Centre d'Information et de documentation du CRA Rhône-Alpes
CRA
Informations pratiques
-
Adresse
Centre d'information et de documentation
du CRA Rhône-Alpes
Centre Hospitalier le Vinatier
bât 211
95, Bd Pinel
69678 Bron CedexHoraires
Lundi au Vendredi
9h00-12h00 13h30-16h00Contact
Tél: +33(0)4 37 91 54 65
Mail
Fax: +33(0)4 37 91 54 37
-
Détail de l'auteur
Auteur Leighton B N. HINKLEY |
Documents disponibles écrits par cet auteur (2)
Faire une suggestion Affiner la recherche
Autism Traits in Individuals with Agenesis of the Corpus Callosum / Yolanda C. LAU in Journal of Autism and Developmental Disorders, 43-5 (May 2013)
[article]
Titre : Autism Traits in Individuals with Agenesis of the Corpus Callosum Type de document : Texte imprimé et/ou numérique Auteurs : Yolanda C. LAU, Auteur ; Leighton B N. HINKLEY, Auteur ; Polina BUKSHPUN, Auteur ; Zoe A. STROMINGER, Auteur ; Mari L. J. WAKAHIRO, Auteur ; Simon BARON-COHEN, Auteur ; Carrie ALLISON, Auteur ; Bonnie AUYEUNG, Auteur ; Rita J. JEREMY, Auteur ; Srikantan S. NAGARAJAN, Auteur ; Elliott H. SHERR, Auteur ; Elysa J. MARCO, Auteur Article en page(s) : p.1106-1118 Langues : Anglais (eng) Mots-clés : Agenesis of the corpus callosum Autism spectrum disorders Autism Spectrum Quotient Functional connectivity Magnetoencephalography Superior temporal gyrus Index. décimale : PER Périodiques Résumé : Autism spectrum disorders (ASD) have numerous etiologies, including structural brain malformations such as agenesis of the corpus callosum (AgCC). We sought to directly measure the occurrence of autism traits in a cohort of individuals with AgCC and to investigate the neural underpinnings of this association. We screened a large AgCC cohort (n = 106) with the Autism Spectrum Quotient (AQ) and found that 45 % of children, 35 % of adolescents, and 18 % of adults exceeded the predetermined autism-screening cut-off. Interestingly, performance on the AQ’s imagination domain was inversely correlated with magnetoencephalography measures of resting-state functional connectivity in the right superior temporal gyrus. Individuals with AgCC should be screened for ASD and disorders of the corpus callosum should be considered in autism diagnostic evaluations as well. En ligne : http://dx.doi.org/10.1007/s10803-012-1653-2 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=195
in Journal of Autism and Developmental Disorders > 43-5 (May 2013) . - p.1106-1118[article] Autism Traits in Individuals with Agenesis of the Corpus Callosum [Texte imprimé et/ou numérique] / Yolanda C. LAU, Auteur ; Leighton B N. HINKLEY, Auteur ; Polina BUKSHPUN, Auteur ; Zoe A. STROMINGER, Auteur ; Mari L. J. WAKAHIRO, Auteur ; Simon BARON-COHEN, Auteur ; Carrie ALLISON, Auteur ; Bonnie AUYEUNG, Auteur ; Rita J. JEREMY, Auteur ; Srikantan S. NAGARAJAN, Auteur ; Elliott H. SHERR, Auteur ; Elysa J. MARCO, Auteur . - p.1106-1118.
