Dépouillements

Issue Information in Autism Research, 9-11 (November 2016)  

Public ISBD [article]  inAutism Research > 9-11 (November 2016) . - p.1121-1123 Titre : Issue Information Type de document : Texte imprimé et/ou numérique Article en page(s) : p.1121-1123 Langues : Anglais (eng) Index. décimale : PER Périodiques En ligne : http://dx.doi.org/10.1002/aur.1556 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=297 [article] Issue Information [Texte imprimé et/ou numérique] . - p.1121-1123. Langues : Anglais (eng) in Autism Research > 9-11 (November 2016) . - p.1121-1123 Index. décimale : PER Périodiques En ligne : http://dx.doi.org/10.1002/aur.1556 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=297

The role of interstimulus interval and “Stimulus-type” in prepotent response inhibition abilities in people with ASD: A quantitative and qualitative review / Marieke W. M. KUIPER in Autism Research, 9-11 (November 2016)  

Public ISBD [article]  inAutism Research > 9-11 (November 2016) . - p.1124-1141 Titre : The role of interstimulus interval and “Stimulus-type” in prepotent response inhibition abilities in people with ASD: A quantitative and qualitative review Type de document : Texte imprimé et/ou numérique Auteurs : Marieke W. M. KUIPER, Auteur ; Elisabeth W. M. VERHOEVEN, Auteur ; Hilde M. GEURTS, Auteur Article en page(s) : p.1124-1141 Langues : Anglais (eng) Mots-clés : autism spectrum disorders  autism  prepotent response inhibition  interstimulus interval  cognitive control  meta-analysis Index. décimale : PER Périodiques Résumé : Autism spectrum disorders (ASD) are associated with prepotent response inhibition difficulties. However, the large variation between studies suggests that understudied factors, such as interstimulus interval (ISI) and “stimulus-type” (both hypothesized proxies of stressors influencing arousal), might influence the inhibitory abilities of people with ASD. Using meta-analysis, we tested whether differences in prepotent response inhibition between people with and without ASD was influenced by ISI. There was not enough variation in “stimulus-type” between the studies to include it as a moderator. Thirty-seven studies met inclusion criteria, with a combined sample size of 950 people with ASD and 966 typically developing controls. Additionally, a qualitative review including studies comparing a neutral and an arousing condition in one experiment was performed to examine whether fast ISI or specific arousing stimuli directly influence prepotent response inhibition. The meta-analysis indicated that ISI was not a relevant moderator. The qualitative review showed that ISI and “stimulus-type” had the same effect for both groups. Although all studies regarding ISI indicated that fast ISI worsened performance, different types of stimuli had either a positive or a negative influence. This could suggest that distinctive stimuli might affect arousal differently. While we replicated the inhibition difficulties in people with ASD (g = .51), our results do not show strong ASD-specific effects of ISI or “stimulus-type” on inhibition. Nonetheless, ISI and “stimulus-type” do seem to influence performance. Future research focusing on potential underlying factors (e.g., baseline physiological arousal) is needed to examine why this is the case. En ligne : http://dx.doi.org/10.1002/aur.1631 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=297 [article] The role of interstimulus interval and “Stimulus-type” in prepotent response inhibition abilities in people with ASD: A quantitative and qualitative review [Texte imprimé et/ou numérique] / Marieke W. M. KUIPER, Auteur ; Elisabeth W. M. VERHOEVEN, Auteur ; Hilde M. GEURTS, Auteur . - p.1124-1141. Langues : Anglais (eng) in Autism Research > 9-11 (November 2016) . - p.1124-1141 Mots-clés : autism spectrum disorders  autism  prepotent response inhibition  interstimulus interval  cognitive control  meta-analysis Index. décimale : PER Périodiques Résumé : Autism spectrum disorders (ASD) are associated with prepotent response inhibition difficulties. However, the large variation between studies suggests that understudied factors, such as interstimulus interval (ISI) and “stimulus-type” (both hypothesized proxies of stressors influencing arousal), might influence the inhibitory abilities of people with ASD. Using meta-analysis, we tested whether differences in prepotent response inhibition between people with and without ASD was influenced by ISI. There was not enough variation in “stimulus-type” between the studies to include it as a moderator. Thirty-seven studies met inclusion criteria, with a combined sample size of 950 people with ASD and 966 typically developing controls. Additionally, a qualitative review including studies comparing a neutral and an arousing condition in one experiment was performed to examine whether fast ISI or specific arousing stimuli directly influence prepotent response inhibition. The meta-analysis indicated that ISI was not a relevant moderator. The qualitative review showed that ISI and “stimulus-type” had the same effect for both groups. Although all studies regarding ISI indicated that fast ISI worsened performance, different types of stimuli had either a positive or a negative influence. This could suggest that distinctive stimuli might affect arousal differently. While we replicated the inhibition difficulties in people with ASD (g = .51), our results do not show strong ASD-specific effects of ISI or “stimulus-type” on inhibition. Nonetheless, ISI and “stimulus-type” do seem to influence performance. Future research focusing on potential underlying factors (e.g., baseline physiological arousal) is needed to examine why this is the case. En ligne : http://dx.doi.org/10.1002/aur.1631 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=297

