Functional MRI connectivity of children with autism and low verbal and cognitive performance / Terisa P. GABRIELSEN in Molecular Autism, 9 (2018)  

Public ISBD [article]  inMolecular Autism > 9 (2018) . - 67 p. Titre : Functional MRI connectivity of children with autism and low verbal and cognitive performance Type de document : texte imprimé Auteurs : Terisa P. GABRIELSEN, Auteur ; Jeffrey S. ANDERSON, Auteur ; Kevin G. STEPHENSON, Auteur ; J. BECK, Auteur ; J.B. KING, Auteur ; R. KELLEMS, Auteur ; D.N. TOP, Auteur ; Nicholas C.C. RUSSELL, Auteur ; Emily I. ANDERBERG, Auteur ; Rebecca A. LUNDWALL, Auteur ; Blake D. HANSEN, Auteur ; Mikle SOUTH, Auteur Article en page(s) : 67 p. Langues : Anglais (eng) Mots-clés : Adolescent  Autistic Disorder/*diagnostic imaging/physiopathology  Case-Control Studies  Child  *Cognition  Female  Humans  Intelligence  *Language Development  Magnetic Resonance Imaging  Male  *Autism spectrum disorder  *Functional connectivity  *Imaging methodology  *Intelligence  *Language  Institutional Review Board, protocol #F25403. Written informed consent was  obtained from parents, with assent obtained from participants following video  review of procedures.The boy who modeled the MRI procedures in the video modeling  procedure was filmed, and the final video was shared, with written permission of  both of his parents and with his own assent.The authors declare that they have no  competing interests.Springer Nature remains neutral with regard to jurisdictional  claims in published maps and institutional affiliations. Index. décimale : PER Périodiques Résumé : Background: Functional neuroimaging research in autism spectrum disorder has reported patterns of decreased long-range, within-network, and interhemispheric connectivity. Research has also reported increased corticostriatal connectivity and between-network connectivity for default and attentional networks. Past studies have excluded individuals with autism and low verbal and cognitive performance (LVCP), so connectivity in individuals more significantly affected with autism has not yet been studied. This represents a critical gap in our understanding of brain function across the autism spectrum. Methods: Using behavioral support procedures adapted from Nordahl, et al. (J Neurodev Disord 8:20-20, 2016), we completed non-sedated structural and functional MRI scans of 56 children ages 7-17, including LVCP children (n = 17, mean IQ = 54), children with autism and higher performance (HVCP, n = 20, mean IQ = 106), and neurotypical children (NT, n = 19, mean IQ = 111). Preparation included detailed intake questionnaires, video modeling, behavioral and anxiety reduction techniques, active noise-canceling headphones, and in-scan presentation of the Inscapes movie paradigm from Vanderwal et al. (Neuroimage 122:222-32, 2015). A high temporal resolution multiband echoplanar fMRI protocol analyzed motion-free time series data, extracted from concatenated volumes to mitigate the influence of motion artifact. All participants had > 200 volumes of motion-free fMRI scanning. Analyses were corrected for multiple comparisons. Results: LVCP showed decreased within-network connectivity in default, salience, auditory, and frontoparietal networks (LVCP < HVCP) and decreased interhemispheric connectivity (LVCP < HVCP=NT). Between-network connectivity was higher for LVCP than NT between default and dorsal attention and frontoparietal networks. Lower IQ was associated with decreased connectivity within the default network and increased connectivity between default and dorsal attention networks. Conclusions: This study demonstrates that with moderate levels of support, including readily available techniques, information about brain similarities and differences in LVCP individuals can be further studied. This initial study suggested decreased network segmentation and integration in LVCP individuals. Further imaging studies of LVCP individuals with larger samples will add to understanding of origins and effects of autism on brain function and behavior. En ligne : https://dx.doi.org/10.1186/s13229-018-0248-y Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=389 [article] Functional MRI connectivity of children with autism and low verbal and cognitive performance [texte imprimé] / Terisa P. GABRIELSEN, Auteur ; Jeffrey S. ANDERSON, Auteur ; Kevin G. STEPHENSON, Auteur ; J. BECK, Auteur ; J.B. KING, Auteur ; R. KELLEMS, Auteur ; D.N. TOP, Auteur ; Nicholas C.C. RUSSELL, Auteur ; Emily I. ANDERBERG, Auteur ; Rebecca A. LUNDWALL, Auteur ; Blake D. HANSEN, Auteur ; Mikle SOUTH, Auteur . - 67 p. Langues : Anglais (eng) in Molecular Autism > 9 (2018) . - 67 p. Mots-clés : Adolescent  Autistic Disorder/*diagnostic imaging/physiopathology  Case-Control Studies  Child  *Cognition  Female  Humans  Intelligence  *Language Development  Magnetic Resonance Imaging  Male  *Autism spectrum disorder  *Functional connectivity  *Imaging methodology  *Intelligence  *Language  Institutional Review Board, protocol #F25403. Written informed consent was  obtained from parents, with assent obtained from participants following video  review of procedures.The boy who modeled the MRI procedures in the video modeling  procedure was filmed, and the final video was shared, with written permission of  both of his parents and with his own assent.The authors declare that they have no  competing interests.Springer Nature remains neutral with regard to jurisdictional  claims in published maps and institutional affiliations. Index. décimale : PER Périodiques Résumé : Background: Functional neuroimaging research in autism spectrum disorder has reported patterns of decreased long-range, within-network, and interhemispheric connectivity. Research has also reported increased corticostriatal connectivity and between-network connectivity for default and attentional networks. Past studies have excluded individuals with autism and low verbal and cognitive performance (LVCP), so connectivity in individuals more significantly affected with autism has not yet been studied. This represents a critical gap in our understanding of brain function across the autism spectrum. Methods: Using behavioral support procedures adapted from Nordahl, et al. (J Neurodev Disord 8:20-20, 2016), we completed non-sedated structural and functional MRI scans of 56 children ages 7-17, including LVCP children (n = 17, mean IQ = 54), children with autism and higher performance (HVCP, n = 20, mean IQ = 106), and neurotypical children (NT, n = 19, mean IQ = 111). Preparation included detailed intake questionnaires, video modeling, behavioral and anxiety reduction techniques, active noise-canceling headphones, and in-scan presentation of the Inscapes movie paradigm from Vanderwal et al. (Neuroimage 122:222-32, 2015). A high temporal resolution multiband echoplanar fMRI protocol analyzed motion-free time series data, extracted from concatenated volumes to mitigate the influence of motion artifact. All participants had > 200 volumes of motion-free fMRI scanning. Analyses were corrected for multiple comparisons. Results: LVCP showed decreased within-network connectivity in default, salience, auditory, and frontoparietal networks (LVCP < HVCP) and decreased interhemispheric connectivity (LVCP < HVCP=NT). Between-network connectivity was higher for LVCP than NT between default and dorsal attention and frontoparietal networks. Lower IQ was associated with decreased connectivity within the default network and increased connectivity between default and dorsal attention networks. Conclusions: This study demonstrates that with moderate levels of support, including readily available techniques, information about brain similarities and differences in LVCP individuals can be further studied. This initial study suggested decreased network segmentation and integration in LVCP individuals. Further imaging studies of LVCP individuals with larger samples will add to understanding of origins and effects of autism on brain function and behavior. En ligne : https://dx.doi.org/10.1186/s13229-018-0248-y Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=389

