Complex effects of dyslexia risk factors account for ADHD traits: evidence from two independent samples / Sara MASCHERETTI in Journal of Child Psychology and Psychiatry, 58-1 (January 2017)  

Public ISBD [article]  inJournal of Child Psychology and Psychiatry > 58-1 (January 2017) . - p.75-82 Titre : Complex effects of dyslexia risk factors account for ADHD traits: evidence from two independent samples Type de document : Texte imprimé et/ou numérique Auteurs : Sara MASCHERETTI, Auteur ; Vittoria TREZZI, Auteur ; Roberto GIORDA, Auteur ; Michel BOIVIN, Auteur ; Vickie PLOURDE, Auteur ; Frank VITARO, Auteur ; Mara BRENDGEN, Auteur ; Ginette DIONNE, Auteur ; Cecilia MARINO, Auteur Article en page(s) : p.75-82 Langues : Anglais (eng) Mots-clés : Developmental dyslexia  attention deficit/hyperactivity disorder  association study  gene-by-environment interaction  gene-by-gene interaction  pleiotropy Index. décimale : PER Périodiques Résumé : Background Developmental dyslexia (DD) and attention deficit/hyperactivity disorder (ADHD) are among the most common neurodevelopmental disorders, whose etiology involves multiple risk factors. DD and ADHD co-occur in the same individuals much more often than would be expected by chance. Several studies have found significant bivariate heritability, and specific genes associated with either DD or ADHD have been investigated for association in the other disorder. Moreover, there are likely to be gene-by-gene and gene-by-environment interaction effects (G × G and G × E, respectively) underlying the comorbidity between DD and ADHD. We investigated the pleiotropic effects of 19 SNPs spanning five DD genes (DYX1C1, DCDC2, KIAA0319, ROBO1, and GRIN2B) and seven DD environmental factors (smoke, miscarriage, birth weight, breastfeeding, parental age, socioeconomic status, and parental education) for main, either (a) genetic or (b) environmental, (c) G × G, and (d) G × E upon inattention and hyperactivity/impulsivity. We then attempted replication of these findings in an independent twin cohort. Methods Marker-trait association was analyzed by implementing the Quantitative Transmission Disequilibrium Test (QTDT). Environmental associations were tested by partial correlations. G × G were investigated by a general linear model equation and a family-based association test. G × E were analyzed through a general test for G × E in sib pair-based association analysis of quantitative traits. Results DCDC2-rs793862 was associated with hyperactivity/impulsivity via G × G (KIAA0319) and G × E (miscarriage). Smoke was significantly correlated with hyperactivity/impulsivity. We replicated the DCDC2 × KIAA0319 interaction upon hyperactivity/impulsivity in the twin cohort. Conclusions En ligne : http://dx.doi.org/10.1111/jcpp.12612 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=298 [article] Complex effects of dyslexia risk factors account for ADHD traits: evidence from two independent samples [Texte imprimé et/ou numérique] / Sara MASCHERETTI, Auteur ; Vittoria TREZZI, Auteur ; Roberto GIORDA, Auteur ; Michel BOIVIN, Auteur ; Vickie PLOURDE, Auteur ; Frank VITARO, Auteur ; Mara BRENDGEN, Auteur ; Ginette DIONNE, Auteur ; Cecilia MARINO, Auteur . - p.75-82. Langues : Anglais (eng) in Journal of Child Psychology and Psychiatry > 58-1 (January 2017) . - p.75-82 Mots-clés : Developmental dyslexia  attention deficit/hyperactivity disorder  association study  gene-by-environment interaction  gene-by-gene interaction  pleiotropy Index. décimale : PER Périodiques Résumé : Background Developmental dyslexia (DD) and attention deficit/hyperactivity disorder (ADHD) are among the most common neurodevelopmental disorders, whose etiology involves multiple risk factors. DD and ADHD co-occur in the same individuals much more often than would be expected by chance. Several studies have found significant bivariate heritability, and specific genes associated with either DD or ADHD have been investigated for association in the other disorder. Moreover, there are likely to be gene-by-gene and gene-by-environment interaction effects (G × G and G × E, respectively) underlying the comorbidity between DD and ADHD. We investigated the pleiotropic effects of 19 SNPs spanning five DD genes (DYX1C1, DCDC2, KIAA0319, ROBO1, and GRIN2B) and seven DD environmental factors (smoke, miscarriage, birth weight, breastfeeding, parental age, socioeconomic status, and parental education) for main, either (a) genetic or (b) environmental, (c) G × G, and (d) G × E upon inattention and hyperactivity/impulsivity. We then attempted replication of these findings in an independent twin cohort. Methods Marker-trait association was analyzed by implementing the Quantitative Transmission Disequilibrium Test (QTDT). Environmental associations were tested by partial correlations. G × G were investigated by a general linear model equation and a family-based association test. G × E were analyzed through a general test for G × E in sib pair-based association analysis of quantitative traits. Results DCDC2-rs793862 was associated with hyperactivity/impulsivity via G × G (KIAA0319) and G × E (miscarriage). Smoke was significantly correlated with hyperactivity/impulsivity. We replicated the DCDC2 × KIAA0319 interaction upon hyperactivity/impulsivity in the twin cohort. Conclusions En ligne : http://dx.doi.org/10.1111/jcpp.12612 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=298

