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Détail de l'auteur
Auteur Leonard ABBEDUTO |
Documents disponibles écrits par cet auteur (22)
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Prevalence and Predictors of Anxiety Disorders in Adolescent and Adult Males with Autism Spectrum Disorder and Fragile X Syndrome / J. EZELL in Journal of Autism and Developmental Disorders, 49-3 (March 2019)
[article]
Titre : Prevalence and Predictors of Anxiety Disorders in Adolescent and Adult Males with Autism Spectrum Disorder and Fragile X Syndrome Type de document : Texte imprimé et/ou numérique Auteurs : J. EZELL, Auteur ; A. HOGAN, Auteur ; A. FAIRCHILD, Auteur ; K. HILLS, Auteur ; J. KLUSEK, Auteur ; Leonard ABBEDUTO, Auteur ; J. ROBERTS, Auteur Article en page(s) : p.1131-1141 Langues : Anglais (eng) Mots-clés : Anxiety Autism spectrum disorder Fragile X syndrome Intellectual disability Index. décimale : PER Périodiques Résumé : Anxiety disorders affect ~ 15-20% of youths without neurodevelopmental disorders, with persons having autism spectrum disorder (ASD) and fragile X syndrome (FXS) at elevated risk for anxiety disorders. Few studies have compared rates and predictors of anxiety disorders in adolescents with FXS or ASD. This study directly compares rates, predictors, and medication of anxiety disorders between age-matched, male adolescents with FXS (n = 31) or ASD (n = 20). Results indicate that 51.6% of FXS and 50.0% of ASD adolescents met criteria for an anxiety disorder. Cognitive scores and ASD severity did not predict anxiety. Of those with anxiety, ~ 40% of the FXS and 20% of the ASD participants were prescribed medications for anxiety. En ligne : http://dx.doi.org/10.1007/s10803-018-3804-6 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=386
in Journal of Autism and Developmental Disorders > 49-3 (March 2019) . - p.1131-1141[article] Prevalence and Predictors of Anxiety Disorders in Adolescent and Adult Males with Autism Spectrum Disorder and Fragile X Syndrome [Texte imprimé et/ou numérique] / J. EZELL, Auteur ; A. HOGAN, Auteur ; A. FAIRCHILD, Auteur ; K. HILLS, Auteur ; J. KLUSEK, Auteur ; Leonard ABBEDUTO, Auteur ; J. ROBERTS, Auteur . - p.1131-1141.
Langues : Anglais (eng)
in Journal of Autism and Developmental Disorders > 49-3 (March 2019) . - p.1131-1141
Mots-clés : Anxiety Autism spectrum disorder Fragile X syndrome Intellectual disability Index. décimale : PER Périodiques Résumé : Anxiety disorders affect ~ 15-20% of youths without neurodevelopmental disorders, with persons having autism spectrum disorder (ASD) and fragile X syndrome (FXS) at elevated risk for anxiety disorders. Few studies have compared rates and predictors of anxiety disorders in adolescents with FXS or ASD. This study directly compares rates, predictors, and medication of anxiety disorders between age-matched, male adolescents with FXS (n = 31) or ASD (n = 20). Results indicate that 51.6% of FXS and 50.0% of ASD adolescents met criteria for an anxiety disorder. Cognitive scores and ASD severity did not predict anxiety. Of those with anxiety, ~ 40% of the FXS and 20% of the ASD participants were prescribed medications for anxiety. En ligne : http://dx.doi.org/10.1007/s10803-018-3804-6 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=386 Receptive Vocabulary in Boys with Autism Spectrum Disorder: Cross-Sectional Developmental Trajectories / Sara T. KOVER in Journal of Autism and Developmental Disorders, 43-11 (November 2013)
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Titre : Receptive Vocabulary in Boys with Autism Spectrum Disorder: Cross-Sectional Developmental Trajectories Type de document : Texte imprimé et/ou numérique Auteurs : Sara T. KOVER, Auteur ; Andrea S. MCDUFFIE, Auteur ; Randi J. HAGERMAN, Auteur ; Leonard ABBEDUTO, Auteur Article en page(s) : p.2696-2709 Langues : Anglais (eng) Mots-clés : Autism Language development Comprehension Production Vocabulary Trajectory Index. décimale : PER Périodiques Résumé : In light of evidence that receptive language may be a relative weakness for individuals with autism spectrum disorder (ASD), this study characterized receptive vocabulary profiles in boys with ASD using cross-sectional developmental trajectories relative to age, nonverbal cognition, and expressive vocabulary. Participants were 49 boys with ASD (4–11 years) and 80 typically developing boys (2–11 years). Receptive vocabulary, assessed with the Peabody Picture Vocabulary Test, was a weakness for boys with ASD relative to age and nonverbal cognition. Relative to expressive vocabulary, assessed with the Expressive Vocabulary Test, receptive vocabulary increased at a lower rate for boys with ASD. Vocabulary trajectories in ASD are distinguished from typical development; however, nonverbal cognition largely accounts for the patterns observed. En ligne : http://dx.doi.org/10.1007/s10803-013-1823-x Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=217