A Pilot Study of a Behavioral Parent Training in the Republic of Macedonia / Blake D. HANSEN in Journal of Autism and Developmental Disorders, 47-6 (June 2017)  

Public ISBD [article]  inJournal of Autism and Developmental Disorders > 47-6 (June 2017) . - p.1878-1889 Titre : A Pilot Study of a Behavioral Parent Training in the Republic of Macedonia Type de document : texte imprimé Auteurs : Blake D. HANSEN, Auteur ; Emma Lucy ORTON, Auteur ; Chase ADAMS, Auteur ; Laura KNECHT, Auteur ; Sophie RINDLISBAKER, Auteur ; Filip JURTOSKI, Auteur ; Vladimir TRAJKOVSKI, Auteur Article en page(s) : p.1878-1889 Langues : Anglais (eng) Mots-clés : Behavioral parent training  International settings  Behavior analysis Index. décimale : PER Périodiques Résumé : Parenting children with autism in countries with limited professional and financial resources can be overwhelming. Parent training led by non-governmental organizations may help alleviate some of these burdens. The present pilot study was conducted in the Republic of Macedonia, a country located in Southeastern Europe. The purpose of the study was to evaluate a parent training model for disseminating evidence-based practices through didactic and pyramidal training strategies. Results indicated that children improved on a number of different behaviors and results provide some evidence that parenting confidence and distress improved. En ligne : http://dx.doi.org/10.1007/s10803-017-3112-6 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=308 [article] A Pilot Study of a Behavioral Parent Training in the Republic of Macedonia [texte imprimé] / Blake D. HANSEN, Auteur ; Emma Lucy ORTON, Auteur ; Chase ADAMS, Auteur ; Laura KNECHT, Auteur ; Sophie RINDLISBAKER, Auteur ; Filip JURTOSKI, Auteur ; Vladimir TRAJKOVSKI, Auteur . - p.1878-1889. Langues : Anglais (eng) in Journal of Autism and Developmental Disorders > 47-6 (June 2017) . - p.1878-1889 Mots-clés : Behavioral parent training  International settings  Behavior analysis Index. décimale : PER Périodiques Résumé : Parenting children with autism in countries with limited professional and financial resources can be overwhelming. Parent training led by non-governmental organizations may help alleviate some of these burdens. The present pilot study was conducted in the Republic of Macedonia, a country located in Southeastern Europe. The purpose of the study was to evaluate a parent training model for disseminating evidence-based practices through didactic and pyramidal training strategies. Results indicated that children improved on a number of different behaviors and results provide some evidence that parenting confidence and distress improved. En ligne : http://dx.doi.org/10.1007/s10803-017-3112-6 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=308

