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Détail de l'auteur
Auteur Motoaki NAKAMURA |
Documents disponibles écrits par cet auteur (2)
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Alterations of local spontaneous brain activity and connectivity in adults with high-functioning autism spectrum disorder / Takashi ITAHASHI in Molecular Autism, (May 2015)
[article]
Titre : Alterations of local spontaneous brain activity and connectivity in adults with high-functioning autism spectrum disorder Type de document : Texte imprimé et/ou numérique Auteurs : Takashi ITAHASHI, Auteur ; Takashi YAMADA, Auteur ; Hiromi WATANABE, Auteur ; Motoaki NAKAMURA, Auteur ; Haruhisa OHTA, Auteur ; Chieko KANAI, Auteur ; Akira IWANAMI, Auteur ; Nobumasa KATO, Auteur ; Ryu-ichiro HASHIMOTO, Auteur Article en page(s) : p.1-14 Langues : Anglais (eng) Index. décimale : PER Périodiques Résumé : Previous autism research has hypothesized that abnormalities of functional connectivity in autism spectrum disorder (ASD) may vary with the spatial distance between two brain regions. Although several resting-state functional magnetic resonance imaging (rsfMRI) studies have extensively examined long-range (or distant) connectivity in the adult ASD brain, short-range (or local) connectivity has been investigated in less depth. Furthermore, the possible relationship between functional connectivity and brain activity level during the resting state remains unclear. En ligne : http://dx.doi.org/10.1186/s13229-015-0026-z Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=277
in Molecular Autism > (May 2015) . - p.1-14[article] Alterations of local spontaneous brain activity and connectivity in adults with high-functioning autism spectrum disorder [Texte imprimé et/ou numérique] / Takashi ITAHASHI, Auteur ; Takashi YAMADA, Auteur ; Hiromi WATANABE, Auteur ; Motoaki NAKAMURA, Auteur ; Haruhisa OHTA, Auteur ; Chieko KANAI, Auteur ; Akira IWANAMI, Auteur ; Nobumasa KATO, Auteur ; Ryu-ichiro HASHIMOTO, Auteur . - p.1-14.
Langues : Anglais (eng)
in Molecular Autism > (May 2015) . - p.1-14
Index. décimale : PER Périodiques Résumé : Previous autism research has hypothesized that abnormalities of functional connectivity in autism spectrum disorder (ASD) may vary with the spatial distance between two brain regions. Although several resting-state functional magnetic resonance imaging (rsfMRI) studies have extensively examined long-range (or distant) connectivity in the adult ASD brain, short-range (or local) connectivity has been investigated in less depth. Furthermore, the possible relationship between functional connectivity and brain activity level during the resting state remains unclear. En ligne : http://dx.doi.org/10.1186/s13229-015-0026-z Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=277 White matter alterations in autism spectrum disorder and attention-deficit/hyperactivity disorder in relation to sensory profile / Haruhisa OHTA in Molecular Autism, 11 (2020)
[article]
Titre : White matter alterations in autism spectrum disorder and attention-deficit/hyperactivity disorder in relation to sensory profile Type de document : Texte imprimé et/ou numérique Auteurs : Haruhisa OHTA, Auteur ; Yuta AOKI, Auteur ; Takashi ITAHASHI, Auteur ; Chieko KANAI, Auteur ; Junya FUJINO, Auteur ; Motoaki NAKAMURA, Auteur ; Nobumasa KATO, Auteur ; Ryu-ichiro HASHIMOTO, Auteur Article en page(s) : 77 p. Langues : Anglais (eng) Mots-clés : Attention-deficit/hyperactivity disorder Autism spectrum disorder Developmental disorder Diffusion tensor imaging Sensory problem Index. décimale : PER Périodiques Résumé : BACKGROUND: Autism spectrum disorder (ASD) and attention-deficit/hyperactivity disorder (ADHD) have high rates of co-occurrence and share atypical behavioral characteristics, including sensory symptoms. The present diffusion tensor imaging (DTI) study was conducted to examine whether and how white matter alterations are observed in adult populations with developmental disorders (DD) and to determine how brain-sensory relationships are either shared between or distinct to ASD and ADHD. METHODS: We collected DTI data from adult population with DD (a primary diagnosis of ASD: n?