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Auteur Chiara NOSARTI |
Documents disponibles écrits par cet auteur (2)
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Amygdala, hippocampal and corpus callosum size following severe early institutional deprivation: The English and Romanian Adoptees Study Pilot / Mitul A. MEHTA in Journal of Child Psychology and Psychiatry, 50-8 (August 2009)
[article]
Titre : Amygdala, hippocampal and corpus callosum size following severe early institutional deprivation: The English and Romanian Adoptees Study Pilot Type de document : Texte imprimé et/ou numérique Auteurs : Mitul A. MEHTA, Auteur ; Michael RUTTER, Auteur ; Emma COLVERT, Auteur ; Edmund J. S. SONUGA-BARKE, Auteur ; Steve C.R. WILLIAMS, Auteur ; Nicole I. GOLEMBO, Auteur ; Chiara NOSARTI, Auteur ; Ashley MOTA, Auteur Année de publication : 2009 Article en page(s) : p.943-951 Langues : Anglais (eng) Mots-clés : Corpus-callosum hippocampus amygdala deprivation neurodevelopment institution-rearing adolescence brain-imaging brain-development Index. décimale : PER Périodiques Résumé : The adoption into the UK of children who have been reared in severely deprived conditions provides an opportunity to study possible association between very early negative experiences and subsequent brain development. This cross-sectional study was a pilot for a planned larger study quantifying the effects of early deprivation on later brain structure. We used magnetic resonance imaging (MRI) to measure the sizes of three key brain regions hypothesized to be sensitive to early adverse experiences. Our sample was a group of adoptee adolescents (N = 14) who had experienced severe early institutional deprivation in Romania and a group of non-institutionalised controls (N = 11). The total grey and white matter volumes were significantly smaller in the institutionalised group compared with a group of non-deprived, non-adopted UK controls. After correcting for difference in brain volume, the institutionalised group had greater amygdala volumes, especially on the right, but no differences were observed in hippocampal volume or corpus callosum mid-sagittal area. The left amygdala volume was also related to the time spent in institutions, with those experiencing longer periods of deprivation having a smaller left amygdala volume. These pilot findings highlight the need for future studies to confirm the sensitivity of the amygdala to early deprivation. En ligne : http://dx.doi.org/10.1111/j.1469-7610.2009.02084.x Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=787
in Journal of Child Psychology and Psychiatry > 50-8 (August 2009) . - p.943-951[article] Amygdala, hippocampal and corpus callosum size following severe early institutional deprivation: The English and Romanian Adoptees Study Pilot [Texte imprimé et/ou numérique] / Mitul A. MEHTA, Auteur ; Michael RUTTER, Auteur ; Emma COLVERT, Auteur ; Edmund J. S. SONUGA-BARKE, Auteur ; Steve C.R. WILLIAMS, Auteur ; Nicole I. GOLEMBO, Auteur ; Chiara NOSARTI, Auteur ; Ashley MOTA, Auteur . - 2009 . - p.943-951.
