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Auteur Amy L. HERNDON |
Documents disponibles écrits par cet auteur (2)
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Genetically inbred Balb/c mice differ from outbred Swiss Webster mice on discrete measures of sociability: relevance to a genetic mouse model of autism spectrum disorders / Luis F. JACOME in Autism Research, 4-6 (December 2011)
[article]
Titre : Genetically inbred Balb/c mice differ from outbred Swiss Webster mice on discrete measures of sociability: relevance to a genetic mouse model of autism spectrum disorders Type de document : Texte imprimé et/ou numérique Auteurs : Luis F. JACOME, Auteur ; Jessica A. BURKET, Auteur ; Amy L. HERNDON, Auteur ; Stephen I. DEUTSCH, Auteur Année de publication : 2012 Article en page(s) : p.393-400 Langues : Anglais (eng) Mots-clés : Balb/c mouse strain sociability autism spectrum disorders Index. décimale : PER Périodiques Résumé : The Balb/c mouse is proposed as a model of human disorders with prominent deficits of sociability, such as autism spectrum disorders (ASDs) that may involve pathophysiological disruption of NMDA receptor-mediated neurotransmission. A standard procedure was used to measure sociability in 8-week-old male genetically inbred Balb/c and outbred Swiss Webster mice. Moreover, because impaired sociability may influence the social behavior of stimulus mice, we also measured the proportion of total episodes of social approach made by the stimulus mouse while test and stimulus mice were allowed to interact freely. Three raters with good inter-rater agreement evaluated operationally defined measures of sociability chosen because of their descriptive similarity to deficits of social behavior reported in persons with ASDs. The data support previous reports that the Balb/c mouse is a genetic mouse model of impaired sociability. The data also show that the behavior of the social stimulus mouse is influenced by the impaired sociability of the Balb/c strain. Interestingly, operationally defined measures of sociability did not necessarily correlate with each other within mouse strain and the profile of correlated measures differed between strains. Finally, “stereotypic” behaviors (i.e. rearing, grooming and wall climbing) recorded during the session of free interaction between the test and social stimulus mice were more intensely displayed by Swiss Webster than Balb/c mice, suggesting that the domains of sociability and “restricted repetitive and stereotyped patterns of behavior” are independent of each other in the Balb/c strain. En ligne : http://dx.doi.org/10.1002/aur.218 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=151
in Autism Research > 4-6 (December 2011) . - p.393-400[article] Genetically inbred Balb/c mice differ from outbred Swiss Webster mice on discrete measures of sociability: relevance to a genetic mouse model of autism spectrum disorders [Texte imprimé et/ou numérique] / Luis F. JACOME, Auteur ; Jessica A. BURKET, Auteur ; Amy L. HERNDON, Auteur ; Stephen I. DEUTSCH, Auteur . - 2012 . - p.393-400.
Langues : Anglais (eng)
in Autism Research > 4-6 (December 2011) . - p.393-400
Mots-clés : Balb/c mouse strain sociability autism spectrum disorders Index. décimale : PER Périodiques Résumé : The Balb/c mouse is proposed as a model of human disorders with prominent deficits of sociability, such as autism spectrum disorders (ASDs) that may involve pathophysiological disruption of NMDA receptor-mediated neurotransmission. A standard procedure was used to measure sociability in 8-week-old male genetically inbred Balb/c and outbred Swiss Webster mice. Moreover, because impaired sociability may influence the social behavior of stimulus mice, we also measured the proportion of total episodes of social approach made by the stimulus mouse while test and stimulus mice were allowed to interact freely. Three raters with good inter-rater agreement evaluated operationally defined measures of sociability chosen because of their descriptive similarity to deficits of social behavior reported in persons with ASDs. The data support previous reports that the Balb/c mouse is a genetic mouse model of impaired sociability. The data also show that the behavior of the social stimulus mouse is influenced by the impaired sociability of the Balb/c strain. Interestingly, operationally defined measures of sociability did not necessarily correlate with each other within mouse strain and the profile of correlated measures differed between strains. Finally, “stereotypic” behaviors (i.e. rearing, grooming and wall climbing) recorded during the session of free interaction between the test and social stimulus mice were more intensely displayed by Swiss Webster than Balb/c mice, suggesting that the domains of sociability and “restricted repetitive and stereotyped patterns of behavior” are independent of each other in the Balb/c strain. En ligne : http://dx.doi.org/10.1002/aur.218 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=151 Impaired Sociability of the Balb/c Mouse, an Animal Model of Autism Spectrum Disorders, is Attenuated by NMDA Receptor Agonist Interventions: Clinical Implications / Stephen I. DEUTSCH
Titre : Impaired Sociability of the Balb/c Mouse, an Animal Model of Autism Spectrum Disorders, is Attenuated by NMDA Receptor Agonist Interventions: Clinical Implications Type de document : Texte imprimé et/ou numérique Auteurs : Stephen I. DEUTSCH, Auteur ; Jessica A. BURKET, Auteur ; Maria R. URBANO, Auteur ; Amy L. HERNDON, Auteur ; Erin E. WINEBARGER, Auteur Année de publication : 2011 Importance : p.323-342 Langues : Anglais (eng) Index. décimale : AUT-B AUT-B - L'Autisme - Ouvrages généraux et scientifiques En ligne : http://dx.doi.org/10.5772/18613 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=143 Impaired Sociability of the Balb/c Mouse, an Animal Model of Autism Spectrum Disorders, is Attenuated by NMDA Receptor Agonist Interventions: Clinical Implications [Texte imprimé et/ou numérique] / Stephen I. DEUTSCH, Auteur ; Jessica A. BURKET, Auteur ; Maria R. URBANO, Auteur ; Amy L. HERNDON, Auteur ; Erin E. WINEBARGER, Auteur . - 2011 . - p.323-342.
Langues : Anglais (eng)
Index. décimale : AUT-B AUT-B - L'Autisme - Ouvrages généraux et scientifiques En ligne : http://dx.doi.org/10.5772/18613 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=143 Exemplaires
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