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Auteur Angelica RONALD |
Documents disponibles écrits par cet auteur (19)
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Relationship between special abilities and autistic-like traits in a large population-based sample of 8-year-olds / Pedro M. VITAL in Journal of Child Psychology and Psychiatry, 50-9 (September 2009)
[article]
Titre : Relationship between special abilities and autistic-like traits in a large population-based sample of 8-year-olds Type de document : Texte imprimé et/ou numérique Auteurs : Pedro M. VITAL, Auteur ; Gregory L. WALLACE, Auteur ; Francesca HAPPE, Auteur ; Angelica RONALD, Auteur Année de publication : 2009 Article en page(s) : p.1093-1101 Langues : Anglais (eng) Mots-clés : Autism-spectrum-disorders autistic-traits special-abilities savant-skills Index. décimale : PER Périodiques Résumé : Background: The raised incidence of special abilities or 'savant skills' among individuals with autism spectrum disorders (ASD) relative to other developmental disorders suggests an association between the traits characteristic of ASD and special abilities. The purpose of this study was to investigate the association between special abilities and ASD-like traits.
Methods: This study compared the scores of 6,426 8-year-olds with and without parent-reported special abilities on a screening questionnaire for ASD-like traits in three areas: social interaction, communication, and restricted and repetitive behaviours and interests. Measures of IQ, sex, and socioeconomic status (SES) were also compared.
Results: From parent report, children with special abilities showed significantly more ASD-like traits than those without such abilities. General intelligence did not mediate this relationship: IQ was found to be positively associated with ability, but negatively associated with ASD-like traits. Special abilities were more strongly associated with restricted/repetitive characteristics than with social or communication traits.
Conclusions: Results support the association between special abilities and ASD-like traits, and expand it to traits in the general population. The type of nonsocial traits most strongly associated with parental reports of special abilities suggests a link to a featural information processing style, or 'weak central coherence'.En ligne : http://dx.doi.org/10.1111/j.1469-7610.2009.02076.x Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=828
in Journal of Child Psychology and Psychiatry > 50-9 (September 2009) . - p.1093-1101[article] Relationship between special abilities and autistic-like traits in a large population-based sample of 8-year-olds [Texte imprimé et/ou numérique] / Pedro M. VITAL, Auteur ; Gregory L. WALLACE, Auteur ; Francesca HAPPE, Auteur ; Angelica RONALD, Auteur . - 2009 . - p.1093-1101.
Langues : Anglais (eng)
in Journal of Child Psychology and Psychiatry > 50-9 (September 2009) . - p.1093-1101
Mots-clés : Autism-spectrum-disorders autistic-traits special-abilities savant-skills Index. décimale : PER Périodiques Résumé : Background: The raised incidence of special abilities or 'savant skills' among individuals with autism spectrum disorders (ASD) relative to other developmental disorders suggests an association between the traits characteristic of ASD and special abilities. The purpose of this study was to investigate the association between special abilities and ASD-like traits.
Methods: This study compared the scores of 6,426 8-year-olds with and without parent-reported special abilities on a screening questionnaire for ASD-like traits in three areas: social interaction, communication, and restricted and repetitive behaviours and interests. Measures of IQ, sex, and socioeconomic status (SES) were also compared.
Results: From parent report, children with special abilities showed significantly more ASD-like traits than those without such abilities. General intelligence did not mediate this relationship: IQ was found to be positively associated with ability, but negatively associated with ASD-like traits. Special abilities were more strongly associated with restricted/repetitive characteristics than with social or communication traits.