Prenatal maternal stress during the COVID-19 pandemic and infant regulatory capacity at 3 months: A longitudinal study / Livio PROVENZI in Development and Psychopathology, 35-1 (February 2023)  

Public ISBD [article]  inDevelopment and Psychopathology > 35-1 (February 2023) . - p.35-43 Titre : Prenatal maternal stress during the COVID-19 pandemic and infant regulatory capacity at 3 months: A longitudinal study Type de document : Texte imprimé et/ou numérique Auteurs : Livio PROVENZI, Auteur ; Serena GRUMI, Auteur ; Lilia ALTIERI, Auteur ; Giulia BENSI, Auteur ; Emanuela BERTAZZOLI, Auteur ; Giacomo BIASUCCI, Auteur ; Anna CAVALLINI, Auteur ; Lidia DECEMBRINO, Auteur ; Rossana FALCONE, Auteur ; Anna FREDDI, Auteur ; Barbara GARDELLA, Auteur ; Roberta GIACCHERO, Auteur ; Roberto GIORDA, Auteur ; Elena GROSSI, Auteur ; Paola GUERINI, Auteur ; Maria Luisa MAGNANI, Auteur ; Paola MARTELLI, Auteur ; Mario MOTTA, Auteur ; Renata NACINOVICH, Auteur ; Dario PANTALEO, Auteur ; Camilla PISONI, Auteur ; Federico PREFUMO, Auteur ; Laura RIVA, Auteur ; Barbara SCELSA, Auteur ; Maria V. SPARTÀ, Auteur ; Arsenio SPINILLO, Auteur ; Patrizia VERGANI, Auteur ; Simona ORCESI, Auteur ; Renato BORGATTI, Auteur Article en page(s) : p.35-43 Langues : Anglais (eng) Mots-clés : anxiety  COVID-19  epidemic  maternal bonding  prenatal stress  regulatory capacity  social support  temperament Index. décimale : PER Périodiques Résumé : The COVID-19 pandemic is a global traumatic experience for citizens, especially during sensitive time windows of heightened plasticity such as pregnancy and neonatal life. Pandemic-related stress experienced by mothers during pregnancy may act as an early risk factor for infants' regulatory capacity development by altering maternal psychosocial well-being (e.g., increased anxiety, reduced social support) and caregiving environment (e.g., greater parenting stress, impaired mother-infant bonding). The aim of the present longitudinal study was to assess the consequences of pandemic-related prenatal stress on infants' regulatory capacity. A sample of 163 mother-infant dyads was enrolled at eight maternity units in northern Italy. They provided complete data about prenatal stress, perceived social support, postnatal anxiety symptoms, parenting stress, mother-infant bonding, and infants' regulatory capacity at 3 months of age. Women who experienced emotional stress and received partial social support during pregnancy reported higher anxious symptoms. Moreover, maternal postnatal anxiety was indirectly linked to the infants' regulatory capacity at 3 months, mediated by parenting stress and mother-infant bonding. Dedicated preventive interventions should be delivered to mothers and should be focused on protecting the mother-infant dyad from the detrimental effects of pandemic-related stress during the COVID-19 healthcare emergency. En ligne : https://doi.org/10.1017/S0954579421000766 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=499 [article] Prenatal maternal