Langues : Anglais (eng)
in Journal of Child Psychology and Psychiatry > 50-8 (August 2009) . - p.943-951
Mots-clés : Corpus-callosum hippocampus amygdala deprivation neurodevelopment institution-rearing adolescence brain-imaging brain-development Index. décimale : PER Périodiques Résumé : The adoption into the UK of children who have been reared in severely deprived conditions provides an opportunity to study possible association between very early negative experiences and subsequent brain development. This cross-sectional study was a pilot for a planned larger study quantifying the effects of early deprivation on later brain structure. We used magnetic resonance imaging (MRI) to measure the sizes of three key brain regions hypothesized to be sensitive to early adverse experiences. Our sample was a group of adoptee adolescents (N = 14) who had experienced severe early institutional deprivation in Romania and a group of non-institutionalised controls (N = 11). The total grey and white matter volumes were significantly smaller in the institutionalised group compared with a group of non-deprived, non-adopted UK controls. After correcting for difference in brain volume, the institutionalised group had greater amygdala volumes, especially on the right, but no differences were observed in hippocampal volume or corpus callosum mid-sagittal area. The left amygdala volume was also related to the time spent in institutions, with those experiencing longer periods of deprivation having a smaller left amygdala volume. These pilot findings highlight the need for future studies to confirm the sensitivity of the amygdala to early deprivation. En ligne : http://dx.doi.org/10.1111/j.1469-7610.2009.02084.x Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=787 Distinct Neurodevelopmental Trajectories in Groups of Very Preterm Children Screening Positively for Autism Spectrum Conditions / Lucy VANES ; Vyacheslav KAROLIS ; Dana KANEL ; Marguerite LEONI ; Francesca HAPPE ; A. David EDWARDS ; Serena J. COUNSELL ; Dafnis BATALLE ; Chiara NOSARTI in Journal of Autism and Developmental Disorders, 54-1 (January 2024)
[article]
Titre : Distinct Neurodevelopmental Trajectories in Groups of Very Preterm Children Screening Positively for Autism Spectrum Conditions Type de document : Texte imprimé et/ou numérique Auteurs : Lucy VANES, Auteur ; Vyacheslav KAROLIS, Auteur ; Dana KANEL, Auteur ; Marguerite LEONI, Auteur ; Francesca HAPPE, Auteur ; A. David EDWARDS, Auteur ; Serena J. COUNSELL, Auteur ; Dafnis BATALLE, Auteur ; Chiara NOSARTI, Auteur Article en page(s) : p.256-269 Index. décimale : PER Périodiques Résumé : Very preterm (VPT;?33 weeks? gestation) toddlers screening positively for autism spectrum conditions (ASC) may display heterogenous neurodevelopmental trajectories. Here we studied neonatal brain volumes and childhood ASC traits evaluated with the Social Responsiveness Scale (SRS-2) in VPT-born toddlers (N?=?371; median age 20.17 months) sub-divided into three groups based on their Modified-Checklist for Autism in Toddlers scores. These were: those screening positively failing at least 2 critical items (critical-positive); failing any 3 items, but less than 2 critical items (non-critical-positive); and screening negatively. Critical-positive scorers had smaller neonatal cerebellar volumes compared to non-critical-positive and negative scorers. However, both positive screening groups exhibited higher childhood ASC traits compared to the negative screening group, suggesting distinct aetiological trajectories associated with ASC outcomes. En ligne : https://doi.org/10.1007/s10803-022-05789-4 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=520
in Journal of Autism and Developmental Disorders > 54-1 (January 2024) . - p.256-269[article] Distinct Neurodevelopmental Trajectories in Groups of Very Preterm Children Screening Positively for Autism Spectrum Conditions [Texte imprimé et/ou numérique] / Lucy VANES, Auteur ; Vyacheslav KAROLIS, Auteur ; Dana KANEL, Auteur ; Marguerite LEONI, Auteur ; Francesca HAPPE, Auteur ; A. David EDWARDS, Auteur ; Serena J. COUNSELL, Auteur ; Dafnis BATALLE, Auteur ; Chiara NOSARTI, Auteur . - p.256-269.
in Journal of Autism and Developmental Disorders > 54-1 (January 2024) . - p.256-269
Index. décimale : PER Périodiques Résumé : Very preterm (VPT;?33 weeks? gestation) toddlers screening positively for autism spectrum conditions (ASC) may display heterogenous neurodevelopmental trajectories. Here we studied neonatal brain volumes and childhood ASC traits evaluated with the Social Responsiveness Scale (SRS-2) in VPT-born toddlers (N?=?371; median age 20.17 months) sub-divided into three groups based on their Modified-Checklist for Autism in Toddlers scores. These were: those screening positively failing at least 2 critical items (critical-positive); failing any 3 items, but less than 2 critical items (non-critical-positive); and screening negatively. Critical-positive scorers had smaller neonatal cerebellar volumes compared to non-critical-positive and negative scorers. However, both positive screening groups exhibited higher childhood ASC traits compared to the negative screening group, suggesting distinct aetiological trajectories associated with ASC outcomes. En ligne : https://doi.org/10.1007/s10803-022-05789-4 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=520