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Auteur Bei FENG |
Documents disponibles écrits par cet auteur (2)
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Contribution of genes and environment to the longitudinal association between childhood impulsive-aggression and suicidality in adolescence / Massimiliano ORRI in Journal of Child Psychology and Psychiatry, 61-6 (June 2020)
[article]
Titre : Contribution of genes and environment to the longitudinal association between childhood impulsive-aggression and suicidality in adolescence Type de document : Texte imprimé et/ou numérique Auteurs : Massimiliano ORRI, Auteur ; Marie-Claude GEOFFROY, Auteur ; Gustavo TURECKI, Auteur ; Bei FENG, Auteur ; Mara BRENDGEN, Auteur ; Frank VITARO, Auteur ; Ginette DIONNE, Auteur ; Stéphane PAQUIN, Auteur ; Cédric GALERA, Auteur ; Johanne RENAUD, Auteur ; Richard E. TREMBLAY, Auteur ; Sylvana M. CÔTÉ, Auteur ; Michel BOIVIN, Auteur Article en page(s) : p.711-720 Langues : Anglais (eng) Mots-clés : Suicide attempt behavioral genetics impulsive-aggression longitudinal suicidal ideation twin study Index. décimale : PER Périodiques Résumé : BACKGROUND: Population-based and family studies showed that impulsive-aggression predicts suicidality; however, the underlying etiological nature of this association is poorly understood. The objective was to determine the contribution of genes and environment to the association between childhood impulsive-aggression and serious suicidal ideation/attempt in young adulthood. METHODS: N = 862 twins (435 families) from the Quebec Newborn Twin Study were followed up from birth to 20 years. Repeated measures of teacher-assessed impulsive-aggression were modeled using a genetically informed latent growth model including intercept and slope parameters reflecting individual differences in the baseline level (age 6 years) and in the change (increase/decrease) of impulsive-aggression during childhood (6 to 12 years), respectively. Lifetime suicidality (serious suicidal ideation/attempt) was self-reported at 20 years. Associations of impulsive-aggression intercept and slope with suicidality were decomposed into additive genetic (A) and unique environmental (E) components. RESULTS: Additive genetic factors accounted for an important part of individual differences in impulsive-aggression intercept (A = 90%, E = 10%) and slope (A = 65%, E = 35%). Genetic (50%) and unique environmental (50%) factors equally contributed to suicidality. We found that 38% of the genetic factors accounting for suicidality were shared with those underlying impulsive-aggression slope, whereas 40% of the environmental factors accounting for suicidality were shared with those associated with impulsive-aggression intercept. The genetic correlation between impulsive-aggression slope and suicidality was 0.60, p = .027. CONCLUSIONS: Genetic and unique environmental factors underlying suicidality significantly overlap with those underlying childhood impulsive-aggression. Future studies should identify putative genetic and environmental factors to inform prevention. En ligne : http://dx.doi.org/10.1111/jcpp.13163 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=426
in Journal of Child Psychology and Psychiatry > 61-6 (June 2020) . - p.711-720[article] Contribution of genes and environment to the longitudinal association between childhood impulsive-aggression and suicidality in adolescence [Texte imprimé et/ou numérique] / Massimiliano ORRI, Auteur ; Marie-Claude GEOFFROY, Auteur ; Gustavo TURECKI, Auteur ; Bei FENG, Auteur ; Mara BRENDGEN, Auteur ; Frank VITARO, Auteur ; Ginette DIONNE, Auteur ; Stéphane PAQUIN, Auteur ; Cédric GALERA, Auteur ; Johanne RENAUD, Auteur ; Richard E. TREMBLAY, Auteur ; Sylvana M. CÔTÉ, Auteur ; Michel BOIVIN, Auteur . - p.711-720.
