A prospective study of toddlers with ASD: short-term diagnostic and cognitive outcomes / Katarzyna CHAWARSKA in Journal of Child Psychology and Psychiatry, 50-10 (October 2009) 

Public ISBD [article]  in Journal of Child Psychology and Psychiatry > 50-10 (October 2009) . - p.1235-1245 Titre : A prospective study of toddlers with ASD: short-term diagnostic and cognitive outcomes Type de document : texte imprimé Auteurs : Katarzyna CHAWARSKA, Auteur ; Fred R. VOLKMAR, Auteur ; Rhea PAUL, Auteur ; Ami KLIN, Auteur ; Suzanne L. MACARI, Auteur Article en page(s) : p.1235-1245 Langues : Anglais (eng) Mots-clés : Autism ASD PDD-NOS toddlers early-diagnosis assessment prospective-studies Index. décimale : PER Périodiques Résumé : Background: Despite recent increases in the number of toddlers referred for a differential diagnosis of autism spectrum disorders (ASD), knowledge of short-term stability of the early diagnosis as well as cognitive outcomes in this cohort is still limited. Method: Cognitive, social, and communication skills of 89 clinic-referred toddlers were assessed at the average age of 21.5 (SD = 4.9) months, and reassessed at 46.9 (SD = 7.7) months. Groups with stable and unstable diagnostic presentation were identified and compared on their profile of cognitive and social-communicative skills obtained at the time of initial diagnosis. Results: Stability of the ASD diagnosis was 100%; diagnosis of autism was stable in 74% of cases as compared to 83% and 81% in PDD-NOS and Non-ASD groups, respectively. Worsening of social disability symptoms resulting in autism diagnosis was noted in 17% of toddlers initially diagnosed with PDD-NOS and in 19% of toddlers with initial diagnosis of non-ASD disorder. However, marked improvement was noted in approximately 1/4 of children initially presenting with autism, warranting diagnostic reassignment to PDD-NOS at follow-up. An analysis of developmental skills profiles suggests particular relevance of the assessment of verbal and nonverbal communication skills to diagnostic differentiation between subtypes within ASD in the second year of life. Conclusions: Stability of ASD diagnosis in toddlers is high, though marked changes in severity of symptoms is to be expected in a minority of cases. Simultaneous consideration of cognitive, social, and communication skills profiles enhances accuracy of diagnostic classification and prediction of outcome. En ligne : http://dx.doi.org/10.1111/j.1469-7610.2009.02101.x Permalink : http://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=8381 [article] A prospective study of toddlers with ASD: short-term diagnostic and cognitive outcomes [texte imprimé] / Katarzyna CHAWARSKA, Auteur ; Fred R. VOLKMAR, Auteur ; Rhea PAUL, Auteur ; Ami KLIN, Auteur ; Suzanne L. MACARI, Auteur . - p.1235-1245. Langues : Anglais (eng) in Journal of Child Psychology and Psychiatry > 50-10 (October 2009) . - p.1235-1245 Mots-clés : Autism ASD PDD-NOS toddlers early-diagnosis assessment prospective-studies Index. décimale : PER Périodiques Résumé : Background: Despite recent increases in the number of toddlers referred for a differential diagnosis of autism spectrum disorders (ASD), knowledge of short-term stability of the early diagnosis as well as cognitive outcomes in this cohort is still limited. Method: Cognitive, social, and communication skills of 89 clinic-referred toddlers were assessed at the average age of 21.5 (SD = 4.9) months, and reassessed at 46.9 (SD = 7.7) months. Groups with stable and unstable diagnostic presentation were identified and compared on their profile of cognitive and social-communicative skills obtained at the time of initial diagnosis. Results: Stability of the ASD diagnosis was 100%; diagnosis of autism was stable in 74% of cases as compared to 83% and 81% in PDD-NOS and Non-ASD groups, respectively. Worsening of social disability symptoms resulting in autism diagnosis was noted in 17% of toddlers initially diagnosed with PDD-NOS and in 19% of toddlers with initial diagnosis of non-ASD disorder. However, marked improvement was noted in approximately 1/4 of children initially presenting with autism, warranting diagnostic reassignment to PDD-NOS at follow-up. An analysis of developmental skills profiles suggests particular relevance of the assessment of verbal and nonverbal communication skills to diagnostic differentiation between subtypes within ASD in the second year of life. Conclusions: Stability of ASD diagnosis in toddlers is high, though marked changes in severity of symptoms is to be expected in a minority of cases. Simultaneous consideration of cognitive, social, and communication skills profiles enhances accuracy of diagnostic classification and prediction of outcome. En ligne : http://dx.doi.org/10.1111/j.1469-7610.2009.02101.x Permalink : http://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=8381

