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Autism Traits in Individuals with Agenesis of the Corpus Callosum / Yolanda C. LAU in Journal of Autism and Developmental Disorders, 43-5 (May 2013)
[article]
Titre : Autism Traits in Individuals with Agenesis of the Corpus Callosum Type de document : Texte imprimé et/ou numérique Auteurs : Yolanda C. LAU, Auteur ; Leighton B N. HINKLEY, Auteur ; Polina BUKSHPUN, Auteur ; Zoe A. STROMINGER, Auteur ; Mari L. J. WAKAHIRO, Auteur ; Simon BARON-COHEN, Auteur ; Carrie ALLISON, Auteur ; Bonnie AUYEUNG, Auteur ; Rita J. JEREMY, Auteur ; Srikantan S. NAGARAJAN, Auteur ; Elliott H. SHERR, Auteur ; Elysa J. MARCO, Auteur Article en page(s) : p.1106-1118 Langues : Anglais (eng) Mots-clés : Agenesis of the corpus callosum Autism spectrum disorders Autism Spectrum Quotient Functional connectivity Magnetoencephalography Superior temporal gyrus Index. décimale : PER Périodiques Résumé : Autism spectrum disorders (ASD) have numerous etiologies, including structural brain malformations such as agenesis of the corpus callosum (AgCC). We sought to directly measure the occurrence of autism traits in a cohort of individuals with AgCC and to investigate the neural underpinnings of this association. We screened a large AgCC cohort (n = 106) with the Autism Spectrum Quotient (AQ) and found that 45 % of children, 35 % of adolescents, and 18 % of adults exceeded the predetermined autism-screening cut-off. Interestingly, performance on the AQ’s imagination domain was inversely correlated with magnetoencephalography measures of resting-state functional connectivity in the right superior temporal gyrus. Individuals with AgCC should be screened for ASD and disorders of the corpus callosum should be considered in autism diagnostic evaluations as well. En ligne : http://dx.doi.org/10.1007/s10803-012-1653-2 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=195
in Journal of Autism and Developmental Disorders > 43-5 (May 2013) . - p.1106-1118[article] Autism Traits in Individuals with Agenesis of the Corpus Callosum [Texte imprimé et/ou numérique] / Yolanda C. LAU, Auteur ; Leighton B N. HINKLEY, Auteur ; Polina BUKSHPUN, Auteur ; Zoe A. STROMINGER, Auteur ; Mari L. J. WAKAHIRO, Auteur ; Simon BARON-COHEN, Auteur ; Carrie ALLISON, Auteur ; Bonnie AUYEUNG, Auteur ; Rita J. JEREMY, Auteur ; Srikantan S. NAGARAJAN, Auteur ; Elliott H. SHERR, Auteur ; Elysa J. MARCO, Auteur . - p.1106-1118.
Langues : Anglais (eng)
in Journal of Autism and Developmental Disorders > 43-5 (May 2013) . - p.1106-1118
Mots-clés : Agenesis of the corpus callosum Autism spectrum disorders Autism Spectrum Quotient Functional connectivity Magnetoencephalography Superior temporal gyrus Index. décimale : PER Périodiques Résumé : Autism spectrum disorders (ASD) have numerous etiologies, including structural brain malformations such as agenesis of the corpus callosum (AgCC). We sought to directly measure the occurrence of autism traits in a cohort of individuals with AgCC and to investigate the neural underpinnings of this association. We screened a large AgCC cohort (n = 106) with the Autism Spectrum Quotient (AQ) and found that 45 % of children, 35 % of adolescents, and 18 % of adults exceeded the predetermined autism-screening cut-off. Interestingly, performance on the AQ’s imagination domain was inversely correlated with magnetoencephalography measures of resting-state functional connectivity in the right superior temporal gyrus. Individuals with AgCC should be screened for ASD and disorders of the corpus callosum should be considered in autism diagnostic evaluations as well. En ligne : http://dx.doi.org/10.1007/s10803-012-1653-2 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=195 Self-referential and social cognition in a case of autism and agenesis of the corpus callosum / Michael V. LOMBARDO in Molecular Autism, (November 2012)
[article]