Dopaminergic variants in siblings at high risk for autism: Associations with initiating joint attention / Devon N. GANGI in Autism Research, 9-11 (November 2016)  

Public ISBD [article]  inAutism Research > 9-11 (November 2016) . - p.1142-1150 Titre : Dopaminergic variants in siblings at high risk for autism: Associations with initiating joint attention Type de document : Texte imprimé et/ou numérique Auteurs : Devon N. GANGI, Auteur ; Daniel S. MESSINGER, Auteur ; Eden R. MARTIN, Auteur ; Michael L. CUCCARO, Auteur Article en page(s) : p.1142-1150 Langues : Anglais (eng) Mots-clés : high-risk siblings  initiating joint attention  dopamine  differential susceptibility  autism spectrum disorder Index. décimale : PER Périodiques Résumé : Younger siblings of children with autism spectrum disorder (ASD; high-risk siblings) exhibit lower levels of initiating joint attention (IJA; sharing an object or experience with a social partner through gaze and/or gesture) than low-risk siblings of children without ASD. However, high-risk siblings also exhibit substantial variability in this domain. The neurotransmitter dopamine is linked to brain areas associated with reward, motivation, and attention, and common dopaminergic variants have been associated with attention difficulties. We examined whether these common dopaminergic variants, DRD4 and DRD2, explain variability in IJA in high-risk (n?=?55) and low-risk (n?=?38) siblings. IJA was assessed in the first year during a semi-structured interaction with an examiner. DRD4 and DRD2 genotypes were coded according to associated dopaminergic functioning to create a gene score, with higher scores indicating more genotypes associated with less efficient dopaminergic functioning. Higher dopamine gene scores (indicative of less efficient dopaminergic functioning) were associated with lower levels of IJA in the first year for high-risk siblings, while the opposite pattern emerged in low-risk siblings. Findings suggest differential susceptibility—IJA was differentially associated with dopaminergic functioning depending on familial ASD risk. Understanding genes linked to ASD-relevant behaviors in high-risk siblings will aid in early identification of children at greatest risk for difficulties in these behavioral domains, facilitating targeted prevention and intervention. En ligne : http://dx.doi.org/10.1002/aur.1623 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=297 [article] Dopaminergic variants in siblings at high risk for autism: Associations with initiating joint attention [Texte imprimé et/ou numérique] / Devon N. GANGI, Auteur ; Daniel S. MESSINGER, Auteur ; Eden R. MARTIN, Auteur ; Michael L. CUCCARO, Auteur . - p.1142-1150. Langues : Anglais (eng) in Autism Research > 9-11 (November 2016) . - p.1142-1150 Mots-clés : high-risk siblings  initiating joint attention  dopamine  differential susceptibility  autism spectrum disorder Index. décimale : PER Périodiques Résumé : Younger siblings of children with autism spectrum disorder (ASD; high-risk siblings) exhibit lower levels of initiating joint attention (IJA; sharing an object or experience with a social partner through gaze and/or gesture) than low-risk siblings of children without ASD. However, high-risk siblings also exhibit substantial variability in this domain. The neurotransmitter dopamine is linked to brain areas associated with reward, motivation, and attention, and common dopaminergic variants have been associated with attention difficulties. We examined whether these common dopaminergic variants, DRD4 and DRD2, explain variability in IJA in high-risk (n?=?55) and low-risk (n?=?38) siblings. IJA was assessed in the first year during a semi-structured interaction with an examiner. DRD4 and DRD2 genotypes were coded according to associated dopaminergic functioning to create a gene score, with higher scores indicating more genotypes associated with less efficient dopaminergic functioning. Higher dopamine gene scores (indicative of less efficient dopaminergic functioning) were associated with lower levels of IJA in the first year for high-risk siblings, while the opposite pattern emerged in low-risk siblings. Findings suggest differential susceptibility—IJA was differentially associated with dopaminergic functioning depending on familial ASD risk. Understanding genes linked to ASD-relevant behaviors in high-risk siblings will aid in early identification of children at greatest risk for difficulties in these behavioral domains, facilitating targeted prevention and intervention. En ligne : http://dx.doi.org/10.1002/aur.1623 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=297

Maternal serotonin transporter genotype affects risk for ASD with exposure to prenatal stress / Patrick M. HECHT in Autism Research, 9-11 (November 2016)  

