Shaping long-term primate development: Telomere length trajectory as an indicator of early maternal maltreatment and predictor of future physiologic regulation / Stacy S. DRURY in Development and Psychopathology, 29-5 (December 2017)  

Public ISBD [article]  inDevelopment and Psychopathology > 29-5 (December 2017) . - p.1539-1551 Titre : Shaping long-term primate development: Telomere length trajectory as an indicator of early maternal maltreatment and predictor of future physiologic regulation Type de document : Texte imprimé et/ou numérique Auteurs : Stacy S. DRURY, Auteur ; Brittany R. HOWELL, Auteur ; Christopher JONES, Auteur ; Kyle ESTEVES, Auteur ; Elyse MORIN, Auteur ; Reid SCHLESINGER, Auteur ; Jerrold S. MEYER, Auteur ; Kate BAKER, Auteur ; Mar M. SANCHEZ, Auteur Article en page(s) : p.1539-1551 Langues : Anglais (eng) Index. décimale : PER Périodiques Résumé : The molecular, neurobiological, and physical health impacts of child maltreatment are well established, yet mechanistic pathways remain inadequately defined. Telomere length (TL) decline is an emerging molecular indicator of stress exposure with definitive links to negative health outcomes in maltreated individuals. The multiple confounders endemic to human maltreatment research impede the identification of causal pathways. This study leverages a unique randomized, cross-foster, study design in a naturalistic translational nonhuman primate model of infant maltreatment. At birth, newborn macaques were randomly assigned to either a maltreating or a competent control mother, balancing for sex, biological mother parenting history, and social rank. Offspring TL was measured longitudinally across the first 6 months of life (infancy) from peripheral blood. Hair cortisol accumulation was also determined at 6, 12, and 18 months of age. TL decline was greater in animals randomized to maltreatment, but also interacted with biological mother group. Shorter TL at 6 months was associated with higher mean cortisol levels through 18 months (juvenile period) when controlling for relevant covariates. These results suggest that even under the equivalent social, nutritional, and environmental conditions feasible in naturalistic translational nonhuman primate models, early adverse caregiving results in lasting molecular scars that foreshadow elevated health risk and physiologic dysregulation. En ligne : http://dx.doi.org/10.1017/S0954579417001225 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=323 [article] Shaping long-term primate development: Telomere length trajectory as an indicator of early maternal maltreatment and predictor of future physiologic regulation [Texte imprimé et/ou numérique] / Stacy S. DRURY, Auteur ; Brittany R. HOWELL, Auteur ; Christopher JONES, Auteur ; Kyle ESTEVES, Auteur ; Elyse MORIN, Auteur ; Reid SCHLESINGER, Auteur ; Jerrold S. MEYER, Auteur ; Kate BAKER, Auteur ; Mar M. SANCHEZ, Auteur . - p.1539-1551. Langues : Anglais (eng) in Development and Psychopathology > 29-5 (December 2017) . - p.1539-1551 Index. décimale : PER Périodiques Résumé : The molecular, neurobiological, and physical health impacts of child maltreatment are well established, yet mechanistic pathways remain inadequately defined. Telomere length (TL) decline is an emerging molecular indicator of stress exposure with definitive links to negative health outcomes in maltreated individuals. The multiple confounders endemic to human maltreatment research impede the identification of causal pathways. This study leverages a unique randomized, cross-foster, study design in a naturalistic translational nonhuman primate model of infant maltreatment. At birth, newborn macaques were randomly assigned to either a maltreating or a competent control mother, balancing for sex, biological mother parenting history, and social rank. Offspring TL was measured longitudinally across the first 6 months of life (infancy) from peripheral blood. Hair cortisol accumulation was also determined at 6, 12, and 18 months of age. TL decline was greater in animals randomized to maltreatment, but also interacted with biological mother group. Shorter TL at 6 months was associated with higher mean cortisol levels through 18 months (juvenile period) when controlling for relevant covariates. These results suggest that even under the equivalent social, nutritional, and environmental conditions feasible in naturalistic translational nonhuman primate models, early adverse caregiving results in lasting molecular scars that foreshadow elevated health risk and physiologic dysregulation. En ligne : http://dx.doi.org/10.1017/S0954579417001225 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=323

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