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Détail de l'auteur
Auteur Ditza A. ZACHOR |
Documents disponibles écrits par cet auteur (22)
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Specific Neurological Phenotypes in Autism Spectrum Disorders Are Associated with Sex Representation / Esther BEN-ITZCHAK in Autism Research, 6-6 (December 2013)
[article]
Titre : Specific Neurological Phenotypes in Autism Spectrum Disorders Are Associated with Sex Representation Type de document : Texte imprimé et/ou numérique Auteurs : Esther BEN-ITZCHAK, Auteur ; Shay BEN-SHACHAR, Auteur ; Ditza A. ZACHOR, Auteur Année de publication : 2013 Article en page(s) : p.596-604 Langues : Anglais (eng) Mots-clés : autism spectrum disorder male:female ratio microcephaly macrocephaly developmental regression, minor neurological and musculoskeletal deficits, seizures Index. décimale : PER Périodiques Résumé : Autism spectrum disorder (ASD) is a heritable disorder occurring predominantly in males. The aim of this study was to compare sex differences in the prevalence of specific neurological phenotypes commonly described in ASD. The study included 663 participants, aged 18 months to 15 years, diagnosed with ASD. Neurological and behavioral assessments were performed using standardized tests, and obtaining medical, developmental, and familial histories from the parents. Phenotypes under investigation were macro- and microcephaly, developmental regression, minor neurological and musculoskeletal deficits (MNMD), and seizures. Male?:?female ratio in the ASD group was 6.7:1. No sex differences in autism severity, cognitive ability, and adaptive functioning were noted. Mean head circumference percentile for males (50.1?±?25.6) was significantly larger than females (43.4?±?30.2). Micro- and macrocephaly were more frequent in ASD than expected (5.9%; 18.1%, respectively). Microcephaly in females (15.1%) was significantly more prevalent than in males (4.5%). The prevalence of macrocephaly in both sexes did not differ significantly. Regression was noted in 30.2% of the females with ASD, significantly higher than in males (18.9%). MNMD was documented in 73.8% of the females, significantly higher than in males (57.1%). M:F ratio decreased in a group with two or more phenotypes (3.6:1), while male predominance was more significant in the group without phenotypes (13.6:1). Neurological phenotypes associated with ASD are more prevalent in females than in males, resulting in more complex clinical and neurological manifestations in females. Therefore, involvement of different etiologies is suggested in ASD in females. En ligne : http://dx.doi.org/10.1002/aur.1319 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=221
in Autism Research > 6-6 (December 2013) . - p.596-604[article] Specific Neurological Phenotypes in Autism Spectrum Disorders Are Associated with Sex Representation [Texte imprimé et/ou numérique] / Esther BEN-ITZCHAK, Auteur ; Shay BEN-SHACHAR, Auteur ; Ditza A. ZACHOR, Auteur . - 2013 . - p.596-604.
Langues : Anglais (eng)
in Autism Research > 6-6 (December 2013) . - p.596-604
Mots-clés : autism spectrum disorder male:female ratio microcephaly macrocephaly developmental regression, minor neurological and musculoskeletal deficits, seizures Index. décimale : PER Périodiques Résumé : Autism spectrum disorder (ASD) is a heritable disorder occurring predominantly in males. The aim of this study was to compare sex differences in the prevalence of specific neurological phenotypes commonly described in ASD. The study included 663 participants, aged 18 months to 15 years, diagnosed with ASD. Neurological and behavioral assessments were performed using standardized tests, and obtaining medical, developmental, and familial histories from the parents. Phenotypes under investigation were macro- and microcephaly, developmental regression, minor neurological and musculoskeletal deficits (MNMD), and seizures. Male?:?female ratio in the ASD group was 6.7:1. No sex differences in autism severity, cognitive ability, and adaptive functioning were noted. Mean head circumference percentile for males (50.1?±?25.6) was significantly larger than females (43.4?±?30.2). Micro- and macrocephaly were more frequent in ASD than expected (5.9%; 18.1%, respectively). Microcephaly in females (15.1%) was significantly more prevalent than in males (4.5%). The prevalence of macrocephaly in both sexes did not differ significantly. Regression was noted in 30.2% of the females with ASD, significantly higher than in males (18.9%). MNMD was documented in 73.8% of the females, significantly higher than in males (57.1%). M:F ratio decreased in a group with two or more phenotypes (3.6:1), while male predominance was more significant in the group without phenotypes (13.6:1). Neurological phenotypes associated with ASD are more prevalent in females than in males, resulting in more complex clinical and neurological manifestations in females. Therefore, involvement of different etiologies is suggested in ASD in females. En ligne : http://dx.doi.org/10.1002/aur.1319 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=221 The Relationship Between Clinical Presentation and Unusual Sensory Interests in Autism Spectrum Disorders: A Preliminary Investigation / Ditza A. ZACHOR in Journal of Autism and Developmental Disorders, 44-1 (January 2014)
