Centre d'Information et de documentation du CRA Rhône-Alpes
CRA
Informations pratiques
-
Adresse
Centre d'information et de documentation
du CRA Rhône-Alpes
Centre Hospitalier le Vinatier
bât 211
95, Bd Pinel
69678 Bron CedexHoraires
Lundi au Vendredi
9h00-12h00 13h30-16h00Contact
Tél: +33(0)4 37 91 54 65
Mail
Fax: +33(0)4 37 91 54 37
-
Détail de l'auteur
Auteur Samuel CARPENTER |
Documents disponibles écrits par cet auteur (1)
Faire une suggestion Affiner la recherche
Early life stress is associated with default system integrity and emotionality during infancy / Alice M. GRAHAM in Journal of Child Psychology and Psychiatry, 56-11 (November 2015)
[article]
Titre : Early life stress is associated with default system integrity and emotionality during infancy Type de document : Texte imprimé et/ou numérique Auteurs : Alice M. GRAHAM, Auteur ; Jennifer H. PFEIFER, Auteur ; Philip A. FISHER, Auteur ; Samuel CARPENTER, Auteur ; Damien A. FAIR, Auteur Article en page(s) : p.1212-1222 Langues : Anglais (eng) Mots-clés : Functional MRI infancy stress family functioning brain development Index. décimale : PER Périodiques Résumé : Background Extensive animal research has demonstrated the vulnerability of the brain to early life stress (ELS) with consequences for emotional development and mental health. However, the influence of moderate and common forms of stress on early human brain development is less well-understood and precisely characterized. To date, most work has focused on severe forms of stress, and/or on brain functioning years after stress exposure. Methods In this report we focused on conflict between parents (interparental conflict), a common and relatively moderate form of ELS that is highly relevant for children's mental health outcomes. We used resting state functional connectivity MRI to examine the coordinated functioning of the infant brain (N = 23; 6–12-months-of-age) in the context of interparental conflict. We focused on the default mode network (DMN) due to its well-characterized developmental trajectory and implications for mental health. We further examined DMN strength as a mediator between conflict and infants’ negative emotionality. Results Higher interparental conflict since birth was associated with infants showing stronger connectivity between two core DMN regions, the posterior cingulate cortex (PCC) and the anterior medial prefrontal cortex (aMPFC). PCC to amygdala connectivity was also increased. Stronger PCC-aMPFC connectivity mediated between higher conflict and higher negative infant emotionality. Conclusions The developing DMN may be an important marker for effects of ELS with relevance for emotional development and subsequent mental health. Increasing understanding of the associations between common forms of family stress and emerging functional brain networks has potential to inform intervention efforts to improve mental health outcomes. En ligne : http://dx.doi.org/10.1111/jcpp.12409 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=270
in Journal of Child Psychology and Psychiatry > 56-11 (November 2015) . - p.1212-1222[article] Early life stress is associated with default system integrity and emotionality during infancy [Texte imprimé et/ou numérique] / Alice M. GRAHAM, Auteur ; Jennifer H. PFEIFER, Auteur ; Philip A. FISHER, Auteur ; Samuel CARPENTER, Auteur ; Damien A. FAIR, Auteur . - p.1212-1222.
Langues : Anglais (eng)
in Journal of Child Psychology and Psychiatry > 56-11 (November 2015) . - p.1212-1222
Mots-clés : Functional MRI infancy stress family functioning brain development Index. décimale : PER Périodiques Résumé : Background Extensive animal research has demonstrated the vulnerability of the brain to early life stress (ELS) with consequences for emotional development and mental health. However, the influence of moderate and common forms of stress on early human brain development is less well-understood and precisely characterized. To date, most work has focused on severe forms of stress, and/or on brain functioning years after stress exposure. Methods In this report we focused on conflict between parents (interparental conflict), a common and relatively moderate form of ELS that is highly relevant for children's mental health outcomes. We used resting state functional connectivity MRI to examine the coordinated functioning of the infant brain (N = 23; 6–12-months-of-age) in the context of interparental conflict. We focused on the default mode network (DMN) due to its well-characterized developmental trajectory and implications for mental health. We further examined DMN strength as a mediator between conflict and infants’ negative emotionality. Results Higher interparental conflict since birth was associated with infants showing stronger connectivity between two core DMN regions, the posterior cingulate cortex (PCC) and the anterior medial prefrontal cortex (aMPFC). PCC to amygdala connectivity was also increased. Stronger PCC-aMPFC connectivity mediated between higher conflict and higher negative infant emotionality. Conclusions The developing DMN may be an important marker for effects of ELS with relevance for emotional development and subsequent mental health. Increasing understanding of the associations between common forms of family stress and emerging functional brain networks has potential to inform intervention efforts to improve mental health outcomes. En ligne : http://dx.doi.org/10.1111/jcpp.12409 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=270