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Auteur Michael K. GEORGIEFF |
Documents disponibles écrits par cet auteur (6)



Atypical fetal development: Fetal alcohol syndrome, nutritional deprivation, teratogens, and risk for neurodevelopmental disorders and psychopathology / Michael K. GEORGIEFF in Development and Psychopathology, 30-3 (August 2018)
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Titre : Atypical fetal development: Fetal alcohol syndrome, nutritional deprivation, teratogens, and risk for neurodevelopmental disorders and psychopathology Type de document : Texte imprimé et/ou numérique Auteurs : Michael K. GEORGIEFF, Auteur ; P. V. TRAN, Auteur ; E. S. CARLSON, Auteur Article en page(s) : p.1063-1086 Langues : Anglais (eng) Index. décimale : PER Périodiques Résumé : Accumulating evidence indicates that the fetal environment plays an important role in brain development and sets the brain on a trajectory across the life span. An abnormal fetal environment results when factors that should be present during a critical period of development are absent or when factors that should not be in the developing brain are present. While these factors may acutely disrupt brain function, the real cost to society resides in the long-term effects, which include important mental health issues. We review the effects of three factors, fetal alcohol exposure, teratogen exposure, and nutrient deficiencies, on the developing brain and the consequent risk for developmental psychopathology. Each is reviewed with respect to the evidence found in epidemiological and clinical studies in humans as well as preclinical molecular and cellular studies that explicate mechanisms of action. En ligne : http://dx.doi.org/10.1017/s0954579418000500 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=367
in Development and Psychopathology > 30-3 (August 2018) . - p.1063-1086[article] Atypical fetal development: Fetal alcohol syndrome, nutritional deprivation, teratogens, and risk for neurodevelopmental disorders and psychopathology [Texte imprimé et/ou numérique] / Michael K. GEORGIEFF, Auteur ; P. V. TRAN, Auteur ; E. S. CARLSON, Auteur . - p.1063-1086.
Langues : Anglais (eng)
in Development and Psychopathology > 30-3 (August 2018) . - p.1063-1086
Index. décimale : PER Périodiques Résumé : Accumulating evidence indicates that the fetal environment plays an important role in brain development and sets the brain on a trajectory across the life span. An abnormal fetal environment results when factors that should be present during a critical period of development are absent or when factors that should not be in the developing brain are present. While these factors may acutely disrupt brain function, the real cost to society resides in the long-term effects, which include important mental health issues. We review the effects of three factors, fetal alcohol exposure, teratogen exposure, and nutrient deficiencies, on the developing brain and the consequent risk for developmental psychopathology. Each is reviewed with respect to the evidence found in epidemiological and clinical studies in humans as well as preclinical molecular and cellular studies that explicate mechanisms of action. En ligne : http://dx.doi.org/10.1017/s0954579418000500 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=367 Early life nutrition and neural plasticity / Michael K. GEORGIEFF in Development and Psychopathology, 27-2 (May 2015)
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Titre : Early life nutrition and neural plasticity Type de document : Texte imprimé et/ou numérique Auteurs : Michael K. GEORGIEFF, Auteur ; Katya E. BRUNETTE, Auteur ; Phu V. TRAN, Auteur Article en page(s) : p.411-423 Langues : Anglais (eng) Index. décimale : PER Périodiques Résumé : The human brain undergoes a remarkable transformation during fetal life and the first postnatal years from a relatively undifferentiated but pluripotent organ to a highly specified and organized one. The outcome of this developmental maturation is highly dependent on a sequence of environmental exposures that can have either positive or negative influences on the ultimate plasticity of the adult brain. Many environmental exposures are beyond the control of the individual, but nutrition is not. An ever-increasing amount of research demonstrates not only that nutrition shapes the brain and affects its function during development but also that several nutrients early in life have profound and long-lasting effects on the brain. Nutrients have been shown to alter opening and closing of critical and sensitive periods of particular brain regions. This paper discusses the roles that various nutrients play in shaping the developing brain, concentrating specifically on recently explicated biological mechanisms by which particularly salient nutrients influence childhood and adult neural plasticity. En ligne : http://dx.doi.org/10.1017/S0954579415000061 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=257
in Development and Psychopathology > 27-2 (May 2015) . - p.411-423[article] Early life nutrition and neural plasticity [Texte imprimé et/ou numérique] / Michael K. GEORGIEFF, Auteur ; Katya E. BRUNETTE, Auteur ; Phu V. TRAN, Auteur . - p.411-423.