in Journal of Autism and Developmental Disorders > 43-11 (November 2013) . - p.2696-2709[article] Receptive Vocabulary in Boys with Autism Spectrum Disorder: Cross-Sectional Developmental Trajectories [Texte imprimé et/ou numérique] / Sara T. KOVER, Auteur ; Andrea S. MCDUFFIE, Auteur ; Randi J. HAGERMAN, Auteur ; Leonard ABBEDUTO, Auteur . - p.2696-2709.
Langues : Anglais (eng)
in Journal of Autism and Developmental Disorders > 43-11 (November 2013) . - p.2696-2709
Mots-clés : Autism Language development Comprehension Production Vocabulary Trajectory Index. décimale : PER Périodiques Résumé : In light of evidence that receptive language may be a relative weakness for individuals with autism spectrum disorder (ASD), this study characterized receptive vocabulary profiles in boys with ASD using cross-sectional developmental trajectories relative to age, nonverbal cognition, and expressive vocabulary. Participants were 49 boys with ASD (4–11 years) and 80 typically developing boys (2–11 years). Receptive vocabulary, assessed with the Peabody Picture Vocabulary Test, was a weakness for boys with ASD relative to age and nonverbal cognition. Relative to expressive vocabulary, assessed with the Expressive Vocabulary Test, receptive vocabulary increased at a lower rate for boys with ASD. Vocabulary trajectories in ASD are distinguished from typical development; however, nonverbal cognition largely accounts for the patterns observed. En ligne : http://dx.doi.org/10.1007/s10803-013-1823-x Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=217 Social Avoidance Emerges in Infancy and Persists into Adulthood in Fragile X Syndrome / J. ROBERTS in Journal of Autism and Developmental Disorders, 49-9 (September 2019)
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Titre : Social Avoidance Emerges in Infancy and Persists into Adulthood in Fragile X Syndrome Type de document : Texte imprimé et/ou numérique Auteurs : J. ROBERTS, Auteur ; Hayley CRAWFORD, Auteur ; A. L. HOGAN, Auteur ; A. FAIRCHILD, Auteur ; B. TONNSEN, Auteur ; A. BREWE, Auteur ; S. O'CONNOR, Auteur ; D. A. ROBERTS, Auteur ; Leonard ABBEDUTO, Auteur Article en page(s) : p.3753-3766 Langues : Anglais (eng) Mots-clés : Autism spectrum disorder Fragile X Infant Social anxiety Social approach Index. décimale : PER Périodiques Résumé : Fragile X syndrome (FXS) is characterized by both social approach and social avoidance. However, the age of emergence and developmental trajectory of social avoidance has not been examined. This study investigates the longitudinal developmental trajectory and dynamic nature of social avoidance in males with FXS from infancy through young adulthood (n = 191). Multiple facets of social avoidance were collected using the Social Avoidance Scale (Roberts et al. 2007, 2009). Overall, 81% of males with FXS displayed social avoidance, which emerged during infancy, increased in severity across childhood, and stabilized through adolescence and early adulthood. An exaggerated "warm up" effect was also observed in FXS. This study delineates the complex profile of social avoidance, a common and impairing behavioral feature of FXS. En ligne : http://dx.doi.org/10.1007/s10803-019-04051-8 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=405
in Journal of Autism and Developmental Disorders > 49-9 (September 2019) . - p.3753-3766[article] Social Avoidance Emerges in Infancy and Persists into Adulthood in Fragile X Syndrome [Texte imprimé et/ou numérique] / J. ROBERTS, Auteur ; Hayley CRAWFORD, Auteur ; A. L. HOGAN, Auteur ; A. FAIRCHILD, Auteur ; B. TONNSEN, Auteur ; A. BREWE, Auteur ; S. O'CONNOR, Auteur ; D. A. ROBERTS, Auteur ; Leonard ABBEDUTO, Auteur . - p.3753-3766.
