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Prenatal stress exposure, oxytocin receptor gene (OXTR) methylation, and child autistic traits: The moderating role of OXTR rs53576 genotype / Jolien RIJLAARSDAM in Autism Research, 10-3 (March 2017)
[article]
Titre : Prenatal stress exposure, oxytocin receptor gene (OXTR) methylation, and child autistic traits: The moderating role of OXTR rs53576 genotype Type de document : Texte imprimé et/ou numérique Auteurs : Jolien RIJLAARSDAM, Auteur ; Marinus H. VAN IJZENDOORN, Auteur ; Frank C. VERHULST, Auteur ; Vincent W.V. JADDOE, Auteur ; Janine F. FELIX, Auteur ; Henning TIEMEIER, Auteur ; Marian J. BAKERMANS-KRANENBURG, Auteur Article en page(s) : p.430-438 Langues : Anglais (eng) Mots-clés : DNA methylation oxytocin receptor gene (OXTR) autistic traits stress exposure Index. décimale : PER Périodiques Résumé : Findings of studies investigating OXTR SNP rs53576 (G-A) variation in social behavior have been inconsistent, possibly because DNA methylation after stress exposure was eliminated from consideration. Our goal was to examine OXTR rs53576 allele-specific sensitivity for neonatal OXTR DNA methylation in relation to (1) a prenatal maternal stress composite, and (2) child autistic traits. Prospective data from fetal life to age 6 years were collected in a total of 743 children participating in the Generation R Study. Prenatal maternal stress exposure was uniquely associated with child autistic traits but was unrelated to OXTR methylation across both OXTR rs53576 G-allele homozygous children and A-allele carriers. For child autistic traits in general and social communication problems in particular, we observed a significant OXTR rs53576 genotype by OXTR methylation interaction in the absence of main effects, suggesting that opposing effects cancelled each other out. Indeed, OXTR methylation levels were positively associated with social problems for OXTR rs53576 G-allele homozygous children but not for A-allele carriers. These results highlight the importance of incorporating epi-allelic information and support the role of OXTR methylation in child autistic traits. En ligne : http://dx.doi.org/10.1002/aur.1681 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=304
in Autism Research > 10-3 (March 2017) . - p.430-438[article] Prenatal stress exposure, oxytocin receptor gene (OXTR) methylation, and child autistic traits: The moderating role of OXTR rs53576 genotype [Texte imprimé et/ou numérique] / Jolien RIJLAARSDAM, Auteur ; Marinus H. VAN IJZENDOORN, Auteur ; Frank C. VERHULST, Auteur ; Vincent W.V. JADDOE, Auteur ; Janine F. FELIX, Auteur ; Henning TIEMEIER, Auteur ; Marian J. BAKERMANS-KRANENBURG, Auteur . - p.430-438.
Langues : Anglais (eng)
in Autism Research > 10-3 (March 2017) . - p.430-438
Mots-clés : DNA methylation oxytocin receptor gene (OXTR) autistic traits stress exposure Index. décimale : PER Périodiques Résumé : Findings of studies investigating OXTR SNP rs53576 (G-A) variation in social behavior have been inconsistent, possibly because DNA methylation after stress exposure was eliminated from consideration. Our goal was to examine OXTR rs53576 allele-specific sensitivity for neonatal OXTR DNA methylation in relation to (1) a prenatal maternal stress composite, and (2) child autistic traits. Prospective data from fetal life to age 6 years were collected in a total of 743 children participating in the Generation R Study. Prenatal maternal stress exposure was uniquely associated with child autistic traits but was unrelated to OXTR methylation across both OXTR rs53576 G-allele homozygous children and A-allele carriers. For child autistic traits in general and social communication problems in particular, we observed a significant OXTR rs53576 genotype by OXTR methylation interaction in the absence of main effects, suggesting that opposing effects cancelled each other out. Indeed, OXTR methylation levels were positively associated with social problems for OXTR rs53576 G-allele homozygous children but not for A-allele carriers. These results highlight the importance of incorporating epi-allelic information and support the role of OXTR methylation in child autistic traits. En ligne : http://dx.doi.org/10.1002/aur.1681 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=304