Dépouillements

Issue Information in Autism Research, 10-3 (March 2017)  

Public ISBD [article]  inAutism Research > 10-3 (March 2017) . - p.379-383 Titre : Issue Information Type de document : Texte imprimé et/ou numérique Article en page(s) : p.379-383 Langues : Anglais (eng) Index. décimale : PER Périodiques En ligne : http://dx.doi.org/10.1002/aur.1696 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=304 [article] Issue Information [Texte imprimé et/ou numérique] . - p.379-383. Langues : Anglais (eng) in Autism Research > 10-3 (March 2017) . - p.379-383 Index. décimale : PER Périodiques En ligne : http://dx.doi.org/10.1002/aur.1696 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=304

“Is voice a marker for Autism spectrum disorder? A systematic review and meta-analysis” / Riccardo FUSAROLI in Autism Research, 10-3 (March 2017)  

Public ISBD [article]  inAutism Research > 10-3 (March 2017) . - p.384-407 Titre : “Is voice a marker for Autism spectrum disorder? A systematic review and meta-analysis” Type de document : Texte imprimé et/ou numérique Auteurs : Riccardo FUSAROLI, Auteur ; Anna LAMBRECHTS, Auteur ; Dan BANG, Auteur ; Dermot M. BOWLER, Auteur ; Sebastian B. GAIGG, Auteur Article en page(s) : p.384-407 Langues : Anglais (eng) Mots-clés : voice  speech  acoustic properties  machine learning  biomarker Index. décimale : PER Périodiques Résumé : Individuals with Autism Spectrum Disorder (ASD) tend to show distinctive, atypical acoustic patterns of speech. These behaviors affect social interactions and social development and could represent a non-invasive marker for ASD. We systematically reviewed the literature quantifying acoustic patterns in ASD. Search terms were: (prosody OR intonation OR inflection OR intensity OR pitch OR fundamental frequency OR speech rate OR voice quality OR acoustic) AND (autis* OR Asperger). Results were filtered to include only: empirical studies quantifying acoustic features of vocal production in ASD, with a sample size >2, and the inclusion of a neurotypical comparison group and/or correlations between acoustic measures and severity of clinical features. We identified 34 articles, including 30 univariate studies and 15 multivariate machine-learning studies. We performed meta-analyses of the univariate studies, identifying significant differences in mean pitch and pitch range between individuals with ASD and comparison participants (Cohen's d of 0.4–0.5 and discriminatory accuracy of about 61–64%). The multivariate studies reported higher accuracies than the univariate studies (63–96%). However, the methods used and the acoustic features investigated were too diverse for performing meta-analysis. We conclude that multivariate studies of acoustic patterns are a promising but yet unsystematic avenue for establishing ASD markers. We outline three recommendations for future studies: open data, open methods, and theory-driven research. En ligne : http://dx.doi.org/10.1002/aur.1678 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=304 [article] “Is voice a marker for Autism spectrum disorder? A systematic review and meta-analysis” [Texte imprimé et/ou numérique] / Riccardo FUSAROLI, Auteur ; Anna LAMBRECHTS, Auteur ; Dan BANG, Auteur ; Dermot M. BOWLER, Auteur ; Sebastian B. GAIGG, Auteur . - p.384-407. Langues : Anglais (eng) in Autism Research > 10-3 (March 2017) . - p.384-407 Mots-clés : voice  speech  acoustic properties  machine learning  biomarker Index. décimale : PER Périodiques Résumé : Individuals with Autism Spectrum Disorder (ASD) tend to show distinctive, atypical acoustic patterns of speech. These behaviors affect social interactions and social development and could represent a non-invasive marker for ASD. We systematically reviewed the literature quantifying acoustic patterns in ASD. Search terms were: (prosody OR intonation OR inflection OR intensity OR pitch OR fundamental frequency OR speech rate OR voice quality OR acoustic) AND (autis* OR Asperger). Results were filtered to include only: empirical studies quantifying acoustic features of vocal production in ASD, with a sample size >2, and the inclusion of a neurotypical comparison group and/or correlations between acoustic measures and severity of clinical features. We identified 34 articles, including 30 univariate studies and 15 multivariate machine-learning studies. We performed meta-analyses of the univariate studies, identifying significant differences in mean pitch and pitch range between individuals with ASD and comparison participants (Cohen's d of 0.4–0.5 and discriminatory accuracy of about 61–64%). The multivariate studies reported higher accuracies than the univariate studies (63–96%). However, the methods used and the acoustic features investigated were too diverse for performing meta-analysis. We conclude that multivariate studies of acoustic patterns are a promising but yet unsystematic avenue for establishing ASD markers. We outline three recommendations for future studies: open data, open methods, and theory-driven research. En ligne : http://dx.doi.org/10.1002/aur.1678 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=304

Measurement of urine indolylacroylglycine is not useful in the diagnosis or dietary management of autism / Neil R. DALTON in Autism Research, 10-3 (March 2017)  

Public ISBD [article]  inAutism Research > 10-3 (March 2017) . - p.408-413 Titre : Measurement of urine indolylacroylglycine is not useful in the diagnosis or dietary management of autism Type de document : Texte imprimé et/ou numérique Auteurs : Neil R. DALTON, Auteur ; Susie CHANDLER, Auteur ; Charles TURNER, Auteur ; Tony CHARMAN, Auteur ; Andrew PICKLES, Auteur ; Emily SIMONOFF, Auteur ; Gillian BAIRD, Auteur Article en page(s) : p.408-413 Langues : Anglais (eng) Mots-clés : autism  indoleacroylglycine  gastrointestinal  regression Index. décimale : PER Périodiques Résumé : To measure urine indolylacroylglycine (IAG) excretion using the IAG:creatinine ratio in children with autism spectrum disorder (ASD) compared with two groups of age matched controls, one with special needs but without ASD (SEN) and one typically developing (TD) and in subgroups with/without current gastrointestinal problems and ASD with and without regression. IAG:creatinine ratio was measured in the urine of 279 children aged 10–14 years: 129 children with ASD (28 with and 101 without regression), 62 SEN controls and 88 TD controls. The prevalence of gastro-intestinal symptoms (GIS) was recorded. No differences were found in the urine IAG:creatinine ratio among groups ASD, TD and SEN; nor in the ASD groups with/without regression, nor in those with/without GIS. This study finds no evidence of increased urine IAG excretion in children with ASD, with or without GIS or with or without regression. Urinary IAG measurements in children with ASD offer no support for increased presence of neuroactive peptides proposed to result from increased gut permeability. We found measurement of urinary IAG to have no value in the diagnosis of autism or in the dietary management of children with ASD. En ligne : http://dx.doi.org/10.1002/aur.1688 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=304 [article] Measurement of urine indolylacroylglycine is not useful in the diagnosis or dietary management of autism [Texte imprimé et/ou numérique] / Neil R. DALTON, Auteur ; Susie CHANDLER, Auteur ; Charles TURNER, Auteur ; Tony CHARMAN, Auteur ; Andrew PICKLES, Auteur ; Emily SIMONOFF, Auteur ; Gillian BAIRD, Auteur . - p.408-413. Langues : Anglais (eng) in Autism Research > 10-3 (March 2017) . - p.408-413 Mots-clés : autism  indoleacroylglycine  gastrointestinal  regression Index. décimale : PER Périodiques Résumé : To measure urine indolylacroylglycine (IAG) excretion using the IAG:creatinine ratio in children with autism spectrum disorder (ASD) compared with two groups of age matched controls, one with special needs but without ASD (SEN) and one typically developing (TD) and in subgroups with/without current gastrointestinal problems and ASD with and without regression. IAG:creatinine ratio was measured in the urine of 279 children aged 10–14 years: 129 children with ASD (28 with and 101 without regression), 62 SEN controls and 88 TD controls. The prevalence of gastro-intestinal symptoms (GIS) was recorded. No differences were found in the urine IAG:creatinine ratio among groups ASD, TD and SEN; nor in the ASD groups with/without regression, nor in those with/without GIS. This study finds no evidence of increased urine IAG excretion in children with ASD, with or without GIS or with or without regression. Urinary IAG measurements in children with ASD offer no support for increased presence of neuroactive peptides proposed to result from increased gut permeability. We found measurement of urinary IAG to have no value in the diagnosis of autism or in the dietary management of children with ASD. En ligne : http://dx.doi.org/10.1002/aur.1688 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=304

