Autism Spectrum Disorders: The Role of Genetics in Diagnosis and Treatment / Stephen I. DEUTSCH  

Public ISBD Titre : Autism Spectrum Disorders: The Role of Genetics in Diagnosis and Treatment Type de document : Texte imprimé et/ou numérique Auteurs : Stephen I. DEUTSCH, Directeur de publication Editeur : Rijeka [Croatie] : InTech Année de publication : 2011 Importance : 198 p. Format : Ebook ISBN/ISSN/EAN : 978-953-307-495-5 Langues : Anglais (eng) Index. décimale : AUT-B AUT-B - L'Autisme - Ouvrages généraux et scientifiques Résumé : Estimated prevalence rates of autism spectrum disorders (ASDs) have increased at an alarming rate over the past decade; current estimates stand as high as 1 in 110 persons in the population with a higher ratio of affected males to females. In addition to their emotional impact on the affected persons and their family members (in fact, the latter are often unrecognized unaffected “patients” themselves), the economic and social impacts of ASDs on society are staggering. Persons with ASDs will need interdisciplinary approaches to complex treatment and life planning, including, but not limited to, special education, speech and language therapy, vocational skills training and rehabilitation, social skills training and cognitive remediation, in addition to pharmacotherapy. The current book highlights some of the recent research on nosology, etiology, and pathophysiology. Additionally, the book touches on the implications of new research for treatment and genetic counseling. Importantly, because the field is advancing rapidly, no book can be considered the final word or finished product; thus, the availability of open access rapid publication is a mechanism that will help to assure that readers remain current and up-to-date. [Résumé d'Auteur/Editeur] En ligne : http://www.intechopen.com/books/show/title/autism-spectrum-disorders-the-role-of [...] Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=143 Autism Spectrum Disorders: The Role of Genetics in Diagnosis and Treatment [Texte imprimé et/ou numérique] / Stephen I. DEUTSCH, Directeur de publication . - Rijeka [Croatie] : InTech, 2011 . - 198 p. ; Ebook. ISBN : 978-953-307-495-5 Langues : Anglais (eng) Index. décimale : AUT-B AUT-B - L'Autisme - Ouvrages généraux et scientifiques Résumé : Estimated prevalence rates of autism spectrum disorders (ASDs) have increased at an alarming rate over the past decade; current estimates stand as high as 1 in 110 persons in the population with a higher ratio of affected males to females. In addition to their emotional impact on the affected persons and their family members (in fact, the latter are often unrecognized unaffected “patients” themselves), the economic and social impacts of ASDs on society are staggering. Persons with ASDs will need interdisciplinary approaches to complex treatment and life planning, including, but not limited to, special education, speech and language therapy, vocational skills training and rehabilitation, social skills training and cognitive remediation, in addition to pharmacotherapy. The current book highlights some of the recent research on nosology, etiology, and pathophysiology. Additionally, the book touches on the implications of new research for treatment and genetic counseling. Importantly, because the field is advancing rapidly, no book can be considered the final word or finished product; thus, the availability of open access rapid publication is a mechanism that will help to assure that readers remain current and up-to-date. [Résumé d'Auteur/Editeur] En ligne : http://www.intechopen.com/books/show/title/autism-spectrum-disorders-the-role-of [...] Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=143

Contenu

• Early Detection of Autism Spectrum Disorders / Jariya CHUTHAPISITH  
• Pervasive Developmental Disorder- not Otherwise Specified: Specifying and Differentiating / Koray KARABEKROGLU  
• Autism and Genetic Syndromes / Willem VERHOEVEN  
• The Genetics of Autism Spectrum Disorders / John J.M. CONNOLLY  
• Genetic Heterogeneity of Autism Spectrum Disorders / Catherine CROFT SWANWICK  
• The Genetic Basis of Phenotypic Diversity: Autism as an Extreme Tail of a Complex Dimensional Trait / Shinji IJICHI  
• A New Genetic Mechanism for Autism / Julie GAUTHIER  
• Common Genetic Etiologies and Biological Pathways Shared Between Autism Spectrum Disorders and Intellectual Disabilities / Liana KAUFMAN  
• Microgenetic Approach to Therapy of Girls with ASD / Katarzyna MARKIEWICZ  
• Genetic Counseling in Autistic Phenotypes / Agnes Cristina FETT-CONTE  

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Genetically inbred Balb/c mice differ from outbred Swiss Webster mice on discrete measures of sociability: relevance to a genetic mouse model of autism spectrum disorders / Luis F. JACOME in Autism Research, 4-6 (December 2011)  