=?105, ADHD: n =?55) as well as age- and sex-matched typically developing (TD) participants (n?=?58). Voxel-wise fractional anisotropy (FA), mean diffusivity, axial diffusivity, and radial diffusivity (RD) were analyzed using tract-based spatial statistics. The severities of sensory symptoms were assessed using the Adolescent/Adult Sensory Profile (AASP). RESULTS: Categorical analyses identified voxel clusters showing significant effects of DD on FA and RD in the posterior portion of the corpus callosum and its extension in the right hemisphere. Furthermore, regression analyses using the AASP scores revealed that slopes in relationships of FA or RD with the degree of sensory symptoms were parallel between the two DDs in large parts of the affected corpus callosum regions. A small but significant cluster did exist showing difference in association between an AASP subscale score and RD across ASD and ADHD. LIMITATIONS: Wide age range of the participants may be oversimplified. CONCLUSIONS: These results indicate that white matter alteration and their relationships to sensory symptoms are largely shared between ASD and ADHD, with localized abnormalities showing significant between-diagnosis differences within DD. En ligne : http://dx.doi.org/10.1186/s13229-020-00379-6 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=433
in Molecular Autism > 11 (2020) . - 77 p.[article] White matter alterations in autism spectrum disorder and attention-deficit/hyperactivity disorder in relation to sensory profile [Texte imprimé et/ou numérique] / Haruhisa OHTA, Auteur ; Yuta AOKI, Auteur ; Takashi ITAHASHI, Auteur ; Chieko KANAI, Auteur ; Junya FUJINO, Auteur ; Motoaki NAKAMURA, Auteur ; Nobumasa KATO, Auteur ; Ryu-ichiro HASHIMOTO, Auteur . - 77 p.
Langues : Anglais (eng)
in Molecular Autism > 11 (2020) . - 77 p.
Mots-clés : Attention-deficit/hyperactivity disorder Autism spectrum disorder Developmental disorder Diffusion tensor imaging Sensory problem Index. décimale : PER Périodiques Résumé : BACKGROUND: Autism spectrum disorder (ASD) and attention-deficit/hyperactivity disorder (ADHD) have high rates of co-occurrence and share atypical behavioral characteristics, including sensory symptoms. The present diffusion tensor imaging (DTI) study was conducted to examine whether and how white matter alterations are observed in adult populations with developmental disorders (DD) and to determine how brain-sensory relationships are either shared between or distinct to ASD and ADHD. METHODS: We collected DTI data from adult population with DD (a primary diagnosis of ASD: n?=?105, ADHD: n =?55) as well as age- and sex-matched typically developing (TD) participants (n?=?58). Voxel-wise fractional anisotropy (FA), mean diffusivity, axial diffusivity, and radial diffusivity (RD) were analyzed using tract-based spatial statistics. The severities of sensory symptoms were assessed using the Adolescent/Adult Sensory Profile (AASP). RESULTS: Categorical analyses identified voxel clusters showing significant effects of DD on FA and RD in the posterior portion of the corpus callosum and its extension in the right hemisphere. Furthermore, regression analyses using the AASP scores revealed that slopes in relationships of FA or RD with the degree of sensory symptoms were parallel between the two DDs in large parts of the affected corpus callosum regions. A small but significant cluster did exist showing difference in association between an AASP subscale score and RD across ASD and ADHD. LIMITATIONS: Wide age range of the participants may be oversimplified. CONCLUSIONS: These results indicate that white matter alteration and their relationships to sensory symptoms are largely shared between ASD and ADHD, with localized abnormalities showing significant between-diagnosis differences within DD. En ligne : http://dx.doi.org/10.1186/s13229-020-00379-6 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=433