broad autism phenotype (BAP).
Results
Reliable group differences were seen primarily for steady-state responses. In the left hemisphere, pASD subjects exhibited lower phase-locked steady-state power in all three conditions. Total γ-band power, including the non-phase-locked component, was also reduced in the pASD group. In addition, pASD subjects had significantly lower PLF than the HC group. Correlations were seen between MEG measures and BAP measures.
Conclusions
The reduction in steady-state γ-band responses in the pASD group is consistent with previous results for children with ASD. Steady-state responses may be more sensitive than transient responses to phase-locking errors in ASD. Together with the lower PLF and phase-locked power in first-degree relatives, correlations between γ-band measures and behavioral measures relevant to the BAP highlight the potential of γ-band deficits as a potential new autism endophenotype.En ligne : http://dx.doi.org/10.1186/2040-2392-2-11 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=141