Rapid video-referenced ratings of reciprocal social behavior in toddlers: a twin study / Natasha MARRUS in Journal of Child Psychology and Psychiatry, 56-12 (December 2015) 

Public ISBD [article]  in Journal of Child Psychology and Psychiatry > 56-12 (December 2015) . - p.1338-1346 Titre : Rapid video-referenced ratings of reciprocal social behavior in toddlers: a twin study Type de document : texte imprimé Auteurs : Natasha MARRUS, Auteur ; Anne L. GLOWINSKI, Auteur ; Theodore JACOB, Auteur ; Ami KLIN, Auteur ; Warren JONES, Auteur ; Caroline E. DRAIN, Auteur ; Kieran E. HOLZHAUER, Auteur ; Vaishnavi HARIPRASAD, Auteur ; Robert T. FITZGERALD, Auteur ; Erika L. MORTENSON, Auteur ; Sayli M. SANT, Auteur ; Lyndsey COLE, Auteur ; Satchel A. SIEGEL, Auteur ; Yi ZHANG, Auteur ; Arpana AGRAWAL, Auteur ; Andrew C. HEATH, Auteur ; John N. CONSTANTINO, Auteur Article en page(s) : p.1338-1346 Langues : Anglais (eng) Mots-clés : Autism  reciprocal social behavior  video  twins  toddlers Index. décimale : PER Périodiques Résumé : Background Reciprocal social behavior (RSB) is a developmental prerequisite for social competency, and deficits in RSB constitute a core feature of autism spectrum disorder (ASD). Although clinical screeners categorically ascertain risk of ASD in early childhood, rapid methods for quantitative measurement of RSB in toddlers are not yet established. Such measurements are critical for tracking developmental trajectories and incremental responses to intervention. Methods We developed and validated a 20-min video-referenced rating scale, the video-referenced rating of reciprocal social behavior (vrRSB), for untrained caregivers to provide standardized ratings of quantitative variation in RSB. Parents of 252 toddler twins [Monozygotic (MZ) = 31 pairs, Dizygotic (DZ) = 95 pairs] ascertained through birth records, rated their twins’ RSB at two time points, on average 6 months apart, and completed two developmental measures, the Modified Checklist for Autism in Toddlers (M-CHAT) and the MacArthur Communicative Development Inventory Short Form (MCDI-s). Results Scores on the vrRSB were fully continuously distributed, with excellent 6-month test–retest reliability ([intraclass correlation coefficient] ICC = 0.704, p < .000). MZ twins displayed markedly greater trait concordance than DZ twins, (MZ ICC = 0.863, p < .000, DZ ICC = 0.231, p < .012). VrRSB score distributions were highly distinct for children passing versus failing the M-CHAT (t = ?8.588, df = 31, p < .000), incrementally improved from 18–24 months, and were inversely correlated with receptive and expressive vocabulary on the MCDI-s. Conclusions Like quantitative autistic trait ratings in school-aged children and adults, toddler scores on the vrRSB are continuously distributed and appear highly heritable. These ratings exhibited minimal measurement error, high inter-individual stability, and developmental progression in RSB as children matured from 18–24 months, supporting their potential utility for serially quantifying the severity of early autistic syndromes over time and in response to intervention. In addition, these findings inform the genetic-environmental structure of RSB in early typical development. En ligne : http://dx.doi.org/10.1111/jcpp.12391 Permalink : http://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=2733 [article] Rapid video-referenced ratings of reciprocal social behavior in toddlers: a twin study [texte imprimé] / Natasha MARRUS, Auteur ; Anne L. GLOWINSKI, Auteur ; Theodore JACOB, Auteur ; Ami KLIN, Auteur ; Warren JONES, Auteur ; Caroline E. DRAIN, Auteur ; Kieran E. HOLZHAUER, Auteur ; Vaishnavi HARIPRASAD, Auteur ; Robert T. FITZGERALD, Auteur ; Erika L. MORTENSON, Auteur ; Sayli M. SANT, Auteur ; Lyndsey COLE, Auteur ; Satchel A. SIEGEL, Auteur ; Yi ZHANG, Auteur ; Arpana AGRAWAL, Auteur ; Andrew C. HEATH, Auteur ; John N. CONSTANTINO, Auteur . - p.1338-1346. Langues : Anglais (eng) in Journal of Child Psychology and Psychiatry > 56-12 (December 2015) . - p.1338-1346 Mots-clés : Autism  reciprocal social behavior  video  twins  toddlers Index. décimale : PER Périodiques Résumé : Background Reciprocal social behavior (RSB) is a developmental prerequisite for social competency, and deficits in RSB constitute a core feature of autism spectrum disorder (ASD). Although clinical screeners categorically ascertain risk of ASD in early childhood, rapid methods for quantitative measurement of RSB in toddlers are not yet established. Such measurements are critical for tracking developmental trajectories and incremental responses to intervention. Methods We developed and validated a 20-min video-referenced rating scale, the video-referenced rating of reciprocal social behavior (vrRSB), for untrained caregivers to provide standardized ratings of quantitative variation in RSB. Parents of 252 toddler twins [Monozygotic (MZ) = 31 pairs, Dizygotic (DZ) = 95 pairs] ascertained through birth records, rated their twins’ RSB at two time points, on average 6 months apart, and completed two developmental measures, the Modified Checklist for Autism in Toddlers (M-CHAT) and the MacArthur Communicative Development Inventory Short Form (MCDI-s). Results Scores on the vrRSB were fully continuously distributed, with excellent 6-month test–retest reliability ([intraclass correlation coefficient] ICC = 0.704, p < .000). MZ twins displayed markedly greater trait concordance than DZ twins, (MZ ICC = 0.863, p < .000, DZ ICC = 0.231, p < .012). VrRSB score distributions were highly distinct for children passing versus failing the M-CHAT (t = ?8.588, df = 31, p < .000), incrementally improved from 18–24 months, and were inversely correlated with receptive and expressive vocabulary on the MCDI-s. Conclusions Like quantitative autistic trait ratings in school-aged children and adults, toddler scores on the vrRSB are continuously distributed and appear highly heritable. These ratings exhibited minimal measurement error, high inter-individual stability, and developmental progression in RSB as children matured from 18–24 months, supporting their potential utility for serially quantifying the severity of early autistic syndromes over time and in response to intervention. In addition, these findings inform the genetic-environmental structure of RSB in early typical development. En ligne : http://dx.doi.org/10.1111/jcpp.12391 Permalink : http://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=2733

Reliability of the ADI-R for the Single Case-Part II: Clinical Versus Statistical Significance / Domenic V. CICCHETTI in Journal of Autism and Developmental Disorders, 44-12 (December 2014) 