SLC9A9 Co-expression modules in autism-associated brain regions / Jameson PATAK in Autism Research, 10-3 (March 2017)  

Public ISBD [article]  inAutism Research > 10-3 (March 2017) . - p.414-429 Titre : SLC9A9 Co-expression modules in autism-associated brain regions Type de document : Texte imprimé et/ou numérique Auteurs : Jameson PATAK, Auteur ; Jonathan L. HESS, Auteur ; Yanli ZHANG-JAMES, Auteur ; Stephen J. GLATT, Auteur ; Stephen V. FARAONE, Auteur Article en page(s) : p.414-429 Langues : Anglais (eng) Mots-clés : SLC9A9  weighted gene co-expression network analysis  Autism spectrum disorder  endosomal pathway  transcriptome Index. décimale : PER Périodiques Résumé : SLC9A9 is a sodium hydrogen exchanger present in the recycling endosome and highly expressed in the brain. It is implicated in neuropsychiatric disorders, including autism spectrum disorders (ASDs). Little research concerning its gene expression patterns and biological pathways has been conducted. We sought to investigate its possible biological roles in autism-associated brain regions throughout development. We conducted a weighted gene co-expression network analysis on RNA-seq data downloaded from Brainspan. We compared prenatal and postnatal gene expression networks for three ASD-associated brain regions known to have high SLC9A9 gene expression. We also performed an ASD-associated single nucleotide polymorphism enrichment analysis and a cell signature enrichment analysis. The modules showed differences in gene constituents (membership), gene number, and connectivity throughout time. SLC9A9 was highly associated with immune system functions, metabolism, apoptosis, endocytosis, and signaling cascades. Gene list comparison with co-immunoprecipitation data was significant for multiple modules. We found a disproportionately high autism risk signal among genes constituting the prenatal hippocampal module. The modules were enriched with astrocyte and oligodendrocyte markers. SLC9A9 is potentially involved in the pathophysiology of ASDs. Our investigation confirmed proposed functions for SLC9A9, such as endocytosis and immune regulation, while also revealing potential roles in mTOR signaling and cell survival.. By providing a concise molecular map and interactions, evidence of cell type and implicated brain regions we hope this will guide future research on SLC9A9. En ligne : http://dx.doi.org/10.1002/aur.1670 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=304 [article] SLC9A9 Co-expression modules in autism-associated brain regions [Texte imprimé et/ou numérique] / Jameson PATAK, Auteur ; Jonathan L. HESS, Auteur ; Yanli ZHANG-JAMES, Auteur ; Stephen J. GLATT, Auteur ; Stephen V. FARAONE, Auteur . - p.414-429. Langues : Anglais (eng) in Autism Research > 10-3 (March 2017) . - p.414-429 Mots-clés : SLC9A9  weighted gene co-expression network analysis  Autism spectrum disorder  endosomal pathway  transcriptome Index. décimale : PER Périodiques Résumé : SLC9A9 is a sodium hydrogen exchanger present in the recycling endosome and highly expressed in the brain. It is implicated in neuropsychiatric disorders, including autism spectrum disorders (ASDs). Little research concerning its gene expression patterns and biological pathways has been conducted. We sought to investigate its possible biological roles in autism-associated brain regions throughout development. We conducted a weighted gene co-expression network analysis on RNA-seq data downloaded from Brainspan. We compared prenatal and postnatal gene expression networks for three ASD-associated brain regions known to have high SLC9A9 gene expression. We also performed an ASD-associated single nucleotide polymorphism enrichment analysis and a cell signature enrichment analysis. The modules showed differences in gene constituents (membership), gene number, and connectivity throughout time. SLC9A9 was highly associated with immune system functions, metabolism, apoptosis, endocytosis, and signaling cascades. Gene list comparison with co-immunoprecipitation data was significant for multiple modules. We found a disproportionately high autism risk signal among genes constituting the prenatal hippocampal module. The modules were enriched with astrocyte and oligodendrocyte markers. SLC9A9 is potentially involved in the pathophysiology of ASDs. Our investigation confirmed proposed functions for SLC9A9, such as endocytosis and immune regulation, while also revealing potential roles in mTOR signaling and cell survival.. By providing a concise molecular map and interactions, evidence of cell type and implicated brain regions we hope this will guide future research on SLC9A9. En ligne : http://dx.doi.org/10.1002/aur.1670 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=304

Prenatal stress exposure, oxytocin receptor gene (OXTR) methylation, and child autistic traits: The moderating role of OXTR rs53576 genotype / Jolien RIJLAARSDAM in Autism Research, 10-3 (March 2017)  

Public ISBD [article]  inAutism Research > 10-3 (March 2017) . - p.430-438 Titre : Prenatal stress exposure, oxytocin receptor gene (OXTR) methylation, and child autistic traits: The moderating role of OXTR rs53576 genotype Type de document : Texte imprimé et/ou numérique Auteurs : Jolien RIJLAARSDAM, Auteur ; Marinus H. VAN IJZENDOORN, Auteur ; Frank C. VERHULST, Auteur ; Vincent W.V. JADDOE, Auteur ; Janine F. FELIX, Auteur ; Henning TIEMEIER, Auteur ; Marian J. BAKERMANS-KRANENBURG, Auteur Article en page(s) : p.430-438 Langues : Anglais (eng) Mots-clés : DNA methylation  oxytocin receptor gene (OXTR)  autistic traits  stress exposure Index. décimale : PER Périodiques Résumé : Findings of studies investigating OXTR SNP rs53576 (G-A) variation in social behavior have been inconsistent, possibly because DNA methylation after stress exposure was eliminated from consideration. Our goal was to examine OXTR rs53576 allele-specific sensitivity for neonatal OXTR DNA methylation in relation to (1) a prenatal maternal stress composite, and (2) child autistic traits. Prospective data from fetal life to age 6 years were collected in a total of 743 children participating in the Generation R Study. Prenatal maternal stress exposure was uniquely associated with child autistic traits but was unrelated to OXTR methylation across both OXTR rs53576 G-allele homozygous children and A-allele carriers. For child autistic traits in general and social communication problems in particular, we observed a significant OXTR rs53576 genotype by OXTR methylation interaction in the absence of main effects, suggesting that opposing effects cancelled each other out. Indeed, OXTR methylation levels were positively associated with social problems for OXTR rs53576 G-allele homozygous children but not for A-allele carriers. These results highlight the importance of incorporating epi-allelic information and support the role of OXTR methylation in child autistic traits. En ligne : http://dx.doi.org/10.1002/aur.1681 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=304 [article] Prenatal stress exposure, oxytocin receptor gene (OXTR) methylation, and child autistic traits: The moderating role of OXTR rs53576 genotype [Texte imprimé et/ou numérique] / Jolien RIJLAARSDAM, Auteur ; Marinus H. VAN IJZENDOORN, Auteur ; Frank C. VERHULST, Auteur ; Vincent W.V. JADDOE, Auteur ; Janine F. FELIX, Auteur ; Henning TIEMEIER, Auteur ; Marian J. BAKERMANS-KRANENBURG, Auteur . - p.430-438. Langues : Anglais (eng) in Autism Research > 10-3 (March 2017) . - p.430-438 Mots-clés : DNA methylation  oxytocin receptor gene (OXTR)  autistic traits  stress exposure Index. décimale : PER Périodiques Résumé : Findings of studies investigating OXTR SNP rs53576 (G-A) variation in social behavior have been inconsistent, possibly because DNA methylation after stress exposure was eliminated from consideration. Our goal was to examine OXTR rs53576 allele-specific sensitivity for neonatal OXTR DNA methylation in relation to (1) a prenatal maternal stress composite, and (2) child autistic traits. Prospective data from fetal life to age 6 years were collected in a total of 743 children participating in the Generation R Study. Prenatal maternal stress exposure was uniquely associated with child autistic traits but was unrelated to OXTR methylation across both OXTR rs53576 G-allele homozygous children and A-allele carriers. For child autistic traits in general and social communication problems in particular, we observed a significant OXTR rs53576 genotype by OXTR methylation interaction in the absence of main effects, suggesting that opposing effects cancelled each other out. Indeed, OXTR methylation levels were positively associated with social problems for OXTR rs53576 G-allele homozygous children but not for A-allele carriers. These results highlight the importance of incorporating epi-allelic information and support the role of OXTR methylation in child autistic traits. En ligne : http://dx.doi.org/10.1002/aur.1681 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=304