Titre : Self-referential and social cognition in a case of autism and agenesis of the corpus callosum Type de document : Texte imprimé et/ou numérique Auteurs : Michael V. LOMBARDO, Auteur ; Bhismadev CHAKRABARTI, Auteur ; Meng-Chuan LAI, Auteur ; MRC AIMS CONSORTIUM,, Auteur ; Simon BARON-COHEN, Auteur Année de publication : 2012 Article en page(s) : 15 p. Langues : Anglais (eng) Mots-clés : Autism Agenesis of the corpus callosum Self Theory of mind Mentalizing Social cognition Index. décimale : PER Périodiques Résumé : BACKGROUND:While models of autism spectrum conditions (ASC) are emerging at the genetic level of analysis, clear models at higher levels of analysis, such as neuroanatomy, are lacking. Here we examine agenesis of the corpus callosum (AgCC) as a model at the level of neuroanatomy that may be relevant for understanding self-referential and social-cognitive difficulties in ASC.METHODS:We examined performance on a wide array of tests in self-referential and social-cognitive domains in a patient with both AgCC and a diagnosis of ASC. Tests included a depth-of-processing memory paradigm with self-referential and social-cognitive manipulations, self-report measures of self-consciousness, alexithymia, and empathy, as well as performance measures of first-person pronoun usage and mentalizing ability. The performance of the AgCC patient was compared to a group of individuals with ASC but without AgCC and with neurotypical controls. These comparison groups come from a prior study where group differences were apparent across many measures. We used bootstrapping to assess whether the AgCC patient exhibited scores that were within or outside the 95% bias-corrected and accelerated bootstrap confidence intervals observed in both comparison groups.RESULTS:Within the depth-of-processing memory paradigm, the AgCC patient showed decreased memory sensitivity that was more extreme than both comparison groups across all conditions. The patient's most pronounced difficulty on this task emerged in the social-cognitive domain related to information-processing about other people. The patient was similar to the ASC group in benefiting less from self-referential processing compared to the control group. Across a variety of other self-referential (i.e. alexithymia, private self-consciousness) and social-cognitive measures (i.e. self-reported imaginative and perspective-taking subscales of empathy, mentalizing), the AgCC patient also showed more extreme scores than those observed for both of the comparison groups. However, the AgCC patient scored within the range observed in the comparison groups on measures of first-person pronoun usage and self-reported affective empathy subscales.CONCLUSIONS:We conclude that AgCC co-occurring with a diagnosis of ASC may be a relevant model at the level of neuroanatomy for understanding mechanisms involved in self-referential and high-level social-cognitive difficulties in ASC. En ligne : http://dx.doi.org/10.1186/2040-2392-3-14 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=202
in Molecular Autism > (November 2012) . - 15 p.[article] Self-referential and social cognition in a case of autism and agenesis of the corpus callosum [Texte imprimé et/ou numérique] / Michael V. LOMBARDO, Auteur ; Bhismadev CHAKRABARTI, Auteur ; Meng-Chuan LAI, Auteur ; MRC AIMS CONSORTIUM,, Auteur ; Simon BARON-COHEN, Auteur . - 2012 . - 15 p.
Langues : Anglais (eng)
in Molecular Autism > (November 2012) . - 15 p.
Mots-clés : Autism Agenesis of the corpus callosum Self Theory of mind Mentalizing Social cognition Index. décimale : PER Périodiques Résumé : BACKGROUND:While models of autism spectrum conditions (ASC) are emerging at the genetic level of analysis, clear models at higher levels of analysis, such as neuroanatomy, are lacking. Here we examine agenesis of the corpus callosum (AgCC) as a model at the level of neuroanatomy that may be relevant for understanding self-referential and social-cognitive difficulties in ASC.METHODS:We examined performance on a wide array of tests in self-referential and social-cognitive domains in a patient with both AgCC and a diagnosis of ASC. Tests included a depth-of-processing memory paradigm with self-referential and social-cognitive manipulations, self-report measures of self-consciousness, alexithymia, and empathy, as well as performance measures of first-person pronoun usage and mentalizing ability. The performance of the AgCC patient was compared to a group of individuals with ASC but without AgCC and with neurotypical controls. These comparison groups come from a prior study where group differences were apparent across many measures. We used bootstrapping to assess whether the AgCC patient exhibited scores that were within or outside the 95% bias-corrected and accelerated bootstrap confidence intervals observed in both comparison groups.RESULTS:Within the depth-of-processing memory paradigm, the AgCC patient showed decreased memory sensitivity that was more extreme than both comparison groups across all conditions. The patient's most pronounced difficulty on