Centre d'Information et de documentation du CRA Rhône-Alpes
CRA
Informations pratiques
-
Adresse
Centre d'information et de documentation
du CRA Rhône-Alpes
Centre Hospitalier le Vinatier
bât 211
95, Bd Pinel
69678 Bron CedexHoraires
Lundi au Vendredi
9h00-12h00 13h30-16h00Contact
Tél: +33(0)4 37 91 54 65
Mail
Fax: +33(0)4 37 91 54 37
-
Résultat de la recherche
1 recherche sur le mot-clé 'Asperger's-disorder autistic-disorder brain-imaging'
Affiner la recherche Générer le flux rss de la recherche
Partager le résultat de cette recherche Faire une suggestion
Distinct patterns of grey matter abnormality in high-functioning autism and Asperger's syndrome / Gráinne M. MCALONAN in Journal of Child Psychology and Psychiatry, 49-12 (December 2008)
[article]
Titre : Distinct patterns of grey matter abnormality in high-functioning autism and Asperger's syndrome Type de document : Texte imprimé et/ou numérique Auteurs : Gráinne M. MCALONAN, Auteur ; John SUCKLING, Auteur ; Naikei WONG, Auteur ; Vinci CHEUNG, Auteur ; Nina LIENENKAEMPER, Auteur ; Charlton CHEUNG, Auteur ; Siew E. CHUA, Auteur Année de publication : 2008 Article en page(s) : p.1287-1295 Langues : Anglais (eng) Mots-clés : Asperger's-disorder autistic-disorder brain-imaging Index. décimale : PER Périodiques Résumé : Background: Autism exists across a wide spectrum and there is considerable debate as to whether children with Asperger's syndrome, who have normal language milestones, should be considered to comprise a subgroup distinct other from high-functioning children with autism (HFA), who have a history of delayed language development. Magnetic resonance imaging (MRI) studies of autism are in disagreement. One possible reason is that the diagnosis of autism takes precedence over Asperger's syndrome and a distinction in language acquisition is rarely made. We therefore planned to examine a whole brain hypothesis that the patterns of grey matter differences in Asperger's syndrome and HFA can be distinguished.
Methods: We used voxel-based computational morphometry to map grey matter volume differences in 33 children with either Asperger's syndrome or high-functioning autism compared to 55 typical developing control children balanced for age, IQ, gender, maternal language and ethnicity.
Results: Children with HFA had significantly smaller grey matter volumes in subcortical, posterior cingulate and precuneus regions than the Asperger's group. Compared to controls, children with HFA had smaller grey matter volumes in predominantly fronto-pallidal regions, while children with Asperger's had less grey matter in mainly bilateral caudate and left thalamus. In addition we found a significant negative correlation between the size of a grey matter cluster around BA44 language area and the age of acquisition of phrase speech in the children with HFA. When the groups were combined we confirmed a mixed picture of smaller grey matter volumes in frontal, basal ganglia, temporal and parietal regions.
Conclusions: Our study suggests that the underlying neurobiology in HFA and Asperger's syndrome is at least partly discrete. Future studies should therefore consider the history of language acquisition as a valuable tool to refine investigation of aetiological factors and management options in pervasive developmental disorders.En ligne : http://dx.doi.org/10.1111/j.1469-7610.2008.01933.x Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=644
in Journal of Child Psychology and Psychiatry > 49-12 (December 2008) . - p.1287-1295[article] Distinct patterns of grey matter abnormality in high-functioning autism and Asperger's syndrome [Texte imprimé et/ou numérique] / Gráinne M. MCALONAN, Auteur ; John SUCKLING, Auteur ; Naikei WONG, Auteur ; Vinci CHEUNG, Auteur ; Nina LIENENKAEMPER, Auteur ; Charlton CHEUNG, Auteur ; Siew E. CHUA, Auteur . - 2008 . - p.1287-1295.
Langues : Anglais (eng)
in Journal of Child Psychology and Psychiatry > 49-12 (December 2008) . - p.1287-1295
Mots-clés : Asperger's-disorder autistic-disorder brain-imaging Index. décimale : PER Périodiques Résumé : Background: Autism exists across a wide spectrum and there is considerable debate as to whether children with Asperger's syndrome, who have normal language milestones, should be considered to comprise a subgroup distinct other from high-functioning children with autism (HFA), who have a history of delayed language development. Magnetic resonance imaging (MRI) studies of autism are in disagreement. One possible reason is that the diagnosis of autism takes precedence over Asperger's syndrome and a distinction in language acquisition is rarely made. We therefore planned to examine a whole brain hypothesis that the patterns of grey matter differences in Asperger's syndrome and HFA can be distinguished.
Methods: We used voxel-based computational morphometry to map grey matter volume differences in 33 children with either Asperger's syndrome or high-functioning autism compared to 55 typical developing control children balanced for age, IQ, gender, maternal language and ethnicity.
Results: Children with HFA had significantly smaller grey matter volumes in subcortical, posterior cingulate and precuneus regions than the Asperger's group. Compared to controls, children with HFA had smaller grey matter volumes in predominantly fronto-pallidal regions, while children with Asperger's had less grey matter in mainly bilateral caudate and left thalamus. In addition we found a significant negative correlation between the size of a grey matter cluster around BA44 language area and the age of acquisition of phrase speech in the children with HFA. When the groups were combined we confirmed a mixed picture of smaller grey matter volumes in frontal, basal ganglia, temporal and parietal regions.
Conclusions: Our study suggests that the underlying neurobiology in HFA and Asperger's syndrome is at least partly discrete. Future studies should therefore consider the history of language acquisition as a valuable tool to refine investigation of aetiological factors and management options in pervasive developmental disorders.En ligne : http://dx.doi.org/10.1111/j.1469-7610.2008.01933.x Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=644