Public ISBD [article]  inAutism Research > 4-6 (December 2011) . - p.393-400 Titre : Genetically inbred Balb/c mice differ from outbred Swiss Webster mice on discrete measures of sociability: relevance to a genetic mouse model of autism spectrum disorders Type de document : Texte imprimé et/ou numérique Auteurs : Luis F. JACOME, Auteur ; Jessica A. BURKET, Auteur ; Amy L. HERNDON, Auteur ; Stephen I. DEUTSCH, Auteur Année de publication : 2012 Article en page(s) : p.393-400 Langues : Anglais (eng) Mots-clés : Balb/c mouse strain  sociability  autism spectrum disorders Index. décimale : PER Périodiques Résumé : The Balb/c mouse is proposed as a model of human disorders with prominent deficits of sociability, such as autism spectrum disorders (ASDs) that may involve pathophysiological disruption of NMDA receptor-mediated neurotransmission. A standard procedure was used to measure sociability in 8-week-old male genetically inbred Balb/c and outbred Swiss Webster mice. Moreover, because impaired sociability may influence the social behavior of stimulus mice, we also measured the proportion of total episodes of social approach made by the stimulus mouse while test and stimulus mice were allowed to interact freely. Three raters with good inter-rater agreement evaluated operationally defined measures of sociability chosen because of their descriptive similarity to deficits of social behavior reported in persons with ASDs. The data support previous reports that the Balb/c mouse is a genetic mouse model of impaired sociability. The data also show that the behavior of the social stimulus mouse is influenced by the impaired sociability of the Balb/c strain. Interestingly, operationally defined measures of sociability did not necessarily correlate with each other within mouse strain and the profile of correlated measures differed between strains. Finally, “stereotypic” behaviors (i.e. rearing, grooming and wall climbing) recorded during the session of free interaction between the test and social stimulus mice were more intensely displayed by Swiss Webster than Balb/c mice, suggesting that the domains of sociability and “restricted repetitive and stereotyped patterns of behavior” are independent of each other in the Balb/c strain. En ligne : http://dx.doi.org/10.1002/aur.218 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=151 [article] Genetically inbred Balb/c mice differ from outbred Swiss Webster mice on discrete measures of sociability: relevance to a genetic mouse model of autism spectrum disorders [Texte imprimé et/ou numérique] / Luis F. JACOME, Auteur ; Jessica A. BURKET, Auteur ; Amy L. HERNDON, Auteur ; Stephen I. DEUTSCH, Auteur . - 2012 . - p.393-400. Langues : Anglais (eng) in Autism Research > 4-6 (December 2011) . - p.393-400 Mots-clés : Balb/c mouse strain  sociability  autism spectrum disorders Index. décimale : PER Périodiques Résumé : The Balb/c mouse is proposed as a model of human disorders with prominent deficits of sociability, such as autism spectrum disorders (ASDs) that may involve pathophysiological disruption of NMDA receptor-mediated neurotransmission. A standard procedure was used to measure sociability in 8-week-old male genetically inbred Balb/c and outbred Swiss Webster mice. Moreover, because impaired sociability may influence the social behavior of stimulus mice, we also measured the proportion of total episodes of social approach made by the stimulus mouse while test and stimulus mice were allowed to interact freely. Three raters with good inter-rater agreement evaluated operationally defined measures of sociability chosen because of their descriptive similarity to deficits of social behavior reported in persons with ASDs. The data support previous reports that the Balb/c mouse is a genetic mouse model of impaired sociability. The data also show that the behavior of the social stimulus mouse is influenced by the impaired sociability of the Balb/c strain. Interestingly, operationally defined measures of sociability did not necessarily correlate with each other within mouse strain and the profile of correlated measures differed between strains. Finally, “stereotypic” behaviors (i.e. rearing, grooming and wall climbing) recorded during the session of free interaction between the test and social stimulus mice were more intensely displayed by Swiss Webster than Balb/c mice, suggesting that the domains of sociability and “restricted repetitive and stereotyped patterns of behavior” are independent of each other in the Balb/c strain. En ligne : http://dx.doi.org/10.1002/aur.218 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=151

Impaired Sociability of the Balb/c Mouse, an Animal Model of Autism Spectrum Disorders, is Attenuated by NMDA Receptor Agonist Interventions: Clinical Implications / Stephen I. DEUTSCH  