Public ISBD [article]  inAutism Research > 9-11 (November 2016) . - p.1151-1160 Titre : Maternal serotonin transporter genotype affects risk for ASD with exposure to prenatal stress Type de document : Texte imprimé et/ou numérique Auteurs : Patrick M. HECHT, Auteur ; Melissa HUDSON, Auteur ; Susan L. CONNORS, Auteur ; Michael R. TILLEY, Auteur ; Xudong LIU, Auteur ; David Q. BEVERSDORF, Auteur Article en page(s) : p.1151-1160 Langues : Anglais (eng) Mots-clés : autism spectrum disorders  serotonin  stress  prenatal stress  development  environmental influences Index. décimale : PER Périodiques Résumé : Stress exposure during gestation is implicated in several neuropsychiatric conditions, including autism spectrum disorder (ASD). Previous research showed that prenatal stress increases risk for ASD with peak exposure during the end of the second and the beginning of the third trimester. However, exposures to prenatal stress do not always result in ASD, suggesting that other factors may interact with environmental stressors to increase ASD risk. The present study examined a maternal genetic variation in the promoter region of the serotonin transporter gene (5-HTTLPR) affecting stress tolerance and its interaction with the effect of environmental stressors on risk for ASD. Two independent cohorts of mothers of ASD children recruited by the University of Missouri and Queen's University were surveyed regarding the prenatal environment and genotyping on 5-HTTLPR was performed to explore this relationship. In both samples, mothers of children with ASD carrying the stress susceptible short allele variant of 5-HTTLPR experienced a greater number of stressors and greater stress severity when compared to mothers carrying the long allele variant. The temporal peak of stressors during gestation in these mothers was consistent with previous findings. Additionally, increased exposure to prenatal stress was not reported in the pregnancies of typically developing siblings from the same mothers, regardless of maternal genotype, suggesting against the possibility that the short allele might increase the recall of stress during pregnancy. The present study provides further evidence of a specific maternal polymorphism that may affect the risk for ASD with exposure to prenatal stress. En ligne : http://dx.doi.org/10.1002/aur.1629 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=297 [article] Maternal serotonin transporter genotype affects risk for ASD with exposure to prenatal stress [Texte imprimé et/ou numérique] / Patrick M. HECHT, Auteur ; Melissa HUDSON, Auteur ; Susan L. CONNORS, Auteur ; Michael R. TILLEY, Auteur ; Xudong LIU, Auteur ; David Q. BEVERSDORF, Auteur . - p.1151-1160. Langues : Anglais (eng) in Autism Research > 9-11 (November 2016) . - p.1151-1160 Mots-clés : autism spectrum disorders  serotonin  stress  prenatal stress  development  environmental influences Index. décimale : PER Périodiques Résumé : Stress exposure during gestation is implicated in several neuropsychiatric conditions, including autism spectrum disorder (ASD). Previous research showed that prenatal stress increases risk for ASD with peak exposure during the end of the second and the beginning of the third trimester. However, exposures to prenatal stress do not always result in ASD, suggesting that other factors may interact with environmental stressors to increase ASD risk. The present study examined a maternal genetic variation in the promoter region of the serotonin transporter gene (5-HTTLPR) affecting stress tolerance and its interaction with the effect of environmental stressors on risk for ASD. Two independent cohorts of mothers of ASD children recruited by the University of Missouri and Queen's University were surveyed regarding the prenatal environment and genotyping on 5-HTTLPR was performed to explore this relationship. In both samples, mothers of children with ASD carrying the stress susceptible short allele variant of 5-HTTLPR experienced a greater number of stressors and greater stress severity when compared to mothers carrying the long allele variant. The temporal peak of stressors during gestation in these mothers was consistent with previous findings. Additionally, increased exposure to prenatal stress was not reported in the pregnancies of typically developing siblings from the same mothers, regardless of maternal genotype, suggesting against the possibility that the short allele might increase the recall of stress during pregnancy. The present study provides further evidence of a specific maternal polymorphism that may affect the risk for ASD with exposure to prenatal stress. En ligne : http://dx.doi.org/10.1002/aur.1629 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=297

Glutamate receptor, metabotropic 7 (GRM7) gene variations and susceptibility to autism: A case–control study / Rezvan NOROOZI in Autism Research, 9-11 (November 2016)  