Langues : Anglais (eng)
in Development and Psychopathology > 27-2 (May 2015) . - p.411-423
Index. décimale : PER Périodiques Résumé : The human brain undergoes a remarkable transformation during fetal life and the first postnatal years from a relatively undifferentiated but pluripotent organ to a highly specified and organized one. The outcome of this developmental maturation is highly dependent on a sequence of environmental exposures that can have either positive or negative influences on the ultimate plasticity of the adult brain. Many environmental exposures are beyond the control of the individual, but nutrition is not. An ever-increasing amount of research demonstrates not only that nutrition shapes the brain and affects its function during development but also that several nutrients early in life have profound and long-lasting effects on the brain. Nutrients have been shown to alter opening and closing of critical and sensitive periods of particular brain regions. This paper discusses the roles that various nutrients play in shaping the developing brain, concentrating specifically on recently explicated biological mechanisms by which particularly salient nutrients influence childhood and adult neural plasticity. En ligne : http://dx.doi.org/10.1017/S0954579415000061 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=257 Hippocampus specific iron deficiency alters competition and cooperation between developing memory systems / E. S. CARLSON in Journal of Neurodevelopmental Disorders, 2-3 (September 2010)
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Titre : Hippocampus specific iron deficiency alters competition and cooperation between developing memory systems Type de document : Texte imprimé et/ou numérique Auteurs : E. S. CARLSON, Auteur ; S. J. FRETHAM, Auteur ; E. UNGER, Auteur ; M. O'CONNOR, Auteur ; A. PETRYK, Auteur ; T. SCHALLERT, Auteur ; R. RAO, Auteur ; I. TKAC, Auteur ; Michael K. GEORGIEFF, Auteur Article en page(s) : p.133-43 Langues : Anglais (eng) Mots-clés : DMT1, Slc11a2, Nuclear magnetic resonance spectroscopy Hippocampus Iron deficiency Memory systems Morris water maze Procedural memory Spatial memory Striatum Index. décimale : PER Périodiques Résumé : UNLABELLED: Iron deficiency (ID) is the most common gestational micronutrient deficiency in the world, targets the fetal hippocampus and striatum and results in long-term behavioral abnormalities. These structures primarily mediate spatial and procedural memory, respectively, in the rodent but have interconnections that result in competition or cooperation during cognitive tasks. We determined whether ID-induced impairment of one alters the function of the other by genetically inducing a 40% reduction of hippocampus iron content in late fetal life in mice and measuring dorsal striatal gene expression and metabolism and the behavioral balance between the two memory systems in adulthood. Slc11a2(hipp/hipp) mice had similar striatum iron content, but 18% lower glucose and 44% lower lactate levels, a 30% higher phosphocreatine:creatine ratio, and reduced iron transporter gene expression compared to wild type (WT) littermates, implying reduced striatal metabolic function. Slc11a2(hipp/hipp) mice had longer mean escape times on a cued task paradigm implying impaired procedural memory. Nevertheless, when hippocampal and striatal memory systems were placed in competition using a Morris Water Maze task that alternates spatial navigation and visual cued responses during training, and forces a choice between hippocampal and striatal strategies during probe trials, Slc11a2(hipp/hipp) mice used the hippocampus-dependent response less often (25%) and the visual cued response more often (75%) compared to WT littermates that used both strategies approximately equally. Hippocampal ID not only reduces spatial recognition memory performance but also affects systems that support procedural memory, suggesting an altered balance between memory systems. ELECTRONIC SUPPLEMENTARY MATERIAL: The online version of this article (doi:10.1007/s11689-010-9049-0) contains supplementary material, which is available to authorized users. En ligne : http://dx.doi.org/10.1007/s11689-010-9049-0 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=342
in Journal of Neurodevelopmental Disorders > 2-3 (September 2010) . - p.133-43[article] Hippocampus specific iron deficiency alters competition and cooperation between developing memory systems [Texte imprimé et/ou numérique] / E. S. CARLSON, Auteur ; S. J. FRETHAM, Auteur ; E. UNGER, Auteur ; M. O'CONNOR, Auteur ; A. PETRYK, Auteur ; T. SCHALLERT, Auteur ; R. RAO, Auteur ; I. TKAC, Auteur ; Michael K. GEORGIEFF, Auteur . - p.133-43.