RNA sequencing of transformed lymphoblastoid cells from siblings discordant for autism spectrum disorders reveals transcriptomic and functional alterations: Evidence for sex-specific effects / Daniel S. TYLEE in Autism Research, 10-3 (March 2017)  

Public ISBD [article]  inAutism Research > 10-3 (March 2017) . - p.439-455 Titre : RNA sequencing of transformed lymphoblastoid cells from siblings discordant for autism spectrum disorders reveals transcriptomic and functional alterations: Evidence for sex-specific effects Type de document : Texte imprimé et/ou numérique Auteurs : Daniel S. TYLEE, Auteur ; Alfred J. ESPINOZA, Auteur ; Jonathan L. HESS, Auteur ; Muhammad A. TAHIR, Auteur ; Sarah Y. MCCOY, Auteur ; Joshua K. RIM, Auteur ; Totadri DHIMAL, Auteur ; Ori S. COHEN, Auteur ; Stephen J. GLATT, Auteur Article en page(s) : p.439-455 Langues : Anglais (eng) Mots-clés : RNA sequencing  transcriptome  lymphoblastoid  autism spectrum disorder  sex-differences  biomarker Index. décimale : PER Périodiques Résumé : Genome-wide expression studies of samples derived from individuals with autism spectrum disorder (ASD) and their unaffected siblings have been widely used to shed light on transcriptomic differences associated with this condition. Females have historically been under-represented in ASD genomic studies. Emerging evidence from studies of structural genetic variants and peripheral biomarkers suggest that sex-differences may exist in the biological correlates of ASD. Relatively few studies have explicitly examined whether sex-differences exist in the transcriptomic signature of ASD. The present study quantified genome-wide expression values by performing RNA sequencing on transformed lymphoblastoid cell lines and identified transcripts differentially expressed between same-sex, proximal-aged sibling pairs. We found that performing separate analyses for each sex improved our ability to detect ASD-related transcriptomic differences; we observed a larger number of dysregulated genes within our smaller set of female samples (n?=?12 sibling pairs), as compared with the set of male samples (n?=?24 sibling pairs), with small, but statistically significant overlap between the sexes. Permutation-based gene-set analyses and weighted gene co-expression network analyses also supported the idea that the transcriptomic signature of ASD may differ between males and females. We discuss our findings in the context of the relevant literature, underscoring the need for future ASD studies to explicitly account for differences between the sexes. En ligne : http://dx.doi.org/10.1002/aur.1679 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=304 [article] RNA sequencing of transformed lymphoblastoid cells from siblings discordant for autism spectrum disorders reveals transcriptomic and functional alterations: Evidence for sex-specific effects [Texte imprimé et/ou numérique] / Daniel S. TYLEE, Auteur ; Alfred J. ESPINOZA, Auteur ; Jonathan L. HESS, Auteur ; Muhammad A. TAHIR, Auteur ; Sarah Y. MCCOY, Auteur ; Joshua K. RIM, Auteur ; Totadri DHIMAL, Auteur ; Ori S. COHEN, Auteur ; Stephen J. GLATT, Auteur . - p.439-455. Langues : Anglais (eng) in Autism Research > 10-3 (March 2017) . - p.439-455 Mots-clés : RNA sequencing  transcriptome  lymphoblastoid  autism spectrum disorder  sex-differences  biomarker Index. décimale : PER Périodiques Résumé : Genome-wide expression studies of samples derived from individuals with autism spectrum disorder (ASD) and their unaffected siblings have been widely used to shed light on transcriptomic differences associated with this condition. Females have historically been under-represented in ASD genomic studies. Emerging evidence from studies of structural genetic variants and peripheral biomarkers suggest that sex-differences may exist in the biological correlates of ASD. Relatively few studies have explicitly examined whether sex-differences exist in the transcriptomic signature of ASD. The present study quantified genome-wide expression values by performing RNA sequencing on transformed lymphoblastoid cell lines and identified transcripts differentially expressed between same-sex, proximal-aged sibling pairs. We found that performing separate analyses for each sex improved our ability to detect ASD-related transcriptomic differences; we observed a larger number of dysregulated genes within our smaller set of female samples (n?=?12 sibling pairs), as compared with the set of male samples (n?=?24 sibling pairs), with small, but statistically significant overlap between the sexes. Permutation-based gene-set analyses and weighted gene co-expression network analyses also supported the idea that the transcriptomic signature of ASD may differ between males and females. We discuss our findings in the context of the relevant literature, underscoring the need for future ASD studies to explicitly account for differences between the sexes. En ligne : http://dx.doi.org/10.1002/aur.1679 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=304

Genetic modifications associated with ketogenic diet treatment in the BTBRT+Tf/J mouse model of autism spectrum disorder / Richelle MYCHASIUK in Autism Research, 10-3 (March 2017)  