Public ISBD [article]  inAutism Research > 9-11 (November 2016) . - p.1161-1168 Titre : Glutamate receptor, metabotropic 7 (GRM7) gene variations and susceptibility to autism: A case–control study Type de document : Texte imprimé et/ou numérique Auteurs : Rezvan NOROOZI, Auteur ; Mohammad TAHERI, Auteur ; Abolfazl MOVAFAGH, Auteur ; Reza MIRFAKHRAIE, Auteur ; Ghasem SOLGI, Auteur ; Arezou SAYAD, Auteur ; Mehrdokht MAZDEH, Auteur ; Hossein DARVISH, Auteur Article en page(s) : p.1161-1168 Langues : Anglais (eng) Mots-clés : autism spectrum disorders  metabotropic glutamate receptor  glutamatergic  polymorphism  GRM7 Index. décimale : PER Périodiques Résumé : Autism spectrum disorder (ASD) as a synaptopathy is revealed to be pertained to aberrant glutamatergic neurotransmission. Glutamate receptor, metabotropic 7 (GRM7), a receptor coding gene of this pathway, is a new candidate gene for autism. The aim of this study was to examine if there is a relationship between genetic variants rs779867 and rs6782011 of GRM7 with ASD. The present research was designed as a population-based, case–control study including 518 ASD patients versus 472 control individuals. The results showed that the frequency of rs779867 G/G genotype was significantly higher in ASD patients compared to healthy controls (P?=?0.0001). Also, the G allele of this SNP was found to be significantly more frequent in the patients than control group (P?=?0.0001). Haplotype analysis exhibited significant association of two estimated block of rs6782011/rs779867 in ASD patients versus control group. We found higher significant frequency of GT haplotype and lower frequencies of AT and AC haplotypes in the patients group compared to healthy controls (P?=?0.001, P?=?0.006, and P?=?0.05, respectively). Our study indicated that the rs779867 polymorphism is associated with ASD; thus, results of this study provide supportive evidence of association of the GRM7 gene with ASD. En ligne : http://dx.doi.org/10.1002/aur.1640 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=297 [article] Glutamate receptor, metabotropic 7 (GRM7) gene variations and susceptibility to autism: A case–control study [Texte imprimé et/ou numérique] / Rezvan NOROOZI, Auteur ; Mohammad TAHERI, Auteur ; Abolfazl MOVAFAGH, Auteur ; Reza MIRFAKHRAIE, Auteur ; Ghasem SOLGI, Auteur ; Arezou SAYAD, Auteur ; Mehrdokht MAZDEH, Auteur ; Hossein DARVISH, Auteur . - p.1161-1168. Langues : Anglais (eng) in Autism Research > 9-11 (November 2016) . - p.1161-1168 Mots-clés : autism spectrum disorders  metabotropic glutamate receptor  glutamatergic  polymorphism  GRM7 Index. décimale : PER Périodiques Résumé : Autism spectrum disorder (ASD) as a synaptopathy is revealed to be pertained to aberrant glutamatergic neurotransmission. Glutamate receptor, metabotropic 7 (GRM7), a receptor coding gene of this pathway, is a new candidate gene for autism. The aim of this study was to examine if there is a relationship between genetic variants rs779867 and rs6782011 of GRM7 with ASD. The present research was designed as a population-based, case–control study including 518 ASD patients versus 472 control individuals. The results showed that the frequency of rs779867 G/G genotype was significantly higher in ASD patients compared to healthy controls (P?=?0.0001). Also, the G allele of this SNP was found to be significantly more frequent in the patients than control group (P?=?0.0001). Haplotype analysis exhibited significant association of two estimated block of rs6782011/rs779867 in ASD patients versus control group. We found higher significant frequency of GT haplotype and lower frequencies of AT and AC haplotypes in the patients group compared to healthy controls (P?=?0.001, P?=?0.006, and P?=?0.05, respectively). Our study indicated that the rs779867 polymorphism is associated with ASD; thus, results of this study provide supportive evidence of association of the GRM7 gene with ASD. En ligne : http://dx.doi.org/10.1002/aur.1640 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=297

Persistence of megalencephaly in a subgroup of young boys with autism spectrum disorder / Lauren E. LIBERO in Autism Research, 9-11 (November 2016)  

