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Auteur Esen YILDIRIM DEMIRDÖ?EN |
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Serum hypoxia-inducible factor-1 alpha (HIF-1?) and apelin levels in children and adolescents diagnosed with autism spectrum disorder / Esen YILDIRIM DEMIRDÖ?EN in Research in Autism Spectrum Disorders, 112 (April 2024)
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Titre : Serum hypoxia-inducible factor-1 alpha (HIF-1?) and apelin levels in children and adolescents diagnosed with autism spectrum disorder Type de document : Texte imprimé et/ou numérique Auteurs : Esen YILDIRIM DEMIRDÖ?EN, Auteur ; Mehmet Akif AKINCI, Auteur ; Abdullah BOZKURT, Auteur ; Özgür ESMERAY, Auteur ; Fatma Betül ÖZGERI?, Auteur ; Nezahat KURT, Auteur ; Neslihan YÜCE, Auteur Article en page(s) : p.102327 Langues : Anglais (eng) Mots-clés : Autism spectrum disorder Hypoxia-inducible factor-1 alpha (HIF-1?) Apelin Index. décimale : PER Périodiques Résumé : Background Autism spectrum disorder (ASD) is a neurodevelopmental disorder in which underlying etiological factors remains unclear. The important environmental factors associated with ASD, include neuroinflammation, hypoxia, and oxidative stress. HIF-1? and apelin are biochemical markers that play important roles in neuroinflammation, hypoxia and oxidative stress. The aim of this study is to determine whether serum HIF-1? and apelin levels differ between children and adolescents with Autism Spectrum Disorder (ASD) and healthy controls. Methods This cross-sectional study included 30 children and adolescents with ASD and 30 healthy controls. HIF-1? and apelin serum levels were measured using commercial enzyme-linked immunosorbent assay kits. Autism symptom severity was evaluated using Childhood Autism Rating Scale (CARS). HIF-1? and apelin serum levels were compared between groups. Additionally, correlations between HIF-1? and apelin serum levels and sociodemographic-clinical variables (age, BMI, CARS total score, ASD severity, psychiatric medication use, psychiatric comorbidity, NLR, SII) were evaluated in the ASD group. Results Serum HIF-1? and apelin levels were statistically significantly higher in the ASD group (p = 0.044, p = 0.041 respectively). Serum apelin levels were negatively correlated with age (r = ?0.430, p = 0.018). Serum HIF-1? levels were positively correlated with NLR (r = 0.627 p < 0.001) and SII (r = 0.609 p < 0.001). There was positive correlation between serum apelin levels and NLR (r = 0.525 p = 0.003) and SII (r = 559 p = 0.002). Conclusion These results suggest that, HIF-1? and apelin may play a potential role in the etiopathogenesis of ASD. Further studies on the subject are needed to reveal the causality between HIF-1?, apelin and ASD. En ligne : https://doi.org/10.1016/j.rasd.2024.102327 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=523
in Research in Autism Spectrum Disorders > 112 (April 2024) . - p.102327[article] Serum hypoxia-inducible factor-1 alpha (HIF-1?) and apelin levels in children and adolescents diagnosed with autism spectrum disorder [Texte imprimé et/ou numérique] / Esen YILDIRIM DEMIRDÖ?EN, Auteur ; Mehmet Akif AKINCI, Auteur ; Abdullah BOZKURT, Auteur ; Özgür ESMERAY, Auteur ; Fatma Betül ÖZGERI?, Auteur ; Nezahat KURT, Auteur ; Neslihan YÜCE, Auteur . - p.102327.
Langues : Anglais (eng)
in Research in Autism Spectrum Disorders > 112 (April 2024) . - p.102327
Mots-clés : Autism spectrum disorder Hypoxia-inducible factor-1 alpha (HIF-1?) Apelin Index. décimale : PER Périodiques Résumé : Background Autism spectrum disorder (ASD) is a neurodevelopmental disorder in which underlying etiological factors remains unclear. The important environmental factors associated with ASD, include neuroinflammation, hypoxia, and oxidative stress. HIF-1? and apelin are biochemical markers that play important roles in neuroinflammation, hypoxia and oxidative stress. The aim of this study is to determine whether serum HIF-1? and apelin levels differ between children and adolescents with Autism Spectrum Disorder (ASD) and healthy controls. Methods This cross-sectional study included 30 children and adolescents with ASD and 30 healthy controls. HIF-1? and apelin serum levels were measured using commercial enzyme-linked immunosorbent assay kits. Autism symptom severity was evaluated using Childhood Autism Rating Scale (CARS). HIF-1? and apelin serum levels were compared between groups. Additionally, correlations between HIF-1? and apelin serum levels and sociodemographic-clinical variables (age, BMI, CARS total score, ASD severity, psychiatric medication use, psychiatric comorbidity, NLR, SII) were evaluated in the ASD group. Results Serum HIF-1? and apelin levels were statistically significantly higher in the ASD group (p = 0.044, p = 0.041 respectively). Serum apelin levels were negatively correlated with age (r = ?0.430, p = 0.018). Serum HIF-1? levels were positively correlated with NLR (r = 0.627 p < 0.001) and SII (r = 0.609 p < 0.001). There was positive correlation between serum apelin levels and NLR (r = 0.525 p = 0.003) and SII (r = 559 p = 0.002). Conclusion These results suggest that, HIF-1? and apelin may play a potential role in the etiopathogenesis of ASD. Further studies on the subject are needed to reveal the causality between HIF-1?, apelin and ASD. En ligne : https://doi.org/10.1016/j.rasd.2024.102327 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=523