Public ISBD [article]  inAutism Research > 10-3 (March 2017) . - p.456-471 Titre : Genetic modifications associated with ketogenic diet treatment in the BTBRT+Tf/J mouse model of autism spectrum disorder Type de document : Texte imprimé et/ou numérique Auteurs : Richelle MYCHASIUK, Auteur ; Jong M. RHO, Auteur Article en page(s) : p.456-471 Langues : Anglais (eng) Mots-clés : autism spectrum disorder  ketogenic diet  RNAseq  temporal cortex  hippocampus  mitochondria  development Index. décimale : PER Périodiques Résumé : Background: Autism spectrum disorder (ASD) is a prevalent and heterogeneous neurodevelopmental disorder characterized by hallmark behavioral features. The spectrum of disorders that fall within the ASD umbrella encompass a distinct but overlapping symptom complex that likely results from an array of molecular and genetic aberrations rather than a single genetic mutation. The ketogenic diet (KD) is a high-fat low-carbohydrate anti-seizure and neuroprotective diet that has demonstrated efficacy in the treatment of ASD-like behaviors in animal and human studies. Methods: We investigated changes in mRNA and gene expression in the BTBR mouse model of ASD that may contribute to the behavioral phenotype. In addition, we sought to examine changes in gene expression following KD treatment in BTBR mice. Results: Despite significant behavioral abnormalities, expression changes in BTBR mice did not differ substantially from controls; only 33 genes were differentially expressed in the temporal cortex, and 48 in the hippocampus. Examination of these differentially expressed genes suggested deficits in the stress response and in neuronal signaling/communication. After treatment with the KD, both brain regions demonstrated improvements in ASD deficits associated with myelin formation and white matter development. Conclusions: Although our study supports many of the previously known impairments associated with ASD, such as excessive myelin formation and impaired GABAergic transmission, the RNAseq data and pathway analysis utilized here identified new therapeutic targets for analysis, such as Vitamin D pathways and cAMP signaling. En ligne : http://dx.doi.org/10.1002/aur.1682 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=304 [article] Genetic modifications associated with ketogenic diet treatment in the BTBRT+Tf/J mouse model of autism spectrum disorder [Texte imprimé et/ou numérique] / Richelle MYCHASIUK, Auteur ; Jong M. RHO, Auteur . - p.456-471. Langues : Anglais (eng) in Autism Research > 10-3 (March 2017) . - p.456-471 Mots-clés : autism spectrum disorder  ketogenic diet  RNAseq  temporal cortex  hippocampus  mitochondria  development Index. décimale : PER Périodiques Résumé : Background: Autism spectrum disorder (ASD) is a prevalent and heterogeneous neurodevelopmental disorder characterized by hallmark behavioral features. The spectrum of disorders that fall within the ASD umbrella encompass a distinct but overlapping symptom complex that likely results from an array of molecular and genetic aberrations rather than a single genetic mutation. The ketogenic diet (KD) is a high-fat low-carbohydrate anti-seizure and neuroprotective diet that has demonstrated efficacy in the treatment of ASD-like behaviors in animal and human studies. Methods: We investigated changes in mRNA and gene expression in the BTBR mouse model of ASD that may contribute to the behavioral phenotype. In addition, we sought to examine changes in gene expression following KD treatment in BTBR mice. Results: Despite significant behavioral abnormalities, expression changes in BTBR mice did not differ substantially from controls; only 33 genes were differentially expressed in the temporal cortex, and 48 in the hippocampus. Examination of these differentially expressed genes suggested deficits in the stress response and in neuronal signaling/communication. After treatment with the KD, both brain regions demonstrated improvements in ASD deficits associated with myelin formation and white matter development. Conclusions: Although our study supports many of the previously known impairments associated with ASD, such as excessive myelin formation and impaired GABAergic transmission, the RNAseq data and pathway analysis utilized here identified new therapeutic targets for analysis, such as Vitamin D pathways and cAMP signaling. En ligne : http://dx.doi.org/10.1002/aur.1682 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=304

Severity of ASD symptoms and their correlation with the presence of copy number variations and exposure to first trimester ultrasound / Sara Jane WEBB in Autism Research, 10-3 (March 2017)  

Public ISBD [article]  inAutism Research > 10-3 (March 2017) . - p.472-484 Titre : Severity of ASD symptoms and their correlation with the presence of copy number variations and exposure to first trimester ultrasound Type de document : Texte imprimé et/ou numérique Auteurs : Sara Jane WEBB, Auteur ; Michelle M. GARRISON, Auteur ; Raphael BERNIER, Auteur ; Abbi M. MCCLINTIC, Auteur ; Bryan H. KING, Auteur ; Pierre D. MOURAD, Auteur Article en page(s) : p.472-484 Langues : Anglais (eng) Mots-clés : epidemiology  genetics  environmental influences  ASD severity  ultrasound Index. décimale : PER Périodiques Résumé : Current research suggests that incidence and heterogeneity of autism spectrum disorder (ASD) symptoms may arise through a variety of exogenous and/or endogenous factors. While subject to routine clinical practice and generally considered safe, there exists speculation, though no human data, that diagnostic ultrasound may also contribute to ASD severity, supported by experimental evidence that exposure to ultrasound early in gestation could perturb brain development and alter behavior. Here we explored a modified triple hit hypothesis [Williams & Casanova, ] to assay for a possible relationship between the severity of ASD symptoms and (1) ultrasound exposure (2) during the first trimester of pregnancy in fetuses with a (3) genetic predisposition to ASD. We did so using retrospective analysis of data from the SSC (Simon's Simplex Collection) autism genetic repository funded by the Simons Foundation Autism Research Initiative. We found that male children with ASD, copy number variations (CNVs), and exposure to first trimester ultrasound had significantly decreased non-verbal IQ and increased repetitive behaviors relative to male children with ASD, with CNVs, and no ultrasound. These data suggest that heterogeneity in ASD symptoms may result, at least in part, from exposure to diagnostic ultrasound during early prenatal development of children with specific genetic vulnerabilities. These results also add weight to on-going concerns expressed by the FDA about non-medical use of diagnostic ultrasound during pregnancy. En ligne : http://dx.doi.org/10.1002/aur.1690 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=304 [article] Severity of ASD symptoms and their correlation with the presence of copy number variations and exposure to first trimester ultrasound [Texte imprimé et/ou numérique] / Sara Jane WEBB, Auteur ; Michelle M. GARRISON, Auteur ; Raphael BERNIER, Auteur ; Abbi M. MCCLINTIC, Auteur ; Bryan H. KING, Auteur ; Pierre D. MOURAD, Auteur . - p.472-484. Langues : Anglais (eng) in Autism Research > 10-3 (March 2017) . - p.472-484 Mots-clés : epidemiology  genetics  environmental influences  ASD severity  ultrasound Index. décimale : PER Périodiques Résumé : Current research suggests that incidence and heterogeneity of autism spectrum disorder (ASD) symptoms may arise through a variety of exogenous and/or endogenous factors. While subject to routine clinical practice and generally considered safe, there exists speculation, though no human data, that diagnostic ultrasound may also contribute to ASD severity, supported by experimental evidence that exposure to ultrasound early in gestation could perturb brain development and alter behavior. Here we explored a modified triple hit hypothesis [Williams & Casanova, ] to assay for a possible relationship between the severity of ASD symptoms and (1) ultrasound exposure (2) during the first trimester of pregnancy in fetuses with a (3) genetic predisposition to ASD. We did so using retrospective analysis of data from the SSC (Simon's Simplex Collection) autism genetic repository funded by the Simons Foundation Autism Research Initiative. We found that male children with ASD, copy number variations (CNVs), and exposure to first trimester ultrasound had significantly decreased non-verbal IQ and increased repetitive behaviors relative to male children with ASD, with CNVs, and no ultrasound. These data suggest that heterogeneity in ASD symptoms may result, at least in part, from exposure to diagnostic ultrasound during early prenatal development of children with specific genetic vulnerabilities. These results also add weight to on-going concerns expressed by the FDA about non-medical use of diagnostic ultrasound during pregnancy. En ligne : http://dx.doi.org/10.1002/aur.1690 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=304

Development and validation of a streamlined autism case confirmation approach for use in epidemiologic risk factor research in prospective cohorts / Craig J. NEWSCHAFFER in Autism Research, 10-3 (March 2017)  

