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Auteur Julio FERNANDEZ-MENDOZA |
Documents disponibles écrits par cet auteur (2)
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Behavioral, neurocognitive, polysomnographic and cardiometabolic profiles associated with obstructive sleep apnea in adolescents with ADHD / Kristina PUZINO in Journal of Child Psychology and Psychiatry, 63-5 (May 2022)
[article]
Titre : Behavioral, neurocognitive, polysomnographic and cardiometabolic profiles associated with obstructive sleep apnea in adolescents with ADHD Type de document : Texte imprimé et/ou numérique Auteurs : Kristina PUZINO, Auteur ; Elizaveta BOURCHTEIN, Auteur ; Susan L. CALHOUN, Auteur ; Fan HE, Auteur ; Alexandros N. VGONTZAS, Auteur ; Duanping LIAO, Auteur ; Edward O BIXLER, Auteur ; Julio FERNANDEZ-MENDOZA, Auteur Article en page(s) : p.544-552 Langues : Anglais (eng) Mots-clés : Adolescent Attention Deficit Disorder with Hyperactivity/complications/epidemiology Cardiovascular Diseases/complications/epidemiology Child Female Humans Male Polysomnography Sleep Sleep Apnea, Obstructive/complications/diagnosis/epidemiology Adhd Osa adolescence Index. décimale : PER Périodiques Résumé : BACKGROUND: A high comorbidity between attention-deficit/hyperactivity disorder (ADHD) and obstructive sleep apnea (OSA) as well as similar impairments across neurobehavioral outcomes has been described in children. However, there is a paucity of research examining the comorbidity of these two disorders in adolescents. This study examined the association of OSA with sleep, neurobehavioral, and cardiometabolic outcomes in adolescents with ADHD from the general population. METHODS: 421 adolescents (16.9?+?2.3?years, 53.9% male) underwent 9-hr polysomnography, neurobehavioral, and physical evaluation. ADHD was ascertained by a parent-or-self-report of a lifetime diagnosis/treatment of ADHD. OSA was defined as an apnea hypopnea index of ?2 events/hour. Groups of controls (n=208), OSA-alone (n=115), ADHD-alone (n=54), and ADHD+OSA (n=44) were studied. Multivariable-adjusted general linear models tested group differences in PSG parameters, neurobehavioral, and cardiometabolic outcomes after controlling for sex, race/ethnicity, age, and/or body mass index percentile. RESULTS: The ADHD+OSA group had significantly longer sleep onset latency, shorter total sleep time, lower sleep efficiency, and higher percent of stage 1 sleep, as compared with all other groups, however, these differences were diminished by excluding adolescents on psychoactive medication. The ADHD-alone group showed significantly higher periodic limb movements than controls. The ADHD+OSA and ADHD-alone groups did not significantly differ on any measure of neurocognitive or behavioral functioning. The ADHD+OSA and OSA-alone groups showed significantly worse cardiometabolic and inflammatory biomarkers when compared to controls or the ADHD-alone, but did not significantly differ between each other. CONCLUSIONS: Adolescents with a diagnosis ADHD+OSA showed phenotypic risk factors for OSA (i.e., overweight/obesity, visceral adiposity, metabolic syndrome, and inflammation) but not worse neurobehavioral outcomes when compared with ADHD-alone. While comorbidity is possible, these data support that adolescents with a suspicion of ADHD should be screened for OSA, before a diagnosis is reached and psychoactive medication initiated. En ligne : http://dx.doi.org/10.1111/jcpp.13491 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=476
in Journal of Child Psychology and Psychiatry > 63-5 (May 2022) . - p.544-552[article] Behavioral, neurocognitive, polysomnographic and cardiometabolic profiles associated with obstructive sleep apnea in adolescents with ADHD [Texte imprimé et/ou numérique] / Kristina PUZINO, Auteur ; Elizaveta BOURCHTEIN, Auteur ; Susan L. CALHOUN, Auteur ; Fan HE, Auteur ; Alexandros N. VGONTZAS, Auteur ; Duanping LIAO, Auteur ; Edward O BIXLER, Auteur ; Julio FERNANDEZ-MENDOZA, Auteur . - p.544-552.
