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Auteur Randy Joseph KULESZA |
Documents disponibles écrits par cet auteur (1)
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Quantification of the Stapedial Reflex Reveals Delayed Responses in Autism / Richard LUKOSE in Autism Research, 6-5 (October 2013)
[article]
Titre : Quantification of the Stapedial Reflex Reveals Delayed Responses in Autism Type de document : Texte imprimé et/ou numérique Auteurs : Richard LUKOSE, Auteur ; Kevin BROWN, Auteur ; Carol M. BARBER, Auteur ; Randy Joseph KULESZA, Auteur Article en page(s) : p.344-353 Langues : Anglais (eng) Mots-clés : autistic auditory superior olive facial nucleus Index. décimale : PER Périodiques Résumé : Autism is a developmental disorder characterized, in part, by sensory abnormalities. It is well established that most if not all patients with autism have problems with auditory processing, ranging from deafness to hyperacusis, and physiological testing of auditory function (i.e. auditory brain stem responses) implicates brain stem dysfunction in autism. Additionally, previous research from this lab has revealed significantly fewer auditory brain stem neurons in autistic subjects as young as 2 years of age. These observations have led us to hypothesize that objective, noninvasive measures of auditory function can be used as an early screening tool to identify neonates with an elevated risk of carrying a diagnosis of autism. Here, we provide a detailed quantitative investigation of the acoustic stapedial reflex (ASR), a three- or four-neuron brain stem circuit, in young autistic subjects and normal developing controls. Indeed, we find significantly lower thresholds, responses occurring at significantly longer latency and right–left asymmetry in autistic subjects. The results from this investigation support deficits in auditory function as a cardinal feature of autism and suggest that individuals with autism can be identified by their ASR responses. En ligne : http://dx.doi.org/10.1002/aur.1297 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=218
in Autism Research > 6-5 (October 2013) . - p.344-353[article] Quantification of the Stapedial Reflex Reveals Delayed Responses in Autism [Texte imprimé et/ou numérique] / Richard LUKOSE, Auteur ; Kevin BROWN, Auteur ; Carol M. BARBER, Auteur ; Randy Joseph KULESZA, Auteur . - p.344-353.
Langues : Anglais (eng)
in Autism Research > 6-5 (October 2013) . - p.344-353
Mots-clés : autistic auditory superior olive facial nucleus Index. décimale : PER Périodiques Résumé : Autism is a developmental disorder characterized, in part, by sensory abnormalities. It is well established that most if not all patients with autism have problems with auditory processing, ranging from deafness to hyperacusis, and physiological testing of auditory function (i.e. auditory brain stem responses) implicates brain stem dysfunction in autism. Additionally, previous research from this lab has revealed significantly fewer auditory brain stem neurons in autistic subjects as young as 2 years of age. These observations have led us to hypothesize that objective, noninvasive measures of auditory function can be used as an early screening tool to identify neonates with an elevated risk of carrying a diagnosis of autism. Here, we provide a detailed quantitative investigation of the acoustic stapedial reflex (ASR), a three- or four-neuron brain stem circuit, in young autistic subjects and normal developing controls. Indeed, we find significantly lower thresholds, responses occurring at significantly longer latency and right–left asymmetry in autistic subjects. The results from this investigation support deficits in auditory function as a cardinal feature of autism and suggest that individuals with autism can be identified by their ASR responses. En ligne : http://dx.doi.org/10.1002/aur.1297 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=218