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Auteur Devon N. GANGI |
Documents disponibles écrits par cet auteur (2)
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Dopaminergic variants in siblings at high risk for autism: Associations with initiating joint attention / Devon N. GANGI in Autism Research, 9-11 (November 2016)
[article]
Titre : Dopaminergic variants in siblings at high risk for autism: Associations with initiating joint attention Type de document : Texte imprimé et/ou numérique Auteurs : Devon N. GANGI, Auteur ; Daniel S. MESSINGER, Auteur ; Eden R. MARTIN, Auteur ; Michael L. CUCCARO, Auteur Article en page(s) : p.1142-1150 Langues : Anglais (eng) Mots-clés : high-risk siblings initiating joint attention dopamine differential susceptibility autism spectrum disorder Index. décimale : PER Périodiques Résumé : Younger siblings of children with autism spectrum disorder (ASD; high-risk siblings) exhibit lower levels of initiating joint attention (IJA; sharing an object or experience with a social partner through gaze and/or gesture) than low-risk siblings of children without ASD. However, high-risk siblings also exhibit substantial variability in this domain. The neurotransmitter dopamine is linked to brain areas associated with reward, motivation, and attention, and common dopaminergic variants have been associated with attention difficulties. We examined whether these common dopaminergic variants, DRD4 and DRD2, explain variability in IJA in high-risk (n?=?55) and low-risk (n?=?38) siblings. IJA was assessed in the first year during a semi-structured interaction with an examiner. DRD4 and DRD2 genotypes were coded according to associated dopaminergic functioning to create a gene score, with higher scores indicating more genotypes associated with less efficient dopaminergic functioning. Higher dopamine gene scores (indicative of less efficient dopaminergic functioning) were associated with lower levels of IJA in the first year for high-risk siblings, while the opposite pattern emerged in low-risk siblings. Findings suggest differential susceptibility—IJA was differentially associated with dopaminergic functioning depending on familial ASD risk. Understanding genes linked to ASD-relevant behaviors in high-risk siblings will aid in early identification of children at greatest risk for difficulties in these behavioral domains, facilitating targeted prevention and intervention. En ligne : http://dx.doi.org/10.1002/aur.1623 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=297
in Autism Research > 9-11 (November 2016) . - p.1142-1150[article] Dopaminergic variants in siblings at high risk for autism: Associations with initiating joint attention [Texte imprimé et/ou numérique] / Devon N. GANGI, Auteur ; Daniel S. MESSINGER, Auteur ; Eden R. MARTIN, Auteur ; Michael L. CUCCARO, Auteur . - p.1142-1150.
Langues : Anglais (eng)
in Autism Research > 9-11 (November 2016) . - p.1142-1150
Mots-clés : high-risk siblings initiating joint attention dopamine differential susceptibility autism spectrum disorder Index. décimale : PER Périodiques Résumé : Younger siblings of children with autism spectrum disorder (ASD; high-risk siblings) exhibit lower levels of initiating joint attention (IJA; sharing an object or experience with a social partner through gaze and/or gesture) than low-risk siblings of children without ASD. However, high-risk siblings also exhibit substantial variability in this domain. The neurotransmitter dopamine is linked to brain areas associated with reward, motivation, and attention, and common dopaminergic variants have been associated with attention difficulties. We examined whether these common dopaminergic variants, DRD4 and DRD2, explain variability in IJA in high-risk (n?=?55) and low-risk (n?=?38) siblings. IJA was assessed in the first year during a semi-structured interaction with an examiner. DRD4 and DRD2 genotypes were coded according to associated dopaminergic functioning to create a gene score, with higher scores indicating more genotypes associated with less efficient dopaminergic functioning. Higher dopamine gene scores (indicative of less efficient dopaminergic functioning) were associated with lower levels of IJA in the first year for high-risk siblings, while the opposite pattern emerged in low-risk siblings. Findings suggest differential susceptibility—IJA was differentially associated with dopaminergic functioning depending on familial ASD risk. Understanding genes linked to ASD-relevant behaviors in high-risk siblings will aid in early identification of children at greatest risk for difficulties in these behavioral domains, facilitating targeted prevention and intervention. En ligne : http://dx.doi.org/10.1002/aur.1623 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=297 Joint Attention Initiation With and Without Positive Affect: Risk Group Differences and Associations with ASD Symptoms / Devon N. GANGI in Journal of Autism and Developmental Disorders, 44-6 (June 2014)
[article]
Titre : Joint Attention Initiation With and Without Positive Affect: Risk Group Differences and Associations with ASD Symptoms Type de document : Texte imprimé et/ou numérique Auteurs : Devon N. GANGI, Auteur ; Lisa V. IBANEZ, Auteur ; Daniel S. MESSINGER, Auteur Article en page(s) : p.1414-1424 Langues : Anglais (eng) Mots-clés : Anticipatory smiling High-risk siblings Autism spectrum disorders Initiating joint attention Index. décimale : PER Périodiques Résumé : Infants at risk for autism spectrum disorders (ASD) may have difficulty integrating smiles into initiating joint attention (IJA) bids. A specific IJA pattern, anticipatory smiling, may communicate preexisting positive affect when an infant smiles at an object and then turns the smile toward the social partner. We compared the development of anticipatory smiling at 8, 10, and 12 months in infant siblings of children with ASD (high-risk siblings) and without ASD (low-risk siblings). High-risk siblings produced less anticipatory smiling than low-risk siblings, suggesting early differences in communicating preexisting positive affect. While early anticipatory smiling distinguished the risk groups, IJA not accompanied by smiling best predicted later severity of ASD-related behavioral characteristics among high-risk siblings. High-risk infants appear to show lower levels of motivation to share positive affect with others. However, facility with initiating joint attention in the absence of a clear index of positive affective motivation appears to be central to the prediction of ASD symptoms. En ligne : http://dx.doi.org/10.1007/s10803-013-2002-9 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=233
in Journal of Autism and Developmental Disorders > 44-6 (June 2014) . - p.1414-1424[article] Joint Attention Initiation With and Without Positive Affect: Risk Group Differences and Associations with ASD Symptoms [Texte imprimé et/ou numérique] / Devon N. GANGI, Auteur ; Lisa V. IBANEZ, Auteur ; Daniel S. MESSINGER, Auteur . - p.1414-1424.
Langues : Anglais (eng)
in Journal of Autism and Developmental Disorders > 44-6 (June 2014) . - p.1414-1424
Mots-clés : Anticipatory smiling High-risk siblings Autism spectrum disorders Initiating joint attention Index. décimale : PER Périodiques Résumé : Infants at risk for autism spectrum disorders (ASD) may have difficulty integrating smiles into initiating joint attention (IJA) bids. A specific IJA pattern, anticipatory smiling, may communicate preexisting positive affect when an infant smiles at an object and then turns the smile toward the social partner. We compared the development of anticipatory smiling at 8, 10, and 12 months in infant siblings of children with ASD (high-risk siblings) and without ASD (low-risk siblings). High-risk siblings produced less anticipatory smiling than low-risk siblings, suggesting early differences in communicating preexisting positive affect. While early anticipatory smiling distinguished the risk groups, IJA not accompanied by smiling best predicted later severity of ASD-related behavioral characteristics among high-risk siblings. High-risk infants appear to show lower levels of motivation to share positive affect with others. However, facility with initiating joint attention in the absence of a clear index of positive affective motivation appears to be central to the prediction of ASD symptoms. En ligne : http://dx.doi.org/10.1007/s10803-013-2002-9 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=233