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Titre : The Relationship Between Clinical Presentation and Unusual Sensory Interests in Autism Spectrum Disorders: A Preliminary Investigation Type de document : Texte imprimé et/ou numérique Auteurs : Ditza A. ZACHOR, Auteur ; Esther BEN-ITZCHAK, Auteur Article en page(s) : p.229-235 Langues : Anglais (eng) Mots-clés : Autism spectrum disorders Unusual sensory interests Negative sensory responses Autism severity Adaptive skills Cognitive ability Index. décimale : PER Périodiques Résumé : Unusual responses to sensory stimuli have been described in autism spectrum disorder (ASD).The study examined the frequencies of ‘unusual sensory interests’ and ‘negative sensory responses’ and their relation to functioning in a large ASD population (n = 679). Having ‘unusual sensory interests’ was reported in 70.4 % and ‘negative sensory responses’ in 66.0 % of the ASD group. Having ‘unusual sensory interests’ was associated with more severe reported and observed autism symptoms, lower cognitive ability and lower adaptive skills. In contrast, having ‘negative sensory responses’ was only associated with more severe reported stereotyped behaviors. It is suggested that having ‘unusual sensory interests’ is a part of a primary more severe type of ASD involving numerous developmental domains that might have a unique neurobiological origin. En ligne : http://dx.doi.org/10.1007/s10803-013-1867-y Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=220
in Journal of Autism and Developmental Disorders > 44-1 (January 2014) . - p.229-235[article] The Relationship Between Clinical Presentation and Unusual Sensory Interests in Autism Spectrum Disorders: A Preliminary Investigation [Texte imprimé et/ou numérique] / Ditza A. ZACHOR, Auteur ; Esther BEN-ITZCHAK, Auteur . - p.229-235.
Langues : Anglais (eng)
in Journal of Autism and Developmental Disorders > 44-1 (January 2014) . - p.229-235
Mots-clés : Autism spectrum disorders Unusual sensory interests Negative sensory responses Autism severity Adaptive skills Cognitive ability Index. décimale : PER Périodiques Résumé : Unusual responses to sensory stimuli have been described in autism spectrum disorder (ASD).The study examined the frequencies of ‘unusual sensory interests’ and ‘negative sensory responses’ and their relation to functioning in a large ASD population (n = 679). Having ‘unusual sensory interests’ was reported in 70.4 % and ‘negative sensory responses’ in 66.0 % of the ASD group. Having ‘unusual sensory interests’ was associated with more severe reported and observed autism symptoms, lower cognitive ability and lower adaptive skills. In contrast, having ‘negative sensory responses’ was only associated with more severe reported stereotyped behaviors. It is suggested that having ‘unusual sensory interests’ is a part of a primary more severe type of ASD involving numerous developmental domains that might have a unique neurobiological origin. En ligne : http://dx.doi.org/10.1007/s10803-013-1867-y Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=220 Toddlers to teenagers: Long-term follow-up study of outcomes in autism spectrum disorder / Esther BEN-ITZCHAK in Autism, 24-1 (January 2020)
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Titre : Toddlers to teenagers: Long-term follow-up study of outcomes in autism spectrum disorder Type de document : Texte imprimé et/ou numérique Auteurs : Esther BEN-ITZCHAK, Auteur ; Ditza A. ZACHOR, Auteur Article en page(s) : p.41-50 Langues : Anglais (eng) Mots-clés : adaptive behavior adolescents autism severity autism spectrum disorders cognitive ability long-term follow-up predictors toddlers Index. décimale : PER Périodiques Résumé : This prospective study examined the developmental changes over time of adolescents diagnosed in toddlerhood with autism spectrum disorder and searched for child characteristics at toddlerhood that predict outcome at adolescence. The study included 65 participants who were divided into low cognitive (developmental quotient < 85; N = 41) and high cognitive (developmental quotient 85; N = 21) groups in adolescence. Participants underwent a comprehensive assessment of cognitive ability, adaptive skills, and autism severity. Significant differences in the current clinical phenotypes and in developmental changes over time were found between the two cognitive groups. At baseline, the high cognitive group had significantly less severe social communication deficits. Only the high cognitive group showed a decrease in social communication deficits over time. Although the two groups did not differ in their adaptive skills at the time of diagnosis, the high cognitive group had better adaptive skills at adolescence. Better adaptive communication skills in toddlerhood were associated with better outcome at adolescence in cognitive ability, adaptive skills, and fewer autism symptoms. Less impaired baseline social affect and better cognitive ability predicted higher cognitive level and adaptive skills at adolescence. Cognitive potential of individuals with autism spectrum disorder plays an important role in long-term outcome and comprehensive evaluations at toddlerhood have strong prognostic value in adolescence. En ligne : http://dx.doi.org/10.1177/1362361319840226 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=414
in Autism > 24-1 (January 2020) . - p.41-50[article] Toddlers to teenagers: Long-term follow-up study of outcomes in autism spectrum disorder [Texte imprimé et/ou numérique] / Esther BEN-ITZCHAK, Auteur ; Ditza A. ZACHOR, Auteur . - p.41-50.