Conclusions: Results support the association between special abilities and ASD-like traits, and expand it to traits in the general population. The type of nonsocial traits most strongly associated with parental reports of special abilities suggests a link to a featural information processing style, or 'weak central coherence'.En ligne : http://dx.doi.org/10.1111/j.1469-7610.2009.02076.x Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=828 Relationship Between Symptom Domains in Autism Spectrum Disorders: A Population Based Twin Study / Katharina DWORZYNSKI in Journal of Autism and Developmental Disorders, 39-8 (August 2009)
[article]
Titre : Relationship Between Symptom Domains in Autism Spectrum Disorders: A Population Based Twin Study Type de document : Texte imprimé et/ou numérique Auteurs : Katharina DWORZYNSKI, Auteur ; Patrick BOLTON, Auteur ; Francesca HAPPE, Auteur ; Angelica RONALD, Auteur Année de publication : 2009 Article en page(s) : p.1197-1210 Langues : Anglais (eng) Mots-clés : Autism-spectrum-disorders Symptom-domains Twins Index. décimale : PER Périodiques Résumé : Factor structure and relationship between core features of autism (social impairments, communication difficulties, and restricted, repetitive behaviours or interests (RRBIs)) were explored in 189 children from the Twins Early Development Study, diagnosed with autistic spectrum disorders (ASDs) using the Development and Wellbeing Assessment (DAWBA; Goodman et al. in J Child Psychol Psyc 41:645–655, 2000). A bottom-up approach (analysis 1) used principal component factor analysis of DAWBA items indicating five factors, the first three mapping on the triad. In analysis 2, applying top-down DSM-IV criteria, correlations between domains were modest, strongest between social and communication difficulties. Cross-twin cross-trait correlations suggested small shared genetic effects between RRBIs and other symptoms. These findings from a clinical sample of twins indicate a fractionation of social/communicative and RRBI symptoms in ASD. En ligne : http://dx.doi.org/10.1007/s10803-009-0736-1 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=789
in Journal of Autism and Developmental Disorders > 39-8 (August 2009) . - p.1197-1210[article] Relationship Between Symptom Domains in Autism Spectrum Disorders: A Population Based Twin Study [Texte imprimé et/ou numérique] / Katharina DWORZYNSKI, Auteur ; Patrick BOLTON, Auteur ; Francesca HAPPE, Auteur ; Angelica RONALD, Auteur . - 2009 . - p.1197-1210.
Langues : Anglais (eng)
in Journal of Autism and Developmental Disorders > 39-8 (August 2009) . - p.1197-1210
Mots-clés : Autism-spectrum-disorders Symptom-domains Twins Index. décimale : PER Périodiques Résumé : Factor structure and relationship between core features of autism (social impairments, communication difficulties, and restricted, repetitive behaviours or interests (RRBIs)) were explored in 189 children from the Twins Early Development Study, diagnosed with autistic spectrum disorders (ASDs) using the Development and Wellbeing Assessment (DAWBA; Goodman et al. in J Child Psychol Psyc 41:645–655, 2000). A bottom-up approach (analysis 1) used principal component factor analysis of DAWBA items indicating five factors, the first three mapping on the triad. In analysis 2, applying top-down DSM-IV criteria, correlations between domains were modest, strongest between social and communication difficulties. Cross-twin cross-trait correlations suggested small shared genetic effects between RRBIs and other symptoms. These findings from a clinical sample of twins indicate a fractionation of social/communicative and RRBI symptoms in ASD. En ligne : http://dx.doi.org/10.1007/s10803-009-0736-1 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=789 The Nature of Covariation Between Autistic Traits and Clumsiness: A Twin Study in a General Population Sample / Sara MORUZZI in Journal of Autism and Developmental Disorders, 41-12 (December 2011)
[article]
Titre : The Nature of Covariation Between Autistic Traits and Clumsiness: A Twin Study in a General Population Sample Type de document : Texte imprimé et/ou numérique Auteurs : Sara MORUZZI, Auteur ; Anna OGLIARI, Auteur ; Angelica RONALD, Auteur ; Francesca HAPPE, Auteur Année de publication : 2011 Article en page(s) : p.1665-1674 Langues : Anglais (eng) Mots-clés : Clumsiness Autistic traits CBCL Comorbidity Twin study Index. décimale : PER Périodiques Résumé : While social impairment, difficulties with communication, and restricted repetitive behaviors are central features of Autism Spectrum Disorders, physical clumsiness is a commonly co-occuring feature. In a sample of 398 twin pairs (aged 8–17 years) from the Italian Twin Registry we investigated the nature of the co-variation between a psychometric index of Clumsiness and the Child Behavior Checklist (CBCL) Autistic scale. Bivariate twin analyses showed that a genetic etiological overlap, rather than direct causation, is a plausible explanation for the association between clumsiness and autistic-like traits, as measured by indices derived from the parent-rated CBCL scale. Additive genetic influences that impinge upon clumsiness/motor problem and autistic-like traits coincided remarkably, with a genetic correlation of 0.63. En ligne : http://dx.doi.org/10.1007/s10803-011-1199-8 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=148
in Journal of Autism and Developmental Disorders > 41-12 (December 2011) . - p.1665-1674[article] The Nature of Covariation Between Autistic Traits and Clumsiness: A Twin Study in a General Population Sample [Texte imprimé et/ou numérique] / Sara MORUZZI, Auteur ; Anna OGLIARI, Auteur ; Angelica RONALD, Auteur ; Francesca HAPPE, Auteur . - 2011 . - p.1665-1674.