stress during the COVID-19 pandemic and infant regulatory capacity at 3 months: A longitudinal study [Texte imprimé et/ou numérique] / Livio PROVENZI, Auteur ; Serena GRUMI, Auteur ; Lilia ALTIERI, Auteur ; Giulia BENSI, Auteur ; Emanuela BERTAZZOLI, Auteur ; Giacomo BIASUCCI, Auteur ; Anna CAVALLINI, Auteur ; Lidia DECEMBRINO, Auteur ; Rossana FALCONE, Auteur ; Anna FREDDI, Auteur ; Barbara GARDELLA, Auteur ; Roberta GIACCHERO, Auteur ; Roberto GIORDA, Auteur ; Elena GROSSI, Auteur ; Paola GUERINI, Auteur ; Maria Luisa MAGNANI, Auteur ; Paola MARTELLI, Auteur ; Mario MOTTA, Auteur ; Renata NACINOVICH, Auteur ; Dario PANTALEO, Auteur ; Camilla PISONI, Auteur ; Federico PREFUMO, Auteur ; Laura RIVA, Auteur ; Barbara SCELSA, Auteur ; Maria V. SPARTÀ, Auteur ; Arsenio SPINILLO, Auteur ; Patrizia VERGANI, Auteur ; Simona ORCESI, Auteur ; Renato BORGATTI, Auteur . - p.35-43. Langues : Anglais (eng) in Development and Psychopathology > 35-1 (February 2023) . - p.35-43 Mots-clés : anxiety  COVID-19  epidemic  maternal bonding  prenatal stress  regulatory capacity  social support  temperament Index. décimale : PER Périodiques Résumé : The COVID-19 pandemic is a global traumatic experience for citizens, especially during sensitive time windows of heightened plasticity such as pregnancy and neonatal life. Pandemic-related stress experienced by mothers during pregnancy may act as an early risk factor for infants' regulatory capacity development by altering maternal psychosocial well-being (e.g., increased anxiety, reduced social support) and caregiving environment (e.g., greater parenting stress, impaired mother-infant bonding). The aim of the present longitudinal study was to assess the consequences of pandemic-related prenatal stress on infants' regulatory capacity. A sample of 163 mother-infant dyads was enrolled at eight maternity units in northern Italy. They provided complete data about prenatal stress, perceived social support, postnatal anxiety symptoms, parenting stress, mother-infant bonding, and infants' regulatory capacity at 3 months of age. Women who experienced emotional stress and received partial social support during pregnancy reported higher anxious symptoms. Moreover, maternal postnatal anxiety was indirectly linked to the infants' regulatory capacity at 3 months, mediated by parenting stress and mother-infant bonding. Dedicated preventive interventions should be delivered to mothers and should be focused on protecting the mother-infant dyad from the detrimental effects of pandemic-related stress during the COVID-19 healthcare emergency. En ligne : https://doi.org/10.1017/S0954579421000766 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=499

Sex-dimorphic pathways in the associations between maternal trait anxiety, infant BDNF methylation, and negative emotionality / Serena GRUMI ; Fabiana MAMBRETTI ; Marco VILLA ; Roberto GIORDA ; Matteo BORDONI ; Orietta PANSARASA ; Renato BORGATTI ; Livio PROVENZI in Development and Psychopathology, 36-2 (May 2024)  

