[article]
| Titre : |
Contribution of genes and environment to the longitudinal association between childhood impulsive-aggression and suicidality in adolescence |
| Type de document : |
Texte imprimé et/ou numérique |
| Auteurs : |
Massimiliano ORRI, Auteur ; Marie-Claude GEOFFROY, Auteur ; Gustavo TURECKI, Auteur ; Bei FENG, Auteur ; Mara BRENDGEN, Auteur ; Frank VITARO, Auteur ; Ginette DIONNE, Auteur ; Stéphane PAQUIN, Auteur ; Cédric GALERA, Auteur ; Johanne RENAUD, Auteur ; Richard E. TREMBLAY, Auteur ; Sylvana M. CÔTÉ, Auteur ; Michel BOIVIN, Auteur |
| Article en page(s) : |
p.711-720 |
| Langues : |
Anglais (eng) |
| Mots-clés : |
Suicide attempt behavioral genetics impulsive-aggression longitudinal suicidal ideation twin study |
| Index. décimale : |
PER Périodiques |
| Résumé : |
BACKGROUND: Population-based and family studies showed that impulsive-aggression predicts suicidality; however, the underlying etiological nature of this association is poorly understood. The objective was to determine the contribution of genes and environment to the association between childhood impulsive-aggression and serious suicidal ideation/attempt in young adulthood. METHODS: N = 862 twins (435 families) from the Quebec Newborn Twin Study were followed up from birth to 20 years. Repeated measures of teacher-assessed impulsive-aggression were modeled using a genetically informed latent growth model including intercept and slope parameters reflecting individual differences in the baseline level (age 6 years) and in the change (increase/decrease) of impulsive-aggression during childhood (6 to 12 years), respectively. Lifetime suicidality (serious suicidal ideation/attempt) was self-reported at 20 years. Associations of impulsive-aggression intercept and slope with suicidality were decomposed into additive genetic (A) and unique environmental (E) components. RESULTS: Additive genetic factors accounted for an important part of individual differences in impulsive-aggression intercept (A = 90%, E = 10%) and slope (A = 65%, E = 35%). Genetic (50%) and unique environmental (50%) factors equally contributed to suicidality. We found that 38% of the genetic factors accounting for suicidality were shared with those underlying impulsive-aggression slope, whereas 40% of the environmental factors accounting for suicidality were shared with those associated with impulsive-aggression intercept. The genetic correlation between impulsive-aggression slope and suicidality was 0.60, p = .027. CONCLUSIONS: Genetic and unique environmental factors underlying suicidality significantly overlap with those underlying childhood impulsive-aggression. Future studies should identify putative genetic and environmental factors to inform prevention. |
| En ligne : |
http://dx.doi.org/10.1111/jcpp.13163 |
| Permalink : |
https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=426 |
in Journal of Child Psychology and Psychiatry > 61-6 (June 2020) . - p.711-720
[article] Contribution of genes and environment to the longitudinal association between childhood impulsive-aggression and suicidality in adolescence [Texte imprimé et/ou numérique] / Massimiliano ORRI, Auteur ; Marie-Claude GEOFFROY, Auteur ; Gustavo TURECKI, Auteur ; Bei FENG, Auteur ; Mara BRENDGEN, Auteur ; Frank VITARO, Auteur ; Ginette DIONNE, Auteur ; Stéphane PAQUIN, Auteur ; Cédric GALERA, Auteur ; Johanne RENAUD, Auteur ; Richard E. TREMBLAY, Auteur ; Sylvana M. CÔTÉ, Auteur ; Michel BOIVIN, Auteur . - p.711-720. Langues : Anglais ( eng) in Journal of Child Psychology and Psychiatry > 61-6 (June 2020) . - p.711-720
| Mots-clés : |
Suicide attempt behavioral genetics impulsive-aggression longitudinal suicidal ideation twin study |
| Index. décimale : |
PER Périodiques |
| Résumé : |
BACKGROUND: Population-based and family studies showed that impulsive-aggression predicts suicidality; however, the underlying etiological nature of this association is poorly understood. The objective was to determine the contribution of genes and environment to the association between childhood impulsive-aggression and serious suicidal ideation/attempt in young adulthood. METHODS: N = 862 twins (435 families) from the Quebec Newborn Twin Study were followed up from birth to 20 years. Repeated measures of teacher-assessed impulsive-aggression were modeled using a genetically informed latent growth model including intercept and slope parameters reflecting individual differences in the baseline level (age 6 years) and in the change (increase/decrease) of impulsive-aggression during childhood (6 to 12 years), respectively. Lifetime suicidality (serious suicidal ideation/attempt) was self-reported at 20 years. Associations of impulsive-aggression intercept and slope with suicidality were decomposed into additive genetic (A) and unique environmental (E) components. RESULTS: Additive genetic factors accounted for an important part of individual differences in impulsive-aggression intercept (A = 90%, E = 10%) and slope (A = 65%, E = 35%). Genetic (50%) and unique environmental (50%) factors equally contributed to suicidality. We found that 38% of the genetic factors accounting for suicidality were shared with those underlying impulsive-aggression slope, whereas 40% of the environmental factors accounting for suicidality were shared with those associated with impulsive-aggression intercept. The genetic correlation between impulsive-aggression slope and suicidality was 0.60, p = .027. CONCLUSIONS: Genetic and unique environmental factors underlying suicidality significantly overlap with those underlying childhood impulsive-aggression. Future studies should identify putative genetic and environmental factors to inform prevention. |
| En ligne : |
http://dx.doi.org/10.1111/jcpp.13163 |
| Permalink : |
https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=426 |
|
Contribution of genes and environment to the longitudinal association between childhood impulsive-aggression and suicidality in adolescence in Journal of Child Psychology and Psychiatry, 61-6 (June 2020)