Public ISBD [article]  inAutism Research > 10-3 (March 2017) . - p.485-501 Titre : Development and validation of a streamlined autism case confirmation approach for use in epidemiologic risk factor research in prospective cohorts Type de document : Texte imprimé et/ou numérique Auteurs : Craig J. NEWSCHAFFER, Auteur ; Emily SCHRIVER, Auteur ; Lindsay BERRIGAN, Auteur ; Rebecca LANDA, Auteur ; Wendy L. STONE, Auteur ; Somer L. BISHOP, Auteur ; Diane BURKOM, Auteur ; Anne GOLDEN, Auteur ; Lisa IBANEZ, Auteur ; Alice KUO, Auteur ; Kimberly D. LAKES, Auteur ; Daniel S. MESSINGER, Auteur ; Sarah J. PATERSON, Auteur ; Zachary WARREN, Auteur Article en page(s) : p.485-501 Langues : Anglais (eng) Mots-clés : autism  ASD  case-confirmation  epidemiology  diagnosis  novel assessments Index. décimale : PER Périodiques Résumé : The cost associated with incorporating standardized observational assessments and diagnostic interviews in large-scale epidemiologic studies of autism spectrum disorders (ASD) risk factors can be substantial. Streamlined approaches for confirming ASD case status would benefit these studies. We conducted a multi-site, cross-sectional criterion validity study in a convenience sample of 382 three-year olds scheduled for neurodevelopmental evaluation. ASD case classification as determined by three novel assessment instruments (the Early Video-guided Autism Screener E-VAS; the Autism Symptom Interview, ASI; the Screening Tool for Autism in Toddlers Expanded, STAT-E) each designed to be administered in less than 30 minutes by lay staff, was compared to ADOS scores and DSM-based diagnostic assessment from a qualified clinician. Sensitivity and specificity of each instrument alone and in combination were estimated. Alternative cutpoints were identified under different criteria and two-stage cross validation was used to avoid overfitting. Findings were interpreted in the context of a large, prospective pregnancy cohort study utilizing a two-stage approach to case identification. Under initial cutpoints, sensitivity ranged from 0.63 to 0.92 and specificity from 0.35 to 0.70. Cutpoints giving equal weight to sensitivity and specificity resulted in sensitivity estimates ranging from 0.45 to 0.83 and specificity ranging from 0.49 to 0.86. Several strategies were well-suited for application as a second-stage case-confirmation. These included the STAT-E alone and the parallel administration of both the E-VAS and the ASI. Use of more streamlined methods of case-confirmation in large-scale prospective cohort epidemiologic investigations of ASD risk factors appears feasible. En ligne : http://dx.doi.org/10.1002/aur.1659 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=304 [article] Development and validation of a streamlined autism case confirmation approach for use in epidemiologic risk factor research in prospective cohorts [Texte imprimé et/ou numérique] / Craig J. NEWSCHAFFER, Auteur ; Emily SCHRIVER, Auteur ; Lindsay BERRIGAN, Auteur ; Rebecca LANDA, Auteur ; Wendy L. STONE, Auteur ; Somer L. BISHOP, Auteur ; Diane BURKOM, Auteur ; Anne GOLDEN, Auteur ; Lisa IBANEZ, Auteur ; Alice KUO, Auteur ; Kimberly D. LAKES, Auteur ; Daniel S. MESSINGER, Auteur ; Sarah J. PATERSON, Auteur ; Zachary WARREN, Auteur . - p.485-501. Langues : Anglais (eng) in Autism Research > 10-3 (March 2017) . - p.485-501 Mots-clés : autism  ASD  case-confirmation  epidemiology  diagnosis  novel assessments Index. décimale : PER Périodiques Résumé : The cost associated with incorporating standardized observational assessments and diagnostic interviews in large-scale epidemiologic studies of autism spectrum disorders (ASD) risk factors can be substantial. Streamlined approaches for confirming ASD case status would benefit these studies. We conducted a multi-site, cross-sectional criterion validity study in a convenience sample of 382 three-year olds scheduled for neurodevelopmental evaluation. ASD case classification as determined by three novel assessment instruments (the Early Video-guided Autism Screener E-VAS; the Autism Symptom Interview, ASI; the Screening Tool for Autism in Toddlers Expanded, STAT-E) each designed to be administered in less than 30 minutes by lay staff, was compared to ADOS scores and DSM-based diagnostic assessment from a qualified clinician. Sensitivity and specificity of each instrument alone and in combination were estimated. Alternative cutpoints were identified under different criteria and two-stage cross validation was used to avoid overfitting. Findings were interpreted in the context of a large, prospective pregnancy cohort study utilizing a two-stage approach to case identification. Under initial cutpoints, sensitivity ranged from 0.63 to 0.92 and specificity from 0.35 to 0.70. Cutpoints giving equal weight to sensitivity and specificity resulted in sensitivity estimates ranging from 0.45 to 0.83 and specificity ranging from 0.49 to 0.86. Several strategies were well-suited for application as a second-stage case-confirmation. These included the STAT-E alone and the parallel administration of both the E-VAS and the ASI. Use of more streamlined methods of case-confirmation in large-scale prospective cohort epidemiologic investigations of ASD risk factors appears feasible. En ligne : http://dx.doi.org/10.1002/aur.1659 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=304

Relationship between repetitive behaviour and fear across normative development, autism spectrum disorder, and down syndrome / Mirko ULJAREVIC in Autism Research, 10-3 (March 2017)  

Public ISBD [article]  inAutism Research > 10-3 (March 2017) . - p.502-507 Titre : Relationship between repetitive behaviour and fear across normative development, autism spectrum disorder, and down syndrome Type de document : Texte imprimé et/ou numérique Auteurs : Mirko ULJAREVIC, Auteur ; David W. EVANS, Auteur Article en page(s) : p.502-507 Langues : Anglais (eng) Mots-clés : repetitive behaviour  fear  autism  down syndrome  typical development Index. décimale : PER Périodiques Résumé : The present study had two aims: first to compare levels of restricted and repetitive behaviours (RRB) across two groups of typically developing (TD) children, and two disorders: Autism Spectrum Disorder (ASD) and Down syndrome (DS), and second to explore the relationship between fear and repetitive behaviours in these four groups. Parents of 41 offspring with ASD (Mage?=?123.39 months, SDage?=?27.67), 38 offspring with DS (Mage?=?125.37 months, SDage?=?45.71), 45 typically developing children matched to the mental age (MA) of the DS group (TD MA; Mage?=?51.13 months, SDage?=?22.1), and 42 chronological age (TD CA; Mage?=?117.93 months, SDage?=?22.91) matched TD children, completed measures of RRB and fear. ANOVAs revealed differences across the four groups on the RRB subscale scores: “Just Right” F(3,162)?=?16.62, P? En ligne : http://dx.doi.org/10.1002/aur.1674 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=304 [article] Relationship between repetitive behaviour and fear across normative development, autism spectrum disorder, and down syndrome [Texte imprimé et/ou numérique] / Mirko ULJAREVIC, Auteur ; David W. EVANS, Auteur . - p.502-507. Langues : Anglais (eng) in Autism Research > 10-3 (March 2017) . - p.502-507 Mots-clés : repetitive behaviour  fear  autism  down syndrome  typical development Index. décimale : PER Périodiques Résumé : The present study had two aims: first to compare levels of restricted and repetitive behaviours (RRB) across two groups of typically developing (TD) children, and two disorders: Autism Spectrum Disorder (ASD) and Down syndrome (DS), and second to explore the relationship between fear and repetitive behaviours in these four groups. Parents of 41 offspring with ASD (Mage?=?123.39 months, SDage?=?27.67), 38 offspring with DS (Mage?=?125.37 months, SDage?=?45.71), 45 typically developing children matched to the mental age (MA) of the DS group (TD MA; Mage?=?51.13 months, SDage?=?22.1), and 42 chronological age (TD CA; Mage?=?117.93 months, SDage?=?22.91) matched TD children, completed measures of RRB and fear. ANOVAs revealed differences across the four groups on the RRB subscale scores: “Just Right” F(3,162)?=?16.62, P? En ligne : http://dx.doi.org/10.1002/aur.1674 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=304

