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2 recherche sur le mot-clé 'Methylenetetrahydrofolate reductase'
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Association between MTHFR Gene Polymorphisms and the Risk of Autism Spectrum Disorders: A Meta-Analysis / Danhua PU in Autism Research, 6-5 (October 2013)
[article]
Titre : Association between MTHFR Gene Polymorphisms and the Risk of Autism Spectrum Disorders: A Meta-Analysis Type de document : Texte imprimé et/ou numérique Auteurs : Danhua PU, Auteur ; Yiping SHEN, Auteur ; Jie WU, Auteur Article en page(s) : p.384-392 Langues : Anglais (eng) Mots-clés : methylenetetrahydrofolate reductase polymorphism autism spectrum disorders folic acidl meta-analysis Index. décimale : PER Périodiques Résumé : Methylenetetrahydrofolate reductase (MTHFR) is essential for DNA biosynthesis and the epigenetic process of DNA methylation, and its gene polymorphisms have been implicated as risk factors for birth defects, neurological disorders, and cancers. However, reports on the association of MTHFR polymorphisms with autism spectrum disorders (ASD) are inconclusive. Therefore, we investigated the relationship of the MTHFR polymorphisms (C677T and A1298C) and the risk of ASD by meta-analysis. Up to December 2012, eight case-control studies involving 1672 patients with ASD and 6760 controls were included for meta-analysis. The results showed that the C677T polymorphism was associated with significantly increased ASD risk in all the comparison models [T vs. C allele (frequency of allele): odds ratio (OR)?=?1.42, 95% confidence interval (CI): 1.09–1.85; CT vs. CC (heterozygote): OR?=?1.48, 95% CI: 1.09–2.00; TT vs. CC (homozygote): OR?=?1.86, 95% CI: 1.08–3.20; CT+TT vs. CC (dominant model): OR?=?1.56, 95% CI: 1.12–2.18; and TT vs. CC+CT (recessive model): OR?=?1.51, 95% CI: 1.02–2.22], whereas the A1298C polymorphism was found to be significantly associated with reduced ASD risk but only in a recessive model (CC vs. AA+AC: OR?=?0.73, 95% CI: 0.56–0.97). In addition, we stratified the patient population based on whether they were from a country with food fortification of folic acid or not. The meta-analysis showed that the C677T polymorphism was found to be associated with ASD only in children from countries without food fortification. Our study indicated that the MTHFR C677T polymorphism contributes to increased ASD risk, and periconceptional folic acid may reduce ASD risk in those with MTHFR 677CT polymorphism. En ligne : http://dx.doi.org/10.1002/aur.1300 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=218
in Autism Research > 6-5 (October 2013) . - p.384-392[article] Association between MTHFR Gene Polymorphisms and the Risk of Autism Spectrum Disorders: A Meta-Analysis [Texte imprimé et/ou numérique] / Danhua PU, Auteur ; Yiping SHEN, Auteur ; Jie WU, Auteur . - p.384-392.
Langues : Anglais (eng)
in Autism Research > 6-5 (October 2013) . - p.384-392
Mots-clés : methylenetetrahydrofolate reductase polymorphism autism spectrum disorders folic acidl meta-analysis Index. décimale : PER Périodiques Résumé : Methylenetetrahydrofolate reductase (MTHFR) is essential for DNA biosynthesis and the epigenetic process of DNA methylation, and its gene polymorphisms have been implicated as risk factors for birth defects, neurological disorders, and cancers. However, reports on the association of MTHFR polymorphisms with autism spectrum disorders (ASD) are inconclusive. Therefore, we investigated the relationship of the MTHFR polymorphisms (C677T and A1298C) and the risk of ASD by meta-analysis. Up to December 2012, eight case-control studies involving 1672 patients with ASD and 6760 controls were included for meta-analysis. The results showed that the C677T polymorphism was associated with significantly increased ASD risk in all the comparison models [T vs. C allele (frequency of allele): odds ratio (OR)?=?1.42, 95% confidence interval (CI): 1.09–1.85; CT vs. CC (heterozygote): OR?=?1.48, 95% CI: 1.09–2.00; TT vs. CC (homozygote): OR?=?1.86, 95% CI: 1.08–3.20; CT+TT vs. CC (dominant model): OR?=?1.56, 95% CI: 1.12–2.18; and TT vs. CC+CT (recessive model): OR?=?1.51, 95% CI: 1.02–2.22], whereas the A1298C polymorphism was found to be significantly associated with reduced ASD risk but only in a recessive model (CC vs. AA+AC: OR?=?0.73, 95% CI: 0.56–0.97). In addition, we stratified the patient population based on whether they were from a country with food fortification of folic acid or not. The meta-analysis showed that the C677T polymorphism was found to be associated with ASD only in children from countries without food fortification. Our study indicated that the MTHFR C677T polymorphism contributes to increased ASD risk, and periconceptional folic acid may reduce ASD risk in those with MTHFR 677CT polymorphism. En ligne : http://dx.doi.org/10.1002/aur.1300 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=218 Association between MTHFR gene polymorphism and susceptibility to autism spectrum disorders: Systematic review and meta-analysis / Bahman RAZI in Research in Autism Spectrum Disorders, 70 (February 2020)
