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Détail de l'auteur
Auteur Elizabeth M. POWELL |
Documents disponibles écrits par cet auteur (2)
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Loss of skills and onset patterns in neurodevelopmental disorders: Understanding the neurobiological mechanisms / Audrey THURM in Autism Research, 11-2 (February 2018)
[article]
Titre : Loss of skills and onset patterns in neurodevelopmental disorders: Understanding the neurobiological mechanisms Type de document : Texte imprimé et/ou numérique Auteurs : Audrey THURM, Auteur ; Elizabeth M. POWELL, Auteur ; Jeffrey L. NEUL, Auteur ; Ann WAGNER, Auteur ; Lonnie ZWAIGENBAUM, Auteur Année de publication : 2018 Article en page(s) : p.212-222 Langues : Anglais (eng) Index. décimale : PER Périodiques Résumé : Patterns of onset in Autism Spectrum Disorder, including a pattern that includes loss of previously acquired skills, have been identified since the first reports of the disorder. However, attempts to study such “regression” have been limited to clinical studies, that until recently mostly involved retrospective reports. The current report reflects discussion that occurred at an NIMH convened meeting in 2016 with the purpose of bridging clinical autism research with basic and translational work in this area. This summary describes the state of the field with respect to clinical studies, describing gaps in knowledge based on limited methods and prospective data collected. Biological mechanisms that have been shown to account for regression early in development in specific conditions are discussed, as well as potential mechanisms that have not yet been explored. Suggestions include use of model systems during the developmental period and cutting?edge methods, including non?invasive imaging that may afford opportunities for a better understanding of the neurobiological pathways that result in loss of previously?attained skills. Autism Res 2018, 11: 212–222. © 2017 International Society for Autism Research, Wiley Periodicals, Inc. Lay Summary Loss of previously acquired skills, or regression, has been reported in Autism Spectrum Disorder since Kanner's reports in the 1950's. The current report reflects discussion from an NIMH convened meeting in 2016 with the purpose of bridging clinical autism research with basic and translational work in this area. This summary describes the state of the field regarding clinical studies and suggests use of model systems during the developmental period and cutting?edge methods, for a better understanding of the neurobiological pathways that result in loss of previously?attained skills. En ligne : https://doi.org/10.1002/aur.1903 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=334
in Autism Research > 11-2 (February 2018) . - p.212-222[article] Loss of skills and onset patterns in neurodevelopmental disorders: Understanding the neurobiological mechanisms [Texte imprimé et/ou numérique] / Audrey THURM, Auteur ; Elizabeth M. POWELL, Auteur ; Jeffrey L. NEUL, Auteur ; Ann WAGNER, Auteur ; Lonnie ZWAIGENBAUM, Auteur . - 2018 . - p.212-222.
Langues : Anglais (eng)
in Autism Research > 11-2 (February 2018) . - p.212-222
Index. décimale : PER Périodiques Résumé : Patterns of onset in Autism Spectrum Disorder, including a pattern that includes loss of previously acquired skills, have been identified since the first reports of the disorder. However, attempts to study such “regression” have been limited to clinical studies, that until recently mostly involved retrospective reports. The current report reflects discussion that occurred at an NIMH convened meeting in 2016 with the purpose of bridging clinical autism research with basic and translational work in this area. This summary describes the state of the field with respect to clinical studies, describing gaps in knowledge based on limited methods and prospective data collected. Biological mechanisms that have been shown to account for regression early in development in specific conditions are discussed, as well as potential mechanisms that have not yet been explored. Suggestions include use of model systems during the developmental period and cutting?edge methods, including non?invasive imaging that may afford opportunities for a better understanding of the neurobiological pathways that result in loss of previously?attained skills. Autism Res 2018, 11: 212–222. © 2017 International Society for Autism Research, Wiley Periodicals, Inc. Lay Summary Loss of previously acquired skills, or regression, has been reported in Autism Spectrum Disorder since Kanner's reports in the 1950's. The current report reflects discussion from an NIMH convened meeting in 2016 with the purpose of bridging clinical autism research with basic and translational work in this area. This summary describes the state of the field regarding clinical studies and suggests use of model systems during the developmental period and cutting?edge methods, for a better understanding of the neurobiological pathways that result in loss of previously?attained skills. En ligne : https://doi.org/10.1002/aur.1903 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=334 Mice with Impaired Met Tyrosine Kinase Signaling Demonstrate Characteristics Relevant to Autism / Jacob M. SMITH in Autism - Open Access, 2-S ([01/12/2012])
[article]
Titre : Mice with Impaired Met Tyrosine Kinase Signaling Demonstrate Characteristics Relevant to Autism Type de document : Texte imprimé et/ou numérique Auteurs : Jacob M. SMITH, Auteur ; Elizabeth M. POWELL, Auteur Article en page(s) : 8 p. Langues : Anglais (eng) Mots-clés : HGF MET Interneuron Forebrain Attentional set-shifting Reversal learning Seizure Plaur Index. décimale : PER Périodiques Résumé : Variants of MET, a receptor tyrosine kinase which binds the ligand Hepatocyte growth factor (HGF), have been linked to elevated risk for developing autism spectrum disorders (ASD) in humans. Though best known as a proto-oncogene, MET also plays important roles during normal development, including the development of the central nervous system. Recent studies in several mouse lines have shown that mice with reduced HGF-Met signaling have altered profiles of interneurons in the cortex, striatum, and hippocampus. Alterations in neuronal development, particularly in the cerebral cortex, may contribute to the pathology of developmental disorders, including autism. Other studies have shown changes in excitatory signaling in the Met-deficient cortex. Interestingly, mice with deficient Met signaling also show behavioral alterations characteristic of autism. Here we review anatomical and behavioral findings in mice with altered HGF - Met signaling. En ligne : https://dx.doi.org/10.4172/2165-7890.S1-002 ER - Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=409
in Autism - Open Access > 2-S [01/12/2012] . - 8 p.[article] Mice with Impaired Met Tyrosine Kinase Signaling Demonstrate Characteristics Relevant to Autism [Texte imprimé et/ou numérique] / Jacob M. SMITH, Auteur ; Elizabeth M. POWELL, Auteur . - 8 p.
Langues : Anglais (eng)
in Autism - Open Access > 2-S [01/12/2012] . - 8 p.
Mots-clés : HGF MET Interneuron Forebrain Attentional set-shifting Reversal learning Seizure Plaur Index. décimale : PER Périodiques Résumé : Variants of MET, a receptor tyrosine kinase which binds the ligand Hepatocyte growth factor (HGF), have been linked to elevated risk for developing autism spectrum disorders (ASD) in humans. Though best known as a proto-oncogene, MET also plays important roles during normal development, including the development of the central nervous system. Recent studies in several mouse lines have shown that mice with reduced HGF-Met signaling have altered profiles of interneurons in the cortex, striatum, and hippocampus. Alterations in neuronal development, particularly in the cerebral cortex, may contribute to the pathology of developmental disorders, including autism. Other studies have shown changes in excitatory signaling in the Met-deficient cortex. Interestingly, mice with deficient Met signaling also show behavioral alterations characteristic of autism. Here we review anatomical and behavioral findings in mice with altered HGF - Met signaling. En ligne : https://dx.doi.org/10.4172/2165-7890.S1-002 ER - Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=409