Public ISBD [article]  inAutism Research > 9-11 (November 2016) . - p.1169-1182 Titre : Persistence of megalencephaly in a subgroup of young boys with autism spectrum disorder Type de document : Texte imprimé et/ou numérique Auteurs : Lauren E. LIBERO, Auteur ; Christine W. NORDAHL, Auteur ; Deana D. LI, Auteur ; Emilio FERRER, Auteur ; Sally J ROGERS, Auteur ; David G. AMARAL, Auteur Article en page(s) : p.1169-1182 Langues : Anglais (eng) Mots-clés : autism spectrum disorder  MRI  longitudinal  brain development  disproportionate megalencephaly Index. décimale : PER Périodiques Résumé : A recurring finding in autism spectrum disorder research is that head and brain growth is disproportionate to body growth in early childhood. Nordahl et al. (2011) demonstrated that this occurs in approximately 15% of boys with autism. While the literature suggests that brain growth normalizes at older ages, this has never been evaluated in a longitudinal study. The current study evaluated head circumference and total cerebral volume in 129 male children with autism and 49 age-matched, typically developing controls. We determined whether 3-year-old boys with brain size disproportionate to height (which we call disproportionate megalencephaly) demonstrated an abnormal trajectory of head growth from birth and whether they maintained an enlarged brain at 5 years of age. Findings were based on longitudinal, structural MRI data collected around 3, 4, and 5 years of age and head circumference data from medical records. At 3 years of age, 19 boys with autism had enlarged brains while 110 had brain sizes in the normal range. Boys with disproportionate megalencephaly had greater total cerebral, gray matter, and white matter volumes from 3–5 years compared to boys with autism and normal sized brains and typically developing boys, but no differences in body size. While head circumference did not differ between groups at birth, it was significantly greater in the disproportionate megalencephaly group by around 2 years. These data suggest that there is a subgroup of boys with autism who have brains disproportionate to body size and that this continues until at least 5 years of age. En ligne : http://dx.doi.org/10.1002/aur.1643 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=297 [article] Persistence of megalencephaly in a subgroup of young boys with autism spectrum disorder [Texte imprimé et/ou numérique] / Lauren E. LIBERO, Auteur ; Christine W. NORDAHL, Auteur ; Deana D. LI, Auteur ; Emilio FERRER, Auteur ; Sally J ROGERS, Auteur ; David G. AMARAL, Auteur . - p.1169-1182. Langues : Anglais (eng) in Autism Research > 9-11 (November 2016) . - p.1169-1182 Mots-clés : autism spectrum disorder  MRI  longitudinal  brain development  disproportionate megalencephaly Index. décimale : PER Périodiques Résumé : A recurring finding in autism spectrum disorder research is that head and brain growth is disproportionate to body growth in early childhood. Nordahl et al. (2011) demonstrated that this occurs in approximately 15% of boys with autism. While the literature suggests that brain growth normalizes at older ages, this has never been evaluated in a longitudinal study. The current study evaluated head circumference and total cerebral volume in 129 male children with autism and 49 age-matched, typically developing controls. We determined whether 3-year-old boys with brain size disproportionate to height (which we call disproportionate megalencephaly) demonstrated an abnormal trajectory of head growth from birth and whether they maintained an enlarged brain at 5 years of age. Findings were based on longitudinal, structural MRI data collected around 3, 4, and 5 years of age and head circumference data from medical records. At 3 years of age, 19 boys with autism had enlarged brains while 110 had brain sizes in the normal range. Boys with disproportionate megalencephaly had greater total cerebral, gray matter, and white matter volumes from 3–5 years compared to boys with autism and normal sized brains and typically developing boys, but no differences in body size. While head circumference did not differ between groups at birth, it was significantly greater in the disproportionate megalencephaly group by around 2 years. These data suggest that there is a subgroup of boys with autism who have brains disproportionate to body size and that this continues until at least 5 years of age. En ligne : http://dx.doi.org/10.1002/aur.1643 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=297

Atypical effective connectivity of thalamo-cortical circuits in autism spectrum disorder / Heng CHEN in Autism Research, 9-11 (November 2016)  

Public ISBD [article]  inAutism Research > 9-11 (November 2016) . - p.1183-1190 Titre : Atypical effective connectivity of thalamo-cortical circuits in autism spectrum disorder Type de document : Texte imprimé et/ou numérique Auteurs : Heng CHEN, Auteur ; Lucina Q. UDDIN, Auteur ; Youxue ZHANG, Auteur ; Xujun DUAN, Auteur ; Huafu CHEN, Auteur Article en page(s) : p.1183-1190 Langues : Anglais (eng) Mots-clés : autism spectrum disorder  thalamus  brain development  granger causality analysis Index. décimale : PER Périodiques Résumé : Autism spectrum disorder (ASD) is a neurodevelopment disorder characterized by atypical connectivity within and across multiple brain systems. We aimed to explore information transmission from the sensory periphery to information processing centers of the brain across thalamo-cortical circuits in ASD. A large multicenter dataset from the autism brain imaging data exchange was utilized. A thalamus template derived from the Automatic Anatomic Labeling atlas was subdivided into six subregions corresponding to six cortical regions using a “winner-takes-all” strategy. Granger causality analysis (GCA) was then applied to calculate effective connectivity from subregions of the thalamus to the corresponding cortical regions. Results demonstrate reduced effective connectivity from the thalamus to left prefrontal cortex (P?=?0.023), right posterior parietal cortex (P?=?0.03), and bilateral temporal cortex (left: P?=?0.014; right: P?=?0.015) in ASD compared with healthy control (HC) participants. The GCA values of the thalamus-bilateral temporal cortex connections were significantly negatively correlated with communication scores as assessed by the autism diagnostic observation schedule in the ASD group (left: P?=?0.037; right: P?=?0.007). Age-related analyses showed that the strengths of the thalamus-bilateral temporal cortex connections were significantly positively correlated with age in the HC group (left: P?=?0.013; right: P?=?0.016), but not in the ASD group (left: P?=?0.506; right: P?=?0.219). These results demonstrate impaired thalamo-cortical information transmission in ASD and suggest that atypical development of thalamus-temporal cortex connections may relate to communication deficits in the disorder. En ligne : http://dx.doi.org/10.1002/aur.1614 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=297 [article] Atypical effective connectivity of thalamo-cortical circuits in autism spectrum disorder [Texte imprimé et/ou numérique] / Heng CHEN, Auteur ; Lucina Q. UDDIN, Auteur ; Youxue ZHANG, Auteur ; Xujun DUAN, Auteur ; Huafu CHEN, Auteur . - p.1183-1190. Langues : Anglais (eng) in Autism Research > 9-11 (November 2016) . - p.1183-1190 Mots-clés : autism spectrum disorder  thalamus  brain development  granger causality analysis Index. décimale : PER Périodiques Résumé : Autism spectrum disorder (ASD) is a neurodevelopment disorder characterized by atypical connectivity within and across multiple brain systems. We aimed to explore information transmission from the sensory periphery to information processing centers of the brain across thalamo-cortical circuits in ASD. A large multicenter dataset from the autism brain imaging data exchange was utilized. A thalamus template derived from the Automatic Anatomic Labeling atlas was subdivided into six subregions corresponding to six cortical regions using a “winner-takes-all” strategy. Granger causality analysis (GCA) was then applied to calculate effective connectivity from subregions of the thalamus to the corresponding cortical regions. Results demonstrate reduced effective connectivity from the thalamus to left prefrontal cortex (P?=?0.023), right posterior parietal cortex (P?=?0.03), and bilateral temporal cortex (left: P?=?0.014; right: P?=?0.015) in ASD compared with healthy control (HC) participants. The GCA values of the thalamus-bilateral temporal cortex connections were significantly negatively correlated with communication scores as assessed by the autism diagnostic observation schedule in the ASD group (left: P?=?0.037; right: P?=?0.007). Age-related analyses showed that the strengths of the thalamus-bilateral temporal cortex connections were significantly positively correlated with age in the HC group (left: P?=?0.013; right: P?=?0.016), but not in the ASD group (left: P?=?0.506; right: P?=?0.219). These results demonstrate impaired thalamo-cortical information transmission in ASD and suggest that atypical development of thalamus-temporal cortex connections may relate to communication deficits in the disorder. En ligne : http://dx.doi.org/10.1002/aur.1614 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=297

