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Dopaminergic variants in siblings at high risk for autism: Associations with initiating joint attention / Devon N. GANGI in Autism Research, 9-11 (November 2016)
[article]
Titre : Dopaminergic variants in siblings at high risk for autism: Associations with initiating joint attention Type de document : Texte imprimé et/ou numérique Auteurs : Devon N. GANGI, Auteur ; Daniel S. MESSINGER, Auteur ; Eden R. MARTIN, Auteur ; Michael L. CUCCARO, Auteur Article en page(s) : p.1142-1150 Langues : Anglais (eng) Mots-clés : high-risk siblings initiating joint attention dopamine differential susceptibility autism spectrum disorder Index. décimale : PER Périodiques Résumé : Younger siblings of children with autism spectrum disorder (ASD; high-risk siblings) exhibit lower levels of initiating joint attention (IJA; sharing an object or experience with a social partner through gaze and/or gesture) than low-risk siblings of children without ASD. However, high-risk siblings also exhibit substantial variability in this domain. The neurotransmitter dopamine is linked to brain areas associated with reward, motivation, and attention, and common dopaminergic variants have been associated with attention difficulties. We examined whether these common dopaminergic variants, DRD4 and DRD2, explain variability in IJA in high-risk (n?=?55) and low-risk (n?=?38) siblings. IJA was assessed in the first year during a semi-structured interaction with an examiner. DRD4 and DRD2 genotypes were coded according to associated dopaminergic functioning to create a gene score, with higher scores indicating more genotypes associated with less efficient dopaminergic functioning. Higher dopamine gene scores (indicative of less efficient dopaminergic functioning) were associated with lower levels of IJA in the first year for high-risk siblings, while the opposite pattern emerged in low-risk siblings. Findings suggest differential susceptibility—IJA was differentially associated with dopaminergic functioning depending on familial ASD risk. Understanding genes linked to ASD-relevant behaviors in high-risk siblings will aid in early identification of children at greatest risk for difficulties in these behavioral domains, facilitating targeted prevention and intervention. En ligne : http://dx.doi.org/10.1002/aur.1623 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=297
in Autism Research > 9-11 (November 2016) . - p.1142-1150[article] Dopaminergic variants in siblings at high risk for autism: Associations with initiating joint attention [Texte imprimé et/ou numérique] / Devon N. GANGI, Auteur ; Daniel S. MESSINGER, Auteur ; Eden R. MARTIN, Auteur ; Michael L. CUCCARO, Auteur . - p.1142-1150.
Langues : Anglais (eng)
in Autism Research > 9-11 (November 2016) . - p.1142-1150
Mots-clés : high-risk siblings initiating joint attention dopamine differential susceptibility autism spectrum disorder Index. décimale : PER Périodiques Résumé : Younger siblings of children with autism spectrum disorder (ASD; high-risk siblings) exhibit lower levels of initiating joint attention (IJA; sharing an object or experience with a social partner through gaze and/or gesture) than low-risk siblings of children without ASD. However, high-risk siblings also exhibit substantial variability in this domain. The neurotransmitter dopamine is linked to brain areas associated with reward, motivation, and attention, and common dopaminergic variants have been associated with attention difficulties. We examined whether these common dopaminergic variants, DRD4 and DRD2, explain variability in IJA in high-risk (n?=?55) and low-risk (n?