Langues : Anglais (eng)
in Journal of Neurodevelopmental Disorders > 2-3 (September 2010) . - p.133-43
Mots-clés : DMT1, Slc11a2, Nuclear magnetic resonance spectroscopy Hippocampus Iron deficiency Memory systems Morris water maze Procedural memory Spatial memory Striatum Index. décimale : PER Périodiques Résumé : UNLABELLED: Iron deficiency (ID) is the most common gestational micronutrient deficiency in the world, targets the fetal hippocampus and striatum and results in long-term behavioral abnormalities. These structures primarily mediate spatial and procedural memory, respectively, in the rodent but have interconnections that result in competition or cooperation during cognitive tasks. We determined whether ID-induced impairment of one alters the function of the other by genetically inducing a 40% reduction of hippocampus iron content in late fetal life in mice and measuring dorsal striatal gene expression and metabolism and the behavioral balance between the two memory systems in adulthood. Slc11a2(hipp/hipp) mice had similar striatum iron content, but 18% lower glucose and 44% lower lactate levels, a 30% higher phosphocreatine:creatine ratio, and reduced iron transporter gene expression compared to wild type (WT) littermates, implying reduced striatal metabolic function. Slc11a2(hipp/hipp) mice had longer mean escape times on a cued task paradigm implying impaired procedural memory. Nevertheless, when hippocampal and striatal memory systems were placed in competition using a Morris Water Maze task that alternates spatial navigation and visual cued responses during training, and forces a choice between hippocampal and striatal strategies during probe trials, Slc11a2(hipp/hipp) mice used the hippocampus-dependent response less often (25%) and the visual cued response more often (75%) compared to WT littermates that used both strategies approximately equally. Hippocampal ID not only reduces spatial recognition memory performance but also affects systems that support procedural memory, suggesting an altered balance between memory systems. ELECTRONIC SUPPLEMENTARY MATERIAL: The online version of this article (doi:10.1007/s11689-010-9049-0) contains supplementary material, which is available to authorized users. En ligne : http://dx.doi.org/10.1007/s11689-010-9049-0 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=342 Research Review: Maternal prenatal distress and poor nutrition – mutually influencing risk factors affecting infant neurocognitive development / Catherine MONK in Journal of Child Psychology and Psychiatry, 54-2 (February 2013)
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Titre : Research Review: Maternal prenatal distress and poor nutrition – mutually influencing risk factors affecting infant neurocognitive development Type de document : Texte imprimé et/ou numérique Auteurs : Catherine MONK, Auteur ; Michael K. GEORGIEFF, Auteur ; Erin A. OSTERHOLM, Auteur Année de publication : 2013 Article en page(s) : p.115-130 Langues : Anglais (eng) Mots-clés : Prenatal stress micronutrient neurocognitive development fetal origins Index. décimale : PER Périodiques Résumé : Background: Accumulating data from animal and human studies indicate that the prenatal environment plays a significant role in shaping children's neurocognitive development. Clinical, epidemiologic, and basic science research suggests that two experiences relatively common in pregnancy – an unhealthy maternal diet and psychosocial distress – significantly affect children's future neurodevelopment. These prenatal experiences exert their influence in the context of one another and yet, almost uniformly, are studied independently. Scope and Method of Review: In this review, we suggest that studying neurocognitive development in children in relation to both prenatal exposures is ecologically most relevant, and methodologically most sound. To support this approach, we selectively review two research topics that demonstrate the need for dual exposure studies, including exemplar findings on (a) the associations between pregnant women's inadequate maternal intake of key nutrients – protein, fat, iron, zinc, and choline – as well as distress in relation to overlapping effects on children's neurocognitive development; and (b) cross-talk between the biology of stress and nutrition that can amplify each experience for the mother and fetus,. We also consider obstacles to this kind of study design, such as questions of statistical methods for ‘disentangling' the exposure effects, and aim to provide some answers. Conclusion: Studies that specifically include both exposures in their design can begin to determine the relative and/or synergistic impact of these prenatal experiences on developmental trajectories – and thereby contribute most fully to the understanding of the early origins of health and disease. En ligne : http://dx.doi.org/10.1111/jcpp.12000 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=188
in Journal of Child Psychology and Psychiatry > 54-2 (February 2013) . - p.115-130[article] Research Review: Maternal prenatal distress and poor nutrition – mutually influencing risk factors affecting infant neurocognitive development [Texte imprimé et/ou numérique] / Catherine MONK, Auteur ; Michael K. GEORGIEFF, Auteur ; Erin A. OSTERHOLM, Auteur . - 2013 . - p.115-130.