The stability and validity of automated vocal analysis in preverbal preschoolers with autism spectrum disorder / Tiffany G. WOYNAROSKI in Autism Research, 10-3 (March 2017)  

Public ISBD [article]  inAutism Research > 10-3 (March 2017) . - p.508-519 Titre : The stability and validity of automated vocal analysis in preverbal preschoolers with autism spectrum disorder Type de document : Texte imprimé et/ou numérique Auteurs : Tiffany G. WOYNAROSKI, Auteur ; D. Kimbrough OLLER, Auteur ; Bahar KECELI-KAYSILI, Auteur ; Dongxin XU, Auteur ; Jeffrey A. RICHARDS, Auteur ; Jill GILKERSON, Auteur ; Sharmistha GRAY, Auteur ; Paul J. YODER, Auteur Article en page(s) : p.508-519 Langues : Anglais (eng) Mots-clés : useful speech  language  vocalizations  automated vocal analysis  LENA  preschool  preverbal  autism Index. décimale : PER Périodiques Résumé : Theory and research suggest that vocal development predicts “useful speech” in preschoolers with autism spectrum disorder (ASD), but conventional methods for measurement of vocal development are costly and time consuming. This longitudinal correlational study examines the reliability and validity of several automated indices of vocalization development relative to an index derived from human coded, conventional communication samples in a sample of preverbal preschoolers with ASD. Automated indices of vocal development were derived using software that is presently “in development” and/or only available for research purposes and using commercially available Language ENvironment Analysis (LENA) software. Indices of vocal development that could be derived using the software available for research purposes: (a) were highly stable with a single day-long audio recording, (b) predicted future spoken vocabulary to a degree that was nonsignificantly different from the index derived from conventional communication samples, and (c) continued to predict future spoken vocabulary even after controlling for concurrent vocabulary in our sample. The score derived from standard LENA software was similarly stable, but was not significantly correlated with future spoken vocabulary. Findings suggest that automated vocal analysis is a valid and reliable alternative to time intensive and expensive conventional communication samples for measurement of vocal development of preverbal preschoolers with ASD in research and clinical practice. En ligne : http://dx.doi.org/10.1002/aur.1667 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=304 [article] The stability and validity of automated vocal analysis in preverbal preschoolers with autism spectrum disorder [Texte imprimé et/ou numérique] / Tiffany G. WOYNAROSKI, Auteur ; D. Kimbrough OLLER, Auteur ; Bahar KECELI-KAYSILI, Auteur ; Dongxin XU, Auteur ; Jeffrey A. RICHARDS, Auteur ; Jill GILKERSON, Auteur ; Sharmistha GRAY, Auteur ; Paul J. YODER, Auteur . - p.508-519. Langues : Anglais (eng) in Autism Research > 10-3 (March 2017) . - p.508-519 Mots-clés : useful speech  language  vocalizations  automated vocal analysis  LENA  preschool  preverbal  autism Index. décimale : PER Périodiques Résumé : Theory and research suggest that vocal development predicts “useful speech” in preschoolers with autism spectrum disorder (ASD), but conventional methods for measurement of vocal development are costly and time consuming. This longitudinal correlational study examines the reliability and validity of several automated indices of vocalization development relative to an index derived from human coded, conventional communication samples in a sample of preverbal preschoolers with ASD. Automated indices of vocal development were derived using software that is presently “in development” and/or only available for research purposes and using commercially available Language ENvironment Analysis (LENA) software. Indices of vocal development that could be derived using the software available for research purposes: (a) were highly stable with a single day-long audio recording, (b) predicted future spoken vocabulary to a degree that was nonsignificantly different from the index derived from conventional communication samples, and (c) continued to predict future spoken vocabulary even after controlling for concurrent vocabulary in our sample. The score derived from standard LENA software was similarly stable, but was not significantly correlated with future spoken vocabulary. Findings suggest that automated vocal analysis is a valid and reliable alternative to time intensive and expensive conventional communication samples for measurement of vocal development of preverbal preschoolers with ASD in research and clinical practice. En ligne : http://dx.doi.org/10.1002/aur.1667 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=304

Context processing in adolescents with autism spectrum disorder: How complex could it be? / Dekel BEN-YOSEF in Autism Research, 10-3 (March 2017)  

Public ISBD [article]  inAutism Research > 10-3 (March 2017) . - p.520-530 Titre : Context processing in adolescents with autism spectrum disorder: How complex could it be? Type de document : Texte imprimé et/ou numérique Auteurs : Dekel BEN-YOSEF, Auteur ; David ANAKI, Auteur ; Ofer GOLAN, Auteur Article en page(s) : p.520-530 Langues : Anglais (eng) Mots-clés : autism spectrum disorder  context processing  priming  central coherence  social cognition  complexity Index. décimale : PER Périodiques Résumé : The ability of individuals with Autism Spectrum Disorder (ASD) to process context has long been debated: According to the Weak Central Coherence theory, ASD is characterized by poor global processing, and consequently—poor context processing. In contrast, the Social Cognition theory argues individuals with ASD will present difficulties only in social context processing. The complexity theory of autism suggests context processing in ASD will depend on task complexity. The current study examined this controversy through two priming tasks, one presenting human stimuli (facial expressions) and the other presenting non-human stimuli (animal faces). Both tasks presented visual targets, preceded by congruent, incongruent, or neutral auditory primes. Local and global processing were examined by presenting the visual targets in three spatial frequency conditions: High frequency, low frequency, and broadband. Tasks were administered to 16 adolescents with high functioning ASD and 16 matched typically developing adolescents. Reaction time and accuracy were measured for each task in each condition. Results indicated that individuals with ASD processed context for both human and non-human stimuli, except in one condition, in which human stimuli had to be processed globally (i.e., target presented in low frequency). The task demands presented in this condition, and the performance deficit shown in the ASD group as a result, could be understood in terms of cognitive overload. These findings provide support for the complexity theory of autism and extend it. Our results also demonstrate how associative priming could support intact context processing of human and non-human stimuli in individuals with ASD. En ligne : http://dx.doi.org/10.1002/aur.1676 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=304 [article] Context processing in adolescents with autism spectrum disorder: How complex could it be? [Texte imprimé et/ou numérique] / Dekel BEN-YOSEF, Auteur ; David ANAKI, Auteur ; Ofer GOLAN, Auteur . - p.520-530. Langues : Anglais (eng) in Autism Research > 10-3 (March 2017) . - p.520-530 Mots-clés : autism spectrum disorder  context processing  priming  central coherence  social cognition  complexity Index. décimale : PER Périodiques Résumé : The ability of individuals with Autism Spectrum Disorder (ASD) to process context has long been debated: According to the Weak Central Coherence theory, ASD is characterized by poor global processing, and consequently—poor context processing. In contrast, the Social Cognition theory argues individuals with ASD will present difficulties only in social context processing. The complexity theory of autism suggests context processing in ASD will depend on task complexity. The current study examined this controversy through two priming tasks, one presenting human stimuli (facial expressions) and the other presenting non-human stimuli (animal faces). Both tasks presented visual targets, preceded by congruent, incongruent, or neutral auditory primes. Local and global processing were examined by presenting the visual targets in three spatial frequency conditions: High frequency, low frequency, and broadband. Tasks were administered to 16 adolescents with high functioning ASD and 16 matched typically developing adolescents. Reaction time and accuracy were measured for each task in each condition. Results indicated that individuals with ASD processed context for both human and non-human stimuli, except in one condition, in which human stimuli had to be processed globally (i.e., target presented in low frequency). The task demands presented in this condition, and the performance deficit shown in the ASD group as a result, could be understood in terms of cognitive overload. These findings provide support for the complexity theory of autism and extend it. Our results also demonstrate how associative priming could support intact context processing of human and non-human stimuli in individuals with ASD. En ligne : http://dx.doi.org/10.1002/aur.1676 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=304

