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Auteur Marie-Julie ALLARD |
Documents disponibles écrits par cet auteur (1)
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A sexually dichotomous, autistic-like phenotype is induced by Group B Streptococcus maternofetal immune activation / Marie-Julie ALLARD in Autism Research, 10-2 (February 2017)
[article]
Titre : A sexually dichotomous, autistic-like phenotype is induced by Group B Streptococcus maternofetal immune activation Type de document : Texte imprimé et/ou numérique Auteurs : Marie-Julie ALLARD, Auteur ; Julie D. BERGERON, Auteur ; Moogeh BAHARNOORI, Auteur ; Lalit K. SRIVASTAVA, Auteur ; Louis-Charles FORTIER, Auteur ; Claire POYART, Auteur ; Guillaume SEBIRE, Auteur Article en page(s) : p.233-245 Langues : Anglais (eng) Mots-clés : autism spectrum disorders behavior chorioamnionitis Group B Streptococcus inflammation prenatal infection Index. décimale : PER Périodiques Résumé : Group B Streptococcus (GBS) is a commensal bacterium present in the lower genital tract of 15–30% of healthy pregnant women. GBS is the leading cause of chorioamnionitis and cerebral injuries in newborns, occurring most often in the absence of maternofetal pathogen translocation. Despite GBS being the most frequent bacterium colonizing pregnant women, no preclinical studies have investigated the impact of end-gestational maternal GBS exposure on the offspring's brain development and its behavioral correlates. Our hypothesis is that GBS-induced gestational infection/inflammation has a deleterious neurodevelopmental impact on uninfected offspring. Our goal was to study the impact of maternal GBS infection on the placental and neurodevelopmental features in the offspring using a new preclinical rat model. GBS-exposed placentas exhibited chorioamnionitis characterized by the presence of Gram-positive cocci and polymorphonuclear cells, with the latter being significantly more prominent in the labyrinth of male offspring. GBS-exposed male offspring had reduced thickness of periventricular white matter. In addition, they exhibited autistic-like behaviors, such as abnormal social interaction and communication, impaired processing of sensory information and hyperactivity. Overall, these data show for the first time that gestational exposure to GBS plays an important role in the generation of neurodevelopmental abnormalities reminiscent of human autism spectrum disorders (ASD). These results provide new evidence in favor of the role of a common and modifiable infectious/inflammatory environmental factor in human ASD pathophysiology. En ligne : http://dx.doi.org/10.1002/aur.1647 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=303
in Autism Research > 10-2 (February 2017) . - p.233-245[article] A sexually dichotomous, autistic-like phenotype is induced by Group B Streptococcus maternofetal immune activation [Texte imprimé et/ou numérique] / Marie-Julie ALLARD, Auteur ; Julie D. BERGERON, Auteur ; Moogeh BAHARNOORI, Auteur ; Lalit K. SRIVASTAVA, Auteur ; Louis-Charles FORTIER, Auteur ; Claire POYART, Auteur ; Guillaume SEBIRE, Auteur . - p.233-245.
Langues : Anglais (eng)
in Autism Research > 10-2 (February 2017) . - p.233-245
Mots-clés : autism spectrum disorders behavior chorioamnionitis Group B Streptococcus inflammation prenatal infection Index. décimale : PER Périodiques Résumé : Group B Streptococcus (GBS) is a commensal bacterium present in the lower genital tract of 15–30% of healthy pregnant women. GBS is the leading cause of chorioamnionitis and cerebral injuries in newborns, occurring most often in the absence of maternofetal pathogen translocation. Despite GBS being the most frequent bacterium colonizing pregnant women, no preclinical studies have investigated the impact of end-gestational maternal GBS exposure on the offspring's brain development and its behavioral correlates. Our hypothesis is that GBS-induced gestational infection/inflammation has a deleterious neurodevelopmental impact on uninfected offspring. Our goal was to study the impact of maternal GBS infection on the placental and neurodevelopmental features in the offspring using a new preclinical rat model. GBS-exposed placentas exhibited chorioamnionitis characterized by the presence of Gram-positive cocci and polymorphonuclear cells, with the latter being significantly more prominent in the labyrinth of male offspring. GBS-exposed male offspring had reduced thickness of periventricular white matter. In addition, they exhibited autistic-like behaviors, such as abnormal social interaction and communication, impaired processing of sensory information and hyperactivity. Overall, these data show for the first time that gestational exposure to GBS plays an important role in the generation of neurodevelopmental abnormalities reminiscent of human autism spectrum disorders (ASD). These results provide new evidence in favor of the role of a common and modifiable infectious/inflammatory environmental factor in human ASD pathophysiology. En ligne : http://dx.doi.org/10.1002/aur.1647 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=303