Centre d'Information et de documentation du CRA Rhône-Alpes
CRA
Informations pratiques
-
Adresse
Centre d'information et de documentation
du CRA Rhône-Alpes
Centre Hospitalier le Vinatier
bât 211
95, Bd Pinel
69678 Bron CedexHoraires
Lundi au Vendredi
9h00-12h00 13h30-16h00Contact
Tél: +33(0)4 37 91 54 65
Mail
Fax: +33(0)4 37 91 54 37
-
Détail de l'auteur
Auteur Anji VARA |
Documents disponibles écrits par cet auteur (1)
Faire une suggestion Affiner la recherche
Is inhibitory control a 'no-go' in adolescents with autism spectrum disorder? / Anji VARA in Molecular Autism, (January 2014)
[article]
Titre : Is inhibitory control a 'no-go' in adolescents with autism spectrum disorder? Type de document : Texte imprimé et/ou numérique Auteurs : Anji VARA, Auteur ; Elizabeth W. PANG, Auteur ; Krissy DOYLE-THOMAS, Auteur ; Julie VIDAL, Auteur ; Margot J. TAYLOR, Auteur ; Evdokia ANAGNOSTOU, Auteur Langues : Anglais (eng) Index. décimale : PER Périodiques Résumé : Autism spectrum disorder (ASD) refers to a range of neurodevelopmental conditions characterized by social communication deficits, repetitive behaviours, and restrictive interests. Impaired inhibition has been suggested to exacerbate the core symptoms of ASD. This is particularly critical during adolescence when social skills are maturing to adult levels. Using magnetoencephalography (MEG), we identified the location and timing pattern of neural activity associated with inhibition in adolescents with autism, compared to typically developing adolescents. The MEG data from 15 adolescents with ASD and 15 age-matched controls (13 to 17 years) were collected during a go/no-go task with inverse ratios of go/no-go trials in two conditions: an inhibition condition (1:2) and a baseline condition (2:1). No-go trials from the two conditions were analyzed using beamformer source localizations from 200ms to 400ms post-stimulus onset. Significant activations were determined using permutation testing. Adolescents with ASD recruited first the right middle frontal gyrus (200 to 250ms) followed by the left postcentral gyrus (250 to 300ms) and finally the left middle frontal and right medial frontal gyri (300 to 400ms). Typically developing adolescents recruited first the left middle frontal gyrus (200 to 250ms), followed by the left superior and inferior frontal gyri (250 to 300ms), then the right middle temporal gyrus (300 to 350ms), and finally the superior and precentral gyri and right inferior lobule (300 to 400ms). Adolescents with ASD showed recruitment limited largely to the frontal cortex unlike typically developing adolescents who recruited parietal and temporal regions as well. These findings support the presence of an atypical, restricted inhibitory network in adolescents with ASD compared to controls. En ligne : http://dx.doi.org/10.1186/2040-2392-5-6 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=227
in Molecular Autism > (January 2014)[article] Is inhibitory control a 'no-go' in adolescents with autism spectrum disorder? [Texte imprimé et/ou numérique] / Anji VARA, Auteur ; Elizabeth W. PANG, Auteur ; Krissy DOYLE-THOMAS, Auteur ; Julie VIDAL, Auteur ; Margot J. TAYLOR, Auteur ; Evdokia ANAGNOSTOU, Auteur.
Langues : Anglais (eng)
in Molecular Autism > (January 2014)
Index. décimale : PER Périodiques Résumé : Autism spectrum disorder (ASD) refers to a range of neurodevelopmental conditions characterized by social communication deficits, repetitive behaviours, and restrictive interests. Impaired inhibition has been suggested to exacerbate the core symptoms of ASD. This is particularly critical during adolescence when social skills are maturing to adult levels. Using magnetoencephalography (MEG), we identified the location and timing pattern of neural activity associated with inhibition in adolescents with autism, compared to typically developing adolescents. The MEG data from 15 adolescents with ASD and 15 age-matched controls (13 to 17 years) were collected during a go/no-go task with inverse ratios of go/no-go trials in two conditions: an inhibition condition (1:2) and a baseline condition (2:1). No-go trials from the two conditions were analyzed using beamformer source localizations from 200ms to 400ms post-stimulus onset. Significant activations were determined using permutation testing. Adolescents with ASD recruited first the right middle frontal gyrus (200 to 250ms) followed by the left postcentral gyrus (250 to 300ms) and finally the left middle frontal and right medial frontal gyri (300 to 400ms). Typically developing adolescents recruited first the left middle frontal gyrus (200 to 250ms), followed by the left superior and inferior frontal gyri (250 to 300ms), then the right middle temporal gyrus (300 to 350ms), and finally the superior and precentral gyri and right inferior lobule (300 to 400ms). Adolescents with ASD showed recruitment limited largely to the frontal cortex unlike typically developing adolescents who recruited parietal and temporal regions as well. These findings support the presence of an atypical, restricted inhibitory network in adolescents with ASD compared to controls. En ligne : http://dx.doi.org/10.1186/2040-2392-5-6 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=227