Langues : Anglais (eng)
in Journal of Autism and Developmental Disorders > 43-5 (May 2013) . - p.1106-1118
Mots-clés : Agenesis of the corpus callosum Autism spectrum disorders Autism Spectrum Quotient Functional connectivity Magnetoencephalography Superior temporal gyrus Index. décimale : PER Périodiques Résumé : Autism spectrum disorders (ASD) have numerous etiologies, including structural brain malformations such as agenesis of the corpus callosum (AgCC). We sought to directly measure the occurrence of autism traits in a cohort of individuals with AgCC and to investigate the neural underpinnings of this association. We screened a large AgCC cohort (n = 106) with the Autism Spectrum Quotient (AQ) and found that 45 % of children, 35 % of adolescents, and 18 % of adults exceeded the predetermined autism-screening cut-off. Interestingly, performance on the AQ’s imagination domain was inversely correlated with magnetoencephalography measures of resting-state functional connectivity in the right superior temporal gyrus. Individuals with AgCC should be screened for ASD and disorders of the corpus callosum should be considered in autism diagnostic evaluations as well. En ligne : http://dx.doi.org/10.1007/s10803-012-1653-2 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=195 Children With Autism Show Reduced Somatosensory Response: An MEG Study / Elysa J. MARCO in Autism Research, 5-5 (October 2012)
[article]
Titre : Children With Autism Show Reduced Somatosensory Response: An MEG Study Type de document : Texte imprimé et/ou numérique Auteurs : Elysa J. MARCO, Auteur ; Kasra KHATIBI, Auteur ; Susanna S. HILL, Auteur ; Bryna SIEGEL, Auteur ; Monica S. ARROYO, Auteur ; Anne F. DOWLING, Auteur ; John M. NEUHAUS, Auteur ; Elliott H. SHERR, Auteur ; Leighton B N. HINKLEY, Auteur ; Srikantan S. NAGARAJAN, Auteur Article en page(s) : p.340-351 Langues : Anglais (eng) Mots-clés : cognitive neuroscience event related potential school age low-level perception magnetoencephalography Index. décimale : PER Périodiques Résumé : The neural underpinnings of sensory processing differences in autism remain poorly understood. This prospective magnetoencephalography (MEG) study investigates whether children with autism show atypical cortical activity in the primary somatosensory cortex (S1) in comparison with matched controls. Tactile stimuli were clearly detectable, and painless taps were applied to the distal phalanx of the second (D2) and third (D3) fingers of the right and left hands. Three tactile paradigms were administered: an oddball paradigm (standard taps to D3 at an interstimulus interval (ISI) of 0.33 and deviant taps to D2 with ISI ranging from 1.32?s to 1.64?s); a slow-rate paradigm (D2) with an ISI matching the deviant taps in the oddball paradigm; and a fast-rate paradigm (D2) with an ISI matching the standard taps in the oddball. Study subjects were boys (age 7–11 years) with and without autism disorder. Sensory behavior was quantified using the Sensory Profile questionnaire. Boys with autism exhibited smaller amplitude left hemisphere S1 response to slow and deviant stimuli during the right-hand paradigms. In post-hoc analysis, tactile behavior directly correlated with the amplitude of cortical response. Consequently, the children were re-categorized by degree of parent-report tactile sensitivity. This regrouping created a more robust distinction between the groups with amplitude diminution in the left and right hemispheres and latency prolongation in the right hemisphere in the deviant and slow-rate paradigms for the affected children. This study suggests that children with autism have early differences in somatosensory processing, which likely influence later stages of cortical activity from integration to motor response. Autism Res 2012, 5: 340–351. © 2012 International Society for Autism Research, Wiley Periodicals, Inc. En ligne : http://dx.doi.org/10.1002/aur.1247 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=183
in Autism Research > 5-5 (October 2012) . - p.340-351[article] Children With Autism Show Reduced Somatosensory Response: An MEG Study [Texte imprimé et/ou numérique] / Elysa J. MARCO, Auteur ; Kasra KHATIBI, Auteur ; Susanna S. HILL, Auteur ; Bryna SIEGEL, Auteur ; Monica S. ARROYO, Auteur ; Anne F. DOWLING, Auteur ; John M. NEUHAUS, Auteur ; Elliott H. SHERR, Auteur ; Leighton B N. HINKLEY, Auteur ; Srikantan S. NAGARAJAN, Auteur . - p.340-351.
Langues : Anglais (eng)
in Autism Research > 5-5 (October 2012) . - p.340-351
Mots-clés : cognitive neuroscience event related potential school age low-level perception magnetoencephalography Index. décimale : PER Périodiques Résumé : The neural underpinnings of sensory processing differences in autism remain poorly understood. This prospective magnetoencephalography (MEG) study investigates whether children with autism show atypical cortical activity in the primary somatosensory cortex (S1) in comparison with matched controls. Tactile stimuli were clearly detectable, and painless taps were applied to the distal phalanx of the second (D2) and third (D3) fingers of the right and left hands. Three tactile paradigms were administered: an oddball paradigm (standard taps to D3 at an interstimulus interval (ISI) of 0.33 and deviant taps to D2 with ISI ranging from 1.32?s to 1.64?s); a slow-rate paradigm (D2) with an ISI matching the deviant taps in the oddball paradigm; and a fast-rate paradigm (D2) with an ISI matching the standard taps in the oddball. Study subjects were boys (age 7–11 years) with and without autism disorder. Sensory behavior was quantified using the Sensory Profile questionnaire. Boys with autism exhibited smaller amplitude left hemisphere S1 response to slow and deviant stimuli during the right-hand paradigms. In post-hoc analysis, tactile behavior directly correlated with the amplitude of cortical response. Consequently, the children were re-categorized by degree of parent-report tactile sensitivity. This regrouping created a more robust distinction between the groups with amplitude diminution in the left and right hemispheres and latency prolongation in the right hemisphere in the deviant and slow-rate paradigms for the affected children. This study suggests that children with autism have early differences in somatosensory processing, which likely influence later stages of cortical activity from integration to motor response. Autism Res 2012, 5: 340–351. © 2012 International Society for Autism Research, Wiley Periodicals, Inc. En ligne : http://dx.doi.org/10.1002/aur.1247 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=183