Langues : Anglais (eng)
in Journal of Child Psychology and Psychiatry > 61-6 (June 2020) . - p.711-720
Mots-clés : Suicide attempt behavioral genetics impulsive-aggression longitudinal suicidal ideation twin study Index. décimale : PER Périodiques Résumé : BACKGROUND: Population-based and family studies showed that impulsive-aggression predicts suicidality; however, the underlying etiological nature of this association is poorly understood. The objective was to determine the contribution of genes and environment to the association between childhood impulsive-aggression and serious suicidal ideation/attempt in young adulthood. METHODS: N = 862 twins (435 families) from the Quebec Newborn Twin Study were followed up from birth to 20 years. Repeated measures of teacher-assessed impulsive-aggression were modeled using a genetically informed latent growth model including intercept and slope parameters reflecting individual differences in the baseline level (age 6 years) and in the change (increase/decrease) of impulsive-aggression during childhood (6 to 12 years), respectively. Lifetime suicidality (serious suicidal ideation/attempt) was self-reported at 20 years. Associations of impulsive-aggression intercept and slope with suicidality were decomposed into additive genetic (A) and unique environmental (E) components. RESULTS: Additive genetic factors accounted for an important part of individual differences in impulsive-aggression intercept (A = 90%, E = 10%) and slope (A = 65%, E = 35%). Genetic (50%) and unique environmental (50%) factors equally contributed to suicidality. We found that 38% of the genetic factors accounting for suicidality were shared with those underlying impulsive-aggression slope, whereas 40% of the environmental factors accounting for suicidality were shared with those associated with impulsive-aggression intercept. The genetic correlation between impulsive-aggression slope and suicidality was 0.60, p = .027. CONCLUSIONS: Genetic and unique environmental factors underlying suicidality significantly overlap with those underlying childhood impulsive-aggression. Future studies should identify putative genetic and environmental factors to inform prevention. En ligne : http://dx.doi.org/10.1111/jcpp.13163 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=426 Evidence of gene–environment correlation for peer difficulties: Disruptive behaviors predict early peer relation difficulties in school through genetic effects / Michel BOIVIN in Development and Psychopathology, 25-1 (February 2013)
[article]
Titre : Evidence of gene–environment correlation for peer difficulties: Disruptive behaviors predict early peer relation difficulties in school through genetic effects Type de document : Texte imprimé et/ou numérique Auteurs : Michel BOIVIN, Auteur ; Mara BRENDGEN, Auteur ; Frank VITARO, Auteur ; Nadine FORGET-DUBOIS, Auteur ; Bei FENG, Auteur ; Richard E. TREMBLAY, Auteur ; Ginette DIONNE, Auteur Article en page(s) : p.79-92 Index. décimale : PER Périodiques Résumé : Early disruptive behaviors, such as aggressive and hyperactive behaviors, known to be influenced by genetic factors, have been found to predict early school peer relation difficulties, such as peer rejection and victimization. However, there is no consensus regarding the developmental processes underlying this predictive association. Genetically informative designs, such as twin studies, are well suited for investigating the underlying genetic and environmental etiology of this association. The main goal of the present study was to examine the possible establishment of an emerging gene–environment correlation linking disruptive behaviors to peer relationship difficulties during the first years of school. Participants were drawn from an ongoing longitudinal study of twins who were assessed with respect to their social behaviors and their peer relation difficulties in kindergarten and in Grade 1 through peer nominations measures and teacher ratings. As predicted, disruptive behaviors were concurrently and predictively associated with peer relation difficulties. Multivariate analyses of these associations indicate that they were mainly accounted for by genetic factors. These results emphasize the need to adopt an early and persistent prevention framework targeting both the child and the peer context to alleviate the establishment of a negative coercive process and its consequences. En ligne : http://dx.doi.org/10.1017/S0954579412000910 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=190
in Development and Psychopathology > 25-1 (February 2013) . - p.79-92[article] Evidence of gene–environment correlation for peer difficulties: Disruptive behaviors predict early peer relation difficulties in school through genetic effects [Texte imprimé et/ou numérique] / Michel BOIVIN, Auteur ; Mara BRENDGEN, Auteur ; Frank VITARO, Auteur ; Nadine FORGET-DUBOIS, Auteur ; Bei FENG, Auteur ; Richard E. TREMBLAY, Auteur ; Ginette DIONNE, Auteur . - p.79-92.
in Development and Psychopathology > 25-1 (February 2013) . - p.79-92
Index. décimale : PER Périodiques Résumé : Early disruptive behaviors, such as aggressive and hyperactive behaviors, known to be influenced by genetic factors, have been found to predict early school peer relation difficulties, such as peer rejection and victimization. However, there is no consensus regarding the developmental processes underlying this predictive association. Genetically informative designs, such as twin studies, are well suited for investigating the underlying genetic and environmental etiology of this association. The main goal of the present study was to examine the possible establishment of an emerging gene–environment correlation linking disruptive behaviors to peer relationship difficulties during the first years of school. Participants were drawn from an ongoing longitudinal study of twins who were assessed with respect to their social behaviors and their peer relation difficulties in kindergarten and in Grade 1 through peer nominations measures and teacher ratings. As predicted, disruptive behaviors were concurrently and predictively associated with peer relation difficulties. Multivariate analyses of these associations indicate that they were mainly accounted for by genetic factors. These results emphasize the need to adopt an early and persistent prevention framework targeting both the child and the peer context to alleviate the establishment of a negative coercive process and its consequences. En ligne : http://dx.doi.org/10.1017/S0954579412000910 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=190