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Auteur Xingming JIN |
Documents disponibles écrits par cet auteur (2)
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Copy number variation and neural pathway analysis of children with autism spectrum disorder from a large Han Chinese population-based cross-sectional study / You YANG in Research in Autism Spectrum Disorders, 51 (July 2018)
[article]
Titre : Copy number variation and neural pathway analysis of children with autism spectrum disorder from a large Han Chinese population-based cross-sectional study Type de document : Texte imprimé et/ou numérique Auteurs : You YANG, Auteur ; Zhijuan JIN, Auteur ; Jian WANG, Auteur ; Shijian LIU, Auteur ; Hong HUANG, Auteur ; Xingming JIN, Auteur Article en page(s) : p.66-74 Langues : Anglais (eng) Mots-clés : Autism spectrum disorder (ASD) Copy number variations (CNVs) Microarray diagnostic testing Pathway analysis Han Chinese Index. décimale : PER Périodiques Résumé : Certain genetic events can be attributed to copy number variations (CNVs). A population in Shanghai, China was screened for autism spectrum disorder (ASD), and their CNV characteristics and possible associations with neural pathways were analyzed. A multi-stage stratified cluster sampling method was used to evaluate 3- to 12-year-old children from the general population who were in kindergarten and primary school in Shanghai. DNA samples were obtained from 133 ASD cases from preparatory ASD screening. An Affymetrix Cytoscan 750k array was used for copy number variant detection. Among the 711 children who had positive results on a survey completed by both their parents and teachers, a total of 663 (93.2%) children underwent diagnostic evaluation. Of these, 203 children were confirmed to have ASD, including 163 (80.3%) children from special education schools, 29 (14.3%) children from general kindergartens, and 11 (5.4%) children from general primary schools. Final consent had been given for blood collection, and 15 CNVs that may contribute to ASD in 133 cases were identified. The mean ages at which the ASD children with and without pathogenic CNVs (pCNVs) began to speak were 45.6 months and 29.2 months, respectively (t?=?2.452, P?=?0.016), and the ages of walking alone were 33.9 months and 17.5 months, respectively (t?=?5.376, P?0.001). ASD patients with pCNVs showed more abnormal facial features and signs of ASD (long faces, large noses, irregular teeth, dental caries, excessive joint extension) than those without pCNVs. The differences in tooth irregularity and dental caries between children with and without pCNVs were statistically significant (P?0.01). These CNVs included a total of 993 genes. Pathway analysis was performed, and five statistically significant pathways were identified in online databases. This was the first population-based, pilot pathway analysis of CNVs in children with ASD under the diagnostic and statistical manual of mental disorders (DSM)-5 diagnostic criteria in China. Results indicate that ASD may be related to gamma-aminobutyric acid (GABA),dopamine, glycine and synaptic proteins. These findings are consistent with those of previous studies and provide new evidence for the role of regulation of proteolysis and endopeptidase activity in ASD. En ligne : https://doi.org/10.1016/j.rasd.2018.04.006 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=362
in Research in Autism Spectrum Disorders > 51 (July 2018) . - p.66-74[article] Copy number variation and neural pathway analysis of children with autism spectrum disorder from a large Han Chinese population-based cross-sectional study [Texte imprimé et/ou numérique] / You YANG, Auteur ; Zhijuan JIN, Auteur ; Jian WANG, Auteur ; Shijian LIU, Auteur ; Hong HUANG, Auteur ; Xingming JIN, Auteur . - p.66-74.
