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Auteur Mario LA ROSA |
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Treatment of infantile spasms with sodium dipropylacetic acid / Lorenzo PAVONE in Developmental Medicine & Child Neurology, 23-4 (August 1981)
[article]
Titre : Treatment of infantile spasms with sodium dipropylacetic acid Type de document : Texte imprimé et/ou numérique Auteurs : Lorenzo PAVONE, Auteur ; Florindo MOLLICA, Auteur ; Gemma INCORPORA, Auteur ; Mario LA ROSA, Auteur ; Salvatore LI VOLTI, Auteur Année de publication : 1981 Article en page(s) : p.454-461 Langues : Anglais (eng) Index. décimale : PER Périodiques Résumé : Eighteen infants with infantile spasms were given sodium dipropylacetate at a dosage of 20mg/kg/day. They were clinically examined before treatment, and again after one to three years of therapy. The short-term clinical response was excellent in four patients, good in eight, poor in four and there was no change in two. At follow-up, two patients were clinically normal, but 10 had severe and six had moderate mental retardation. Seven patients still had residual seizures. Since these results do not differ significantly from those obtained with hormonal treatment, the authors suggest using sodium dipropylacetate (which has less frequent and less severe side-effects than adreno-corticotropic hormone) as the only initial drug, and to use hormonal treatment only in unresponsive patients. Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=522
in Developmental Medicine & Child Neurology > 23-4 (August 1981) . - p.454-461[article] Treatment of infantile spasms with sodium dipropylacetic acid [Texte imprimé et/ou numérique] / Lorenzo PAVONE, Auteur ; Florindo MOLLICA, Auteur ; Gemma INCORPORA, Auteur ; Mario LA ROSA, Auteur ; Salvatore LI VOLTI, Auteur . - 1981 . - p.454-461.
Langues : Anglais (eng)
in Developmental Medicine & Child Neurology > 23-4 (August 1981) . - p.454-461
Index. décimale : PER Périodiques Résumé : Eighteen infants with infantile spasms were given sodium dipropylacetate at a dosage of 20mg/kg/day. They were clinically examined before treatment, and again after one to three years of therapy. The short-term clinical response was excellent in four patients, good in eight, poor in four and there was no change in two. At follow-up, two patients were clinically normal, but 10 had severe and six had moderate mental retardation. Seven patients still had residual seizures. Since these results do not differ significantly from those obtained with hormonal treatment, the authors suggest using sodium dipropylacetate (which has less frequent and less severe side-effects than adreno-corticotropic hormone) as the only initial drug, and to use hormonal treatment only in unresponsive patients. Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=522