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Research Review: Maternal prenatal distress and poor nutrition – mutually influencing risk factors affecting infant neurocognitive development / Catherine MONK in Journal of Child Psychology and Psychiatry, 54-2 (February 2013)
[article]
Titre : Research Review: Maternal prenatal distress and poor nutrition – mutually influencing risk factors affecting infant neurocognitive development Type de document : Texte imprimé et/ou numérique Auteurs : Catherine MONK, Auteur ; Michael K. GEORGIEFF, Auteur ; Erin A. OSTERHOLM, Auteur Année de publication : 2013 Article en page(s) : p.115-130 Langues : Anglais (eng) Mots-clés : Prenatal stress micronutrient neurocognitive development fetal origins Index. décimale : PER Périodiques Résumé : Background: Accumulating data from animal and human studies indicate that the prenatal environment plays a significant role in shaping children's neurocognitive development. Clinical, epidemiologic, and basic science research suggests that two experiences relatively common in pregnancy – an unhealthy maternal diet and psychosocial distress – significantly affect children's future neurodevelopment. These prenatal experiences exert their influence in the context of one another and yet, almost uniformly, are studied independently. Scope and Method of Review: In this review, we suggest that studying neurocognitive development in children in relation to both prenatal exposures is ecologically most relevant, and methodologically most sound. To support this approach, we selectively review two research topics that demonstrate the need for dual exposure studies, including exemplar findings on (a) the associations between pregnant women's inadequate maternal intake of key nutrients – protein, fat, iron, zinc, and choline – as well as distress in relation to overlapping effects on children's neurocognitive development; and (b) cross-talk between the biology of stress and nutrition that can amplify each experience for the mother and fetus,. We also consider obstacles to this kind of study design, such as questions of statistical methods for ‘disentangling' the exposure effects, and aim to provide some answers. Conclusion: Studies that specifically include both exposures in their design can begin to determine the relative and/or synergistic impact of these prenatal experiences on developmental trajectories – and thereby contribute most fully to the understanding of the early origins of health and disease. En ligne : http://dx.doi.org/10.1111/jcpp.12000 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=188
in Journal of Child Psychology and Psychiatry > 54-2 (February 2013) . - p.115-130[article] Research Review: Maternal prenatal distress and poor nutrition – mutually influencing risk factors affecting infant neurocognitive development [Texte imprimé et/ou numérique] / Catherine MONK, Auteur ; Michael K. GEORGIEFF, Auteur ; Erin A. OSTERHOLM, Auteur . - 2013 . - p.115-130.
Langues : Anglais (eng)
in Journal of Child Psychology and Psychiatry > 54-2 (February 2013) . - p.115-130
Mots-clés : Prenatal stress micronutrient neurocognitive development fetal origins Index. décimale : PER Périodiques Résumé : Background: Accumulating data from animal and human studies indicate that the prenatal environment plays a significant role in shaping children's neurocognitive development. Clinical, epidemiologic, and basic science research suggests that two experiences relatively common in pregnancy – an unhealthy maternal diet and psychosocial distress – significantly affect children's future neurodevelopment. These prenatal experiences exert their influence in the context of one another and yet, almost uniformly, are studied independently. Scope and Method of Review: In this review, we suggest that studying neurocognitive development in children in relation to both prenatal exposures is ecologically most relevant, and methodologically most sound. To support this approach, we selectively review two research topics that demonstrate the need for dual exposure studies, including exemplar findings on (a) the associations between pregnant women's inadequate maternal intake of key nutrients – protein, fat, iron, zinc, and choline – as well as distress in relation to overlapping effects on children's neurocognitive development; and (b) cross-talk between the biology of stress and nutrition that can amplify each experience for the mother and fetus,. We also consider obstacles to this kind of study design, such as questions of statistical methods for ‘disentangling' the exposure effects, and aim to provide some answers. Conclusion: Studies that specifically include both exposures in their design can begin to determine the relative and/or synergistic impact of these prenatal experiences on developmental trajectories – and thereby contribute most fully to the understanding of the early origins of health and disease. En ligne : http://dx.doi.org/10.1111/jcpp.12000 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=188 A 13-year follow-up of Finnish patients with Salla disease / L. E. PAAVOLA in Journal of Neurodevelopmental Disorders, 7-1 (December 2015)