Langues : Anglais (eng)
in Research in Autism Spectrum Disorders > 51 (July 2018) . - p.66-74
Mots-clés : Autism spectrum disorder (ASD) Copy number variations (CNVs) Microarray diagnostic testing Pathway analysis Han Chinese Index. décimale : PER Périodiques Résumé : Certain genetic events can be attributed to copy number variations (CNVs). A population in Shanghai, China was screened for autism spectrum disorder (ASD), and their CNV characteristics and possible associations with neural pathways were analyzed. A multi-stage stratified cluster sampling method was used to evaluate 3- to 12-year-old children from the general population who were in kindergarten and primary school in Shanghai. DNA samples were obtained from 133 ASD cases from preparatory ASD screening. An Affymetrix Cytoscan 750k array was used for copy number variant detection. Among the 711 children who had positive results on a survey completed by both their parents and teachers, a total of 663 (93.2%) children underwent diagnostic evaluation. Of these, 203 children were confirmed to have ASD, including 163 (80.3%) children from special education schools, 29 (14.3%) children from general kindergartens, and 11 (5.4%) children from general primary schools. Final consent had been given for blood collection, and 15 CNVs that may contribute to ASD in 133 cases were identified. The mean ages at which the ASD children with and without pathogenic CNVs (pCNVs) began to speak were 45.6 months and 29.2 months, respectively (t?=?2.452, P?=?0.016), and the ages of walking alone were 33.9 months and 17.5 months, respectively (t?=?5.376, P?0.001). ASD patients with pCNVs showed more abnormal facial features and signs of ASD (long faces, large noses, irregular teeth, dental caries, excessive joint extension) than those without pCNVs. The differences in tooth irregularity and dental caries between children with and without pCNVs were statistically significant (P?0.01). These CNVs included a total of 993 genes. Pathway analysis was performed, and five statistically significant pathways were identified in online databases. This was the first population-based, pilot pathway analysis of CNVs in children with ASD under the diagnostic and statistical manual of mental disorders (DSM)-5 diagnostic criteria in China. Results indicate that ASD may be related to gamma-aminobutyric acid (GABA),dopamine, glycine and synaptic proteins. These findings are consistent with those of previous studies and provide new evidence for the role of regulation of proteolysis and endopeptidase activity in ASD. En ligne : https://doi.org/10.1016/j.rasd.2018.04.006 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=362 Risk factors for ASD / Yuanyuan LIN in Journal of Autism and Developmental Disorders, 53-8 (August 2023)
[article]
Titre : Risk factors for ASD Type de document : Texte imprimé et/ou numérique Auteurs : Yuanyuan LIN, Auteur ; Guanghai WANG, Auteur ; You YANG, Auteur ; Xingming JIN, Auteur ; Hong HUANG, Auteur ; Yiwen ZHANG, Auteur ; Zhijuan JIN, Auteur Article en page(s) : p.2954-2963 Langues : Anglais (eng) Index. décimale : PER Périodiques Résumé : Autism spectrum disorder (ASD) is a pervasive neurodevelopmental disorder that brings heavy burdens to families and the society. This case-control study explored risk factors for ASD based on 74,252 children aged 3-12 years who were recruited from general education kindergartens, primary schools, and special education schools in Shanghai, China. One hundred ninety-two children were identified with ASD according to the Diagnostic and Statistical Manual of Mental Disorders-Fifth Edition. Male sex, the presence of anoxia or asphyxia at birth, artificial feeding, adverse maternal psychological status, complications during pregnancy and higher paternal education were associated with ASD even after controlling for age, residential district, family history of mental disorders, parental personality, and amount of daily TV viewing. En ligne : https://doi.org/10.1007/s10803-022-05603-1 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=508
in Journal of Autism and Developmental Disorders > 53-8 (August 2023) . - p.2954-2963[article] Risk factors for ASD [Texte imprimé et/ou numérique] / Yuanyuan LIN, Auteur ; Guanghai WANG, Auteur ; You YANG, Auteur ; Xingming JIN, Auteur ; Hong HUANG, Auteur ; Yiwen ZHANG, Auteur ; Zhijuan JIN, Auteur . - p.2954-2963.
Langues : Anglais (eng)
in Journal of Autism and Developmental Disorders > 53-8 (August 2023) . - p.2954-2963
Index. décimale : PER Périodiques Résumé : Autism spectrum disorder (ASD) is a pervasive neurodevelopmental disorder that brings heavy burdens to families and the society. This case-control study explored risk factors for ASD based on 74,252 children aged 3-12 years who were recruited from general education kindergartens, primary schools, and special education schools in Shanghai, China. One hundred ninety-two children were identified with ASD according to the Diagnostic and Statistical Manual of Mental Disorders-Fifth Edition. Male sex, the presence of anoxia or asphyxia at birth, artificial feeding, adverse maternal psychological status, complications during pregnancy and higher paternal education were associated with ASD even after controlling for age, residential district, family history of mental disorders, parental personality, and amount of daily TV viewing. En ligne : https://doi.org/10.1007/s10803-022-05603-1 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=508