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Brain function and gaze fixation during facial-emotion processing in fragile X and autism / Kim M. DALTON in Autism Research, 1-4 (August 2008)
[article]
Titre : Brain function and gaze fixation during facial-emotion processing in fragile X and autism Type de document : Texte imprimé et/ou numérique Auteurs : Kim M. DALTON, Auteur ; Laura HOLSEN, Auteur ; Leonard ABBEDUTO, Auteur ; Richard J. DAVIDSON, Auteur Année de publication : 2008 Article en page(s) : p.231-239 Langues : Anglais (eng) Mots-clés : fragile-X-syndrome autism face-processing brain-function fMRI Index. décimale : PER Périodiques Résumé : Fragile X syndrome (FXS) is the most commonly known genetic disorder associated with autism spectrum disorder (ASD). Overlapping features in these populations include gaze aversion, communication deficits, and social withdrawal. Although the association between FXS and ASD has been well documented at the behavioral level, the underlying neural mechanisms associated with the social/emotional deficits in these groups remain unclear. We collected functional brain images and eye-gaze fixations from 9 individuals with FXS and 14 individuals with idiopathic ASD, as well as 15 typically developing (TD) individuals, while they performed a facial-emotion discrimination task. The FXS group showed a similar yet less aberrant pattern of gaze fixations compared with the ASD group. The FXS group also showed fusiform gyrus (FG) hypoactivation compared with the TD control group. Activation in FG was strongly and positively associated with average eye fixation and negatively associated with ASD characteristics in the FXS group. The FXS group displayed significantly greater activation than both the TD control and ASD groups in the left hippocampus (HIPP), left superior temporal gyrus (STG), right insula (INS), and left postcentral gyrus (PCG). These group differences in brain activation are important as they suggest unique underlying face-processing neural circuitry in FXS versus idiopathic ASD, largely supporting the hypothesis that ASD characteristics in FXS and idiopathic ASD reflect partially divergent impairments at the neural level, at least in FXS individuals without a co-morbid diagnosis of ASD. En ligne : http://dx.doi.org/10.1002/aur.32 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=932
in Autism Research > 1-4 (August 2008) . - p.231-239[article] Brain function and gaze fixation during facial-emotion processing in fragile X and autism [Texte imprimé et/ou numérique] / Kim M. DALTON, Auteur ; Laura HOLSEN, Auteur ; Leonard ABBEDUTO, Auteur ; Richard J. DAVIDSON, Auteur . - 2008 . - p.231-239.
Langues : Anglais (eng)
in Autism Research > 1-4 (August 2008) . - p.231-239
Mots-clés : fragile-X-syndrome autism face-processing brain-function fMRI Index. décimale : PER Périodiques Résumé : Fragile X syndrome (FXS) is the most commonly known genetic disorder associated with autism spectrum disorder (ASD). Overlapping features in these populations include gaze aversion, communication deficits, and social withdrawal. Although the association between FXS and ASD has been well documented at the behavioral level, the underlying neural mechanisms associated with the social/emotional deficits in these groups remain unclear. We collected functional brain images and eye-gaze fixations from 9 individuals with FXS and 14 individuals with idiopathic ASD, as well as 15 typically developing (TD) individuals, while they performed a facial-emotion discrimination task. The FXS group showed a similar yet less aberrant pattern of gaze fixations compared with the ASD group. The FXS group also showed fusiform gyrus (FG) hypoactivation compared with the TD control group. Activation in FG was strongly and positively associated with average eye fixation and negatively associated with ASD characteristics in the FXS group. The FXS group displayed significantly greater activation than both the TD control and ASD groups in the left hippocampus (HIPP), left superior temporal gyrus (STG), right insula (INS), and left postcentral gyrus (PCG). These group differences in brain activation are important as they suggest unique underlying face-processing neural circuitry in FXS versus idiopathic ASD, largely supporting the hypothesis that ASD characteristics in FXS and idiopathic ASD reflect partially divergent impairments at the neural level, at least in FXS individuals without a co-morbid diagnosis of ASD. En ligne : http://dx.doi.org/10.1002/aur.32 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=932