=?38) siblings. IJA was assessed in the first year during a semi-structured interaction with an examiner. DRD4 and DRD2 genotypes were coded according to associated dopaminergic functioning to create a gene score, with higher scores indicating more genotypes associated with less efficient dopaminergic functioning. Higher dopamine gene scores (indicative of less efficient dopaminergic functioning) were associated with lower levels of IJA in the first year for high-risk siblings, while the opposite pattern emerged in low-risk siblings. Findings suggest differential susceptibility—IJA was differentially associated with dopaminergic functioning depending on familial ASD risk. Understanding genes linked to ASD-relevant behaviors in high-risk siblings will aid in early identification of children at greatest risk for difficulties in these behavioral domains, facilitating targeted prevention and intervention. En ligne : http://dx.doi.org/10.1002/aur.1623 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=297 Mid-childhood outcomes of infant siblings at familial high-risk of autism spectrum disorder / Elizabeth SHEPHARD in Autism Research, 10-3 (March 2017)
[article]
Titre : Mid-childhood outcomes of infant siblings at familial high-risk of autism spectrum disorder Type de document : Texte imprimé et/ou numérique Auteurs : Elizabeth SHEPHARD, Auteur ; Bosiljka MILOSAVLJEVIC, Auteur ; Greg PASCO, Auteur ; Emily J. H. JONES, Auteur ; Teodora GLIGA, Auteur ; Francesca HAPPE, Auteur ; Mark H. JOHNSON, Auteur ; Tony CHARMAN, Auteur ; THE BASIS TEAM,, Auteur Article en page(s) : p.546-557 Langues : Anglais (eng) Mots-clés : high-risk siblings clinical outcomes ADHD anxiety broader autism phenotype Index. décimale : PER Périodiques Résumé : Almost 20% of infants with an older sibling with autism spectrum disorder (ASD) exhibit ASD themselves by age 3 years. The longer-term outcomes of high-risk infants are less clear. We examined symptoms of ASD, attention-deficit/hyperactivity disorder (ADHD) and anxiety, language, IQ, and adaptive behaviour at age 7 years in high- and low-risk children prospectively studied since the first year of life. Clinical outcomes were compared between high-risk children who met diagnostic criteria for ASD at age 7 (HR-ASD-7 group, n = 15), high-risk children without ASD (HR-Non-ASD-7 group, n = 24), and low-risk control children (LR group, n = 37). Diagnostic stability between age 3 and 7 years was moderate, with five children who did not meet diagnostic criteria for ASD at age 3 years being assigned the diagnosis at age 7, and three children showing the opposite pattern. The HR-ASD-7 group showed elevated ADHD and anxiety symptoms and had lower adaptive behaviour scores than LR controls. The HR-Non-ASD-7 group had higher repetitive behaviour, lower adaptive functioning and elevated scores on one anxiety subscale (Separation Anxiety) compared to LR controls, but evidence for subclinical ASD symptoms (the broader autism phenotype, BAP) was limited in the group as a whole, although we identified a subgroup with elevated ASD traits. The difficulties experienced by high-risk siblings at school-age extend beyond ASD symptoms. The pattern of difficulties exhibited by the HR-ASD-7 group may inform our understanding of developmental trajectories of co-occurring psychopathology in ASD. En ligne : http://dx.doi.org/10.1002/aur.1733 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=304
in Autism Research > 10-3 (March 2017) . - p.546-557[article] Mid-childhood outcomes of infant siblings at familial high-risk of autism spectrum disorder [Texte imprimé et/ou numérique] / Elizabeth SHEPHARD, Auteur ; Bosiljka MILOSAVLJEVIC, Auteur ; Greg PASCO, Auteur ; Emily J. H. JONES, Auteur ; Teodora GLIGA, Auteur ; Francesca HAPPE, Auteur ; Mark H. JOHNSON, Auteur ; Tony CHARMAN, Auteur ; THE BASIS TEAM,, Auteur . - p.546-557.