Langues : Anglais (eng)
in Autism > 24-1 (January 2020) . - p.41-50
Mots-clés : adaptive behavior adolescents autism severity autism spectrum disorders cognitive ability long-term follow-up predictors toddlers Index. décimale : PER Périodiques Résumé : This prospective study examined the developmental changes over time of adolescents diagnosed in toddlerhood with autism spectrum disorder and searched for child characteristics at toddlerhood that predict outcome at adolescence. The study included 65 participants who were divided into low cognitive (developmental quotient < 85; N = 41) and high cognitive (developmental quotient 85; N = 21) groups in adolescence. Participants underwent a comprehensive assessment of cognitive ability, adaptive skills, and autism severity. Significant differences in the current clinical phenotypes and in developmental changes over time were found between the two cognitive groups. At baseline, the high cognitive group had significantly less severe social communication deficits. Only the high cognitive group showed a decrease in social communication deficits over time. Although the two groups did not differ in their adaptive skills at the time of diagnosis, the high cognitive group had better adaptive skills at adolescence. Better adaptive communication skills in toddlerhood were associated with better outcome at adolescence in cognitive ability, adaptive skills, and fewer autism symptoms. Less impaired baseline social affect and better cognitive ability predicted higher cognitive level and adaptive skills at adolescence. Cognitive potential of individuals with autism spectrum disorder plays an important role in long-term outcome and comprehensive evaluations at toddlerhood have strong prognostic value in adolescence. En ligne : http://dx.doi.org/10.1177/1362361319840226 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=414 Treatment approach, autism severity and intervention outcomes in young children / Ditza A. ZACHOR in Research in Autism Spectrum Disorders, 4-3 (July-September 2010)
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Titre : Treatment approach, autism severity and intervention outcomes in young children Type de document : Texte imprimé et/ou numérique Auteurs : Ditza A. ZACHOR, Auteur ; Esther BEN-ITZCHAK, Auteur Année de publication : 2010 Article en page(s) : p.425-432 Langues : Anglais (eng) Mots-clés : Autism-spectrum-disorders Intervention Applied-behavioral-analysis Eclectic Autism-severity Index. décimale : PER Périodiques Résumé : The current study examined the relation between autism severity at baseline, type of intervention employed and outcomes in young children with autism spectrum disorder (ASD). Seventy-eight children with ASD, aged 15–35 months (M = 25.4, SD = 4.2), received either applied behavioral analysis (ABA) or integration of several intervention approaches (Eclectic) in community center-based programs. Outcome was measured after 1 year of intervention using standardized autism diagnostic tests, and cognitive and adaptive skills evaluations. ASD diagnosis was highly stable (99%). Both intervention groups improved significantly in verbal cognitive abilities and in socialization and communication adaptive skills, but no significant difference between the intervention groups was documented. Less severe autism symptoms at baseline were associated with better progress in adaptive skills and in cognitive abilities. Within the group with less severe autism symptoms, those who received Eclectic intervention had a better outcome than those who received ABA in communication and socialization adaptive skills as reported by the parents, but not in the standardized cognitive test results. The child's baseline social abilities and deficits appear to be crucial variables for intervention outcomes and should be considered in treatment approach decision-making. En ligne : http://dx.doi.org/10.1016/j.rasd.2009.10.013 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=100
in Research in Autism Spectrum Disorders > 4-3 (July-September 2010) . - p.425-432[article] Treatment approach, autism severity and intervention outcomes in young children [Texte imprimé et/ou numérique] / Ditza A. ZACHOR, Auteur ; Esther BEN-ITZCHAK, Auteur . - 2010 . - p.425-432.
