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Auteur Marla SOKOLOWSKI |
Documents disponibles écrits par cet auteur (2)
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A DRD4 gene by maternal sensitivity interaction predicts risk for overweight or obesity in two independent cohorts of preschool children / Robert D. LEVITAN in Journal of Child Psychology and Psychiatry, 58-2 (February 2017)
[article]
Titre : A DRD4 gene by maternal sensitivity interaction predicts risk for overweight or obesity in two independent cohorts of preschool children Type de document : Texte imprimé et/ou numérique Auteurs : Robert D. LEVITAN, Auteur ; Pauline JANSEN, Auteur ; Barbara WENDLAND, Auteur ; Henning TIEMEIER, Auteur ; Vincent W.V. JADDOE, Auteur ; Patricia P. SILVEIRA, Auteur ; James L. KENNEDY, Auteur ; Leslie ATKINSON, Auteur ; Alison FLEMING, Auteur ; Marla SOKOLOWSKI, Auteur ; Helene GAUDREAU, Auteur ; Meir STEINER, Auteur ; Laurette DUBE, Auteur ; Jill HAMILTON, Auteur ; Ellen MOSS, Auteur ; Ashley WAZANA, Auteur ; Michael MEANEY, Auteur Année de publication : 2017 Article en page(s) : p.180-188 Langues : Anglais (eng) Mots-clés : Maternal sensitivity DRD4 obesity sex differences Index. décimale : PER Périodiques Résumé : Background Recent evidence suggests that early exposure to low maternal sensitivity is a risk factor for obesity in children and adolescents. A separate line of study shows that the seven-repeat (7R) allele of the dopamine-4 receptor gene (DRD4) increases susceptibility to environmental factors including maternal sensitivity. The current study integrates these lines of work by examining whether preschoolers carrying the 7R allele are more vulnerable to low maternal sensitivity as it relates to overweight/obesity risk. Method The Maternal Adversity Vulnerability and Neurodevelopment (MAVAN) project in Canada was used as the discovery cohort (N = 203), while the Generation R study in the Netherlands was used as a replication sample (N = 270). Regression models to predict both continuous BMI z-scores and membership in any higher BMI category based on established World Health Organization (WHO) cutoffs for 48 months of age were completed. Results In both cohorts, there was a significant maternal sensitivity by DRD4 by sex interaction predicting higher body mass indices and/or obesity risk. As hypothesized, post hoc testing revealed an inverse relationship between maternal sensitivity and body mass indices in 7R allele carriers relative to noncarriers. This finding was strongest in girls in the Canadian cohort and in boys in the Dutch cohort. Conclusions Many children who carry the 7R allele of DRD4 appear to be more influenced by maternal sensitivity as it relates to overweight/obesity risk, consistent with a plasticity effect. Given the relatively small sample sizes available for these analyses, further replications will be needed to confirm and extend these results. En ligne : http://dx.doi.org/10.1111/jcpp.12646 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=299
in Journal of Child Psychology and Psychiatry > 58-2 (February 2017) . - p.180-188[article] A DRD4 gene by maternal sensitivity interaction predicts risk for overweight or obesity in two independent cohorts of preschool children [Texte imprimé et/ou numérique] / Robert D. LEVITAN, Auteur ; Pauline JANSEN, Auteur ; Barbara WENDLAND, Auteur ; Henning TIEMEIER, Auteur ; Vincent W.V. JADDOE, Auteur ; Patricia P. SILVEIRA, Auteur ; James L. KENNEDY, Auteur ; Leslie ATKINSON, Auteur ; Alison FLEMING, Auteur ; Marla SOKOLOWSKI, Auteur ; Helene GAUDREAU, Auteur ; Meir STEINER, Auteur ; Laurette DUBE, Auteur ; Jill HAMILTON, Auteur ; Ellen MOSS, Auteur ; Ashley WAZANA, Auteur ; Michael MEANEY, Auteur . - 2017 . - p.180-188.