Langues : Anglais (eng)
in Journal of Autism and Developmental Disorders > 41-12 (December 2011) . - p.1665-1674
Mots-clés : Clumsiness Autistic traits CBCL Comorbidity Twin study Index. décimale : PER Périodiques Résumé : While social impairment, difficulties with communication, and restricted repetitive behaviors are central features of Autism Spectrum Disorders, physical clumsiness is a commonly co-occuring feature. In a sample of 398 twin pairs (aged 8–17 years) from the Italian Twin Registry we investigated the nature of the co-variation between a psychometric index of Clumsiness and the Child Behavior Checklist (CBCL) Autistic scale. Bivariate twin analyses showed that a genetic etiological overlap, rather than direct causation, is a plausible explanation for the association between clumsiness and autistic-like traits, as measured by indices derived from the parent-rated CBCL scale. Additive genetic influences that impinge upon clumsiness/motor problem and autistic-like traits coincided remarkably, with a genetic correlation of 0.63. En ligne : http://dx.doi.org/10.1007/s10803-011-1199-8 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=148 Trajectories leading to autism spectrum disorders are affected by paternal age: findings from two nationally representative twin studies / Sebastian LUNDSTROM in Journal of Child Psychology and Psychiatry, 51-7 (July 2010)
[article]
Titre : Trajectories leading to autism spectrum disorders are affected by paternal age: findings from two nationally representative twin studies Type de document : Texte imprimé et/ou numérique Auteurs : Sebastian LUNDSTROM, Auteur ; Christopher GILLBERG, Auteur ; Henrik ANCKARSATER, Auteur ; Christina M. HULTMAN, Auteur ; Eva CARLSTROM, Auteur ; Abraham REICHENBERG, Auteur ; Jonathan MILL, Auteur ; Angelica RONALD, Auteur ; Robert PLOMIN, Auteur ; Maria RASTAM, Auteur ; Paul LICHTENSTEIN, Auteur ; Claire Margaret Alison HAWORTH, Auteur Année de publication : 2010 Article en page(s) : p.850-856 Langues : Anglais (eng) Mots-clés : Autism-spectrum-disorders paternal-age autistic-traits behavioral-genetics Index. décimale : PER Périodiques Résumé : Background: Despite extensive efforts, the causes of autism remain unknown. Advancing paternal age has been associated with various neurodevelopmental disorders. We aim to investigate three unresolved questions: (a) What is the association between paternal age and autism spectrum disorders (ASD)?; (b) Does paternal age moderate the genetic and environmental etiological factors for ASD? (c) Does paternal age affect normal variation in autistic-like traits?
Methods: Two nationally representative twin studies from Sweden (n = 11, 122, assessed at age 9 or 12) and the UK (n = 13, 524, assessed at age 9) were used. Categorical and continuous measures of ASD, autistic-like traits and autistic similarity were calculated and compared over paternal age categories.
Results: Both cohorts showed a strong association between paternal age and the risk for ASD. A U-shaped risk association could be discerned since the offspring of both the youngest and oldest fathers showed an elevation in the risk for ASD. Autistic similarity increased with advancing paternal age in both monozygotic and dizygotic twins. Both cohorts showed significantly higher autistic-like traits in the offspring of the youngest and oldest fathers.