Langues : Anglais (eng)
in Journal of Autism and Developmental Disorders > 49-9 (September 2019) . - p.3753-3766
Mots-clés : Autism spectrum disorder Fragile X Infant Social anxiety Social approach Index. décimale : PER Périodiques Résumé : Fragile X syndrome (FXS) is characterized by both social approach and social avoidance. However, the age of emergence and developmental trajectory of social avoidance has not been examined. This study investigates the longitudinal developmental trajectory and dynamic nature of social avoidance in males with FXS from infancy through young adulthood (n = 191). Multiple facets of social avoidance were collected using the Social Avoidance Scale (Roberts et al. 2007, 2009). Overall, 81% of males with FXS displayed social avoidance, which emerged during infancy, increased in severity across childhood, and stabilized through adolescence and early adulthood. An exaggerated "warm up" effect was also observed in FXS. This study delineates the complex profile of social avoidance, a common and impairing behavioral feature of FXS. En ligne : http://dx.doi.org/10.1007/s10803-019-04051-8 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=405 Symptoms of Autism in Males with Fragile X Syndrome: A Comparison to Nonsyndromic ASD Using Current ADI-R Scores / Andrea MCDUFFIE in Journal of Autism and Developmental Disorders, 45-7 (July 2015)
[article]
Titre : Symptoms of Autism in Males with Fragile X Syndrome: A Comparison to Nonsyndromic ASD Using Current ADI-R Scores Type de document : Texte imprimé et/ou numérique Auteurs : Andrea MCDUFFIE, Auteur ; Angela John THURMAN, Auteur ; Randi J. HAGERMAN, Auteur ; Leonard ABBEDUTO, Auteur Année de publication : 2015 Article en page(s) : p.1925-1937 Langues : Anglais (eng) Mots-clés : Autism spectrum disorder Fragile X syndrome ADI-R Index. décimale : PER Périodiques Résumé : Symptoms of autism are frequent in males with fragile X syndrome (FXS), but it is not clear whether symptom profiles differ from those of nonsyndromic ASD. Using individual item scores from the Autism Diagnostic Inventory-Revised, we examined which current symptoms of autism differed in boys with FXS relative to same-aged boys diagnosed with nonsyndromic ASD. In addition, different subsamples of participants were matched on autism diagnostic status and severity of autism symptoms. Between-group comparisons revealed that boys with FXS showed significantly less impairment in Social Smiling than did age-, diagnostic-, and severity-matched boys with nonsyndromic ASD. Severity-matched boys with FXS showed more impairment in complex mannerisms than did boys with nonsyndromic ASD. Behavioral differences between FXS and nonsyndromic ASD may be of theoretical importance in understanding the causes and correlates of ASD in FXS and in developing and implementing appropriate treatments. En ligne : http://dx.doi.org/10.1007/s10803-013-2013-6 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=261
in Journal of Autism and Developmental Disorders > 45-7 (July 2015) . - p.1925-1937[article] Symptoms of Autism in Males with Fragile X Syndrome: A Comparison to Nonsyndromic ASD Using Current ADI-R Scores [Texte imprimé et/ou numérique] / Andrea MCDUFFIE, Auteur ; Angela John THURMAN, Auteur ; Randi J. HAGERMAN, Auteur ; Leonard ABBEDUTO, Auteur . - 2015 . - p.1925-1937.