Cerebellar gray matter differentiates children with early language delay in autism / Anila M. D'MELLO in Autism Research, 9-11 (November 2016)  

Public ISBD [article]  inAutism Research > 9-11 (November 2016) . - p.1191-1204 Titre : Cerebellar gray matter differentiates children with early language delay in autism Type de document : Texte imprimé et/ou numérique Auteurs : Anila M. D'MELLO, Auteur ; Dorothea M. MOORE, Auteur ; Deana CROCETTI, Auteur ; Stewart H. MOSTOFSKY, Auteur ; Catherine J. STOODLEY, Auteur Article en page(s) : p.1191-1204 Langues : Anglais (eng) Mots-clés : autism  cerebellum  early language delay  voxel-based morphometry  ADOS  imaging Index. décimale : PER Périodiques Résumé : Early language delay (ELD) is one of the earliest indicators of autism spectrum disorder (ASD), and predicts later cognitive and behavioral outcomes. We aimed to determine the neural correlates of ELD in autism, and examine the relationships between gray matter (GM), age of first word/phrase, and core ASD symptoms. We used voxel-based morphometry to examine whole-brain differences in GM in 8–13 year old children with autism (n?=?13 ELD; n?=?22 non-ELD) and 35 age-matched typically developing (TD) children. Multiple regression analyses examined the relationships between GM, age of first word/phrase, and autism diagnostic observation schedule (ADOS) scores. Composite age of first word/phrase negatively correlated with GM throughout the cerebellum. Both ASD groups (ELD and non-ELD) had reduced GM in right cerebellar Crus I/II when compared to TD children. Left cerebellar Crus I/II was the only region in the brain that differentiated ELD and non-ELD children, with ELD children showing reduced GM relative to both non-ELD and TD groups. Group×score interactions converged in left Crus I/II, such that the non-ELD group showed poorer ADOS scores with increasing GM, whereas the ELD group showed poorer ADOS scores as GM decreased. Reduced GM in right cerebellar Crus I/I was related ASD diagnosis, while children with ELD showed additional reduced GM in left Crus I/II. These findings highlight the importance of specific cerebellar networks in both ASD and early language development, and suggest that bilateral disruption in cerebellar regions that interconnect with fronto-parietal networks could impact language acquisition in ASD. En ligne : http://dx.doi.org/10.1002/aur.1622 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=297 [article] Cerebellar gray matter differentiates children with early language delay in autism [Texte imprimé et/ou numérique] / Anila M. D'MELLO, Auteur ; Dorothea M. MOORE, Auteur ; Deana CROCETTI, Auteur ; Stewart H. MOSTOFSKY, Auteur ; Catherine J. STOODLEY, Auteur . - p.1191-1204. Langues : Anglais (eng) in Autism Research > 9-11 (November 2016) . - p.1191-1204 Mots-clés : autism  cerebellum  early language delay  voxel-based morphometry  ADOS  imaging Index. décimale : PER Périodiques Résumé : Early language delay (ELD) is one of the earliest indicators of autism spectrum disorder (ASD), and predicts later cognitive and behavioral outcomes. We aimed to determine the neural correlates of ELD in autism, and examine the relationships between gray matter (GM), age of first word/phrase, and core ASD symptoms. We used voxel-based morphometry to examine whole-brain differences in GM in 8–13 year old children with autism (n?=?13 ELD; n?=?22 non-ELD) and 35 age-matched typically developing (TD) children. Multiple regression analyses examined the relationships between GM, age of first word/phrase, and autism diagnostic observation schedule (ADOS) scores. Composite age of first word/phrase negatively correlated with GM throughout the cerebellum. Both ASD groups (ELD and non-ELD) had reduced GM in right cerebellar Crus I/II when compared to TD children. Left cerebellar Crus I/II was the only region in the brain that differentiated ELD and non-ELD children, with ELD children showing reduced GM relative to both non-ELD and TD groups. Group×score interactions converged in left Crus I/II, such that the non-ELD group showed poorer ADOS scores with increasing GM, whereas the ELD group showed poorer ADOS scores as GM decreased. Reduced GM in right cerebellar Crus I/I was related ASD diagnosis, while children with ELD showed additional reduced GM in left Crus I/II. These findings highlight the importance of specific cerebellar networks in both ASD and early language development, and suggest that bilateral disruption in cerebellar regions that interconnect with fronto-parietal networks could impact language acquisition in ASD. En ligne : http://dx.doi.org/10.1002/aur.1622 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=297