[article]
Titre : Association between MTHFR gene polymorphism and susceptibility to autism spectrum disorders: Systematic review and meta-analysis Type de document : Texte imprimé et/ou numérique Auteurs : Bahman RAZI, Auteur ; Danyal IMANI, Auteur ; Masoud HASSANZADEH MAKOUI, Auteur ; Ramazan REZAEI, Auteur ; Saeed ASLANI, Auteur Article en page(s) : p.101473 Langues : Anglais (eng) Mots-clés : Methylenetetrahydrofolate reductase Autism spectrum disorder Meta-analysis Polymorphism Index. décimale : PER Périodiques Résumé : Objective A growing number of studies have highlighted the potential link between MTHFR gene polymorphisms and autism spectrum disorder (ASD), however, the results are conflictive. Therefore, this meta-analysis was conducted to find a persuasive answer for possible association or lack of association between MTHFR gene polymorphism and ASD risk. Methods Systematic search was conducted in PubMed, Web of Science, and Scopus considering the association between MTHFR gene (C677?T and A1298C) polymorphisms and the risk of ASD prior to Jun 2019. Results A total of 17 studies for C677T and 8 studies for A1298C MTHFR gene polymorphism recognized eligible. The pooled results suggested a significant association between C677T SNP and ASD risk under dominant model (OR?=?1.47, 95%CI?=?1.13–2.93, REM), allelic model (OR?=?1.37, 95% CI?=?1.08–1.74, REM), and CT vs CC model (OR?=?1.45, 95% CI?=?1.13–1.85, REM). Moreover, the pooled results of subgroup analysis confirmed increased risk of ASD in Caucasians across all genetic models except recessive model. Besides, in spite of no significant association between A1298C SNP and ASD in overall population, subgroup analysis revealed that presence of A1298C SNP decrease risk of ASD in Caucasians. Conclusion This meta-analysis suggested a significant association between MTHFR gene polymorphism (C677T and A1298C) and ASD risk. En ligne : https://doi.org/10.1016/j.rasd.2019.101473 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=414
in Research in Autism Spectrum Disorders > 70 (February 2020) . - p.101473[article] Association between MTHFR gene polymorphism and susceptibility to autism spectrum disorders: Systematic review and meta-analysis [Texte imprimé et/ou numérique] / Bahman RAZI, Auteur ; Danyal IMANI, Auteur ; Masoud HASSANZADEH MAKOUI, Auteur ; Ramazan REZAEI, Auteur ; Saeed ASLANI, Auteur . - p.101473.
Langues : Anglais (eng)
in Research in Autism Spectrum Disorders > 70 (February 2020) . - p.101473
Mots-clés : Methylenetetrahydrofolate reductase Autism spectrum disorder Meta-analysis Polymorphism Index. décimale : PER Périodiques Résumé : Objective A growing number of studies have highlighted the potential link between MTHFR gene polymorphisms and autism spectrum disorder (ASD), however, the results are conflictive. Therefore, this meta-analysis was conducted to find a persuasive answer for possible association or lack of association between MTHFR gene polymorphism and ASD risk. Methods Systematic search was conducted in PubMed, Web of Science, and Scopus considering the association between MTHFR gene (C677?T and A1298C) polymorphisms and the risk of ASD prior to Jun 2019. Results A total of 17 studies for C677T and 8 studies for A1298C MTHFR gene polymorphism recognized eligible. The pooled results suggested a significant association between C677T SNP and ASD risk under dominant model (OR?=?1.47, 95%CI?=?1.13–2.93, REM), allelic model (OR?=?1.37, 95% CI?=?1.08–1.74, REM), and CT vs CC model (OR?=?1.45, 95% CI?=?1.13–1.85, REM). Moreover, the pooled results of subgroup analysis confirmed increased risk of ASD in Caucasians across all genetic models except recessive model. Besides, in spite of no significant association between A1298C SNP and ASD in overall population, subgroup analysis revealed that presence of A1298C SNP decrease risk of ASD in Caucasians. Conclusion This meta-analysis suggested a significant association between MTHFR gene polymorphism (C677T and A1298C) and ASD risk. En ligne : https://doi.org/10.1016/j.rasd.2019.101473 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=414