Langues : Anglais (eng)
in Journal of Autism and Developmental Disorders > 45-7 (July 2015) . - p.1925-1937
Mots-clés : Autism spectrum disorder Fragile X syndrome ADI-R Index. décimale : PER Périodiques Résumé : Symptoms of autism are frequent in males with fragile X syndrome (FXS), but it is not clear whether symptom profiles differ from those of nonsyndromic ASD. Using individual item scores from the Autism Diagnostic Inventory-Revised, we examined which current symptoms of autism differed in boys with FXS relative to same-aged boys diagnosed with nonsyndromic ASD. In addition, different subsamples of participants were matched on autism diagnostic status and severity of autism symptoms. Between-group comparisons revealed that boys with FXS showed significantly less impairment in Social Smiling than did age-, diagnostic-, and severity-matched boys with nonsyndromic ASD. Severity-matched boys with FXS showed more impairment in complex mannerisms than did boys with nonsyndromic ASD. Behavioral differences between FXS and nonsyndromic ASD may be of theoretical importance in understanding the causes and correlates of ASD in FXS and in developing and implementing appropriate treatments. En ligne : http://dx.doi.org/10.1007/s10803-013-2013-6 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=261 The NIH Toolbox Cognitive Battery for intellectual disabilities: three preliminary studies and future directions / D. HESSL in Journal of Neurodevelopmental Disorders, 8-1 (December 2016)
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Titre : The NIH Toolbox Cognitive Battery for intellectual disabilities: three preliminary studies and future directions Type de document : Texte imprimé et/ou numérique Auteurs : D. HESSL, Auteur ; Stephanie M. SANSONE, Auteur ; Elizabeth BERRY-KRAVIS, Auteur ; K. RILEY, Auteur ; K. F. WIDAMAN, Auteur ; Leonard ABBEDUTO, Auteur ; A. SCHNEIDER, Auteur ; J. COLEMAN, Auteur ; D. OAKLANDER, Auteur ; K. C. RHODES, Auteur ; R. C. GERSHON, Auteur Article en page(s) : p.35 Langues : Anglais (eng) Mots-clés : Assessment Cognition Down syndrome FMR1 gene Fragile X syndrome Outcome measures Index. décimale : PER Périodiques Résumé : BACKGROUND: Recent advances in understanding molecular and synaptic mechanisms of intellectual disabilities (ID) in fragile X syndrome (FXS) and Down syndrome (DS) through animal models have led to targeted controlled trials with pharmacological agents designed to normalize these underlying mechanisms and improve clinical outcomes. However, several human clinical trials have failed to demonstrate efficacy of these targeted treatments to improve surrogate behavioral endpoints. Because the ultimate index of disease modification in these disorders is amelioration of ID, the validation of cognitive measures for tracking treatment response is essential. Here, we present preliminary research to validate the National Institutes of Health Toolbox Cognitive Battery (NIH-TCB) for ID. METHODS: We completed three pilot studies of patients with FXS (total n = 63; mean age 19.3 +/- 8.3 years, mean mental age 5.3 +/- 1.6 years), DS (n = 47; mean age 16.1 +/- 6.2, mean mental age 5.4 +/- 2.0), and idiopathic ID (IID; n = 16; mean age 16.1 +/- 5.0, mean mental age 6.6 +/- 2.3) measuring processing speed, executive function, episodic memory, word/letter reading, receptive vocabulary, and working memory using the web-based NIH-TB-CB, addressing feasibility, test-retest reliability, construct validity, ecological validity, and syndrome differences and profiles. RESULTS: Feasibility was good to excellent (>/=80 % of participants with valid scores) for above mental age 4 years for all tests except list sorting (working memory). Test-retest stability was good to excellent, and convergent validity was similar to or better than results obtained from typically developing children in the normal sample for executive function and language measures. Examination of ecological validity revealed moderate to very strong correlations between the NIH-TCB composite and adaptive behavior and full-scale IQ measures. Syndrome/group comparisons demonstrated significant deficits for the FXS and DS groups relative to IID on attention and inhibitory control, a significant reading weakness for FXS, and a receptive vocabulary weakness for DS. CONCLUSIONS: The NIH-TCB has potential for assessing important dimensions of cognition in persons with ID, and several tests may be useful for tracking response to intervention. However, more extensive psychometric studies, evaluation of the NIH-TCB's sensitivity to change, both developmentally and in the context of treatment, and perhaps establishing links to brain function in these populations, are required to determine the true utility of the battery as a set of outcome measures. En ligne : http://dx.doi.org/10.1186/s11689-016-9167-4 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=349
in Journal of Neurodevelopmental Disorders > 8-1 (December 2016) . - p.35[article] The NIH Toolbox Cognitive Battery for intellectual disabilities: three preliminary studies and future directions [Texte imprimé et/ou numérique] / D. HESSL, Auteur ; Stephanie M. SANSONE, Auteur ; Elizabeth BERRY-KRAVIS, Auteur ; K. RILEY, Auteur ; K. F. WIDAMAN, Auteur ; Leonard ABBEDUTO, Auteur ; A. SCHNEIDER, Auteur ; J. COLEMAN, Auteur ; D. OAKLANDER, Auteur ; K. C. RHODES, Auteur ; R. C. GERSHON, Auteur . - p.35.