Development of the anxiety scale for children with autism spectrum disorder (ASC-ASD) / Jacqui RODGERS in Autism Research, 9-11 (November 2016)  

Public ISBD [article]  inAutism Research > 9-11 (November 2016) . - p.1205-1215 Titre : Development of the anxiety scale for children with autism spectrum disorder (ASC-ASD) Type de document : Texte imprimé et/ou numérique Auteurs : Jacqui RODGERS, Auteur ; Sarah WIGHAM, Auteur ; Helen MCCONACHIE, Auteur ; Mark FREESTON, Auteur ; Emma HONEY, Auteur ; Jeremy R. PARR, Auteur Article en page(s) : p.1205-1215 Langues : Anglais (eng) Mots-clés : anxiety  measurement  child report  parent report  clinical psychology Index. décimale : PER Périodiques Résumé : Many children with autism spectrum disorder (ASD) experience high levels of anxiety. A widely used measure for typically developing children is the Revised Child Anxiety and Depression Scale (RCADS). However, such anxiety measures may require adaptation to accommodate characteristics of those with ASD. An adapted version of the RCADS was created based on empirical evidence of anxiety phenomenology in ASD, which included additional items related to sensory anxiety, intolerance of uncertainty, and phobias. Content validity was refined during focus groups with parents. Polychoric factor analysis was undertaken on data from 170 children with ASD, aged 8-16, and their parents. This process resulted in the creation of a new 24 item scale (self and parent report) each with four subscales: Performance Anxiety, Uncertainty, Anxious Arousal, and Separation Anxiety, with evidence of good reliability and validity. The freely available Anxiety Scale for Children - ASD, Parent and Child versions (ASC-ASD) has promising psychometric properties including good internal consistency, validity, and 1 month test–retest reliability. En ligne : http://dx.doi.org/10.1002/aur.1603 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=297 [article] Development of the anxiety scale for children with autism spectrum disorder (ASC-ASD) [Texte imprimé et/ou numérique] / Jacqui RODGERS, Auteur ; Sarah WIGHAM, Auteur ; Helen MCCONACHIE, Auteur ; Mark FREESTON, Auteur ; Emma HONEY, Auteur ; Jeremy R. PARR, Auteur . - p.1205-1215. Langues : Anglais (eng) in Autism Research > 9-11 (November 2016) . - p.1205-1215 Mots-clés : anxiety  measurement  child report  parent report  clinical psychology Index. décimale : PER Périodiques Résumé : Many children with autism spectrum disorder (ASD) experience high levels of anxiety. A widely used measure for typically developing children is the Revised Child Anxiety and Depression Scale (RCADS). However, such anxiety measures may require adaptation to accommodate characteristics of those with ASD. An adapted version of the RCADS was created based on empirical evidence of anxiety phenomenology in ASD, which included additional items related to sensory anxiety, intolerance of uncertainty, and phobias. Content validity was refined during focus groups with parents. Polychoric factor analysis was undertaken on data from 170 children with ASD, aged 8-16, and their parents. This process resulted in the creation of a new 24 item scale (self and parent report) each with four subscales: Performance Anxiety, Uncertainty, Anxious Arousal, and Separation Anxiety, with evidence of good reliability and validity. The freely available Anxiety Scale for Children - ASD, Parent and Child versions (ASC-ASD) has promising psychometric properties including good internal consistency, validity, and 1 month test–retest reliability. En ligne : http://dx.doi.org/10.1002/aur.1603 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=297

Atypical development of the central auditory system in young children with Autism spectrum disorder / Yuko YOSHIMURA in Autism Research, 9-11 (November 2016)  