Langues : Anglais (eng)
in Journal of Child Psychology and Psychiatry > 63-5 (May 2022) . - p.544-552
Mots-clés : Adolescent Attention Deficit Disorder with Hyperactivity/complications/epidemiology Cardiovascular Diseases/complications/epidemiology Child Female Humans Male Polysomnography Sleep Sleep Apnea, Obstructive/complications/diagnosis/epidemiology Adhd Osa adolescence Index. décimale : PER Périodiques Résumé : BACKGROUND: A high comorbidity between attention-deficit/hyperactivity disorder (ADHD) and obstructive sleep apnea (OSA) as well as similar impairments across neurobehavioral outcomes has been described in children. However, there is a paucity of research examining the comorbidity of these two disorders in adolescents. This study examined the association of OSA with sleep, neurobehavioral, and cardiometabolic outcomes in adolescents with ADHD from the general population. METHODS: 421 adolescents (16.9?+?2.3?years, 53.9% male) underwent 9-hr polysomnography, neurobehavioral, and physical evaluation. ADHD was ascertained by a parent-or-self-report of a lifetime diagnosis/treatment of ADHD. OSA was defined as an apnea hypopnea index of ?2 events/hour. Groups of controls (n=208), OSA-alone (n=115), ADHD-alone (n=54), and ADHD+OSA (n=44) were studied. Multivariable-adjusted general linear models tested group differences in PSG parameters, neurobehavioral, and cardiometabolic outcomes after controlling for sex, race/ethnicity, age, and/or body mass index percentile. RESULTS: The ADHD+OSA group had significantly longer sleep onset latency, shorter total sleep time, lower sleep efficiency, and higher percent of stage 1 sleep, as compared with all other groups, however, these differences were diminished by excluding adolescents on psychoactive medication. The ADHD-alone group showed significantly higher periodic limb movements than controls. The ADHD+OSA and ADHD-alone groups did not significantly differ on any measure of neurocognitive or behavioral functioning. The ADHD+OSA and OSA-alone groups showed significantly worse cardiometabolic and inflammatory biomarkers when compared to controls or the ADHD-alone, but did not significantly differ between each other. CONCLUSIONS: Adolescents with a diagnosis ADHD+OSA showed phenotypic risk factors for OSA (i.e., overweight/obesity, visceral adiposity, metabolic syndrome, and inflammation) but not worse neurobehavioral outcomes when compared with ADHD-alone. While comorbidity is possible, these data support that adolescents with a suspicion of ADHD should be screened for OSA, before a diagnosis is reached and psychoactive medication initiated. En ligne : http://dx.doi.org/10.1111/jcpp.13491 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=476 Sleep Disturbances Increase the Impact of Working Memory Deficits on Learning Problems in Adolescents with High-Functioning Autism Spectrum Disorder / Susan L. CALHOUN in Journal of Autism and Developmental Disorders, 50-5 (May 2020)
[article]
Titre : Sleep Disturbances Increase the Impact of Working Memory Deficits on Learning Problems in Adolescents with High-Functioning Autism Spectrum Disorder Type de document : Texte imprimé et/ou numérique Auteurs : Susan L. CALHOUN, Auteur ; Amanda M. PEARL, Auteur ; Julio FERNANDEZ-MENDOZA, Auteur ; Krina C. DURICA, Auteur ; Susan D. MAYES, Auteur ; Michael J. MURRAY, Auteur Article en page(s) : p.1701-1713 Langues : Anglais (eng) Mots-clés : High-functioning autism Learning problems Sleep Working memory Index. décimale : PER Périodiques Résumé : Sleep disturbances (SD) are prevalent in individuals diagnosed with Autism Spectrum Disorder (ASD). Less is known about the effects of SD on cognition and learning in adolescents with high-functioning ASD (HF-ASD). Adolescents with HF-ASD (N = 96) were evaluated for the relationships of SD to working memory and learning problems. Results found SD to modify the relationship between working memory and learning problems. Working memory deficits were associated with learning problems among those with SD, while not among those without SD. SD and working memory deficits should be targeted in interventions for these adolescents with HF-ASD (e.g., cognitive behavior therapy for insomnia, pharmacological treatments). Future studies should examine if improvement in SD reduces the impact of working memory deficits on learning problems. En ligne : http://dx.doi.org/10.1007/s10803-019-03928-y Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=422
in Journal of Autism and Developmental Disorders > 50-5 (May 2020) . - p.1701-1713[article] Sleep Disturbances Increase the Impact of Working Memory Deficits on Learning Problems in Adolescents with High-Functioning Autism Spectrum Disorder [Texte imprimé et/ou numérique] / Susan L. CALHOUN, Auteur ; Amanda M. PEARL, Auteur ; Julio FERNANDEZ-MENDOZA, Auteur ; Krina C. DURICA, Auteur ; Susan D. MAYES, Auteur ; Michael J. MURRAY, Auteur . - p.1701-1713.
Langues : Anglais (eng)
in Journal of Autism and Developmental Disorders > 50-5 (May 2020) . - p.1701-1713
Mots-clés : High-functioning autism Learning problems Sleep Working memory Index. décimale : PER Périodiques Résumé : Sleep disturbances (SD) are prevalent in individuals diagnosed with Autism Spectrum Disorder (ASD). Less is known about the effects of SD on cognition and learning in adolescents with high-functioning ASD (HF-ASD). Adolescents with HF-ASD (N = 96) were evaluated for the relationships of SD to working memory and learning problems. Results found SD to modify the relationship between working memory and learning problems. Working memory deficits were associated with learning problems among those with SD, while not among those without SD. SD and working memory deficits should be targeted in interventions for these adolescents with HF-ASD (e.g., cognitive behavior therapy for insomnia, pharmacological treatments). Future studies should examine if improvement in SD reduces the impact of working memory deficits on learning problems. En ligne : http://dx.doi.org/10.1007/s10803-019-03928-y Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=422