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Auteur Bart BOETS |
Documents disponibles écrits par cet auteur (22)
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Oxytocin receptor gene (OXTR) DNA methylation is associated with autism and related social traits – A systematic review / Matthijs MOERKERKE in Research in Autism Spectrum Disorders, 85 (July 2021)
[article]
Titre : Oxytocin receptor gene (OXTR) DNA methylation is associated with autism and related social traits – A systematic review Type de document : Texte imprimé et/ou numérique Auteurs : Matthijs MOERKERKE, Auteur ; Marie-Laure BONTE, Auteur ; Nicky DANIELS, Auteur ; Viktoria CHUBAR, Auteur ; Kaat ALAERTS, Auteur ; Jean STEYAERT, Auteur ; Bart BOETS, Auteur Article en page(s) : 101785 Langues : Anglais (eng) Mots-clés : Oxytocin receptor gene Epigenetics DNA methylation Autism Social behaviour Index. décimale : PER Périodiques Résumé : There is emerging evidence implicating oxytocin receptor gene (OXTR) DNA methylation (DNAm) in social behaviour. This review investigated its association with autism spectrum disorder (ASD) characteristics and related social dimensions, both in individuals with and without ASD. Twelve articles investigating OXTR DNAm in relation to ASD, social perception/cognition and social anxiety were included. We found that hypermethylation is associated with (i) higher quantitative autism traits in adults, reflecting a higher incidence of autism characteristics, (ii) increased brain activity while performing social tasks (indicating a higher need for resources) and (iii) decreased functional connectivity. (iv) Contradictory, hypomethylation was found to be present in children (especially boys) with ASD and was also associated with more social anxiety. While the included studies displayed a large variability, for example in terms of population characteristics, analysed OXTR DNAm regions, and adopted scales/questionnaires, an initial developmental pattern of results emerged, suggesting an association between hypermethylation of OXTR and autism traits in adults. Nonetheless, future studies are warranted to corroborate these initial conclusions. En ligne : https://doi.org/10.1016/j.rasd.2021.101785 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=458
in Research in Autism Spectrum Disorders > 85 (July 2021) . - 101785[article] Oxytocin receptor gene (OXTR) DNA methylation is associated with autism and related social traits – A systematic review [Texte imprimé et/ou numérique] / Matthijs MOERKERKE, Auteur ; Marie-Laure BONTE, Auteur ; Nicky DANIELS, Auteur ; Viktoria CHUBAR, Auteur ; Kaat ALAERTS, Auteur ; Jean STEYAERT, Auteur ; Bart BOETS, Auteur . - 101785.
Langues : Anglais (eng)
in Research in Autism Spectrum Disorders > 85 (July 2021) . - 101785
Mots-clés : Oxytocin receptor gene Epigenetics DNA methylation Autism Social behaviour Index. décimale : PER Périodiques Résumé : There is emerging evidence implicating oxytocin receptor gene (OXTR) DNA methylation (DNAm) in social behaviour. This review investigated its association with autism spectrum disorder (ASD) characteristics and related social dimensions, both in individuals with and without ASD. Twelve articles investigating OXTR DNAm in relation to ASD, social perception/cognition and social anxiety were included. We found that hypermethylation is associated with (i) higher quantitative autism traits in adults, reflecting a higher incidence of autism characteristics, (ii) increased brain activity while performing social tasks (indicating a higher need for resources) and (iii) decreased functional connectivity. (iv) Contradictory, hypomethylation was found to be present in children (especially boys) with ASD and was also associated with more social anxiety. While the included studies displayed a large variability, for example in terms of population characteristics, analysed OXTR DNAm regions, and adopted scales/questionnaires, an initial developmental pattern of results emerged, suggesting an association between hypermethylation of OXTR and autism traits in adults. Nonetheless, future studies are warranted to corroborate these initial conclusions. En ligne : https://doi.org/10.1016/j.rasd.2021.101785 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=458 Rapid neural categorization of angry and fearful faces is specifically impaired in boys with autism spectrum disorder / Stephanie VAN DER DONCK in Journal of Child Psychology and Psychiatry, 61-9 (September 2020)
[article]
Titre : Rapid neural categorization of angry and fearful faces is specifically impaired in boys with autism spectrum disorder Type de document : Texte imprimé et/ou numérique Auteurs : Stephanie VAN DER DONCK, Auteur ; Milena DZHELYOVA, Auteur ; Sofie VETTORI, Auteur ; Soha Sadat MAHDI, Auteur ; Peter CLAES, Auteur ; Jean STEYAERT, Auteur ; Bart BOETS, Auteur Article en page(s) : p.1019-1029 Langues : Anglais (eng) Mots-clés : Autism electroencephalography facial emotion processing fast periodic visual stimulation implicit expression detection Index. décimale : PER Périodiques Résumé : BACKGROUND: Difficulties with facial expression processing may be associated with the characteristic social impairments in individuals with autism spectrum disorder (ASD). Emotional face processing in ASD has been investigated in an abundance of behavioral and EEG studies, yielding, however, mixed and inconsistent results. METHODS: We combined fast periodic visual stimulation (FPVS) with EEG to assess the neural sensitivity to implicitly detect briefly presented facial expressions among a stream of neutral faces, in 23 boys with ASD and 23 matched typically developing (TD) boys. Neutral faces with different identities were presented at 6 Hz, periodically interleaved with an expressive face (angry, fearful, happy, sad in separate sequences) every fifth image (i.e., 1.2 Hz oddball frequency). These distinguishable frequency tags for neutral and expressive stimuli allowed direct and objective quantification of the expression-categorization responses, needing only four sequences of 60 s of recording per condition. RESULTS: Both groups show equal neural synchronization to the general face stimulation and similar neural responses to happy and sad faces. However, the ASD group displays significantly reduced responses to angry and fearful faces, compared to TD boys. At the individual subject level, these neural responses allow to predict membership of the ASD group with an accuracy of 87%. Whereas TD participants show a significantly lower sensitivity to sad faces than to the other expressions, ASD participants show an equally low sensitivity to all the expressions. CONCLUSIONS: Our results indicate an emotion-specific processing deficit, instead of a general emotion-processing problem: Boys with ASD are less sensitive than TD boys to rapidly and implicitly detect angry and fearful faces. The implicit, fast, and straightforward nature of FPVS-EEG opens new perspectives for clinical diagnosis. En ligne : http://dx.doi.org/10.1111/jcpp.13201 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=430
in Journal of Child Psychology and Psychiatry > 61-9 (September 2020) . - p.1019-1029[article] Rapid neural categorization of angry and fearful faces is specifically impaired in boys with autism spectrum disorder [Texte imprimé et/ou numérique] / Stephanie VAN DER DONCK, Auteur ; Milena DZHELYOVA, Auteur ; Sofie VETTORI, Auteur ; Soha Sadat MAHDI, Auteur ; Peter CLAES, Auteur ; Jean STEYAERT, Auteur ; Bart BOETS, Auteur . - p.1019-1029.
Langues : Anglais (eng)
in Journal of Child Psychology and Psychiatry > 61-9 (September 2020) . - p.1019-1029
Mots-clés : Autism electroencephalography facial emotion processing fast periodic visual stimulation implicit expression detection Index. décimale : PER Périodiques Résumé : BACKGROUND: Difficulties with facial expression processing may be associated with the characteristic social impairments in individuals with autism spectrum disorder (ASD). Emotional face processing in ASD has been investigated in an abundance of behavioral and EEG studies, yielding, however, mixed and inconsistent results. METHODS: We combined fast periodic visual stimulation (FPVS) with EEG to assess the neural sensitivity to implicitly detect briefly presented facial expressions among a stream of neutral faces, in 23 boys with ASD and 23 matched typically developing (TD) boys. Neutral faces with different identities were presented at 6 Hz, periodically interleaved with an expressive face (angry, fearful, happy, sad in separate sequences) every fifth image (i.e., 1.2 Hz oddball frequency). These distinguishable frequency tags for neutral and expressive stimuli allowed direct and objective quantification of the expression-categorization responses, needing only four sequences of 60 s of recording per condition. RESULTS: Both groups show equal neural synchronization to the general face stimulation and similar neural responses to happy and sad faces. However, the ASD group displays significantly reduced responses to angry and fearful faces, compared to TD boys. At the individual subject level, these neural responses allow to predict membership of the ASD group with an accuracy of 87%. Whereas TD participants show a significantly lower sensitivity to sad faces than to the other expressions, ASD participants show an equally low sensitivity to all the expressions. CONCLUSIONS: Our results indicate an emotion-specific processing deficit, instead of a general emotion-processing problem: Boys with ASD are less sensitive than TD boys to rapidly and implicitly detect angry and fearful faces. The implicit, fast, and straightforward nature of FPVS-EEG opens new perspectives for clinical diagnosis. En ligne : http://dx.doi.org/10.1111/jcpp.13201 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=430 A review of behavioural and electrophysiological studies on auditory processing and speech perception in autism spectrum disorders / Birgitt HAESEN in Research in Autism Spectrum Disorders, 5-2 (April-June 2011)
[article]
Titre : A review of behavioural and electrophysiological studies on auditory processing and speech perception in autism spectrum disorders Type de document : Texte imprimé et/ou numérique Auteurs : Birgitt HAESEN, Auteur ; Bart BOETS, Auteur ; Johan WAGEMANS, Auteur Année de publication : 2011 Article en page(s) : p.701-714 Langues : Anglais (eng) Mots-clés : Autism spectrum disorder Auditory processing Speech perception Local processing Global processing Index. décimale : PER Périodiques Résumé : This literature review aims to interpret behavioural and electrophysiological studies addressing auditory processing in children and adults with autism spectrum disorder (ASD). Data have been organised according to the applied methodology (behavioural versus electrophysiological studies) and according to stimulus complexity (pure versus complex tones versus speech sounds). In line with the weak central coherence (WCC) theory of autism we aimed to investigate whether individuals with ASD show a more locally and less globally oriented processing style in the auditory modality. To avoid the possible confound of stimulus complexity, this influence was taken into account as an additional hypothesis. The review reveals that the identification and discrimination of isolated acoustic features (in particular pitch processing) is generally intact or enhanced in individuals with ASD, for pure as well as for complex tones and speech sounds. It thus appears that the local processing advantage is not influenced by stimulus complexity. Individuals with ASD are also less susceptible to global interference of speech-like material. A deficit in global auditory processing, however, is less universally confirmed. We propose that the observed pattern of auditory enhancements and deficits in ASD may be related to an atypical pattern of right hemisphere dominance. As the right and left hemisphere are relatively more specialized in spectral versus temporal auditory processing, respectively, right hemisphere dominance in ASD could provoke enhanced pitch and vowel processing, whereas left hemisphere deficiencies might explain speech perception problems and temporal processing deficits. En ligne : http://dx.doi.org/10.1016/j.rasd.2010.11.006 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=114
in Research in Autism Spectrum Disorders > 5-2 (April-June 2011) . - p.701-714[article] A review of behavioural and electrophysiological studies on auditory processing and speech perception in autism spectrum disorders [Texte imprimé et/ou numérique] / Birgitt HAESEN, Auteur ; Bart BOETS, Auteur ; Johan WAGEMANS, Auteur . - 2011 . - p.701-714.
Langues : Anglais (eng)
in Research in Autism Spectrum Disorders > 5-2 (April-June 2011) . - p.701-714
Mots-clés : Autism spectrum disorder Auditory processing Speech perception Local processing Global processing Index. décimale : PER Périodiques Résumé : This literature review aims to interpret behavioural and electrophysiological studies addressing auditory processing in children and adults with autism spectrum disorder (ASD). Data have been organised according to the applied methodology (behavioural versus electrophysiological studies) and according to stimulus complexity (pure versus complex tones versus speech sounds). In line with the weak central coherence (WCC) theory of autism we aimed to investigate whether individuals with ASD show a more locally and less globally oriented processing style in the auditory modality. To avoid the possible confound of stimulus complexity, this influence was taken into account as an additional hypothesis. The review reveals that the identification and discrimination of isolated acoustic features (in particular pitch processing) is generally intact or enhanced in individuals with ASD, for pure as well as for complex tones and speech sounds. It thus appears that the local processing advantage is not influenced by stimulus complexity. Individuals with ASD are also less susceptible to global interference of speech-like material. A deficit in global auditory processing, however, is less universally confirmed. We propose that the observed pattern of auditory enhancements and deficits in ASD may be related to an atypical pattern of right hemisphere dominance. As the right and left hemisphere are relatively more specialized in spectral versus temporal auditory processing, respectively, right hemisphere dominance in ASD could provoke enhanced pitch and vowel processing, whereas left hemisphere deficiencies might explain speech perception problems and temporal processing deficits. En ligne : http://dx.doi.org/10.1016/j.rasd.2010.11.006 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=114 Speech-in-noise perception in autistic adolescents with and without early language delay / Diego RUIZ CALLEJO in Autism Research, 16-9 (September 2023)
[article]
Titre : Speech-in-noise perception in autistic adolescents with and without early language delay Type de document : Texte imprimé et/ou numérique Auteurs : Diego RUIZ CALLEJO, Auteur ; Jan WOUTERS, Auteur ; Bart BOETS, Auteur Article en page(s) : p.1719-1727 Langues : Anglais (eng) Index. décimale : PER Périodiques Résumé : Abstract Speech-in-noise perception seems aberrant in individuals with autism spectrum disorder (ASD). Potential aggravating factors are the level of linguistic skills and impairments in auditory temporal processing. Here, we investigated autistic adolescents with and without language delay as compared to non-autistic peers, and we assessed speech perception in steady-state noise, temporally modulated noise, and concurrent speech. We found that autistic adolescents with intact language capabilities and not those with language delay performed worse than NT peers on words-in-stationary-noise perception. For the perception of sentences in stationary noise, we did not observe significant group differences, although autistic adolescents with language delay tend to perform worse in comparison to their TD peers. We also found evidence for a robust deficit in speech-in-concurrent-speech processing in ASD independent of language ability, as well as an association between early language delay in ASD and inadequate temporal speech processing. We propose that reduced voice stream segregation and inadequate social attentional orienting in ASD result in disproportional informational masking of the speech signal. These findings indicate a speech-in-speech processing deficit in autistic adolescents with broad implications for the quality of social communication. En ligne : https://doi.org/10.1002/aur.2966 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=510
in Autism Research > 16-9 (September 2023) . - p.1719-1727[article] Speech-in-noise perception in autistic adolescents with and without early language delay [Texte imprimé et/ou numérique] / Diego RUIZ CALLEJO, Auteur ; Jan WOUTERS, Auteur ; Bart BOETS, Auteur . - p.1719-1727.
Langues : Anglais (eng)
in Autism Research > 16-9 (September 2023) . - p.1719-1727
Index. décimale : PER Périodiques Résumé : Abstract Speech-in-noise perception seems aberrant in individuals with autism spectrum disorder (ASD). Potential aggravating factors are the level of linguistic skills and impairments in auditory temporal processing. Here, we investigated autistic adolescents with and without language delay as compared to non-autistic peers, and we assessed speech perception in steady-state noise, temporally modulated noise, and concurrent speech. We found that autistic adolescents with intact language capabilities and not those with language delay performed worse than NT peers on words-in-stationary-noise perception. For the perception of sentences in stationary noise, we did not observe significant group differences, although autistic adolescents with language delay tend to perform worse in comparison to their TD peers. We also found evidence for a robust deficit in speech-in-concurrent-speech processing in ASD independent of language ability, as well as an association between early language delay in ASD and inadequate temporal speech processing. We propose that reduced voice stream segregation and inadequate social attentional orienting in ASD result in disproportional informational masking of the speech signal. These findings indicate a speech-in-speech processing deficit in autistic adolescents with broad implications for the quality of social communication. En ligne : https://doi.org/10.1002/aur.2966 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=510 The underlying symptom structure of autism spectrum disorders: A factor analytic approach using the developmental, dimensional and diagnostic interview / Wouter DE LA MARCHE in Research in Autism Spectrum Disorders, 12 (April 2015)
[article]
Titre : The underlying symptom structure of autism spectrum disorders: A factor analytic approach using the developmental, dimensional and diagnostic interview Type de document : Texte imprimé et/ou numérique Auteurs : Wouter DE LA MARCHE, Auteur ; Ilse NOENS, Auteur ; Bart BOETS, Auteur ; Sofie KUPPENS, Auteur ; Jean STEYAERT, Auteur Article en page(s) : p.40-51 Langues : Anglais (eng) Mots-clés : Autism spectrum disorders DSM-5 Factor analysis 3di Index. décimale : PER Périodiques Résumé : Abstract Several studies have focused on the underlying symptom structure of Autism Spectrum Disorders (ASD), but results have been equivocal. We performed a confirmatory factor analysis on data of the Developmental, Dimensional and Diagnostic Interview of 275 participants with ASD between 3 and 23 years of age, aimed at strengthening the empirical evidence of previously published factor structure solutions using the same instrument. As none of these hypothesised models fitted our data, an exploratory factor analysis was undertaken. Results pointed towards a five factor model. A ‘Restricted and Repetitive Behaviour and Interest’ factor could be separated from ‘Shaking and Nodding’, ‘Emotional Reciprocity’ and two other factors that both represented deficits in social interaction and communication. Although not completely confirming, our results are generally in favour of the present DSM-5 criteria. By showing that the items did not fully segregate according to theoretically postulated subdomains, we offer a possible explanation for the heterogeneity in proposed factor structures for ASD. En ligne : http://dx.doi.org/10.1016/j.rasd.2014.11.002 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=260
in Research in Autism Spectrum Disorders > 12 (April 2015) . - p.40-51[article] The underlying symptom structure of autism spectrum disorders: A factor analytic approach using the developmental, dimensional and diagnostic interview [Texte imprimé et/ou numérique] / Wouter DE LA MARCHE, Auteur ; Ilse NOENS, Auteur ; Bart BOETS, Auteur ; Sofie KUPPENS, Auteur ; Jean STEYAERT, Auteur . - p.40-51.
Langues : Anglais (eng)
in Research in Autism Spectrum Disorders > 12 (April 2015) . - p.40-51
Mots-clés : Autism spectrum disorders DSM-5 Factor analysis 3di Index. décimale : PER Périodiques Résumé : Abstract Several studies have focused on the underlying symptom structure of Autism Spectrum Disorders (ASD), but results have been equivocal. We performed a confirmatory factor analysis on data of the Developmental, Dimensional and Diagnostic Interview of 275 participants with ASD between 3 and 23 years of age, aimed at strengthening the empirical evidence of previously published factor structure solutions using the same instrument. As none of these hypothesised models fitted our data, an exploratory factor analysis was undertaken. Results pointed towards a five factor model. A ‘Restricted and Repetitive Behaviour and Interest’ factor could be separated from ‘Shaking and Nodding’, ‘Emotional Reciprocity’ and two other factors that both represented deficits in social interaction and communication. Although not completely confirming, our results are generally in favour of the present DSM-5 criteria. By showing that the items did not fully segregate according to theoretically postulated subdomains, we offer a possible explanation for the heterogeneity in proposed factor structures for ASD. En ligne : http://dx.doi.org/10.1016/j.rasd.2014.11.002 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=260 Visual Processing in Adolescents with Autism Spectrum Disorder: Evidence from Embedded Figures and Configural Superiority Tests / Claudia DILLEN in Journal of Autism and Developmental Disorders, 45-5 (May 2015)
PermalinkVisual Search in ASD: Instructed Versus Spontaneous Local and Global Processing / Ruth VAN DER HALLEN in Journal of Autism and Developmental Disorders, 46-9 (September 2016)
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