Sensory atypicalities in dyads of children with autism spectrum disorder (ASD) and their parents / Magdalena GLOD in Autism Research, 10-3 (March 2017)  

Public ISBD [article]  inAutism Research > 10-3 (March 2017) . - p.531-538 Titre : Sensory atypicalities in dyads of children with autism spectrum disorder (ASD) and their parents Type de document : Texte imprimé et/ou numérique Auteurs : Magdalena GLOD, Auteur ; Deborah M. RIBY, Auteur ; Emma HONEY, Auteur ; Jacqui RODGERS, Auteur Article en page(s) : p.531-538 Langues : Anglais (eng) Mots-clés : sensory atypicality  parent-child dyads  autism spectrum disorder  broader autism phenotype Index. décimale : PER Périodiques Résumé : Sensory atypicalities are a common feature of autism spectrum disorder (ASD). To date, the relationship between sensory atypicalities in dyads of children with ASD and their parents has not been investigated. Exploring these relationships can contribute to an understanding of how phenotypic profiles may be inherited, and the extent to which familial factors might contribute towards children's sensory profiles and constitute an aspect of the broader autism phenotype (BAP). Parents of 44 children with ASD and 30 typically developing (TD) children, aged between 3 and 14 years, participated. Information about children's sensory experiences was collected through parent report using the Sensory Profile questionnaire. Information about parental sensory experiences was collected via self-report using the Adolescent/Adult Sensory Profile. Parents of children with ASD had significantly higher scores than parents of TD children in relation to low registration, over responsivity, and taste/smell sensory processing. Similar levels of agreement were obtained within ASD and TD parent-child dyads on a number of sensory atypicalities; nevertheless significant correlations were found between parents and children in ASD families but not TD dyads for sensation avoiding and auditory, visual, and vestibular sensory processing. The findings suggest that there are similarities in sensory processing profiles between parents and their children in both ASD and TD dyads. Familial sensory processing factors are likely to contribute towards the BAP. Further work is needed to explore genetic and environmental influences on the developmental pathways of the sensory atypicalities in ASD. En ligne : http://dx.doi.org/10.1002/aur.1680 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=304 [article] Sensory atypicalities in dyads of children with autism spectrum disorder (ASD) and their parents [Texte imprimé et/ou numérique] / Magdalena GLOD, Auteur ; Deborah M. RIBY, Auteur ; Emma HONEY, Auteur ; Jacqui RODGERS, Auteur . - p.531-538. Langues : Anglais (eng) in Autism Research > 10-3 (March 2017) . - p.531-538 Mots-clés : sensory atypicality  parent-child dyads  autism spectrum disorder  broader autism phenotype Index. décimale : PER Périodiques Résumé : Sensory atypicalities are a common feature of autism spectrum disorder (ASD). To date, the relationship between sensory atypicalities in dyads of children with ASD and their parents has not been investigated. Exploring these relationships can contribute to an understanding of how phenotypic profiles may be inherited, and the extent to which familial factors might contribute towards children's sensory profiles and constitute an aspect of the broader autism phenotype (BAP). Parents of 44 children with ASD and 30 typically developing (TD) children, aged between 3 and 14 years, participated. Information about children's sensory experiences was collected through parent report using the Sensory Profile questionnaire. Information about parental sensory experiences was collected via self-report using the Adolescent/Adult Sensory Profile. Parents of children with ASD had significantly higher scores than parents of TD children in relation to low registration, over responsivity, and taste/smell sensory processing. Similar levels of agreement were obtained within ASD and TD parent-child dyads on a number of sensory atypicalities; nevertheless significant correlations were found between parents and children in ASD families but not TD dyads for sensation avoiding and auditory, visual, and vestibular sensory processing. The findings suggest that there are similarities in sensory processing profiles between parents and their children in both ASD and TD dyads. Familial sensory processing factors are likely to contribute towards the BAP. Further work is needed to explore genetic and environmental influences on the developmental pathways of the sensory atypicalities in ASD. En ligne : http://dx.doi.org/10.1002/aur.1680 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=304

Reduced visual disengagement but intact phasic alerting in young children with autism / Johan Lundin KLEBERG in Autism Research, 10-3 (March 2017)  

Public ISBD [article]  inAutism Research > 10-3 (March 2017) . - p.539-545 Titre : Reduced visual disengagement but intact phasic alerting in young children with autism Type de document : Texte imprimé et/ou numérique Auteurs : Johan Lundin KLEBERG, Auteur ; Emilia THORUP, Auteur ; Terje FALCK-YTTER, Auteur Article en page(s) : p.539-545 Langues : Anglais (eng) Mots-clés : autism  attention  gap effect  visual disengagement  alerting  orienting  arousal Index. décimale : PER Périodiques Résumé : Children with autism may have difficulties with visual disengagement—that is, inhibiting current fixations and orienting to new stimuli in the periphery. These difficulties may limit these children's ability to flexibly monitor the environment, regulate their internal states, and interact with others. In typical development, visual disengagement is influenced by a phasic alerting network that increases the processing speed of the visual system after salient events. The role of the phasic alerting effect in the putative atypical disengagement performance in autism spectrum disorder (ASD) is not known. Here, we compared visual disengagement in six-year-old children with autism (N?=?18) and typically developing children (N?=?17) matched for age and nonverbal IQ. We manipulated phasic alerting during a visual disengagement task by adding spatially nonpredictive sounds shortly before the onset of the visual peripheral targets. Children with ASD showed evidence of delayed disengagement compared to the control group. Sounds facilitated visual disengagement similarly in both groups, suggesting typical modulation by phasic alerting in ASD in the context of this task. These results support the view that atypical visual disengagement in ASD is related to other factors than atypicalities in the alerting network. En ligne : http://dx.doi.org/10.1002/aur.1675 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=304 [article] Reduced visual disengagement but intact phasic alerting in young children with autism [Texte imprimé et/ou numérique] / Johan Lundin KLEBERG, Auteur ; Emilia THORUP, Auteur ; Terje FALCK-YTTER, Auteur . - p.539-545. Langues : Anglais (eng) in Autism Research > 10-3 (March 2017) . - p.539-545 Mots-clés : autism  attention  gap effect  visual disengagement  alerting  orienting  arousal Index. décimale : PER Périodiques Résumé : Children with autism may have difficulties with visual disengagement—that is, inhibiting current fixations and orienting to new stimuli in the periphery. These difficulties may limit these children's ability to flexibly monitor the environment, regulate their internal states, and interact with others. In typical development, visual disengagement is influenced by a phasic alerting network that increases the processing speed of the visual system after salient events. The role of the phasic alerting effect in the putative atypical disengagement performance in autism spectrum disorder (ASD) is not known. Here, we compared visual disengagement in six-year-old children with autism (N?=?18) and typically developing children (N?=?17) matched for age and nonverbal IQ. We manipulated phasic alerting during a visual disengagement task by adding spatially nonpredictive sounds shortly before the onset of the visual peripheral targets. Children with ASD showed evidence of delayed disengagement compared to the control group. Sounds facilitated visual disengagement similarly in both groups, suggesting typical modulation by phasic alerting in ASD in the context of this task. These results support the view that atypical visual disengagement in ASD is related to other factors than atypicalities in the alerting network. En ligne : http://dx.doi.org/10.1002/aur.1675 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=304

