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Détail de l'auteur
Auteur Mirabella CHAU |
Documents disponibles écrits par cet auteur (1)
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Circuits underlying social function and dysfunction / Ziwen WANG in Autism Research, 16-7 (July 2023)
[article]
Titre : Circuits underlying social function and dysfunction Type de document : Texte imprimé et/ou numérique Auteurs : Ziwen WANG, Auteur ; Hannah YUEH, Auteur ; Mirabella CHAU, Auteur ; Jeremy VEENSTRA-VANDERWEELE, Auteur ; Kally C. O'REILLY, Auteur Article en page(s) : p.1268-1288 Langues : Anglais (eng) Index. décimale : PER Périodiques Résumé : Abstract Substantial advances have been made toward understanding the genetic and environmental risk factors for autism, a neurodevelopmental disorder with social impairment as a core feature. In combination with optogenetic and chemogenetic tools to manipulate neural circuits in vivo, it is now possible to use model systems to test how specific neural circuits underlie social function and dysfunction. Here, we review the literature that has identified circuits associated with social interest (sociability), social reward, social memory, dominance, and aggression, and we outline a preliminary roadmap of the neural circuits driving these social behaviors. We highlight the neural circuitry underlying each behavioral domain, as well as develop an interactive map of how these circuits overlap across domains. We find that some of the circuits underlying social behavior are general and are involved in the control of multiple behavioral aspects, whereas other circuits appear to be specialized for specific aspects of social behavior. Our overlapping circuit map therefore helps to delineate the circuits involved in the various domains of social behavior and to identify gaps in knowledge. En ligne : https://doi.org/10.1002/aur.2978 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=510
in Autism Research > 16-7 (July 2023) . - p.1268-1288[article] Circuits underlying social function and dysfunction [Texte imprimé et/ou numérique] / Ziwen WANG, Auteur ; Hannah YUEH, Auteur ; Mirabella CHAU, Auteur ; Jeremy VEENSTRA-VANDERWEELE, Auteur ; Kally C. O'REILLY, Auteur . - p.1268-1288.
Langues : Anglais (eng)
in Autism Research > 16-7 (July 2023) . - p.1268-1288
Index. décimale : PER Périodiques Résumé : Abstract Substantial advances have been made toward understanding the genetic and environmental risk factors for autism, a neurodevelopmental disorder with social impairment as a core feature. In combination with optogenetic and chemogenetic tools to manipulate neural circuits in vivo, it is now possible to use model systems to test how specific neural circuits underlie social function and dysfunction. Here, we review the literature that has identified circuits associated with social interest (sociability), social reward, social memory, dominance, and aggression, and we outline a preliminary roadmap of the neural circuits driving these social behaviors. We highlight the neural circuitry underlying each behavioral domain, as well as develop an interactive map of how these circuits overlap across domains. We find that some of the circuits underlying social behavior are general and are involved in the control of multiple behavioral aspects, whereas other circuits appear to be specialized for specific aspects of social behavior. Our overlapping circuit map therefore helps to delineate the circuits involved in the various domains of social behavior and to identify gaps in knowledge. En ligne : https://doi.org/10.1002/aur.2978 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=510