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Détail de l'auteur
Auteur Daniele Yumi SUNAGA |
Documents disponibles écrits par cet auteur (2)
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Stem Cells as a Good Tool to Investigate Dysregulated Biological Systems in Autism Spectrum Disorders / Karina GRIESI-OLIVEIRA in Autism Research, 6-5 (October 2013)
[article]
Titre : Stem Cells as a Good Tool to Investigate Dysregulated Biological Systems in Autism Spectrum Disorders Type de document : Texte imprimé et/ou numérique Auteurs : Karina GRIESI-OLIVEIRA, Auteur ; Daniele Yumi SUNAGA, Auteur ; Lucas ALVIZI, Auteur ; Estevão VADASZ, Auteur ; Maria Rita PASSOS-BUENO, Auteur Article en page(s) : p.354-361 Langues : Anglais (eng) Mots-clés : expression studies androgen signaling CHD8 stem cells of human exfoliated deciduous teeth Index. décimale : PER Périodiques Résumé : Identification of the causes of autism spectrum disorders (ASDs) is hampered by their genetic heterogeneity; however, the different genetic alterations leading to ASD seem to be implicated in the disturbance of common molecular pathways or biological processes. In this scenario, the search for differentially expressed genes (DEGs) between ASD patients and controls is a good alternative to identify the molecular etiology of such disorders. Here, we employed genome-wide expression analysis to compare the transcriptome of stem cells of human exfoliated deciduous teeth (SHEDs) of idiopathic autistic patients (n?=?7) and control samples (n?=?6). Nearly half of the 683 identified DEGs are expressed in the brain (P?=?0.003), and a significant number of them are involved in mechanisms previously associated with ASD such as protein synthesis, cytoskeleton regulation, cellular adhesion and alternative splicing, which validate the use of SHEDs to disentangle the causes of autism. Autistic patients also presented overexpression of genes regulated by androgen receptor (AR), and AR itself, which in turn interacts with CHD8 (chromodomain helicase DNA binding protein 8), a gene recently shown to be associated with the cause of autism and found to be upregulated in some patients tested here. These data provide a rationale for the mechanisms through which CHD8 leads to these diseases. In summary, our results suggest that ASD share deregulated pathways and revealed that SHEDs represent an alternative cell source to be used in the understanding of the biological mechanisms involved in the etiology of ASD. En ligne : http://dx.doi.org/10.1002/aur.1296 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=218
in Autism Research > 6-5 (October 2013) . - p.354-361[article] Stem Cells as a Good Tool to Investigate Dysregulated Biological Systems in Autism Spectrum Disorders [Texte imprimé et/ou numérique] / Karina GRIESI-OLIVEIRA, Auteur ; Daniele Yumi SUNAGA, Auteur ; Lucas ALVIZI, Auteur ; Estevão VADASZ, Auteur ; Maria Rita PASSOS-BUENO, Auteur . - p.354-361.
Langues : Anglais (eng)
in Autism Research > 6-5 (October 2013) . - p.354-361
Mots-clés : expression studies androgen signaling CHD8 stem cells of human exfoliated deciduous teeth Index. décimale : PER Périodiques Résumé : Identification of the causes of autism spectrum disorders (ASDs) is hampered by their genetic heterogeneity; however, the different genetic alterations leading to ASD seem to be implicated in the disturbance of common molecular pathways or biological processes. In this scenario, the search for differentially expressed genes (DEGs) between ASD patients and controls is a good alternative to identify the molecular etiology of such disorders. Here, we employed genome-wide expression analysis to compare the transcriptome of stem cells of human exfoliated deciduous teeth (SHEDs) of idiopathic autistic patients (n?=?7) and control samples (n?=?6). Nearly half of the 683 identified DEGs are expressed in the brain (P?=?0.003), and a significant number of them are involved in mechanisms previously associated with ASD such as protein synthesis, cytoskeleton regulation, cellular adhesion and alternative splicing, which validate the use of SHEDs to disentangle the causes of autism. Autistic patients also presented overexpression of genes regulated by androgen receptor (AR), and AR itself, which in turn interacts with CHD8 (chromodomain helicase DNA binding protein 8), a gene recently shown to be associated with the cause of autism and found to be upregulated in some patients tested here. These data provide a rationale for the mechanisms through which CHD8 leads to these diseases. In summary, our results suggest that ASD share deregulated pathways and revealed that SHEDs represent an alternative cell source to be used in the understanding of the biological mechanisms involved in the etiology of ASD. En ligne : http://dx.doi.org/10.1002/aur.1296 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=218 Stem Cells as a Good Tool to Investigate Dysregulated Biological Systems in Autism Spectrum Disorders / Karina GRIESI-OLIVEIRA in Autism Research, 8-1 (February 2015)
[article]
Titre : Stem Cells as a Good Tool to Investigate Dysregulated Biological Systems in Autism Spectrum Disorders Type de document : Texte imprimé et/ou numérique Auteurs : Karina GRIESI-OLIVEIRA, Auteur ; Daniele Yumi SUNAGA, Auteur ; Lucas Alvizi CRUZ, Auteur ; Estevão VADASZ, Auteur ; Maria Rita PASSOS-BUENO, Auteur Article en page(s) : p.121-121 Langues : Anglais (eng) Index. décimale : PER Périodiques En ligne : http://dx.doi.org/10.1002/aur.1330 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=256
in Autism Research > 8-1 (February 2015) . - p.121-121[article] Stem Cells as a Good Tool to Investigate Dysregulated Biological Systems in Autism Spectrum Disorders [Texte imprimé et/ou numérique] / Karina GRIESI-OLIVEIRA, Auteur ; Daniele Yumi SUNAGA, Auteur ; Lucas Alvizi CRUZ, Auteur ; Estevão VADASZ, Auteur ; Maria Rita PASSOS-BUENO, Auteur . - p.121-121.
Langues : Anglais (eng)
in Autism Research > 8-1 (February 2015) . - p.121-121
Index. décimale : PER Périodiques En ligne : http://dx.doi.org/10.1002/aur.1330 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=256