[article]
Titre : A 13-year follow-up of Finnish patients with Salla disease Type de document : Texte imprimé et/ou numérique Auteurs : L. E. PAAVOLA, Auteur ; A. M. REMES, Auteur ; M. J. HARILA, Auteur ; T. T. VARHO, Auteur ; T. T. KORHONEN, Auteur ; K. MAJAMAA, Auteur Article en page(s) : p.20 Langues : Anglais (eng) Mots-clés : Dysmyelination Follow-up study Free sialic acid storage Neurocognitive development Rare diseases Index. décimale : PER Périodiques Résumé : BACKGROUND: Salla disease (SD) is a rare lysosomal storage disorder leading to severe intellectual disability. SD belongs to the Finnish disease heritage, and it is caused by mutations in the SLC17A5 gene. The aim of the study was to investigate the course of neurocognitive features of SD patients in a long-term follow-up. METHODS: Neuropsychological and neurological investigations were carried out on 24 SD patients, aged 16-65 years, 13 years after a similar examination. RESULTS: The survival analysis showed excess mortality among patients with SD after the age of 30 years. The course of the disease was progressive, but follow-up of SD patients revealed that motor skills improved till the age of 20 years, while mental abilities improved in most patients till 40 years of age. Verbal comprehension skills did not diminish during the follow-up, but productive speech deteriorated because of dyspraxia and dysarthria. Motor deficits were marked. Ataxia was prominent in childhood, but it was replaced by athetotic movements during the teens. Spasticity became more obvious with age especially in severely disabled SD patients. CONCLUSIONS: Younger SD patients performed better in almost every task measuring mental abilities that then seem to remain fairly constant till early sixties. Thus, the results indicate better prognosis in cognitive skills than earlier assumed. There is an apparent decline in motor skills after the age of 20 years. The early neurocognitive development predicts the later course of motor and cognitive development. En ligne : http://dx.doi.org/10.1186/s11689-015-9116-7 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=347
in Journal of Neurodevelopmental Disorders > 7-1 (December 2015) . - p.20[article] A 13-year follow-up of Finnish patients with Salla disease [Texte imprimé et/ou numérique] / L. E. PAAVOLA, Auteur ; A. M. REMES, Auteur ; M. J. HARILA, Auteur ; T. T. VARHO, Auteur ; T. T. KORHONEN, Auteur ; K. MAJAMAA, Auteur . - p.20.
Langues : Anglais (eng)
in Journal of Neurodevelopmental Disorders > 7-1 (December 2015) . - p.20
Mots-clés : Dysmyelination Follow-up study Free sialic acid storage Neurocognitive development Rare diseases Index. décimale : PER Périodiques Résumé : BACKGROUND: Salla disease (SD) is a rare lysosomal storage disorder leading to severe intellectual disability. SD belongs to the Finnish disease heritage, and it is caused by mutations in the SLC17A5 gene. The aim of the study was to investigate the course of neurocognitive features of SD patients in a long-term follow-up. METHODS: Neuropsychological and neurological investigations were carried out on 24 SD patients, aged 16-65 years, 13 years after a similar examination. RESULTS: The survival analysis showed excess mortality among patients with SD after the age of 30 years. The course of the disease was progressive, but follow-up of SD patients revealed that motor skills improved till the age of 20 years, while mental abilities improved in most patients till 40 years of age. Verbal comprehension skills did not diminish during the follow-up, but productive speech deteriorated because of dyspraxia and dysarthria. Motor deficits were marked. Ataxia was prominent in childhood, but it was replaced by athetotic movements during the teens. Spasticity became more obvious with age especially in severely disabled SD patients. CONCLUSIONS: Younger SD patients performed better in almost every task measuring mental abilities that then seem to remain fairly constant till early sixties. Thus, the results indicate better prognosis in cognitive skills than earlier assumed. There is an apparent decline in motor skills after the age of 20 years. The early neurocognitive development predicts the later course of motor and cognitive development. En ligne : http://dx.doi.org/10.1186/s11689-015-9116-7 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=347