Public ISBD [article]  inDevelopment and Psychopathology > 36-2 (May 2024) . - p.908-918 Titre : Sex-dimorphic pathways in the associations between maternal trait anxiety, infant BDNF methylation, and negative emotionality Type de document : Texte imprimé et/ou numérique Auteurs : Serena GRUMI, Auteur ; Fabiana MAMBRETTI, Auteur ; Marco VILLA, Auteur ; Roberto GIORDA, Auteur ; Matteo BORDONI, Auteur ; Orietta PANSARASA, Auteur ; Renato BORGATTI, Auteur ; Livio PROVENZI, Auteur Article en page(s) : p.908-918 Langues : Anglais (eng) Mots-clés : Anxiety  Brain-derived neurotrophic factor  Methylation  Pregnancy  Temperament Index. décimale : PER Périodiques Résumé : Maternal antenatal anxiety is an emerging risk factor for child emotional development. Both sex and epigenetic mechanisms, such as DNA methylation, may contribute to the embedding of maternal distress into emotional outcomes. Here, we investigated sex-dependent patterns in the association between antenatal maternal trait anxiety, methylation of the brain-derived neurotrophic factor gene (BDNF DNAm), and infant negative emotionality (NE). Mother-infant dyads (N = 276) were recruited at delivery. Maternal trait anxiety, as a marker of antenatal chronic stress exposure, was assessed soon after delivery using the Stait-Trait Anxiety Inventory (STAI-Y). Infants' BDNF DNAm at birth was assessed in 11 CpG sites in buccal cells whereas infants' NE was assessed at 3 (N = 225) and 6 months (N = 189) using the Infant Behavior Questionnaire-Revised (IBQ-R). Hierarchical linear analyses showed that higher maternal antenatal anxiety was associated with greater 6-month-olds' NE. Furthermore, maternal antenatal anxiety predicted greater infants' BDNF DNAm in five CpG sites in males but not in females. Higher methylation at these sites was associated with greater 3-to-6-month NE increase, independently of infants' sex. Maternal antenatal anxiety emerged as a risk factor for infant?s NE. BDNF DNAm might mediate this effect in males. These results may inform the development of strategies to promote mothers and infants' emotional well-being. En ligne : https://dx.doi.org/10.1017/S0954579423000172 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=528 [article] Sex-dimorphic pathways in the associations between maternal trait anxiety, infant BDNF methylation, and negative emotionality [Texte imprimé et/ou numérique] / Serena GRUMI, Auteur ; Fabiana MAMBRETTI, Auteur ; Marco VILLA, Auteur ; Roberto GIORDA, Auteur ; Matteo BORDONI, Auteur ; Orietta PANSARASA, Auteur ; Renato BORGATTI, Auteur ; Livio PROVENZI, Auteur . - p.908-918. Langues : Anglais (eng) in Development and Psychopathology > 36-2 (May 2024) . - p.908-918 Mots-clés : Anxiety  Brain-derived neurotrophic factor  Methylation  Pregnancy  Temperament Index. décimale : PER Périodiques Résumé : Maternal antenatal anxiety is an emerging risk factor for child emotional development. Both sex and epigenetic mechanisms, such as DNA methylation, may contribute to the embedding of maternal distress into emotional outcomes. Here, we investigated sex-dependent patterns in the association between antenatal maternal trait anxiety, methylation of the brain-derived neurotrophic factor gene (BDNF DNAm), and infant negative emotionality (NE). Mother-infant dyads (N = 276) were recruited at delivery. Maternal trait anxiety, as a marker of antenatal chronic stress exposure, was assessed soon after delivery using the Stait-Trait Anxiety Inventory (STAI-Y). Infants' BDNF DNAm at birth was assessed in 11 CpG sites in buccal cells whereas infants' NE was assessed at 3 (N = 225) and 6 months (N = 189) using the Infant Behavior Questionnaire-Revised (IBQ-R). Hierarchical linear analyses showed that higher maternal antenatal anxiety was associated with greater 6-month-olds' NE. Furthermore, maternal antenatal anxiety predicted greater infants' BDNF DNAm in five CpG sites in males but not in females. Higher methylation at these sites was associated with greater 3-to-6-month NE increase, independently of infants' sex. Maternal antenatal anxiety emerged as a risk factor for infant?s NE. BDNF DNAm might mediate this effect in males. These results may inform the development of strategies to promote mothers and infants' emotional well-being. En ligne : https://dx.doi.org/10.1017/S0954579423000172 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=528

Socioeconomic status mediates the genetic contribution of the dopamine receptor D4 and serotonin transporter linked promoter region repeat polymorphisms to externalization in preadolescence / Maria NOBILE in Development and Psychopathology, 19-4 (Fall 2007)  

