Early childhood social communication deficits in youth at clinical high-risk for psychosis: Associations with functioning and risk / K. Juston OSBORNE in Development and Psychopathology, 32-2 (May 2020)  

Public ISBD [article]  inDevelopment and Psychopathology > 32-2 (May 2020) . - p.559-572 Titre : Early childhood social communication deficits in youth at clinical high-risk for psychosis: Associations with functioning and risk Type de document : Texte imprimé et/ou numérique Auteurs : K. Juston OSBORNE, Auteur ; Teresa VARGAS, Auteur ; Vijay A. MITTAL, Auteur Article en page(s) : p.559-572 Langues : Anglais (eng) Mots-clés : clinical high-risk  early childhood  premorbid  psychosis  social communication Index. décimale : PER Périodiques Résumé : Effective social functioning requires a broad range of social communication skills that are impaired in psychosis populations. However, little is known about early childhood (4- to 5-year period) social communication during the premorbid (pre-illness) stage of psychosis. The present study utilized retrospective parent reports to examine total early childhood social communication deficits, as well as deficits in two distinct domains, reciprocal social interaction (social smiling/eye gaze) and communication (social chat/gesture), in youth at clinical high-risk (CHR) for psychosis (ages 13-21; 37.2% female). Furthermore, associations between early childhood social communication and CHR youth's current functioning (social, academic/work), symptoms (positive/negative), and risk for conversion to psychosis were examined. Compared to healthy controls, CHR individuals had greater deficits in total and communication-specific early childhood social communication. Early childhood total, communication, and reciprocal social interaction deficits were associated with worse current functioning and greater current negative symptom severity (amotivation/anhedonia) in CHR youth. Early childhood total and reciprocal social interaction deficits were also associated with increased risk for conversion. These findings inform the field's understanding of the etiology and pathophysiology of psychosis by extending the current developmental literature on premorbid deficits in psychosis populations to specific domains of social behavior in a critical developmental period. En ligne : http://dx.doi.org/10.1017/s0954579419000385 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=426 [article] Early childhood social communication deficits in youth at clinical high-risk for psychosis: Associations with functioning and risk [Texte imprimé et/ou numérique] / K. Juston OSBORNE, Auteur ; Teresa VARGAS, Auteur ; Vijay A. MITTAL, Auteur . - p.559-572. Langues : Anglais (eng) in Development and Psychopathology > 32-2 (May 2020) . - p.559-572 Mots-clés : clinical high-risk  early childhood  premorbid  psychosis  social communication Index. décimale : PER Périodiques Résumé : Effective social functioning requires a broad range of social communication skills that are impaired in psychosis populations. However, little is known about early childhood (4- to 5-year period) social communication during the premorbid (pre-illness) stage of psychosis. The present study utilized retrospective parent reports to examine total early childhood social communication deficits, as well as deficits in two distinct domains, reciprocal social interaction (social smiling/eye gaze) and communication (social chat/gesture), in youth at clinical high-risk (CHR) for psychosis (ages 13-21; 37.2% female). Furthermore, associations between early childhood social communication and CHR youth's current functioning (social, academic/work), symptoms (positive/negative), and risk for conversion to psychosis were examined. Compared to healthy controls, CHR individuals had greater deficits in total and communication-specific early childhood social communication. Early childhood total, communication, and reciprocal social interaction deficits were associated with worse current functioning and greater current negative symptom severity (amotivation/anhedonia) in CHR youth. Early childhood total and reciprocal social interaction deficits were also associated with increased risk for conversion. These findings inform the field's understanding of the etiology and pathophysiology of psychosis by extending the current developmental literature on premorbid deficits in psychosis populations to specific domains of social behavior in a critical developmental period. En ligne : http://dx.doi.org/10.1017/s0954579419000385 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=426

Translating RDoC to real-world impact in developmental psychopathology: A neurodevelopmental framework for application of mental health risk calculators / Leigha A. MACNEILL in Development and Psychopathology, 33-5 (December 2021)  