Langues : Anglais (eng)
in Research in Autism Spectrum Disorders > 4-3 (July-September 2010) . - p.425-432
Mots-clés : Autism-spectrum-disorders Intervention Applied-behavioral-analysis Eclectic Autism-severity Index. décimale : PER Périodiques Résumé : The current study examined the relation between autism severity at baseline, type of intervention employed and outcomes in young children with autism spectrum disorder (ASD). Seventy-eight children with ASD, aged 15–35 months (M = 25.4, SD = 4.2), received either applied behavioral analysis (ABA) or integration of several intervention approaches (Eclectic) in community center-based programs. Outcome was measured after 1 year of intervention using standardized autism diagnostic tests, and cognitive and adaptive skills evaluations. ASD diagnosis was highly stable (99%). Both intervention groups improved significantly in verbal cognitive abilities and in socialization and communication adaptive skills, but no significant difference between the intervention groups was documented. Less severe autism symptoms at baseline were associated with better progress in adaptive skills and in cognitive abilities. Within the group with less severe autism symptoms, those who received Eclectic intervention had a better outcome than those who received ABA in communication and socialization adaptive skills as reported by the parents, but not in the standardized cognitive test results. The child's baseline social abilities and deficits appear to be crucial variables for intervention outcomes and should be considered in treatment approach decision-making. En ligne : http://dx.doi.org/10.1016/j.rasd.2009.10.013 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=100 Understanding One’s Own Emotions in Cognitively-Able Preadolescents with Autism Spectrum Disorder / Esther BEN-ITZCHAK in Journal of Autism and Developmental Disorders, 46-7 (July 2016)
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Titre : Understanding One’s Own Emotions in Cognitively-Able Preadolescents with Autism Spectrum Disorder Type de document : Texte imprimé et/ou numérique Auteurs : Esther BEN-ITZCHAK, Auteur ; Shira ABUTBUL, Auteur ; Hadas BELA, Auteur ; Tom SHAI, Auteur ; Ditza A. ZACHOR, Auteur Article en page(s) : p.2363-2371 Langues : Anglais (eng) Mots-clés : Autism spectrum disorder Understanding one’s own emotions Coherence Autism symptoms severity Index. décimale : PER Périodiques Résumé : There are still no straightforward answers as to whether understanding one’s own emotions is impaired in autism spectrum disorder (ASD). This study evaluated the perception of one’s own different emotions, based on the relevant section of the Autism Diagnostic Observation Schedule Module 3 test. Forty boys, aged 8–11 years, 20 diagnosed with ASD (IQ ? 85) and 20 typically developing children were included. Description of events that elicited specific emotions in ASD was characterized by more ‘odd’ statements and ‘no responses’ and less use of content related to ‘social situations’, ‘interpersonal’ and ‘self-awareness’. More ‘no responses’ and odd statements were associated with the severity of ASD symptoms. Clinicians should be aware of these differentiating factors during the diagnostic process of ASD. En ligne : http://dx.doi.org/10.1007/s10803-016-2769-6 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=290
in Journal of Autism and Developmental Disorders > 46-7 (July 2016) . - p.2363-2371[article] Understanding One’s Own Emotions in Cognitively-Able Preadolescents with Autism Spectrum Disorder [Texte imprimé et/ou numérique] / Esther BEN-ITZCHAK, Auteur ; Shira ABUTBUL, Auteur ; Hadas BELA, Auteur ; Tom SHAI, Auteur ; Ditza A. ZACHOR, Auteur . - p.2363-2371.
Langues : Anglais (eng)
in Journal of Autism and Developmental Disorders > 46-7 (July 2016) . - p.2363-2371
Mots-clés : Autism spectrum disorder Understanding one’s own emotions Coherence Autism symptoms severity Index. décimale : PER Périodiques Résumé : There are still no straightforward answers as to whether understanding one’s own emotions is impaired in autism spectrum disorder (ASD). This study evaluated the perception of one’s own different emotions, based on the relevant section of the Autism Diagnostic Observation Schedule Module 3 test. Forty boys, aged 8–11 years, 20 diagnosed with ASD (IQ ? 85) and 20 typically developing children were included. Description of events that elicited specific emotions in ASD was characterized by more ‘odd’ statements and ‘no responses’ and less use of content related to ‘social situations’, ‘interpersonal’ and ‘self-awareness’. More ‘no responses’ and odd statements were associated with the severity of ASD symptoms. Clinicians should be aware of these differentiating factors during the diagnostic process of ASD. En ligne : http://dx.doi.org/10.1007/s10803-016-2769-6 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=290 Who benefits from early intervention in autism spectrum disorders? / Esther BEN-ITZCHAK in Research in Autism Spectrum Disorders, 5-1 (January-March 2011)
PermalinkYounger age is associated with better outcomes in autism severity, language, and adaptive skills after one school year in autism special education classes / Ronit SABAN-BEZALEL in Research in Autism Spectrum Disorders, 113 (May 2024)
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