Public ISBD [article]  in Journal of Autism and Developmental Disorders > 44-12 (December 2014) . - p.3154-3160 Titre : Reliability of the ADI-R for the Single Case-Part II: Clinical Versus Statistical Significance Type de document : texte imprimé Auteurs : Domenic V. CICCHETTI, Auteur ; Catherine LORD, Auteur ; Kathy KOENIG, Auteur ; Ami KLIN, Auteur ; Fred R. VOLKMAR, Auteur Article en page(s) : p.3154-3160 Langues : Anglais (eng) Mots-clés : Autism  Clinical significance  Statistical significance  Inter-rater reliability  Multiple raters, one patient Index. décimale : PER Périodiques Résumé : In an earlier investigation, the authors assessed the reliability of the ADI-R when multiple clinicians evaluated a single case, here a female 3 year old toddler suspected of having an autism spectrum disorder (Cicchetti et al. in J Autism Dev Disord 38:764–770, 2008). Applying the clinical criteria of Cicchetti and Sparrow (Am J Men Def 86:127–137, 1981); and those of Cicchetti et al. (Child Neuropsychol 126–137, 1995): 74 % of the ADI-R items showed 100 % agreement; 6 % showed excellent agreement; 7 % showed good agreement; 3 % manifested average agreement; and the remaining 10 % evidenced poor agreement. In this follow-up investigation, the authors described and applied a novel method for determining levels of statistical significance of the reliability coefficients obtained in the earlier investigation. It is based upon a modification of the Z test for comparing a given level of inter-examiner reliability with a lower limit value of 70 % (Dixon and Massey in Introduction to statistical analysis. McGraw-Hill, New York, 1957). Results indicated that every item producing a clinically acceptable level of inter-examiner reliability was also statistically significant. However, the reverse was not true, since a number of the items with statistically significant reliability levels did not reach levels of agreement that were clinically meaningful. This indicated that clinical significance was an accurate marker of statistical significance. The generalization of these findings to other areas of diagnostic interest and importance is also examined. En ligne : http://dx.doi.org/10.1007/s10803-014-2177-8 Permalink : http://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=2437 [article] Reliability of the ADI-R for the Single Case-Part II: Clinical Versus Statistical Significance [texte imprimé] / Domenic V. CICCHETTI, Auteur ; Catherine LORD, Auteur ; Kathy KOENIG, Auteur ; Ami KLIN, Auteur ; Fred R. VOLKMAR, Auteur . - p.3154-3160. Langues : Anglais (eng) in Journal of Autism and Developmental Disorders > 44-12 (December 2014) . - p.3154-3160 Mots-clés : Autism  Clinical significance  Statistical significance  Inter-rater reliability  Multiple raters, one patient Index. décimale : PER Périodiques Résumé : In an earlier investigation, the authors assessed the reliability of the ADI-R when multiple clinicians evaluated a single case, here a female 3 year old toddler suspected of having an autism spectrum disorder (Cicchetti et al. in J Autism Dev Disord 38:764–770, 2008). Applying the clinical criteria of Cicchetti and Sparrow (Am J Men Def 86:127–137, 1981); and those of Cicchetti et al. (Child Neuropsychol 126–137, 1995): 74 % of the ADI-R items showed 100 % agreement; 6 % showed excellent agreement; 7 % showed good agreement; 3 % manifested average agreement; and the remaining 10 % evidenced poor agreement. In this follow-up investigation, the authors described and applied a novel method for determining levels of statistical significance of the reliability coefficients obtained in the earlier investigation. It is based upon a modification of the Z test for comparing a given level of inter-examiner reliability with a lower limit value of 70 % (Dixon and Massey in Introduction to statistical analysis. McGraw-Hill, New York, 1957). Results indicated that every item producing a clinically acceptable level of inter-examiner reliability was also statistically significant. However, the reverse was not true, since a number of the items with statistically significant reliability levels did not reach levels of agreement that were clinically meaningful. This indicated that clinical significance was an accurate marker of statistical significance. The generalization of these findings to other areas of diagnostic interest and importance is also examined. En ligne : http://dx.doi.org/10.1007/s10803-014-2177-8 Permalink : http://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=2437

Reliability of the ADI-R: Multiple Examiners Evaluate a Single Case / Domenic V. CICCHETTI in Journal of Autism and Developmental Disorders, 38-4 (April 2008) 