Mid-childhood outcomes of infant siblings at familial high-risk of autism spectrum disorder / Elizabeth SHEPHARD in Autism Research, 10-3 (March 2017)  

Public ISBD [article]  inAutism Research > 10-3 (March 2017) . - p.546-557 Titre : Mid-childhood outcomes of infant siblings at familial high-risk of autism spectrum disorder Type de document : Texte imprimé et/ou numérique Auteurs : Elizabeth SHEPHARD, Auteur ; Bosiljka MILOSAVLJEVIC, Auteur ; Greg PASCO, Auteur ; Emily J. H. JONES, Auteur ; Teodora GLIGA, Auteur ; Francesca HAPPE, Auteur ; Mark H. JOHNSON, Auteur ; Tony CHARMAN, Auteur ; THE BASIS TEAM,, Auteur Article en page(s) : p.546-557 Langues : Anglais (eng) Mots-clés : high-risk siblings  clinical outcomes  ADHD  anxiety  broader autism phenotype Index. décimale : PER Périodiques Résumé : Almost 20% of infants with an older sibling with autism spectrum disorder (ASD) exhibit ASD themselves by age 3 years. The longer-term outcomes of high-risk infants are less clear. We examined symptoms of ASD, attention-deficit/hyperactivity disorder (ADHD) and anxiety, language, IQ, and adaptive behaviour at age 7 years in high- and low-risk children prospectively studied since the first year of life. Clinical outcomes were compared between high-risk children who met diagnostic criteria for ASD at age 7 (HR-ASD-7 group, n = 15), high-risk children without ASD (HR-Non-ASD-7 group, n = 24), and low-risk control children (LR group, n = 37). Diagnostic stability between age 3 and 7 years was moderate, with five children who did not meet diagnostic criteria for ASD at age 3 years being assigned the diagnosis at age 7, and three children showing the opposite pattern. The HR-ASD-7 group showed elevated ADHD and anxiety symptoms and had lower adaptive behaviour scores than LR controls. The HR-Non-ASD-7 group had higher repetitive behaviour, lower adaptive functioning and elevated scores on one anxiety subscale (Separation Anxiety) compared to LR controls, but evidence for subclinical ASD symptoms (the broader autism phenotype, BAP) was limited in the group as a whole, although we identified a subgroup with elevated ASD traits. The difficulties experienced by high-risk siblings at school-age extend beyond ASD symptoms. The pattern of difficulties exhibited by the HR-ASD-7 group may inform our understanding of developmental trajectories of co-occurring psychopathology in ASD. En ligne : http://dx.doi.org/10.1002/aur.1733 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=304 [article] Mid-childhood outcomes of infant siblings at familial high-risk of autism spectrum disorder [Texte imprimé et/ou numérique] / Elizabeth SHEPHARD, Auteur ; Bosiljka MILOSAVLJEVIC, Auteur ; Greg PASCO, Auteur ; Emily J. H. JONES, Auteur ; Teodora GLIGA, Auteur ; Francesca HAPPE, Auteur ; Mark H. JOHNSON, Auteur ; Tony CHARMAN, Auteur ; THE BASIS TEAM,, Auteur . - p.546-557. Langues : Anglais (eng) in Autism Research > 10-3 (March 2017) . - p.546-557 Mots-clés : high-risk siblings  clinical outcomes  ADHD  anxiety  broader autism phenotype Index. décimale : PER Périodiques Résumé : Almost 20% of infants with an older sibling with autism spectrum disorder (ASD) exhibit ASD themselves by age 3 years. The longer-term outcomes of high-risk infants are less clear. We examined symptoms of ASD, attention-deficit/hyperactivity disorder (ADHD) and anxiety, language, IQ, and adaptive behaviour at age 7 years in high- and low-risk children prospectively studied since the first year of life. Clinical outcomes were compared between high-risk children who met diagnostic criteria for ASD at age 7 (HR-ASD-7 group, n = 15), high-risk children without ASD (HR-Non-ASD-7 group, n = 24), and low-risk control children (LR group, n = 37). Diagnostic stability between age 3 and 7 years was moderate, with five children who did not meet diagnostic criteria for ASD at age 3 years being assigned the diagnosis at age 7, and three children showing the opposite pattern. The HR-ASD-7 group showed elevated ADHD and anxiety symptoms and had lower adaptive behaviour scores than LR controls. The HR-Non-ASD-7 group had higher repetitive behaviour, lower adaptive functioning and elevated scores on one anxiety subscale (Separation Anxiety) compared to LR controls, but evidence for subclinical ASD symptoms (the broader autism phenotype, BAP) was limited in the group as a whole, although we identified a subgroup with elevated ASD traits. The difficulties experienced by high-risk siblings at school-age extend beyond ASD symptoms. The pattern of difficulties exhibited by the HR-ASD-7 group may inform our understanding of developmental trajectories of co-occurring psychopathology in ASD. En ligne : http://dx.doi.org/10.1002/aur.1733 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=304

Scientific Summaries for Families with ASD in Autism Research, 10-3 (March 2017)  

Public ISBD [article]  inAutism Research > 10-3 (March 2017) . - p.558-563 Titre : Scientific Summaries for Families with ASD Type de document : Texte imprimé et/ou numérique Article en page(s) : p.558-563 Langues : Anglais (eng) Index. décimale : PER Périodiques En ligne : http://dx.doi.org/10.1002/aur.1783 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=304 [article] Scientific Summaries for Families with ASD [Texte imprimé et/ou numérique] . - p.558-563. Langues : Anglais (eng) in Autism Research > 10-3 (March 2017) . - p.558-563 Index. décimale : PER Périodiques En ligne : http://dx.doi.org/10.1002/aur.1783 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=304

International society for autism research news www.autism-insar.org in Autism Research, 10-3 (March 2017)  

Public ISBD [article]  inAutism Research > 10-3 (March 2017) . - p.564-564 Titre : International society for autism research news www.autism-insar.org Type de document : Texte imprimé et/ou numérique Article en page(s) : p.564-564 Langues : Anglais (eng) Index. décimale : PER Périodiques En ligne : http://dx.doi.org/10.1002/aur.1784 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=304 [article] International society for autism research news www.autism-insar.org [Texte imprimé et/ou numérique] . - p.564-564. Langues : Anglais (eng) in Autism Research > 10-3 (March 2017) . - p.564-564 Index. décimale : PER Périodiques En ligne : http://dx.doi.org/10.1002/aur.1784 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=304