Langues : Anglais (eng)
in Autism Research > 10-3 (March 2017) . - p.546-557
Mots-clés : high-risk siblings clinical outcomes ADHD anxiety broader autism phenotype Index. décimale : PER Périodiques Résumé : Almost 20% of infants with an older sibling with autism spectrum disorder (ASD) exhibit ASD themselves by age 3 years. The longer-term outcomes of high-risk infants are less clear. We examined symptoms of ASD, attention-deficit/hyperactivity disorder (ADHD) and anxiety, language, IQ, and adaptive behaviour at age 7 years in high- and low-risk children prospectively studied since the first year of life. Clinical outcomes were compared between high-risk children who met diagnostic criteria for ASD at age 7 (HR-ASD-7 group, n = 15), high-risk children without ASD (HR-Non-ASD-7 group, n = 24), and low-risk control children (LR group, n = 37). Diagnostic stability between age 3 and 7 years was moderate, with five children who did not meet diagnostic criteria for ASD at age 3 years being assigned the diagnosis at age 7, and three children showing the opposite pattern. The HR-ASD-7 group showed elevated ADHD and anxiety symptoms and had lower adaptive behaviour scores than LR controls. The HR-Non-ASD-7 group had higher repetitive behaviour, lower adaptive functioning and elevated scores on one anxiety subscale (Separation Anxiety) compared to LR controls, but evidence for subclinical ASD symptoms (the broader autism phenotype, BAP) was limited in the group as a whole, although we identified a subgroup with elevated ASD traits. The difficulties experienced by high-risk siblings at school-age extend beyond ASD symptoms. The pattern of difficulties exhibited by the HR-ASD-7 group may inform our understanding of developmental trajectories of co-occurring psychopathology in ASD. En ligne : http://dx.doi.org/10.1002/aur.1733 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=304 Observed Social Emotional Behavior at 22 Months Predicts a Later ASD Diagnosis in High-Risk Siblings / Jessie B. NORTHRUP in Journal of Autism and Developmental Disorders, 51-9 (September 2021)
[article]
Titre : Observed Social Emotional Behavior at 22 Months Predicts a Later ASD Diagnosis in High-Risk Siblings Type de document : Texte imprimé et/ou numérique Auteurs : Jessie B. NORTHRUP, Auteur ; N. B. LEEZENBAUM, Auteur ; S. B. CAMPBELL, Auteur Article en page(s) : p.3187-3198 Langues : Anglais (eng) Mots-clés : Autism Spectrum Disorder/diagnosis Child, Preschool Emotions Empathy Humans Siblings Social Behavior Autism spectrum disorder Empathic concern High-risk siblings Pretend play Social engagement Index. décimale : PER Périodiques Résumé : Social engagement, pretend play, and concern for another's distress represent fundamental features of typical social-emotional development in the second year. Children with autism spectrum disorder (ASD) display delays and deficits in these areas, and research on toddlers at heightened risk for ASD (HR; younger siblings of children with ASD) indicates these deficits may be apparent in toddlerhood. Prior research has examined these aspects of social-emotional development individually in HR toddlers. The present paper examines them jointly as predictors of ASD. We show that social engagement, pretend play, and empathic concern at 22-months each contribute uniquely to predicting later ASD diagnosis with high specificity and moderate sensitivity. Results have important implications for early diagnosis and intervention in young children with ASD. En ligne : http://dx.doi.org/10.1007/s10803-020-04789-6 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=453
in Journal of Autism and Developmental Disorders > 51-9 (September 2021) . - p.3187-3198[article] Observed Social Emotional Behavior at 22 Months Predicts a Later ASD Diagnosis in High-Risk Siblings [Texte imprimé et/ou numérique] / Jessie B. NORTHRUP, Auteur ; N. B. LEEZENBAUM, Auteur ; S. B. CAMPBELL, Auteur . - p.3187-3198.