Langues : Anglais (eng)
in Journal of Child Psychology and Psychiatry > 58-2 (February 2017) . - p.180-188
Mots-clés : Maternal sensitivity DRD4 obesity sex differences Index. décimale : PER Périodiques Résumé : Background Recent evidence suggests that early exposure to low maternal sensitivity is a risk factor for obesity in children and adolescents. A separate line of study shows that the seven-repeat (7R) allele of the dopamine-4 receptor gene (DRD4) increases susceptibility to environmental factors including maternal sensitivity. The current study integrates these lines of work by examining whether preschoolers carrying the 7R allele are more vulnerable to low maternal sensitivity as it relates to overweight/obesity risk. Method The Maternal Adversity Vulnerability and Neurodevelopment (MAVAN) project in Canada was used as the discovery cohort (N = 203), while the Generation R study in the Netherlands was used as a replication sample (N = 270). Regression models to predict both continuous BMI z-scores and membership in any higher BMI category based on established World Health Organization (WHO) cutoffs for 48 months of age were completed. Results In both cohorts, there was a significant maternal sensitivity by DRD4 by sex interaction predicting higher body mass indices and/or obesity risk. As hypothesized, post hoc testing revealed an inverse relationship between maternal sensitivity and body mass indices in 7R allele carriers relative to noncarriers. This finding was strongest in girls in the Canadian cohort and in boys in the Dutch cohort. Conclusions Many children who carry the 7R allele of DRD4 appear to be more influenced by maternal sensitivity as it relates to overweight/obesity risk, consistent with a plasticity effect. Given the relatively small sample sizes available for these analyses, further replications will be needed to confirm and extend these results. En ligne : http://dx.doi.org/10.1111/jcpp.12646 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=299 The interplay of birth weight, dopamine receptor D4 gene (DRD4), and early maternal care in the prediction of disorganized attachment at 36 months of age / Ashley WAZANA in Development and Psychopathology, 27-4 (Part 1) (November 2015)
[article]
Titre : The interplay of birth weight, dopamine receptor D4 gene (DRD4), and early maternal care in the prediction of disorganized attachment at 36 months of age Type de document : Texte imprimé et/ou numérique Auteurs : Ashley WAZANA, Auteur ; Ellen MOSS, Auteur ; Alexis JOLICOEUR-MARTINEAU, Auteur ; Justin GRAFFI, Auteur ; Gal TSABARI, Auteur ; Vanessa LECOMPTE, Auteur ; Katherine PASCUZZO, Auteur ; Vanessa BABINEAU, Auteur ; Cathryn GORDON-GREEN, Auteur ; Viara MILEVA, Auteur ; Leslie ATKINSON, Auteur ; Klaus MINDE, Auteur ; Andrée-Anne BOUVETTE-TURCOT, Auteur ; Roberto SASSI, Auteur ; Martin ST.-ANDRE, Auteur ; Normand J. CARREY, Auteur ; Stephen MATTHEWS, Auteur ; Marla SOKOLOWSKI, Auteur ; John LYDON, Auteur ; Helene GAUDREAU, Auteur ; Meir STEINER, Auteur ; James L. KENNEDY, Auteur ; Alison FLEMING, Auteur ; Robert LEVITAN, Auteur ; Michael J. MEANEY, Auteur Année de publication : 2015 Article en page(s) : p.1145-1161 Langues : Anglais (eng) Index. décimale : PER Périodiques Résumé : Disorganized attachment is an important early risk factor for socioemotional problems throughout childhood and into adulthood. Prevailing models of the etiology of disorganized attachment emphasize the role of highly dysfunctional parenting, to the exclusion of complex models examining the interplay of child and parental factors. Decades of research have established that extreme child birth weight may have long-term effects on developmental processes. These effects are typically negative, but this is not always the case. Recent studies have also identified the dopamine D4 receptor (DRD4) as a moderator of childrearing effects on the development of disorganized attachment. However, there are inconsistent findings concerning which variant of the polymorphism (seven-repeat long-form allele or non–seven-repeat short-form allele) is most likely to interact with caregiving in predicting disorganized versus organized attachment. In this study, we examined possible two- and three-way interactions and child DRD4 polymorphisms and birth weight and maternal caregiving at age 6 months in longitudinally predicting attachment disorganization at 36 months. Our sample is from the Maternal Adversity, Vulnerability and Neurodevelopment project, a sample of 650 mother–child dyads. Birth weight was cross-referenced with normative data to calculate birth weight percentile. Infant DRD4 was obtained with buccal swabs and categorized according to the presence of the putative allele seven repeat. Macroanalytic and microanalytic measures of maternal behavior were extracted from a videotaped session of 20 min of nonfeeding interaction followed by a 10-min divided attention maternal task at 6 months. Attachment was assessed at 36 months using the Strange Situation procedure, and categorized into disorganized attachment and others. The results indicated that