Public ISBD in A Comprehensive Book on Autism Spectrum Disorders / Mohammad Reza MOHAMMADI   Titre : Impaired Sociability of the Balb/c Mouse, an Animal Model of Autism Spectrum Disorders, is Attenuated by NMDA Receptor Agonist Interventions: Clinical Implications Type de document : Texte imprimé et/ou numérique Auteurs : Stephen I. DEUTSCH, Auteur ; Jessica A. BURKET, Auteur ; Maria R. URBANO, Auteur ; Amy L. HERNDON, Auteur ; Erin E. WINEBARGER, Auteur Année de publication : 2011 Importance : p.323-342 Langues : Anglais (eng) Index. décimale : AUT-B AUT-B - L'Autisme - Ouvrages généraux et scientifiques En ligne : http://dx.doi.org/10.5772/18613 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=143 in A Comprehensive Book on Autism Spectrum Disorders / Mohammad Reza MOHAMMADI   Impaired Sociability of the Balb/c Mouse, an Animal Model of Autism Spectrum Disorders, is Attenuated by NMDA Receptor Agonist Interventions: Clinical Implications [Texte imprimé et/ou numérique] / Stephen I. DEUTSCH, Auteur ; Jessica A. BURKET, Auteur ; Maria R. URBANO, Auteur ; Amy L. HERNDON, Auteur ; Erin E. WINEBARGER, Auteur . - 2011 . - p.323-342. Langues : Anglais (eng) Index. décimale : AUT-B AUT-B - L'Autisme - Ouvrages généraux et scientifiques En ligne : http://dx.doi.org/10.5772/18613 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=143

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Sexuality in the Autism Spectrum Study (SASS): Reports from Young Adults and Parents / K. HARTMANN in Journal of Autism and Developmental Disorders, 49-9 (September 2019)  

Public ISBD [article]  inJournal of Autism and Developmental Disorders > 49-9 (September 2019) . - p.3638-3655 Titre : Sexuality in the Autism Spectrum Study (SASS): Reports from Young Adults and Parents Type de document : Texte imprimé et/ou numérique Auteurs : K. HARTMANN, Auteur ; M. R. URBANO, Auteur ; C. T. RAFFAELE, Auteur ; L. R. QUALLS, Auteur ; T. V. WILLIAMS, Auteur ; C. WARREN, Auteur ; N. L. KREISER, Auteur ; D. E. ELKINS, Auteur ; Stephen I. DEUTSCH, Auteur Article en page(s) : p.3638-3655 Langues : Anglais (eng) Mots-clés : Autism spectrum disorder  Family  Parents  Sexuality  Young adults Index. décimale : PER Périodiques Résumé : Previous research indicates that although those with ASD desire sexual relationships, they may not effectively engage in romantic and intimate interactions. The purpose of this study was to compare reports from young adults with ASD and parents from the same families on the young adult's sexual behavior, experiences, knowledge, and communication. 100 young adults (18-30 years) and parents completed an online survey. Results indicated that young adults reported more typical privacy and sexual behaviors, and higher sexual victimization than their parents reported on their behalf. Our findings indicated that individuals with ASD desire and pursue sexual relationships typical of most people and suggest the need for sex education and communication about topics generally covered for neurotypically developing young adults. En ligne : http://dx.doi.org/10.1007/s10803-019-04077-y Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=405 [article] Sexuality in the Autism Spectrum Study (SASS): Reports from Young Adults and Parents [Texte imprimé et/ou numérique] / K. HARTMANN, Auteur ; M. R. URBANO, Auteur ; C. T. RAFFAELE, Auteur ; L. R. QUALLS, Auteur ; T. V. WILLIAMS, Auteur ; C. WARREN, Auteur ; N. L. KREISER, Auteur ; D. E. ELKINS, Auteur ; Stephen I. DEUTSCH, Auteur . - p.3638-3655. Langues : Anglais (eng) in Journal of Autism and Developmental Disorders > 49-9 (September 2019) . - p.3638-3655 Mots-clés : Autism spectrum disorder  Family  Parents  Sexuality  Young adults Index. décimale : PER Périodiques Résumé : Previous research indicates that although those with ASD desire sexual relationships, they may not effectively engage in romantic and intimate interactions. The purpose of this study was to compare reports from young adults with ASD and parents from the same families on the young adult's sexual behavior, experiences, knowledge, and communication. 100 young adults (18-30 years) and parents completed an online survey. Results indicated that young adults reported more typical privacy and sexual behaviors, and higher sexual victimization than their parents reported on their behalf. Our findings indicated that individuals with ASD desire and pursue sexual relationships typical of most people and suggest the need for sex education and communication about topics generally covered for neurotypically developing young adults. En ligne : http://dx.doi.org/10.1007/s10803-019-04077-y Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=405

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