Langues : Anglais (eng)
in Journal of Child Psychology and Psychiatry > 54-2 (February 2013) . - p.115-130
Mots-clés : Prenatal stress micronutrient neurocognitive development fetal origins Index. décimale : PER Périodiques Résumé : Background: Accumulating data from animal and human studies indicate that the prenatal environment plays a significant role in shaping children's neurocognitive development. Clinical, epidemiologic, and basic science research suggests that two experiences relatively common in pregnancy – an unhealthy maternal diet and psychosocial distress – significantly affect children's future neurodevelopment. These prenatal experiences exert their influence in the context of one another and yet, almost uniformly, are studied independently. Scope and Method of Review: In this review, we suggest that studying neurocognitive development in children in relation to both prenatal exposures is ecologically most relevant, and methodologically most sound. To support this approach, we selectively review two research topics that demonstrate the need for dual exposure studies, including exemplar findings on (a) the associations between pregnant women's inadequate maternal intake of key nutrients – protein, fat, iron, zinc, and choline – as well as distress in relation to overlapping effects on children's neurocognitive development; and (b) cross-talk between the biology of stress and nutrition that can amplify each experience for the mother and fetus,. We also consider obstacles to this kind of study design, such as questions of statistical methods for ‘disentangling' the exposure effects, and aim to provide some answers. Conclusion: Studies that specifically include both exposures in their design can begin to determine the relative and/or synergistic impact of these prenatal experiences on developmental trajectories – and thereby contribute most fully to the understanding of the early origins of health and disease. En ligne : http://dx.doi.org/10.1111/jcpp.12000 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=188 Social brain circuitry and social cognition in infants born preterm / A. FENOGLIO in Journal of Neurodevelopmental Disorders, 9-1 (December 2017)
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Titre : Social brain circuitry and social cognition in infants born preterm Type de document : Texte imprimé et/ou numérique Auteurs : A. FENOGLIO, Auteur ; Michael K. GEORGIEFF, Auteur ; J. T. ELISON, Auteur Article en page(s) : p.27 Langues : Anglais (eng) Mots-clés : Neurodevelopment Neuroplasticity Prematurity Social brain Social cognition Index. décimale : PER Périodiques Résumé : Preterm birth is associated with an increased risk of adverse neurologic, psychiatric, and cognitive outcomes. The brain circuits involved in processing social information are critical to all of these domains, but little work has been done to examine whether and how these circuits may be especially sensitive to prematurity. This paper contains a brief summary of some of the cognitive, psychiatric, and social outcomes associated with prematurity, followed by a description of findings from the modest body of research into social-cognitive development in infants and children born preterm. Next, findings from studies of structural and functional brain development in infants born preterm are reviewed, with an eye toward the distinctive role of the brain circuits implicated in social functioning. The goal of this review is to investigate the extent to which the putative "social brain" may have particular developmental susceptibilities to the insults associated with preterm birth, and the role of early social-cognitive development in later neurodevelopmental outcomes. Much work has been done to characterize neurobehavioral outcomes in the preterm population, but future research must incorporate both brain and behavioral measures to identify early biomarkers linked to later emerging social-cognitive clinical impairment in order to guide effective, targeted intervention. En ligne : http://dx.doi.org/10.1186/s11689-017-9206-9 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=350
in Journal of Neurodevelopmental Disorders > 9-1 (December 2017) . - p.27[article] Social brain circuitry and social cognition in infants born preterm [Texte imprimé et/ou numérique] / A. FENOGLIO, Auteur ; Michael K. GEORGIEFF, Auteur ; J. T. ELISON, Auteur . - p.27.
Langues : Anglais (eng)
in Journal of Neurodevelopmental Disorders > 9-1 (December 2017) . - p.27
Mots-clés : Neurodevelopment Neuroplasticity Prematurity Social brain Social cognition Index. décimale : PER Périodiques Résumé : Preterm birth is associated with an increased risk of adverse neurologic, psychiatric, and cognitive outcomes. The brain circuits involved in processing social information are critical to all of these domains, but little work has been done to examine whether and how these circuits may be especially sensitive to prematurity. This paper contains a brief summary of some of the cognitive, psychiatric, and social outcomes associated with prematurity, followed by a description of findings from the modest body of research into social-cognitive development in infants and children born preterm. Next, findings from studies of structural and functional brain development in infants born preterm are reviewed, with an eye toward the distinctive role of the brain circuits implicated in social functioning. The goal of this review is to investigate the extent to which the putative "social brain" may have particular developmental susceptibilities to the insults associated with preterm birth, and the role of early social-cognitive development in later neurodevelopmental outcomes. Much work has been done to characterize neurobehavioral outcomes in the preterm population, but future research must incorporate both brain and behavioral measures to identify early biomarkers linked to later emerging social-cognitive clinical impairment in order to guide effective, targeted intervention. En ligne : http://dx.doi.org/10.1186/s11689-017-9206-9 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=350 Social brain circuitry and social cognition in infants born preterm / A. FENOGLIO in Journal of Neurodevelopmental Disorders, 9-1 (December 2017)
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