this task emerged in the social-cognitive domain related to information-processing about other people. The patient was similar to the ASC group in benefiting less from self-referential processing compared to the control group. Across a variety of other self-referential (i.e. alexithymia, private self-consciousness) and social-cognitive measures (i.e. self-reported imaginative and perspective-taking subscales of empathy, mentalizing), the AgCC patient also showed more extreme scores than those observed for both of the comparison groups. However, the AgCC patient scored within the range observed in the comparison groups on measures of first-person pronoun usage and self-reported affective empathy subscales.CONCLUSIONS:We conclude that AgCC co-occurring with a diagnosis of ASC may be a relevant model at the level of neuroanatomy for understanding mechanisms involved in self-referential and high-level social-cognitive difficulties in ASC. En ligne : http://dx.doi.org/10.1186/2040-2392-3-14 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=202 Social Inferences in Agenesis of the Corpus Callosum and Autism: Semantic Analysis and Topic Modeling / T. RENTERIA-VAZQUEZ in Journal of Autism and Developmental Disorders, 52-2 (February 2022)
[article]
Titre : Social Inferences in Agenesis of the Corpus Callosum and Autism: Semantic Analysis and Topic Modeling Type de document : Texte imprimé et/ou numérique Auteurs : T. RENTERIA-VAZQUEZ, Auteur ; W. S. BROWN, Auteur ; C. KANG, Auteur ; M. GRAVES, Auteur ; F. CASTELLI, Auteur ; L. K. PAUL, Auteur Article en page(s) : p.569-583 Langues : Anglais (eng) Mots-clés : Adult Agenesis of Corpus Callosum Autism Spectrum Disorder Autistic Disorder Corpus Callosum Humans Semantics Agenesis of the corpus callosum Autism Mental attribution Social inference Index. décimale : PER Périodiques Résumé : Impoverished capacity for social inference is one of several symptoms that are common to both agenesis of the corpus callosum (AgCC) and Autism Spectrum Disorder (ASD). This research compared the ability of 14 adults with AgCC, 13 high-functioning adults with ASD and 14 neurotypical controls to accurately attribute social meaning to the interactions of animated triangles. Descriptions of the animations were analyzed in three ways: subjective ratings, Linguistic Inquiry and Word Count, and topic modeling (Latent Dirichlet Allocation). Although subjective ratings indicated that all groups made similar inferences from the animations, the index of perplexity (atypicality of topic) generated from topic modeling revealed that inferences from individuals with AgCC or ASD displayed significantly less social imagination than those of controls. En ligne : http://dx.doi.org/10.1007/s10803-021-04957-2 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=455
in Journal of Autism and Developmental Disorders > 52-2 (February 2022) . - p.569-583[article] Social Inferences in Agenesis of the Corpus Callosum and Autism: Semantic Analysis and Topic Modeling [Texte imprimé et/ou numérique] / T. RENTERIA-VAZQUEZ, Auteur ; W. S. BROWN, Auteur ; C. KANG, Auteur ; M. GRAVES, Auteur ; F. CASTELLI, Auteur ; L. K. PAUL, Auteur . - p.569-583.
Langues : Anglais (eng)
in Journal of Autism and Developmental Disorders > 52-2 (February 2022) . - p.569-583
Mots-clés : Adult Agenesis of Corpus Callosum Autism Spectrum Disorder Autistic Disorder Corpus Callosum Humans Semantics Agenesis of the corpus callosum Autism Mental attribution Social inference Index. décimale : PER Périodiques Résumé : Impoverished capacity for social inference is one of several symptoms that are common to both agenesis of the corpus callosum (AgCC) and Autism Spectrum Disorder (ASD). This research compared the ability of 14 adults with AgCC, 13 high-functioning adults with ASD and 14 neurotypical controls to accurately attribute social meaning to the interactions of animated triangles. Descriptions of the animations were analyzed in three ways: subjective ratings, Linguistic Inquiry and Word Count, and topic modeling (Latent Dirichlet Allocation). Although subjective ratings indicated that all groups made similar inferences from the animations, the index of perplexity (atypicality of topic) generated from topic modeling revealed that inferences from individuals with AgCC or ASD displayed significantly less social imagination than those of controls. En ligne : http://dx.doi.org/10.1007/s10803-021-04957-2 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=455