Relationship between brain stem volume and aggression in children diagnosed with autism spectrum disorder / Rebecca A. LUNDWALL in Research in Autism Spectrum Disorders, 34 (February 2017)  

Public ISBD [article]  inResearch in Autism Spectrum Disorders > 34 (February 2017) . - p.44-51 Titre : Relationship between brain stem volume and aggression in children diagnosed with autism spectrum disorder Type de document : texte imprimé Auteurs : Rebecca A. LUNDWALL, Auteur ; Kevin G. STEPHENSON, Auteur ; E. Shannon NEELEY-TASS, Auteur ; Jonathan C. COX, Auteur ; Mikle SOUTH, Auteur ; Erin D. BIGLER, Auteur ; Emily I. ANDERBERG, Auteur ; Molly D.B. PRIGGE, Auteur ; Blake D. HANSEN, Auteur ; Janet E. LAINHART, Auteur ; Ryan O. KELLEMS, Auteur ; Jo Ann PETRIE, Auteur ; Terisa P. GABRIELSEN, Auteur Article en page(s) : p.44-51 Langues : Anglais (eng) Mots-clés : Autism  Aggression  Imaging  Brainstem  Structural MRI Index. décimale : PER Périodiques Résumé : AbstractBackground Aggressive behaviors are common in individuals diagnosed with autism spectrum disorder (ASD) and may be phenotypic indicators of different subtypes within ASD. In current research literature for non-ASD samples, aggression has been linked to several brain structures associated with emotion and behavioral control. However, few if any studies exist investigating brain volume differences in individuals with ASD who have comorbid aggression as indicated by standardized diagnostic and behavioral measures. Method We examined neuroimaging data from individuals rigorously diagnosed with ASD versus typically developing (TD) controls. We began with data from brain volume regions of interest (ROI) taken from previous literature on aggression including the brainstem, amygdala, orbitofrontal cortex, anterior cingulate cortex, and dorsolateral prefrontal cortex. We defined aggression status using the Irritability subscale of the Aberrant Behavior Checklist and used lasso logistic regression to select among these predictor variables. Brainstem volume was the only variable shown to be a predictor of aggression status. Results We found that smaller brainstem volumes are associated with higher odds of being in the high aggression group. Conclusions Understanding brain differences in individuals with ASD who engage in aggressive behavior from those with ASD who do not can inform treatment approaches. Future research should investigate brainstem structure and function in ASD to identify possible mechanisms related to arousal and aggression. En ligne : http://dx.doi.org/10.1016/j.rasd.2016.12.001 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=298 [article] Relationship between brain stem volume and aggression in children diagnosed with autism spectrum disorder [texte imprimé] / Rebecca A. LUNDWALL, Auteur ; Kevin G. STEPHENSON, Auteur ; E. Shannon NEELEY-TASS, Auteur ; Jonathan C. COX, Auteur ; Mikle SOUTH, Auteur ; Erin D. BIGLER, Auteur ; Emily I. ANDERBERG, Auteur ; Molly D.B. PRIGGE, Auteur ; Blake D. HANSEN, Auteur ; Janet E. LAINHART, Auteur ; Ryan O. KELLEMS, Auteur ; Jo Ann PETRIE, Auteur ; Terisa P. GABRIELSEN, Auteur . - p.44-51. Langues : Anglais (eng) in Research in Autism Spectrum Disorders > 34 (February 2017) . - p.44-51 Mots-clés : Autism  Aggression  Imaging  Brainstem  Structural MRI Index. décimale : PER Périodiques Résumé : AbstractBackground Aggressive behaviors are common in individuals diagnosed with autism spectrum disorder (ASD) and may be phenotypic indicators of different subtypes within ASD. In current research literature for non-ASD samples, aggression has been linked to several brain structures associated with emotion and behavioral control. However, few if any studies exist investigating brain volume differences in individuals with ASD who have comorbid aggression as indicated by standardized diagnostic and behavioral measures. Method We examined neuroimaging data from individuals rigorously diagnosed with ASD versus typically developing (TD) controls. We began with data from brain volume regions of interest (ROI) taken from previous literature on aggression including the brainstem, amygdala, orbitofrontal cortex, anterior cingulate cortex, and dorsolateral prefrontal cortex. We defined aggression status using the Irritability subscale of the Aberrant Behavior Checklist and used lasso logistic regression to select among these predictor variables. Brainstem volume was the only variable shown to be a predictor of aggression status. Results We found that smaller brainstem volumes are associated with higher odds of being in the high aggression group. Conclusions Understanding brain differences in individuals with ASD who engage in aggressive behavior from those with ASD who do not can inform treatment approaches. Future research should investigate brainstem structure and function in ASD to identify possible mechanisms related to arousal and aggression. En ligne : http://dx.doi.org/10.1016/j.rasd.2016.12.001 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=298

---

1 (1 - 3 / 3) Par page : 25 50 100 200