Conclusions: Phenomena associated with paternal age are clearly involved in the trajectories leading to autistic-like traits and ASD. Mechanisms influencing the trajectories might differ between older and younger fathers. Molecular genetic studies are now needed in order to further understand the association between paternal age and ASD, as well as normal variation in social, language, and repetitive behaviors in the general population.En ligne : http://dx.doi.org/10.1111/j.1469-7610.2010.02223.x Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=102
in Journal of Child Psychology and Psychiatry > 51-7 (July 2010) . - p.850-856[article] Trajectories leading to autism spectrum disorders are affected by paternal age: findings from two nationally representative twin studies [Texte imprimé et/ou numérique] / Sebastian LUNDSTROM, Auteur ; Christopher GILLBERG, Auteur ; Henrik ANCKARSATER, Auteur ; Christina M. HULTMAN, Auteur ; Eva CARLSTROM, Auteur ; Abraham REICHENBERG, Auteur ; Jonathan MILL, Auteur ; Angelica RONALD, Auteur ; Robert PLOMIN, Auteur ; Maria RASTAM, Auteur ; Paul LICHTENSTEIN, Auteur ; Claire Margaret Alison HAWORTH, Auteur . - 2010 . - p.850-856.
Langues : Anglais (eng)
in Journal of Child Psychology and Psychiatry > 51-7 (July 2010) . - p.850-856
Mots-clés : Autism-spectrum-disorders paternal-age autistic-traits behavioral-genetics Index. décimale : PER Périodiques Résumé : Background: Despite extensive efforts, the causes of autism remain unknown. Advancing paternal age has been associated with various neurodevelopmental disorders. We aim to investigate three unresolved questions: (a) What is the association between paternal age and autism spectrum disorders (ASD)?; (b) Does paternal age moderate the genetic and environmental etiological factors for ASD? (c) Does paternal age affect normal variation in autistic-like traits?
Methods: Two nationally representative twin studies from Sweden (n = 11, 122, assessed at age 9 or 12) and the UK (n = 13, 524, assessed at age 9) were used. Categorical and continuous measures of ASD, autistic-like traits and autistic similarity were calculated and compared over paternal age categories.
Results: Both cohorts showed a strong association between paternal age and the risk for ASD. A U-shaped risk association could be discerned since the offspring of both the youngest and oldest fathers showed an elevation in the risk for ASD. Autistic similarity increased with advancing paternal age in both monozygotic and dizygotic twins. Both cohorts showed significantly higher autistic-like traits in the offspring of the youngest and oldest fathers.
Conclusions: Phenomena associated with paternal age are clearly involved in the trajectories leading to autistic-like traits and ASD. Mechanisms influencing the trajectories might differ between older and younger fathers. Molecular genetic studies are now needed in order to further understand the association between paternal age and ASD, as well as normal variation in social, language, and repetitive behaviors in the general population.En ligne : http://dx.doi.org/10.1111/j.1469-7610.2010.02223.x Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=102 Using DNA to predict behaviour problems from preschool to adulthood / Agnieszka GIDZIELA in Journal of Child Psychology and Psychiatry, 63-7 (July 2022)
[article]
Titre : Using DNA to predict behaviour problems from preschool to adulthood Type de document : Texte imprimé et/ou numérique Auteurs : Agnieszka GIDZIELA, Auteur ; Kaili RIMFELD, Auteur ; Margherita MALANCHINI, Auteur ; Andrea G. ALLEGRINI, Auteur ; Andrew MCMILLAN, Auteur ; Saskia SELZAM, Auteur ; Angelica RONALD, Auteur ; Essi VIDING, Auteur ; Sophie VON STUMM, Auteur ; Thalia C. ELEY, Auteur ; Robert PLOMIN, Auteur Article en page(s) : p.781-792 Langues : Anglais (eng) Mots-clés : Adolescent Adult Child Child, Preschool Dna Educational Status Genome-Wide Association Study Humans Multifactorial Inheritance Problem Behavior Young Adult Behaviour problems composites externalising internalising polygenic scores twin study Index. décimale : PER Périodiques Résumé : BACKGROUND: One goal of the DNA revolution is to predict problems in order to prevent them. We tested here if the prediction of behaviour problems from genome-wide polygenic scores (GPS) can be improved by creating composites across ages and across raters and by using a multi-GPS approach that includes GPS for adult