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Maternal metabolic risk factors for autism spectrum disorder—An analysis of electronic medical records and linked birth data / Natalia CONNOLLY in Autism Research, 9-8 (August 2016)
[article]
Titre : Maternal metabolic risk factors for autism spectrum disorder—An analysis of electronic medical records and linked birth data Type de document : Texte imprimé et/ou numérique Auteurs : Natalia CONNOLLY, Auteur ; Julia ANIXT, Auteur ; Patty MANNING, Auteur ; Daniel PING-I LIN, Auteur ; Keith A. MARSOLO, Auteur ; Katherine BOWERS, Auteur Article en page(s) : p.829-837 Langues : Anglais (eng) Mots-clés : autism obesity gestational diabetes mellitus epidemiology electronic medical records Index. décimale : PER Périodiques Résumé : Past studies have suggested that conditions experienced by women during pregnancy (e.g. obesity and gestational diabetes mellitus (GDM)) may be associated with having a child with autism spectrum disorder (ASD). Our objective was to compare mothers who had a child diagnosed with ASD to mothers of children with a non-ASD developmental disorder (DD) or without any reported DD (controls). To accomplish the objective we collected medical record data from patients who resided in the Cincinnati Children's Hospital Medical Center's (CCHMC) primary catchment area and linked those data to data from birth certificates (to identify risk factors). Two comparison groups were analyzed; one with DD; and the other, controls without a reported ASD or DD. Descriptive statistics and regression analyses evaluated differences. Differences were greater comparing mothers of ASD to controls than comparing ASD to DD. Maternal obesity and GDM were associated with a statistically significant approximately 1.5-fold increased odds of having a child with an ASD. For mothers with both GDM and obesity, the association was twofold for having a child with ASD compared with controls. Maternal obesity and GDM might be associated with an increased risk of ASD in the offspring; however, no difference in risk of ASD according to BMI and GDM was seen when comparing to DD. Autism Res 2016, 9: 829–837,. © 2016 En ligne : http://dx.doi.org/10.1002/aur.1586 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=293
in Autism Research > 9-8 (August 2016) . - p.829-837[article] Maternal metabolic risk factors for autism spectrum disorder—An analysis of electronic medical records and linked birth data [Texte imprimé et/ou numérique] / Natalia CONNOLLY, Auteur ; Julia ANIXT, Auteur ; Patty MANNING, Auteur ; Daniel PING-I LIN, Auteur ; Keith A. MARSOLO, Auteur ; Katherine BOWERS, Auteur . - p.829-837.
Langues : Anglais (eng)
in Autism Research > 9-8 (August 2016) . - p.829-837
Mots-clés : autism obesity gestational diabetes mellitus epidemiology electronic medical records Index. décimale : PER Périodiques Résumé : Past studies have suggested that conditions experienced by women during pregnancy (e.g. obesity and gestational diabetes mellitus (GDM)) may be associated with having a child with autism spectrum disorder (ASD). Our objective was to compare mothers who had a child diagnosed with ASD to mothers of children with a non-ASD developmental disorder (DD) or without any reported DD (controls). To accomplish the objective we collected medical record data from patients who resided in the Cincinnati Children's Hospital Medical Center's (CCHMC) primary catchment area and linked those data to data from birth certificates (to identify risk factors). Two comparison groups were analyzed; one with DD; and the other, controls without a reported ASD or DD. Descriptive statistics and regression analyses evaluated differences. Differences were greater comparing mothers of ASD to controls than comparing ASD to DD. Maternal obesity and GDM were associated with a statistically significant approximately 1.5-fold increased odds of having a child with an ASD. For mothers with both GDM and obesity, the association was twofold for having a child with ASD compared with controls. Maternal obesity and GDM might be associated with an increased risk of ASD in the offspring; however, no difference in risk of ASD according to BMI and GDM was seen when comparing to DD. Autism Res 2016, 9: 829–837,. © 2016 En ligne : http://dx.doi.org/10.1002/aur.1586 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=293