Public ISBD [article]  inDevelopment and Psychopathology > 19-4 (Fall 2007) . - p.1147-1160 Titre : Socioeconomic status mediates the genetic contribution of the dopamine receptor D4 and serotonin transporter linked promoter region repeat polymorphisms to externalization in preadolescence Type de document : Texte imprimé et/ou numérique Auteurs : Maria NOBILE, Auteur ; Roberto GIORDA, Auteur ; Cecilia MARINO, Auteur ; Ombretta CARLET, Auteur ; Valentina PASTORE, Auteur ; Laura VANZIN, Auteur ; Monica BELLINA, Auteur ; Massimo MOLTENI, Auteur ; Marco BATTAGLIA, Auteur Année de publication : 2007 Article en page(s) : p.1147-1160 Langues : Anglais (eng) Index. décimale : PER Périodiques Résumé : The impact of socioeconomic status (SES) and genetic polymorphisms on individual differences for externalized behaviors have often been investigated separately in studies of children and adults. In a general population sample of 607 Italian preadolescents, we examined the independent and joint effects of SES and the dopamine receptor D4 (DRD4) and serotonin transporter linked promoter region (5-HTTLPR) polymorphisms upon rule-breaking and aggressive behaviors measured with the Child Behavior CheckList/6–18. We found evidence, which was based on both one locus and two-loci genotype analyses, that low SES and DRD4 long and 5-HTTLPR long alleles, both alone and in interaction, are associated with higher aggressive behavior scores. The effects were similar but more modest and limited to one locus genotype analyses for rule-breaking behavior. Consistent with studies that showed the effects of societal moderators on the heritability of externalized behaviors across different segments of the population, we suggest that diminished social constraints associated with low parental SES may act as enhancers of the genetic influence of specific DRD4 and 5-HTTLPR alleles over aggressive behaviors in preadolescence. En ligne : http://dx.doi.org/10.1017/s0954579407000594 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=182 [article] Socioeconomic status mediates the genetic contribution of the dopamine receptor D4 and serotonin transporter linked promoter region repeat polymorphisms to externalization in preadolescence [Texte imprimé et/ou numérique] / Maria NOBILE, Auteur ; Roberto GIORDA, Auteur ; Cecilia MARINO, Auteur ; Ombretta CARLET, Auteur ; Valentina PASTORE, Auteur ; Laura VANZIN, Auteur ; Monica BELLINA, Auteur ; Massimo MOLTENI, Auteur ; Marco BATTAGLIA, Auteur . - 2007 . - p.1147-1160. Langues : Anglais (eng) in Development and Psychopathology > 19-4 (Fall 2007) . - p.1147-1160 Index. décimale : PER Périodiques Résumé : The impact of socioeconomic status (SES) and genetic polymorphisms on individual differences for externalized behaviors have often been investigated separately in studies of children and adults. In a general population sample of 607 Italian preadolescents, we examined the independent and joint effects of SES and the dopamine receptor D4 (DRD4) and serotonin transporter linked promoter region (5-HTTLPR) polymorphisms upon rule-breaking and aggressive behaviors measured with the Child Behavior CheckList/6–18. We found evidence, which was based on both one locus and two-loci genotype analyses, that low SES and DRD4 long and 5-HTTLPR long alleles, both alone and in interaction, are associated with higher aggressive behavior scores. The effects were similar but more modest and limited to one locus genotype analyses for rule-breaking behavior. Consistent with studies that showed the effects of societal moderators on the heritability of externalized behaviors across different segments of the population, we suggest that diminished social constraints associated with low parental SES may act as enhancers of the genetic influence of specific DRD4 and 5-HTTLPR alleles over aggressive behaviors in preadolescence. En ligne : http://dx.doi.org/10.1017/s0954579407000594 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=182

The influence of family structure, the TPH2 G-703T and the 5-HTTLPR serotonergic genes upon affective problems in children aged 10–14 years / Maria NOBILE in Journal of Child Psychology and Psychiatry, 50-3 (March 2009)  