a main effect for DRD4 and a two-way interaction of birth weight and 6-month maternal attention (frequency of maternal looking away behavior) and sensitivity predicted disorganized attachment in robust logistic regression models adjusted for social demographic covariates. Specifically, children in the midrange of birth weight were more likely to develop a disorganized attachment when exposed to less attentive maternal care. However, the association reversed with extreme birth weight (low and high). The DRD4 seven-repeat allele was associated with less disorganized attachment (protective), while non–seven-repeat children were more likely to be classified as disorganized attachment. The implications for understanding inconsistencies in the literature about which DRD4 genotype is the risk direction are also considered. Suggestions for intervention with families with infants at different levels of biological risk and caregiving risk are also discussed. En ligne : http://dx.doi.org/10.1017/S0954579415000735 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=268
in Development and Psychopathology > 27-4 (Part 1) (November 2015) . - p.1145-1161[article] The interplay of birth weight, dopamine receptor D4 gene (DRD4), and early maternal care in the prediction of disorganized attachment at 36 months of age [Texte imprimé et/ou numérique] / Ashley WAZANA, Auteur ; Ellen MOSS, Auteur ; Alexis JOLICOEUR-MARTINEAU, Auteur ; Justin GRAFFI, Auteur ; Gal TSABARI, Auteur ; Vanessa LECOMPTE, Auteur ; Katherine PASCUZZO, Auteur ; Vanessa BABINEAU, Auteur ; Cathryn GORDON-GREEN, Auteur ; Viara MILEVA, Auteur ; Leslie ATKINSON, Auteur ; Klaus MINDE, Auteur ; Andrée-Anne BOUVETTE-TURCOT, Auteur ; Roberto SASSI, Auteur ; Martin ST.-ANDRE, Auteur ; Normand J. CARREY, Auteur ; Stephen MATTHEWS, Auteur ; Marla SOKOLOWSKI, Auteur ; John LYDON, Auteur ; Helene GAUDREAU, Auteur ; Meir STEINER, Auteur ; James L. KENNEDY, Auteur ; Alison FLEMING, Auteur ; Robert LEVITAN, Auteur ; Michael J. MEANEY, Auteur . - 2015 . - p.1145-1161.
Langues : Anglais (eng)
in Development and Psychopathology > 27-4 (Part 1) (November 2015) . - p.1145-1161
Index. décimale : PER Périodiques Résumé : Disorganized attachment is an important early risk factor for socioemotional problems throughout childhood and into adulthood. Prevailing models of the etiology of disorganized attachment emphasize the role of highly dysfunctional parenting, to the exclusion of complex models examining the interplay of child and parental factors. Decades of research have established that extreme child birth weight may have long-term effects on developmental processes. These effects are typically negative, but this is not always the case. Recent studies have also identified the dopamine D4 receptor (DRD4) as a moderator of childrearing effects on the development of disorganized attachment. However, there are inconsistent findings concerning which variant of the polymorphism (seven-repeat long-form allele or non–seven-repeat short-form allele) is most likely to interact with caregiving in predicting disorganized versus organized attachment. In this study, we examined possible two- and three-way interactions and child DRD4 polymorphisms and birth weight and maternal caregiving at age 6 months in longitudinally predicting attachment disorganization at 36 months. Our sample is from the Maternal Adversity, Vulnerability and Neurodevelopment project, a sample of 650 mother–child dyads. Birth weight was cross-referenced with normative data to calculate birth weight percentile. Infant DRD4 was obtained with buccal swabs and categorized according to the presence of the putative allele seven repeat. Macroanalytic and microanalytic measures of maternal behavior were extracted from a videotaped session of 20 min of nonfeeding interaction followed by a 10-min divided attention maternal task at 6 months. Attachment was assessed at 36 months using the Strange Situation procedure, and categorized into disorganized attachment and others. The results indicated that a main effect for DRD4 and a two-way interaction of birth weight and 6-month maternal attention (frequency of maternal looking away behavior) and sensitivity predicted disorganized attachment in robust logistic regression models adjusted for social demographic covariates. Specifically, children in the midrange of birth weight were more likely to develop a disorganized attachment when exposed to less attentive maternal care. However, the association reversed with extreme birth weight (low and high). The DRD4 seven-repeat allele was associated with less disorganized attachment (protective), while non–seven-repeat children were more likely to be classified as disorganized attachment. The implications for understanding inconsistencies in the literature about which DRD4 genotype is the risk direction are also considered. Suggestions for intervention with families with infants at different levels of biological risk and caregiving risk are also discussed. En ligne : http://dx.doi.org/10.1017/S0954579415000735 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=268