Public ISBD [article]  in Journal of Autism and Developmental Disorders > 38-4 (April 2008) . - p.764-770 Titre : Reliability of the ADI-R: Multiple Examiners Evaluate a Single Case Type de document : texte imprimé Auteurs : Domenic V. CICCHETTI, Auteur ; Fred R. VOLKMAR, Auteur ; Ami KLIN, Auteur ; Catherine LORD, Auteur ; Kathleen KOENIG, Auteur Article en page(s) : p.764-770 Langues : Anglais (eng) Mots-clés : ADI-R Reliability Single-Case Index. décimale : PER Périodiques Résumé : The authors assessed the reliability of the Autism Diagnostic Interview (ADI-R). Seven Clinical Examiners evaluated a three and one half year old female toddler suspected of being on the Autism Spectrum. Examiners showed agreement levels of 94–96% across all items, with weighted kappa (Kw) between .80 and .88. They were in 100% agreement on 74% of the items; in excellent agreement on 6% of the items (93–96%, with Kw between .78 and .85); in good agreement on 7% (89–90%, with Kw between .62 and 0.68); and in fair agreement on 3% (82 – 84%, with Kw between .40 and .47). For the remaining 10% of ADI-R items, examiners showed poor agreement (50–81% with Kw between −.67 and .37). En ligne : http://dx.doi.org/10.1007/s10803-007-0448-3 Permalink : http://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=3417 [article] Reliability of the ADI-R: Multiple Examiners Evaluate a Single Case [texte imprimé] / Domenic V. CICCHETTI, Auteur ; Fred R. VOLKMAR, Auteur ; Ami KLIN, Auteur ; Catherine LORD, Auteur ; Kathleen KOENIG, Auteur . - p.764-770. Langues : Anglais (eng) in Journal of Autism and Developmental Disorders > 38-4 (April 2008) . - p.764-770 Mots-clés : ADI-R Reliability Single-Case Index. décimale : PER Périodiques Résumé : The authors assessed the reliability of the Autism Diagnostic Interview (ADI-R). Seven Clinical Examiners evaluated a three and one half year old female toddler suspected of being on the Autism Spectrum. Examiners showed agreement levels of 94–96% across all items, with weighted kappa (Kw) between .80 and .88. They were in 100% agreement on 74% of the items; in excellent agreement on 6% of the items (93–96%, with Kw between .78 and .85); in good agreement on 7% (89–90%, with Kw between .62 and 0.68); and in fair agreement on 3% (82 – 84%, with Kw between .40 and .47). For the remaining 10% of ADI-R items, examiners showed poor agreement (50–81% with Kw between −.67 and .37). En ligne : http://dx.doi.org/10.1007/s10803-007-0448-3 Permalink : http://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=3417

Screening for autism in older and younger toddlers with the Modified Checklist for Autism in Toddlers / Juhi PANDEY in Autism, 12-5 (September 2008) 