psychiatric disorders as well as for childhood behaviour problems. METHOD: Our sample included 3,065 genotyped unrelated individuals from the Twins Early Development Study who were assessed longitudinally for hyperactivity, conduct, emotional problems, and peer problems as rated by parents, teachers, and children themselves. GPS created from 15 genome-wide association studies were used separately and jointly to test the prediction of behaviour problems composites (general behaviour problems, externalising, and internalising) across ages (from age 2 to 21) and across raters in penalised regression models. Based on the regression weights, we created multi-trait GPS reflecting the best prediction of behaviour problems. We compared GPS prediction to twin heritability using the same sample and measures. RESULTS: Multi-GPS prediction of behaviour problems increased from <2% of the variance for observed traits to up to 6% for cross-age and cross-rater composites. Twin study estimates of heritability, although to a lesser extent, mirrored patterns of multi-GPS prediction as they increased from <40% to 83%. CONCLUSIONS: The ability of GPS to predict behaviour problems can be improved by using multiple GPS, cross-age composites and cross-rater composites, although the effect sizes remain modest, up to 6%. Our approach can be used in any genotyped sample to create multi-trait GPS predictors of behaviour problems that will be more predictive than polygenic scores based on a single age, rater, or GPS. En ligne : http://dx.doi.org/10.1111/jcpp.13519 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=477
in Journal of Child Psychology and Psychiatry > 63-7 (July 2022) . - p.781-792[article] Using DNA to predict behaviour problems from preschool to adulthood [Texte imprimé et/ou numérique] / Agnieszka GIDZIELA, Auteur ; Kaili RIMFELD, Auteur ; Margherita MALANCHINI, Auteur ; Andrea G. ALLEGRINI, Auteur ; Andrew MCMILLAN, Auteur ; Saskia SELZAM, Auteur ; Angelica RONALD, Auteur ; Essi VIDING, Auteur ; Sophie VON STUMM, Auteur ; Thalia C. ELEY, Auteur ; Robert PLOMIN, Auteur . - p.781-792.
Langues : Anglais (eng)
in Journal of Child Psychology and Psychiatry > 63-7 (July 2022) . - p.781-792
Mots-clés : Adolescent Adult Child Child, Preschool Dna Educational Status Genome-Wide Association Study Humans Multifactorial Inheritance Problem Behavior Young Adult Behaviour problems composites externalising internalising polygenic scores twin study Index. décimale : PER Périodiques Résumé : BACKGROUND: One goal of the DNA revolution is to predict problems in order to prevent them. We tested here if the prediction of behaviour problems from genome-wide polygenic scores (GPS) can be improved by creating composites across ages and across raters and by using a multi-GPS approach that includes GPS for adult psychiatric disorders as well as for childhood behaviour problems. METHOD: Our sample included 3,065 genotyped unrelated individuals from the Twins Early Development Study who were assessed longitudinally for hyperactivity, conduct, emotional problems, and peer problems as rated by parents, teachers, and children themselves. GPS created from 15 genome-wide association studies were used separately and jointly to test the prediction of behaviour problems composites (general behaviour problems, externalising, and internalising) across ages (from age 2 to 21) and across raters in penalised regression models. Based on the regression weights, we created multi-trait GPS reflecting the best prediction of behaviour problems. We compared GPS prediction to twin heritability using the same sample and measures. RESULTS: Multi-GPS prediction of behaviour problems increased from <2% of the variance for observed traits to up to 6% for cross-age and cross-rater composites. Twin study estimates of heritability, although to a lesser extent, mirrored patterns of multi-GPS prediction as they increased from <40% to 83%. CONCLUSIONS: The ability of GPS to predict behaviour problems can be improved by using multiple GPS, cross-age composites and cross-rater composites, although the effect sizes remain modest, up to 6%. Our approach can be used in any genotyped sample to create multi-trait GPS predictors of behaviour problems that will be more predictive than polygenic scores based on a single age, rater, or GPS. En ligne : http://dx.doi.org/10.1111/jcpp.13519 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=477