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Détail de l'auteur
Auteur Bradley S. PETERSON |
Documents disponibles écrits par cet auteur (2)
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Editorial: Biomarkers in precision medicine for mental illnesses / Bradley S. PETERSON in Journal of Child Psychology and Psychiatry, 61-12 (December 2020)
[article]
Titre : Editorial: Biomarkers in precision medicine for mental illnesses Type de document : Texte imprimé et/ou numérique Auteurs : Bradley S. PETERSON, Auteur Article en page(s) : p.1279-1281 Langues : Anglais (eng) Mots-clés : Precision medicine biomarkers endophenotype mental illness personalized medicine prediction public health treatment validation Index. décimale : PER Périodiques Résumé : Precision medicine and biomarker development have become the prevailing paradigm for mental health research. Despite its conceptual elegance and dominance as a research framework, precision medicine has a very limited track record of demonstrable success thus far for mental illnesses, due in varying degrees to the complexity of both the brain and the pathophysiology of mental illnesses, which limits our ability to develop, replicate, and validate biomarkers for use in enhancing clinical care for mental illnesses, especially in high-risk and complex clinical populations. Research and funding priorities should integrate biomarker development and precision medicine interventions that target the robust behavioral, environmental, and social determinants that we know are important for population-based mental health. En ligne : http://dx.doi.org/10.1111/jcpp.13357 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=434
in Journal of Child Psychology and Psychiatry > 61-12 (December 2020) . - p.1279-1281[article] Editorial: Biomarkers in precision medicine for mental illnesses [Texte imprimé et/ou numérique] / Bradley S. PETERSON, Auteur . - p.1279-1281.
Langues : Anglais (eng)
in Journal of Child Psychology and Psychiatry > 61-12 (December 2020) . - p.1279-1281
Mots-clés : Precision medicine biomarkers endophenotype mental illness personalized medicine prediction public health treatment validation Index. décimale : PER Périodiques Résumé : Precision medicine and biomarker development have become the prevailing paradigm for mental health research. Despite its conceptual elegance and dominance as a research framework, precision medicine has a very limited track record of demonstrable success thus far for mental illnesses, due in varying degrees to the complexity of both the brain and the pathophysiology of mental illnesses, which limits our ability to develop, replicate, and validate biomarkers for use in enhancing clinical care for mental illnesses, especially in high-risk and complex clinical populations. Research and funding priorities should integrate biomarker development and precision medicine interventions that target the robust behavioral, environmental, and social determinants that we know are important for population-based mental health. En ligne : http://dx.doi.org/10.1111/jcpp.13357 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=434 Prenatal exposure to polycyclic aromatic hydrocarbons modifies the effects of early life stress on attention and Thought Problems in late childhood / David PAGLIACCIO in Journal of Child Psychology and Psychiatry, 61-11 (November 2020)
[article]
Titre : Prenatal exposure to polycyclic aromatic hydrocarbons modifies the effects of early life stress on attention and Thought Problems in late childhood Type de document : Texte imprimé et/ou numérique Auteurs : David PAGLIACCIO, Auteur ; Julie B. HERBSTMAN, Auteur ; Frederica PERERA, Auteur ; Deliang TANG, Auteur ; Jeff GOLDSMITH, Auteur ; Bradley S. PETERSON, Auteur ; Virginia RAUH, Auteur ; Amy E. MARGOLIS, Auteur Article en page(s) : p.1253-1265 Langues : Anglais (eng) Mots-clés : Attention deficit hyperactivity disorder adversity child behavior checklist child development toxicants Index. décimale : PER Périodiques Résumé : BACKGROUND: Risk for childhood psychopathology is complex and multifactorial, implicating direct and interacting effects of familial and environmental factors. The role of environmental neurotoxicants in psychiatric risk is of growing concern, including polycyclic aromatic hydrocarbons (PAH), common in air pollution. Prenatal PAH exposure is linked to adverse physical, behavioral, and cognitive outcomes as well as increasing psychiatric risk. It is unclear whether environmental exposures, like PAH, magnify the effects of exposure to early life stress (ELS), a critical risk factor for psychopathology. The current work aimed to test potential interactions between prenatal PAH exposure and psychosocial/socioeconomic stress on psychiatric symptoms in school-age children. METHODS: Data were from the Columbia Center for Children's Environmental Health Mothers and Newborns longitudinal birth cohort study. Prenatal PAH exposure was ascertained though air monitoring during pregnancy and maternal PAH-DNA adducts at delivery. Mothers reported on ELS (child age 5) and on child psychiatric symptoms across childhood (child age 5, 7, 9, and 11) using the Child Behavior Checklist (CBCL). RESULTS: Significant prenatal airborne PAH × ELS interactions (FDR-corrected) predicted CBCL Attention (? = 0.22, t(307) = 3.47, p < .001, p(fdr ) = .003) and Thought Problems T-scores (? = 0.21, t(307) = 3.29, p = .001, p(fdr ) = .004) at age 11 (n = 319). Relative to those with lower exposure, children with higher prenatal PAH exposure exhibited stronger positive associations between ELS and CBCL Attention and Thought Problem T-scores. This interaction was also significant examining convergent ADHD measures (Conners, DuPaul) and examining maternal PAH-DNA adducts (? = 0.29, t(261) = 2.48, p = .01; n = 273). A three-way interaction with assessment wave indicated that the PAH × ELS interaction on Attention Problems was stronger later in development (? = 0.03, t(1,601) = 2.19, p = .03; n = 477). CONCLUSIONS: Prenatal exposure to PAH, a common neurotoxicant in air pollution, may magnify or sustain the effects of early life psychosocial/socioeconomic stress on psychiatric outcomes later in child development. This work highlights the critical role of air pollution exposure on child mental health. En ligne : http://dx.doi.org/10.1111/jcpp.13189 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=434
in Journal of Child Psychology and Psychiatry > 61-11 (November 2020) . - p.1253-1265[article] Prenatal exposure to polycyclic aromatic hydrocarbons modifies the effects of early life stress on attention and Thought Problems in late childhood [Texte imprimé et/ou numérique] / David PAGLIACCIO, Auteur ; Julie B. HERBSTMAN, Auteur ; Frederica PERERA, Auteur ; Deliang TANG, Auteur ; Jeff GOLDSMITH, Auteur ; Bradley S. PETERSON, Auteur ; Virginia RAUH, