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Auteur Varun RAZDAN |
Documents disponibles écrits par cet auteur (2)
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Cross-sectional and longitudinal abnormalities in brain structure in children with severe mood dysregulation or bipolar disorder / Nancy E. ADLEMAN in Journal of Child Psychology and Psychiatry, 53-11 (November 2012)
[article]
Titre : Cross-sectional and longitudinal abnormalities in brain structure in children with severe mood dysregulation or bipolar disorder Type de document : Texte imprimé et/ou numérique Auteurs : Nancy E. ADLEMAN, Auteur ; Stephen J. FROMM, Auteur ; Varun RAZDAN, Auteur ; Reilly KAYSER, Auteur ; Daniel P. DICKSTEIN, Auteur ; Melissa A. BROTMAN, Auteur ; Daniel Samuel PINE, Auteur ; Ellen LEIBENLUFT, Auteur Année de publication : 2012 Article en page(s) : p.1149-1156 Langues : Anglais (eng) Mots-clés : Severe mood dysregulation bipolar disorder pediatric longitudinal neuroimaging voxel-based morphometry Trouble de l'humeur Index. décimale : PER Périodiques Résumé : Background: There is debate as to whether chronic irritability (operationalized as severe mood dysregulation, SMD) is a developmental form of bipolar disorder (BD). Although structural brain abnormalities in BD have been demonstrated, no study compares neuroanatomy among SMD, BD, and healthy volunteers (HV) either cross-sectionally or over time. Furthermore, the developmental trajectories of structural abnormalities in BD or SMD are unknown. This study provides such data in BD, SMD, and HV. Methods: An optimized, modulated voxel-based morphometry (VBM) analysis was conducted on structural MRI scans from 201 children (78 SMD, 55 BD, and 68 HV). In addition, 92 children (31 SMD, 34 BD, and 27 HV) were rescanned after 2 years (mean interval 1.99 ± 0.94 years), to compare time-related changes among the three groups. Results: Cross-sectionally, the groups differed in gray matter (GM) volume in presupplementary motor area (pre-SMA), dorsolateral prefrontal cortex (DLPFC), insula, and globus pallidus. The cortical differences were driven mainly by increased GM volume in HV compared with BD and SMD. In globus pallidus, there was increased GM in BD compared with HV and SMD. Longitudinally, group-by-time interactions were evident in two clusters in the superior/inferior parietal lobule (R SPL/IPL) and in the precuneus. In both clusters, the interactions were driven by an abnormal increase in volume in BD. Conclusions: Cross-sectionally, both BD and SMD are associated with structural abnormalities in frontal cortex, insula, and basal ganglia. Although some of these deficits overlap (insula and DLPFC), others differentiate SMD and BD (pre-SMA and globus pallidus). Abnormal developmental trajectories in lateral parietal cortex and precuneus are present in, and unique to, BD. Because of the high proportion of co-occurring ADHD in the SMD subjects, we could not separate effects of ADHD from those of SMD, and future research including a nonirritable ADHD group must address this issue. En ligne : http://dx.doi.org/10.1111/j.1469-7610.2012.02568.x Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=182
in Journal of Child Psychology and Psychiatry > 53-11 (November 2012) . - p.1149-1156[article] Cross-sectional and longitudinal abnormalities in brain structure in children with severe mood dysregulation or bipolar disorder [Texte imprimé et/ou numérique] / Nancy E. ADLEMAN, Auteur ; Stephen J. FROMM, Auteur ; Varun RAZDAN, Auteur ; Reilly KAYSER, Auteur ; Daniel P. DICKSTEIN, Auteur ; Melissa A. BROTMAN, Auteur ; Daniel Samuel PINE, Auteur ; Ellen LEIBENLUFT, Auteur . - 2012 . - p.1149-1156.
Langues : Anglais (eng)
in Journal of Child Psychology and Psychiatry > 53-11 (November 2012) . - p.1149-1156
Mots-clés : Severe mood dysregulation bipolar disorder pediatric longitudinal neuroimaging voxel-based morphometry Trouble de l'humeur Index. décimale : PER Périodiques Résumé : Background: There is debate as to whether chronic irritability (operationalized as severe mood dysregulation, SMD) is a developmental form of bipolar disorder (BD). Although structural brain abnormalities in BD have been demonstrated, no study compares neuroanatomy among SMD, BD, and healthy volunteers (HV) either cross-sectionally or over time. Furthermore, the developmental trajectories of structural abnormalities in BD or SMD are unknown. This study provides such data in BD, SMD, and HV. Methods: An optimized, modulated voxel-based morphometry (VBM) analysis was conducted on structural MRI scans from 201 children (78 SMD, 55 BD, and 68 HV). In addition, 92 children (31 SMD, 34 BD, and 27 HV) were rescanned after 2 years (mean interval 1.99 ± 0.94 years), to compare time-related changes among the three groups. Results: Cross-sectionally, the groups differed in gray matter (GM) volume in presupplementary motor area (pre-SMA), dorsolateral prefrontal cortex (DLPFC), insula, and globus pallidus. The cortical differences were driven mainly by increased GM volume in HV compared with BD and SMD. In globus pallidus, there was increased GM in BD compared with HV and SMD. Longitudinally, group-by-time interactions were evident in two clusters in the superior/inferior parietal lobule (R SPL/IPL) and in the precuneus. In both clusters, the interactions were driven by an abnormal increase in volume in BD. Conclusions: Cross-sectionally, both BD and SMD are associated with structural abnormalities in frontal cortex, insula, and basal ganglia. Although some of these deficits overlap (insula and DLPFC), others differentiate SMD and BD (pre-SMA and globus pallidus). Abnormal developmental trajectories in lateral parietal cortex and precuneus are present in, and unique to, BD. Because of the high proportion of co-occurring ADHD in the SMD subjects, we could not separate effects of ADHD from those of SMD, and future research including a nonirritable ADHD group must address this issue. En ligne : http://dx.doi.org/10.1111/j.1469-7610.2012.02568.x Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=182 The Affective Reactivity Index: a concise irritability scale for clinical and research settings / Argyris STRINGARIS in Journal of Child Psychology and Psychiatry, 53-11 (November 2012)
[article]
Titre : The Affective Reactivity Index: a concise irritability scale for clinical and research settings Type de document : Texte imprimé et/ou numérique Auteurs : Argyris STRINGARIS, Auteur ; Robert GOODMAN, Auteur ; Sumudu FERDINANDO, Auteur ; Varun RAZDAN, Auteur ; Eli MUHRER, Auteur ; Ellen LEIBENLUFT, Auteur ; Melissa A. BROTMAN, Auteur Année de publication : 2012 Article en page(s) : p.1109-1117 Langues : Anglais (eng) Mots-clés : Mood dysregulation Affective Reactivity Index irritability depression bipolar Index. décimale : PER Périodiques Résumé : Background: Irritable mood has recently become a matter of intense scientific interest. Here, we present data from two samples, one from the United States and the other from the United Kingdom, demonstrating the clinical and research utility of the parent- and self-report forms of the Affective Reactivity Index (ARI), a concise dimensional measure of irritability. Methods: The US sample (n = 218) consisted of children and adolescents recruited at the National Institute of Mental Health meeting criteria for bipolar disorder (BD, n = 39), severe mood dysregulation (SMD, n = 67), children at family risk for BD (n = 35), or were healthy volunteers (n = 77). The UK sample (n = 88) was comprised of children from a generic mental health setting and healthy volunteers from primary and secondary schools. Results: Parent- and self-report scales of the ARI showed excellent internal consistencies and formed a single factor in the two samples. In the US sample, the ARI showed a gradation with irritability significantly increasing from healthy volunteers through to SMD. Irritability was significantly higher in SMD than in BD by parent-report, but this did not reach significance by self-report. In the UK sample, parent-rated irritability was differentially related to emotional problems. Conclusions: Irritability can be measured using a concise instrument both in a highly specialized US, as well as a general UK child mental health setting. En ligne : http://dx.doi.org/10.1111/j.1469-7610.2012.02561.x Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=182
in Journal of Child Psychology and Psychiatry > 53-11 (November 2012) . - p.1109-1117[article] The Affective Reactivity Index: a concise irritability scale for clinical and research settings [Texte imprimé et/ou numérique] / Argyris STRINGARIS, Auteur ; Robert GOODMAN, Auteur ; Sumudu FERDINANDO, Auteur ; Varun RAZDAN, Auteur ; Eli MUHRER, Auteur ; Ellen LEIBENLUFT, Auteur ; Melissa A. BROTMAN, Auteur . - 2012 . - p.1109-1117.
Langues : Anglais (eng)
in Journal of Child Psychology and Psychiatry > 53-11 (November 2012) . - p.1109-1117
Mots-clés : Mood dysregulation Affective Reactivity Index irritability depression bipolar Index. décimale : PER Périodiques Résumé : Background: Irritable mood has recently become a matter of intense scientific interest. Here, we present data from two samples, one from the United States and the other from the United Kingdom, demonstrating the clinical and research utility of the parent- and self-report forms of the Affective Reactivity Index (ARI), a concise dimensional measure of irritability. Methods: The US sample (n = 218) consisted of children and adolescents recruited at the National Institute of Mental Health meeting criteria for bipolar disorder (BD, n = 39), severe mood dysregulation (SMD, n = 67), children at family risk for BD (n = 35), or were healthy volunteers (n = 77). The UK sample (n = 88) was comprised of children from a generic mental health setting and healthy volunteers from primary and secondary schools. Results: Parent- and self-report scales of the ARI showed excellent internal consistencies and formed a single factor in the two samples. In the US sample, the ARI showed a gradation with irritability significantly increasing from healthy volunteers through to SMD. Irritability was significantly higher in SMD than in BD by parent-report, but this did not reach significance by self-report. In the UK sample, parent-rated irritability was differentially related to emotional problems. Conclusions: Irritability can be measured using a concise instrument both in a highly specialized US, as well as a general UK child mental health setting. En ligne : http://dx.doi.org/10.1111/j.1469-7610.2012.02561.x Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=182