Langues : Anglais (eng)
in Journal of Neurodevelopmental Disorders > 8-1 (December 2016) . - p.35
Mots-clés : Assessment Cognition Down syndrome FMR1 gene Fragile X syndrome Outcome measures Index. décimale : PER Périodiques Résumé : BACKGROUND: Recent advances in understanding molecular and synaptic mechanisms of intellectual disabilities (ID) in fragile X syndrome (FXS) and Down syndrome (DS) through animal models have led to targeted controlled trials with pharmacological agents designed to normalize these underlying mechanisms and improve clinical outcomes. However, several human clinical trials have failed to demonstrate efficacy of these targeted treatments to improve surrogate behavioral endpoints. Because the ultimate index of disease modification in these disorders is amelioration of ID, the validation of cognitive measures for tracking treatment response is essential. Here, we present preliminary research to validate the National Institutes of Health Toolbox Cognitive Battery (NIH-TCB) for ID. METHODS: We completed three pilot studies of patients with FXS (total n = 63; mean age 19.3 +/- 8.3 years, mean mental age 5.3 +/- 1.6 years), DS (n = 47; mean age 16.1 +/- 6.2, mean mental age 5.4 +/- 2.0), and idiopathic ID (IID; n = 16; mean age 16.1 +/- 5.0, mean mental age 6.6 +/- 2.3) measuring processing speed, executive function, episodic memory, word/letter reading, receptive vocabulary, and working memory using the web-based NIH-TB-CB, addressing feasibility, test-retest reliability, construct validity, ecological validity, and syndrome differences and profiles. RESULTS: Feasibility was good to excellent (>/=80 % of participants with valid scores) for above mental age 4 years for all tests except list sorting (working memory). Test-retest stability was good to excellent, and convergent validity was similar to or better than results obtained from typically developing children in the normal sample for executive function and language measures. Examination of ecological validity revealed moderate to very strong correlations between the NIH-TCB composite and adaptive behavior and full-scale IQ measures. Syndrome/group comparisons demonstrated significant deficits for the FXS and DS groups relative to IID on attention and inhibitory control, a significant reading weakness for FXS, and a receptive vocabulary weakness for DS. CONCLUSIONS: The NIH-TCB has potential for assessing important dimensions of cognition in persons with ID, and several tests may be useful for tracking response to intervention. However, more extensive psychometric studies, evaluation of the NIH-TCB's sensitivity to change, both developmentally and in the context of treatment, and perhaps establishing links to brain function in these populations, are required to determine the true utility of the battery as a set of outcome measures. En ligne : http://dx.doi.org/10.1186/s11689-016-9167-4 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=349 Updated report on tools to measure outcomes of clinical trials in fragile X syndrome / Dejan B. BUDIMIROVIC in Journal of Neurodevelopmental Disorders, 9-1 (December 2017)
PermalinkUse of Emotional Cues for Lexical Learning: A Comparison of Autism Spectrum Disorder and Fragile X Syndrome / Angela John THURMAN in Journal of Autism and Developmental Disorders, 45-4 (April 2015)
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