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Détail de l'auteur
Auteur Mary A. CARSKADON |
Documents disponibles écrits par cet auteur (2)
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Editorial Perspective: Adolescents' fragile sleep-shining light on a time of risk to mental health / Mary A. CARSKADON in Journal of Child Psychology and Psychiatry, 61-10 (October 2020)
[article]
Titre : Editorial Perspective: Adolescents' fragile sleep-shining light on a time of risk to mental health Type de document : Texte imprimé et/ou numérique Auteurs : Mary A. CARSKADON, Auteur ; David H. BARKER, Auteur Article en page(s) : p.1058-1060 Langues : Anglais (eng) Index. décimale : PER Périodiques Résumé : As many other facets of life-biological, behavioral, psychological, cognitive, and social-undergo change during adolescence, so too does sleep. The context of sleep behavior is modified by alterations to underlying bioregulatory processes that challenge sleep's timing, regularity, and quantity. The buildup of sleep pressure during the day gets slower, opening the door for youth to stay awake later; however, the amount of sleep required does not diminish. Further, the circadian timing system delays, again providing the biological impetus for later sleep. When these changes meet societal demands for early wake, most teens cannot find a way to get enough sleep at a consistent time from night to night. Insufficient and irregular sleep provides a fragile foundation to support mental health. En ligne : http://dx.doi.org/10.1111/jcpp.13275 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=432
in Journal of Child Psychology and Psychiatry > 61-10 (October 2020) . - p.1058-1060[article] Editorial Perspective: Adolescents' fragile sleep-shining light on a time of risk to mental health [Texte imprimé et/ou numérique] / Mary A. CARSKADON, Auteur ; David H. BARKER, Auteur . - p.1058-1060.
Langues : Anglais (eng)
in Journal of Child Psychology and Psychiatry > 61-10 (October 2020) . - p.1058-1060
Index. décimale : PER Périodiques Résumé : As many other facets of life-biological, behavioral, psychological, cognitive, and social-undergo change during adolescence, so too does sleep. The context of sleep behavior is modified by alterations to underlying bioregulatory processes that challenge sleep's timing, regularity, and quantity. The buildup of sleep pressure during the day gets slower, opening the door for youth to stay awake later; however, the amount of sleep required does not diminish. Further, the circadian timing system delays, again providing the biological impetus for later sleep. When these changes meet societal demands for early wake, most teens cannot find a way to get enough sleep at a consistent time from night to night. Insufficient and irregular sleep provides a fragile foundation to support mental health. En ligne : http://dx.doi.org/10.1111/jcpp.13275 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=432 Genome-wide DNA methylation patterns associated with sleep and mental health in children: a population-based study / Maria Elisabeth KOOPMAN-VERHOEFF in Journal of Child Psychology and Psychiatry, 61-10 (October 2020)
[article]
Titre : Genome-wide DNA methylation patterns associated with sleep and mental health in children: a population-based study Type de document : Texte imprimé et/ou numérique Auteurs : Maria Elisabeth KOOPMAN-VERHOEFF, Auteur ; Rosa H. MULDER, Auteur ; Jared M. SALETIN, Auteur ; Irwin REISS, Auteur ; Gijsbertus T. J. VAN DER HORST, Auteur ; Janine F. FELIX, Auteur ; Mary A. CARSKADON, Auteur ; Henning TIEMEIER, Auteur ; Charlotte A. M. CECIL, Auteur Article en page(s) : p.1061-1069 Langues : Anglais (eng) Mots-clés : DNA methylation accelerometer epigenetics epigenome psychopathology sleep Index. décimale : PER Périodiques Résumé : BACKGROUND: DNA methylation (DNAm) has been implicated in the biology of sleep. Yet, how DNAm patterns across the genome relate to different sleep outcomes, and whether these associations overlap with mental health is currently unknown. Here, we investigated associations of DNAm with sleep and mental health in a pediatric population. METHODS: This cross-sectional study included 465 10-year-old children (51.3% female) from the Generation R Study. Genome-wide DNAm levels were measured using the Illumina 450K array (peripheral blood). Sleep problems were assessed from self-report and mental health outcomes from maternal questionnaires. Wrist actigraphy was used in 188 11-year-old children to calculate sleep duration and midpoint sleep. Weighted gene co-expression network analysis was used to identify highly comethylated DNAm 'modules', which were tested for associations with sleep and mental health outcomes. RESULTS: We identified 64 DNAm modules, one of which associated with sleep duration after covariate and multiple testing adjustment. This module included CpG sites spanning 9 genes on chromosome 17, including MAPT - a key regulator of Tau proteins in the brain involved in neuronal function - as well as genes previously implicated in sleep duration. Follow-up analyses suggested that DNAm variation in this region is under considerable genetic control and shows strong blood-brain concordance. DNAm modules associated with sleep did not overlap with those associated with mental health. CONCLUSIONS: We identified one DNAm region associated with sleep duration, including genes previously reported by recent GWAS studies. Further research is warranted to examine the functional role of this region and its longitudinal association with sleep. En ligne : http://dx.doi.org/10.1111/jcpp.13252 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=432
in Journal of Child Psychology and Psychiatry > 61-10 (October 2020) . - p.1061-1069[article] Genome-wide DNA methylation patterns associated with sleep and mental health in children: a population-based study [Texte imprimé et/ou numérique] / Maria Elisabeth KOOPMAN-VERHOEFF, Auteur ; Rosa H. MULDER, Auteur ; Jared M. SALETIN, Auteur ; Irwin REISS, Auteur ; Gijsbertus T. J. VAN DER HORST, Auteur ; Janine F. FELIX, Auteur ; Mary A. CARSKADON, Auteur ; Henning TIEMEIER, Auteur ; Charlotte A. M. CECIL, Auteur . - p.1061-1069.
Langues : Anglais (eng)
in Journal of Child Psychology and Psychiatry > 61-10 (October 2020) . - p.1061-1069
Mots-clés : DNA methylation accelerometer epigenetics epigenome psychopathology sleep Index. décimale : PER Périodiques Résumé : BACKGROUND: DNA methylation (DNAm) has been implicated in the biology of sleep. Yet, how DNAm patterns across the genome relate to different sleep outcomes, and whether these associations overlap with mental health is currently unknown. Here, we investigated associations of DNAm with sleep and mental health in a pediatric population. METHODS: This cross-sectional study included 465 10-year-old children (51.3% female) from the Generation R Study. Genome-wide DNAm levels were measured using the Illumina 450K array (peripheral blood). Sleep problems were assessed from self-report and mental health outcomes from maternal questionnaires. Wrist actigraphy was used in 188 11-year-old children to calculate sleep duration and midpoint sleep. Weighted gene co-expression network analysis was used to identify highly comethylated DNAm 'modules', which were tested for associations with sleep and mental health outcomes. RESULTS: We identified 64 DNAm modules, one of which associated with sleep duration after covariate and multiple testing adjustment. This module included CpG sites spanning 9 genes on chromosome 17, including MAPT - a key regulator of Tau proteins in the brain involved in neuronal function - as well as genes previously implicated in sleep duration. Follow-up analyses suggested that DNAm variation in this region is under considerable genetic control and shows strong blood-brain concordance. DNAm modules associated with sleep did not overlap with those associated with mental health. CONCLUSIONS: We identified one DNAm region associated with sleep duration, including genes previously reported by recent GWAS studies. Further research is warranted to examine the functional role of this region and its longitudinal association with sleep. En ligne : http://dx.doi.org/10.1111/jcpp.13252 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=432