Public ISBD [article]  inAutism Research > 9-11 (November 2016) . - p.1216-1226 Titre : Atypical development of the central auditory system in young children with Autism spectrum disorder Type de document : Texte imprimé et/ou numérique Auteurs : Yuko YOSHIMURA, Auteur ; Mitsuru KIKUCHI, Auteur ; Hirotoshi HIRAISHI, Auteur ; Chiaki HASEGAWA, Auteur ; Tetsuya TAKAHASHI, Auteur ; Gerard B. REMIJN, Auteur ; Manabu OI, Auteur ; Toshio MUNESUE, Auteur ; Haruhiro HIGASHIDA, Auteur ; Yoshio MINABE, Auteur ; Haruyuki KOJIMA, Auteur Article en page(s) : p.1216-1226 Langues : Anglais (eng) Mots-clés : autism spectrum disorder  magnetoencephalography  P1m  young children Index. décimale : PER Périodiques Résumé : The P1m component of the auditory evoked magnetic field is the earliest cortical response associated with language acquisition. However, the growth curve of the P1m component is unknown in both typically developing (TD) and atypically developing children. The aim of this study is to clarify the developmental pattern of this component when evoked by binaural human voice stimulation using child-customized magnetoencephalography. A total of 35 young TD children (32–121 months of age) and 35 children with autism spectrum disorder (ASD) (38–111 months of age) participated in this study. This is the first report to demonstrate an inverted U-shaped growth curve for the P1m dipole intensity in the left hemisphere in TD children. In addition, our results revealed a more diversified age-related distribution of auditory brain responses in 3- to 9-year-old children with ASD. These results demonstrate the diversified growth curve of the P1m component in ASD during young childhood, which is a crucial period for first language acquisition. En ligne : http://dx.doi.org/10.1002/aur.1604 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=297 [article] Atypical development of the central auditory system in young children with Autism spectrum disorder [Texte imprimé et/ou numérique] / Yuko YOSHIMURA, Auteur ; Mitsuru KIKUCHI, Auteur ; Hirotoshi HIRAISHI, Auteur ; Chiaki HASEGAWA, Auteur ; Tetsuya TAKAHASHI, Auteur ; Gerard B. REMIJN, Auteur ; Manabu OI, Auteur ; Toshio MUNESUE, Auteur ; Haruhiro HIGASHIDA, Auteur ; Yoshio MINABE, Auteur ; Haruyuki KOJIMA, Auteur . - p.1216-1226. Langues : Anglais (eng) in Autism Research > 9-11 (November 2016) . - p.1216-1226 Mots-clés : autism spectrum disorder  magnetoencephalography  P1m  young children Index. décimale : PER Périodiques Résumé : The P1m component of the auditory evoked magnetic field is the earliest cortical response associated with language acquisition. However, the growth curve of the P1m component is unknown in both typically developing (TD) and atypically developing children. The aim of this study is to clarify the developmental pattern of this component when evoked by binaural human voice stimulation using child-customized magnetoencephalography. A total of 35 young TD children (32–121 months of age) and 35 children with autism spectrum disorder (ASD) (38–111 months of age) participated in this study. This is the first report to demonstrate an inverted U-shaped growth curve for the P1m dipole intensity in the left hemisphere in TD children. In addition, our results revealed a more diversified age-related distribution of auditory brain responses in 3- to 9-year-old children with ASD. These results demonstrate the diversified growth curve of the P1m component in ASD during young childhood, which is a crucial period for first language acquisition. En ligne : http://dx.doi.org/10.1002/aur.1604 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=297

Scientific Summaries for Families with ASD in Autism Research, 9-11 (November 2016)  

Public ISBD [article]  inAutism Research > 9-11 (November 2016) . - p.1227-1230 Titre : Scientific Summaries for Families with ASD Type de document : Texte imprimé et/ou numérique Article en page(s) : p.1227-1230 Langues : Anglais (eng) Index. décimale : PER Périodiques En ligne : http://dx.doi.org/10.1002/aur.1728 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=297 [article] Scientific Summaries for Families with ASD [Texte imprimé et/ou numérique] . - p.1227-1230. Langues : Anglais (eng) in Autism Research > 9-11 (November 2016) . - p.1227-1230 Index. décimale : PER Périodiques En ligne : http://dx.doi.org/10.1002/aur.1728 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=297

International society for autism research news www.autism-insar.org in Autism Research, 9-11 (November 2016)  

Public ISBD [article]  inAutism Research > 9-11 (November 2016) . - p.1231-1231 Titre : International society for autism research news www.autism-insar.org Type de document : Texte imprimé et/ou numérique Article en page(s) : p.1231-1231 Langues : Anglais (eng) Index. décimale : PER Périodiques En ligne : http://dx.doi.org/10.1002/aur.1729 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=297 [article] International society for autism research news www.autism-insar.org [Texte imprimé et/ou numérique] . - p.1231-1231. Langues : Anglais (eng) in Autism Research > 9-11 (November 2016) . - p.1231-1231 Index. décimale : PER Périodiques En ligne : http://dx.doi.org/10.1002/aur.1729 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=297