Public ISBD [article]  inDevelopment and Psychopathology > 33-5 (December 2021) . - p.1665-1684 Titre : Translating RDoC to real-world impact in developmental psychopathology: A neurodevelopmental framework for application of mental health risk calculators Type de document : Texte imprimé et/ou numérique Auteurs : Leigha A. MACNEILL, Auteur ; Norrina B. ALLEN, Auteur ; Roshaye B. POLEON, Auteur ; Teresa VARGAS, Auteur ; K. Juston OSBORNE, Auteur ; Katherine S. F. DAMME, Auteur ; Deanna M. BARCH, Auteur ; Sheila KROGH-JESPERSEN, Auteur ; Ashley N. NIELSEN, Auteur ; Elizabeth S. NORTON, Auteur ; Christopher D. SMYSER, Auteur ; Cynthia E. ROGERS, Auteur ; Joan L. LUBY, Auteur ; Vijay A. MITTAL, Auteur ; Lauren S. WAKSCHLAG, Auteur Article en page(s) : p.1665-1684 Langues : Anglais (eng) Mots-clés : developmental change  prevention/intervention  psychopathology  RDoC  risk calculator Index. décimale : PER Périodiques Résumé : The National Institute of Mental Health's Research Domain Criteria (RDoC) framework has prompted a paradigm shift from categorical psychiatric disorders to considering multiple levels of vulnerability for probabilistic risk of disorder. However, the lack of neurodevelopmentally based tools for clinical decision making has limited the real-world impact of the RDoC. Integration with developmental psychopathology principles and statistical methods actualize the clinical implementation of RDoC to inform neurodevelopmental risk. In this conceptual paper, we introduce the probabilistic mental health risk calculator as an innovation for such translation and lay out a research agenda for generating an RDoC- and developmentally informed paradigm that could be applied to predict a range of developmental psychopathologies from early childhood to young adulthood. We discuss methods that weigh the incremental utility for prediction based on intensity and burden of assessment, the addition of developmental change patterns, considerations for assessing outcomes, and integrative data approaches. Throughout, we illustrate the risk calculator approach with different neurodevelopmental pathways and phenotypes. Finally, we discuss real-world implementation of these methods for improving early identification and prevention of developmental psychopathology. We propose that mental health risk calculators can build a needed bridge between the RDoC multiple units of analysis and developmental science. En ligne : http://dx.doi.org/10.1017/S0954579421000651 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=457 [article] Translating RDoC to real-world impact in developmental psychopathology: A neurodevelopmental framework for application of mental health risk calculators [Texte imprimé et/ou numérique] / Leigha A. MACNEILL, Auteur ; Norrina B. ALLEN, Auteur ; Roshaye B. POLEON, Auteur ; Teresa VARGAS, Auteur ; K. Juston OSBORNE, Auteur ; Katherine S. F. DAMME, Auteur ; Deanna M. BARCH, Auteur ; Sheila KROGH-JESPERSEN, Auteur ; Ashley N. NIELSEN, Auteur ; Elizabeth S. NORTON, Auteur ; Christopher D. SMYSER, Auteur ; Cynthia E. ROGERS, Auteur ; Joan L. LUBY, Auteur ; Vijay A. MITTAL, Auteur ; Lauren S. WAKSCHLAG, Auteur . - p.1665-1684. Langues : Anglais (eng) in Development and Psychopathology > 33-5 (December 2021) . - p.1665-1684 Mots-clés : developmental change  prevention/intervention  psychopathology  RDoC  risk calculator Index. décimale : PER Périodiques Résumé : The National Institute of Mental Health's Research Domain Criteria (RDoC) framework has prompted a paradigm shift from categorical psychiatric disorders to considering multiple levels of vulnerability for probabilistic risk of disorder. However, the lack of neurodevelopmentally based tools for clinical decision making has limited the real-world impact of the RDoC. Integration with developmental psychopathology principles and statistical methods actualize the clinical implementation of RDoC to inform neurodevelopmental risk. In this conceptual paper, we introduce the probabilistic mental health risk calculator as an innovation for such translation and lay out a research agenda for generating an RDoC- and developmentally informed paradigm that could be applied to predict a range of developmental psychopathologies from early childhood to young adulthood. We discuss methods that weigh the incremental utility for prediction based on intensity and burden of assessment, the addition of developmental change patterns, considerations for assessing outcomes, and integrative data approaches. Throughout, we illustrate the risk calculator approach with different neurodevelopmental pathways and phenotypes. Finally, we discuss real-world implementation of these methods for improving early identification and prevention of developmental psychopathology. We propose that mental health risk calculators can build a needed bridge between the RDoC multiple units of analysis and developmental science. En ligne : http://dx.doi.org/10.1017/S0954579421000651 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=457

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