Langues : Anglais (eng)
in Journal of Autism and Developmental Disorders > 51-9 (September 2021) . - p.3187-3198
Mots-clés : Autism Spectrum Disorder/diagnosis Child, Preschool Emotions Empathy Humans Siblings Social Behavior Autism spectrum disorder Empathic concern High-risk siblings Pretend play Social engagement Index. décimale : PER Périodiques Résumé : Social engagement, pretend play, and concern for another's distress represent fundamental features of typical social-emotional development in the second year. Children with autism spectrum disorder (ASD) display delays and deficits in these areas, and research on toddlers at heightened risk for ASD (HR; younger siblings of children with ASD) indicates these deficits may be apparent in toddlerhood. Prior research has examined these aspects of social-emotional development individually in HR toddlers. The present paper examines them jointly as predictors of ASD. We show that social engagement, pretend play, and empathic concern at 22-months each contribute uniquely to predicting later ASD diagnosis with high specificity and moderate sensitivity. Results have important implications for early diagnosis and intervention in young children with ASD. En ligne : http://dx.doi.org/10.1007/s10803-020-04789-6 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=453 Screening for Autism Spectrum Disorders in 12-Month-Old High-Risk Siblings by Parental Report / Justin ROWBERRY in Journal of Autism and Developmental Disorders, 45-1 (January 2015)
[article]
Titre : Screening for Autism Spectrum Disorders in 12-Month-Old High-Risk Siblings by Parental Report Type de document : Texte imprimé et/ou numérique Auteurs : Justin ROWBERRY, Auteur ; Suzanne MACARI, Auteur ; Grace M. CHEN, Auteur ; Daniel B. CAMPBELL, Auteur ; John M. LEVENTHAL, Auteur ; Carol WEITZMAN, Auteur ; Katarzyna CHAWARSKA, Auteur Article en page(s) : p.221-229 Langues : Anglais (eng) Mots-clés : ASD High-risk siblings Screening Imitation Index. décimale : PER Périodiques Résumé : This study examines whether parental report of social-communicative and repetitive behaviors at 12 months can be helpful in identifying autism spectrum disorder (ASD) in younger siblings of children with ASD [high-risk (HR)-siblings]. Parents of HR-siblings and infants without a family history of ASD completed the First Year Inventory at 12 months. Developmental outcomes were based on 24- or 36-month assessments. HR-siblings later diagnosed with ASD showed greater impairments in social communication than those with other developmental outcomes based on parental and clinician ratings. Parental report of decline in play and communication and impaired vocal imitation correctly classified a majority of ASD cases with high specificity. These preliminary findings have important implications for the development of early screening instruments for ASD in HR-siblings. En ligne : http://dx.doi.org/10.1007/s10803-014-2211-x Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=258
in Journal of Autism and Developmental Disorders > 45-1 (January 2015) . - p.221-229[article] Screening for Autism Spectrum Disorders in 12-Month-Old High-Risk Siblings by Parental Report [Texte imprimé et/ou numérique] / Justin ROWBERRY, Auteur ; Suzanne MACARI, Auteur ; Grace M. CHEN, Auteur ; Daniel B. CAMPBELL, Auteur ; John M. LEVENTHAL, Auteur ; Carol WEITZMAN, Auteur ; Katarzyna CHAWARSKA, Auteur . - p.221-229.
Langues : Anglais (eng)
in Journal of Autism and Developmental Disorders > 45-1 (January 2015) . - p.221-229
Mots-clés : ASD High-risk siblings Screening Imitation Index. décimale : PER Périodiques Résumé : This study examines whether parental report of social-communicative and repetitive behaviors at 12 months can be helpful in identifying autism spectrum disorder (ASD) in younger siblings of children with ASD [high-risk (HR)-siblings]. Parents of HR-siblings and infants without a family history of ASD completed the First Year Inventory at 12 months. Developmental outcomes were based on 24- or 36-month assessments. HR-siblings later diagnosed with ASD showed greater impairments in social communication than those with other developmental outcomes based on parental and clinician ratings. Parental report of decline in play and communication and impaired vocal imitation correctly classified a majority of ASD cases with high specificity. These preliminary findings have important implications for the development of early screening instruments for ASD in HR-siblings. En ligne : http://dx.doi.org/10.1007/s10803-014-2211-x Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=258 Social Smiling and Its Components in High-Risk Infant Siblings Without Later ASD Symptomatology / Caitlin MCMAHON NICHOLS in Journal of Autism and Developmental Disorders, 44-4 (April 2014)