Public ISBD [article]  inJournal of Child Psychology and Psychiatry > 50-3 (March 2009) . - p.317-325 Titre : The influence of family structure, the TPH2 G-703T and the 5-HTTLPR serotonergic genes upon affective problems in children aged 10–14 years Type de document : Texte imprimé et/ou numérique Auteurs : Maria NOBILE, Auteur ; Roberto GIORDA, Auteur ; Cecilia MARINO, Auteur ; Ombretta CARLET, Auteur ; Laura VANZIN, Auteur ; Monica BELLINA, Auteur ; Massimo MOLTENI, Auteur ; Marco BATTAGLIA, Auteur ; Marianna RUSCONI, Auteur Année de publication : 2009 Article en page(s) : p.317-325 Langues : Anglais (eng) Mots-clés : Children depression gene–environment-interaction serotonin divorce family affective-disorders Index. décimale : PER Périodiques Résumé : Background: Both genetic and psychosocial risk factors influence the risk for depression in development. While the impacts of family structure and of serotonergic polymorphisms upon individual differences for affective problems have been investigated separately, they have never been considered together in a gene–environment interplay perspective. Methods: We examined the effects of family structure and two serotonergic polymorphisms (the TPH2 G-703T and the 5-HTTLPR) upon depressive symptoms assessed by the new CBCL/6-18 DSM-oriented Affective Problems scale in a general population sample of 607 Italian children aged 10–14 years. Results: Belonging to 'one-parent' families, the TPH2 G-703T 'G variant', and the 5-HTTLPR 'short' alleles were associated – both alone and in apparent gene-by-environment interaction – with higher Affective Problems scores. As predicted by quantitative genetics theory, both polymorphisms contributed with a small effect size, while 'family structure' had a moderate effect size. Conclusions: A putative hazard factor impinging on individual risk at the family-wide level, namely family structure, appears to act interactively with two pivotal serotonergic genes in heightening risk for Affective Problems. Although it remains to be demonstrated that belonging to a one- rather than a two-parent family has true environmental causal effects on Affective Problems, these data may contribute to identify/prevent risk for depression in childhood. En ligne : http://dx.doi.org/10.1111/j.1469-7610.2008.01958.x Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=719 [article] The influence of family structure, the TPH2 G-703T and the 5-HTTLPR serotonergic genes upon affective problems in children aged 10–14 years [Texte imprimé et/ou numérique] / Maria NOBILE, Auteur ; Roberto GIORDA, Auteur ; Cecilia MARINO, Auteur ; Ombretta CARLET, Auteur ; Laura VANZIN, Auteur ; Monica BELLINA, Auteur ; Massimo MOLTENI, Auteur ; Marco BATTAGLIA, Auteur ; Marianna RUSCONI, Auteur . - 2009 . - p.317-325. Langues : Anglais (eng) in Journal of Child Psychology and Psychiatry > 50-3 (March 2009) . - p.317-325 Mots-clés : Children depression gene–environment-interaction serotonin divorce family affective-disorders Index. décimale : PER Périodiques Résumé : Background: Both genetic and psychosocial risk factors influence the risk for depression in development. While the impacts of family structure and of serotonergic polymorphisms upon individual differences for affective problems have been investigated separately, they have never been considered together in a gene–environment interplay perspective. Methods: We examined the effects of family structure and two serotonergic polymorphisms (the TPH2 G-703T and the 5-HTTLPR) upon depressive symptoms assessed by the new CBCL/6-18 DSM-oriented Affective Problems scale in a general population sample of 607 Italian children aged 10–14 years. Results: Belonging to 'one-parent' families, the TPH2 G-703T 'G variant', and the 5-HTTLPR 'short' alleles were associated – both alone and in apparent gene-by-environment interaction – with higher Affective Problems scores. As predicted by quantitative genetics theory, both polymorphisms contributed with a small effect size, while 'family structure' had a moderate effect size. Conclusions: A putative hazard factor impinging on individual risk at the family-wide level, namely family structure, appears to act interactively with two pivotal serotonergic genes in heightening risk for Affective Problems. Although it remains to be demonstrated that belonging to a one- rather than a two-parent family has true environmental causal effects on Affective Problems, these data may contribute to identify/prevent risk for depression in childhood. En ligne : http://dx.doi.org/10.1111/j.1469-7610.2008.01958.x Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=719

The role played by the interaction between genetic factors and attachment in the stress response in infancy / Alessandra FRIGERIO in Journal of Child Psychology and Psychiatry, 50-12 (December 2009)  

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