Public ISBD [article]  in Autism > 12-5 (September 2008) . - p.513-535 Titre : Screening for autism in older and younger toddlers with the Modified Checklist for Autism in Toddlers Type de document : texte imprimé Auteurs : Juhi PANDEY, Auteur ; Fred R. VOLKMAR, Auteur ; Deborah A. FEIN, Auteur ; Alyssa D. VERBALIS, Auteur ; Tammy BABITZ, Auteur ; Hilary BOORSTEIN, Auteur ; Diana L. ROBINS, Auteur ; James GREEN, Auteur ; Katarzyna CHAWARSKA, Auteur ; Ami KLIN, Auteur ; Marianne L. BARTON, Auteur Article en page(s) : p.513-535 Langues : Anglais (eng) Mots-clés : autism-spectrum-disorders early-detection early-identification pediatric-screening Index. décimale : PER Périodiques Résumé : The Modified Checklist for Autism in Toddlers (M—CHAT) was used to screen younger (16—23 months) versus older (24—30 months) high- and low-risk toddlers. Refusal rates for follow-up interview showed no group differences, but parents of younger/low-risk children were more likely to refuse evaluation than parents of high-risk children. PPP for an ASD diagnosis was: younger/high-risk 0.79, older/high-risk 0.74, younger/low-risk 0.28, and older/low-risk 0.61, with PPP differing by age within the low-risk group. Most of the children in all groups, however, were diagnosed with a developmental disorder. Symptom severity generally did not differ among groups. Cognitive and adaptive measures showed minimal group differences. Therefore, older and younger toddlers had similar symptomatology and developmental delays; PPP for ASD is better at 24 than 18 months for low-risk children; however, these children are still highly likely to show a developmental disorder. Clinical decision making should balance early identification against the lower specificity of M—CHAT screening for the younger/low-risk group. En ligne : http://dx.doi.org/10.1177/1362361308094503 Permalink : http://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=6013 [article] Screening for autism in older and younger toddlers with the Modified Checklist for Autism in Toddlers [texte imprimé] / Juhi PANDEY, Auteur ; Fred R. VOLKMAR, Auteur ; Deborah A. FEIN, Auteur ; Alyssa D. VERBALIS, Auteur ; Tammy BABITZ, Auteur ; Hilary BOORSTEIN, Auteur ; Diana L. ROBINS, Auteur ; James GREEN, Auteur ; Katarzyna CHAWARSKA, Auteur ; Ami KLIN, Auteur ; Marianne L. BARTON, Auteur . - p.513-535. Langues : Anglais (eng) in Autism > 12-5 (September 2008) . - p.513-535 Mots-clés : autism-spectrum-disorders early-detection early-identification pediatric-screening Index. décimale : PER Périodiques Résumé : The Modified Checklist for Autism in Toddlers (M—CHAT) was used to screen younger (16—23 months) versus older (24—30 months) high- and low-risk toddlers. Refusal rates for follow-up interview showed no group differences, but parents of younger/low-risk children were more likely to refuse evaluation than parents of high-risk children. PPP for an ASD diagnosis was: younger/high-risk 0.79, older/high-risk 0.74, younger/low-risk 0.28, and older/low-risk 0.61, with PPP differing by age within the low-risk group. Most of the children in all groups, however, were diagnosed with a developmental disorder. Symptom severity generally did not differ among groups. Cognitive and adaptive measures showed minimal group differences. Therefore, older and younger toddlers had similar symptomatology and developmental delays; PPP for ASD is better at 24 than 18 months for low-risk children; however, these children are still highly likely to show a developmental disorder. Clinical decision making should balance early identification against the lower specificity of M—CHAT screening for the younger/low-risk group. En ligne : http://dx.doi.org/10.1177/1362361308094503 Permalink : http://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=6013

Social and Communication Abilities and Disabilities in Higher Functioning Individuals with Autism Spectrum Disorders: The Vineland and the ADOS / Ami KLIN in Journal of Autism and Developmental Disorders, 37-4 (April 2007) 

Permalink

Social Development in Autism / Alice S. CARTER

Permalink

Studying the Emergence of Autism Spectrum Disorders in High-risk Infants: Methodological and Practical Issues / Lonnie ZWAIGENBAUM in Journal of Autism and Developmental Disorders, 37-3 (March 2007) 

Permalink

Subtyping the Autism Spectrum Disorders: Theoretical, Research, and Clinical Considerations / Ami KLIN

Permalink

Supporting More Able Students on the Autism Spectrum: College and Beyond / Ernst O. VANBERGEIJK in Journal of Autism and Developmental Disorders, 38-7 (August 2008) 

Permalink

The Enactive Mind—From Actions to Cognition: Lessons from Autism / Ami KLIN

Permalink

The Modified Checklist for Autism in Toddlers: A Follow-up Study Investigating the Early Detection of Autism Spectrum Disorders / Jamie KLEINMAN in Journal of Autism and Developmental Disorders, 38-5 (May 2008) 

Permalink

Theory of mind in action : developmental perspectives on social neuroscience / Ami KLIN

Permalink

Verbal Bias in Recognition of Facial Emotions in Children with Asperger Syndrome / James B. GROSSMAN in Journal of Child Psychology and Psychiatry, 41-3 (March 2000)

Permalink

What Can Help People with ASC Find and Keep Employment? / Ernst O. VANBERGEIJK

Permalink