[article]
Titre : Social Smiling and Its Components in High-Risk Infant Siblings Without Later ASD Symptomatology Type de document : Texte imprimé et/ou numérique Auteurs : Caitlin MCMAHON NICHOLS, Auteur ; Lisa V. IBANEZ, Auteur ; Jennifer H. FOSS-FEIG, Auteur ; Wendy L. STONE, Auteur Année de publication : 2014 Article en page(s) : p.894-902 Langues : Anglais (eng) Mots-clés : Autism High-risk siblings Infants Social smiling Index. décimale : PER Périodiques Résumé : Impaired affective expression, including social smiling, is common in children with autism spectrum disorder (ASD), and may represent an early marker for ASD in their infant siblings (Sibs-ASD). Social smiling and its component behaviors (eye contact and non-social smiling) were examined at 15 months in Sibs-ASD who demonstrated later ASD symptomatology (Sibs-ASD/AS), those who did not (Sibs-ASD/NS), and low-risk controls (Sibs-TD). Both Sibs-ASD subgroups demonstrated lower levels of social smiling than Sibs-TD, suggesting that early social smiling may reflect elevated genetic vulnerability rather than a specific marker for ASD. Only the Sibs-ASD/AS demonstrated less eye contact and non-social smiling than Sibs-TD, suggesting that different processes, threshold effects, or protective factors may underlie social smiling development in the two Sibs-ASD subgroups. En ligne : http://dx.doi.org/10.1007/s10803-013-1944-2 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=228
in Journal of Autism and Developmental Disorders > 44-4 (April 2014) . - p.894-902[article] Social Smiling and Its Components in High-Risk Infant Siblings Without Later ASD Symptomatology [Texte imprimé et/ou numérique] / Caitlin MCMAHON NICHOLS, Auteur ; Lisa V. IBANEZ, Auteur ; Jennifer H. FOSS-FEIG, Auteur ; Wendy L. STONE, Auteur . - 2014 . - p.894-902.
Langues : Anglais (eng)
in Journal of Autism and Developmental Disorders > 44-4 (April 2014) . - p.894-902
Mots-clés : Autism High-risk siblings Infants Social smiling Index. décimale : PER Périodiques Résumé : Impaired affective expression, including social smiling, is common in children with autism spectrum disorder (ASD), and may represent an early marker for ASD in their infant siblings (Sibs-ASD). Social smiling and its component behaviors (eye contact and non-social smiling) were examined at 15 months in Sibs-ASD who demonstrated later ASD symptomatology (Sibs-ASD/AS), those who did not (Sibs-ASD/NS), and low-risk controls (Sibs-TD). Both Sibs-ASD subgroups demonstrated lower levels of social smiling than Sibs-TD, suggesting that early social smiling may reflect elevated genetic vulnerability rather than a specific marker for ASD. Only the Sibs-ASD/AS demonstrated less eye contact and non-social smiling than Sibs-TD, suggesting that different processes, threshold effects, or protective factors may underlie social smiling development in the two Sibs-ASD subgroups. En ligne : http://dx.doi.org/10.1007/s10803-013-1944-2 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=228 Concern for Another’s Distress in Toddlers at High and Low Genetic Risk for Autism Spectrum Disorder / Susan B. CAMPBELL in Journal of Autism and Developmental Disorders, 45-11 (November 2015)
PermalinkExploring receptive and expressive language components at the age of 36 months in siblings at risk for autism spectrum disorder / Eva BRUYNEEL in Research in Autism Spectrum Disorders, 66 (October 2019)
PermalinkPretend Play and Social Engagement in Toddlers at High and Low Genetic Risk for Autism Spectrum Disorder / Susan B. CAMPBELL in Journal of Autism and Developmental Disorders, 46-7 (July 2016)
PermalinkRandomised trial of a parent-mediated intervention for infants at high risk for autism: longitudinal outcomes to age 3 years / Jonathan GREEN in Journal of Child Psychology and Psychiatry, 58-12 (December 2017)
PermalinkEarly Language Profiles in Infants at High-Risk for Autism Spectrum Disorders / Kristelle HUDRY in Journal of Autism and Developmental Disorders, 44-1 (January 2014)
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