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Brief Report: Phenotypic Differences and their Relationship to Paternal Age and Gender in Autism Spectrum Disorder / Esther VIERCK in Journal of Autism and Developmental Disorders, 45-6 (June 2015)
[article]
Titre : Brief Report: Phenotypic Differences and their Relationship to Paternal Age and Gender in Autism Spectrum Disorder Type de document : Texte imprimé et/ou numérique Auteurs : Esther VIERCK, Auteur ; Jeremy M. SILVERMAN, Auteur Article en page(s) : p.1915-1924 Langues : Anglais (eng) Mots-clés : Autism De novo mutations Paternal age Phenotype Maternal age Index. décimale : PER Périodiques Résumé : Two modes of inheritance have been proposed in autism spectrum disorder, transmission though pre-existing variants and de novo mutations. Different modes may lead to different symptom expressions in affected individuals. De novo mutations become more likely with advancing paternal age suggesting that paternal age may predict phenotypic differences. To test this possibility we measured IQ, adaptive behavior, and autistic symptoms in 830 probands from simplex families. We conducted multiple linear regression analysis to estimate the predictive value of paternal age, maternal age, and gender on behavioral measures and IQ. We found a differential effect of parental age and sex on repetitive and restricted behaviors. Findings suggest effects of paternal age on phenotypic differences in simplex families with ASD. En ligne : http://dx.doi.org/10.1007/s10803-014-2346-9 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=259
in Journal of Autism and Developmental Disorders > 45-6 (June 2015) . - p.1915-1924[article] Brief Report: Phenotypic Differences and their Relationship to Paternal Age and Gender in Autism Spectrum Disorder [Texte imprimé et/ou numérique] / Esther VIERCK, Auteur ; Jeremy M. SILVERMAN, Auteur . - p.1915-1924.
Langues : Anglais (eng)
in Journal of Autism and Developmental Disorders > 45-6 (June 2015) . - p.1915-1924
Mots-clés : Autism De novo mutations Paternal age Phenotype Maternal age Index. décimale : PER Périodiques Résumé : Two modes of inheritance have been proposed in autism spectrum disorder, transmission though pre-existing variants and de novo mutations. Different modes may lead to different symptom expressions in affected individuals. De novo mutations become more likely with advancing paternal age suggesting that paternal age may predict phenotypic differences. To test this possibility we measured IQ, adaptive behavior, and autistic symptoms in 830 probands from simplex families. We conducted multiple linear regression analysis to estimate the predictive value of paternal age, maternal age, and gender on behavioral measures and IQ. We found a differential effect of parental age and sex on repetitive and restricted behaviors. Findings suggest effects of paternal age on phenotypic differences in simplex families with ASD. En ligne : http://dx.doi.org/10.1007/s10803-014-2346-9 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=259 Commentary: We've only just begun: unravelling the underlying genetics of neurodevelopmental disorders – a commentary on Kiser et al. () / David COGHILL in Journal of Child Psychology and Psychiatry, 56-3 (March 2015)
[article]
Titre : Commentary: We've only just begun: unravelling the underlying genetics of neurodevelopmental disorders – a commentary on Kiser et al. () Type de document : Texte imprimé et/ou numérique Auteurs : David COGHILL, Auteur Article en page(s) : p.296-298 Langues : Anglais (eng) Mots-clés : Neurodevelopmental disorders genetic variations genomics neurobiology shared cognitive deficits de novo mutations Index. décimale : PER Périodiques Résumé : Kiser and colleagues (this issue) have presented us with a comprehensive and bold review that describes current understanding of the genetic influences that underpin three of the most important neurodevelopmental disorders: attention deficit hyperactivity disorder (ADHD), autism spectrum disorder (ASD) and intellectual disability (ID), and explores several new avenues of thinking that are opening up based on this knowledge. Based on phenotypic overlap, comorbidity and a sharing of genetic and environmental risks they propose that ADHD, ASD and ID together form part of a continuum. The idea that disorders we have traditionally seen as being separate are in fact inter-related is, of course, not an entirely new one and indeed has similarly been proposed for the developmental disorders by Gillberg and in a more general way as a part of the NIMH Research Domain Criteria (RDoC) project. Where this review differs is in the authors’ attempts to look at several possible mechanisms for these. En ligne : http://dx.doi.org/10.1111/jcpp.12399 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=260
in Journal of Child Psychology and Psychiatry > 56-3 (March 2015) . - p.296-298[article] Commentary: We've only just begun: unravelling the underlying genetics of neurodevelopmental disorders – a commentary on Kiser et al. () [Texte imprimé et/ou numérique] / David COGHILL, Auteur . - p.296-298.
Langues : Anglais (eng)
in Journal of Child Psychology and Psychiatry > 56-3 (March 2015) . - p.296-298
Mots-clés : Neurodevelopmental disorders genetic variations genomics neurobiology shared cognitive deficits de novo mutations Index. décimale : PER Périodiques Résumé : Kiser and colleagues (this issue) have presented us with a comprehensive and bold review that describes current understanding of the genetic influences that underpin three of the most important neurodevelopmental disorders: attention deficit hyperactivity disorder (ADHD), autism spectrum disorder (ASD) and intellectual disability (ID), and explores several new avenues of thinking that are opening up based on this knowledge. Based on phenotypic overlap, comorbidity and a sharing of genetic and environmental risks they propose that ADHD, ASD and ID together form part of a continuum. The idea that disorders we have traditionally seen as being separate are in fact inter-related is, of course, not an entirely new one and indeed has similarly been proposed for the developmental disorders by Gillberg and in a more general way as a part of the NIMH Research Domain Criteria (RDoC) project. Where this review differs is in the authors’ attempts to look at several possible mechanisms for these. En ligne : http://dx.doi.org/10.1111/jcpp.12399 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=260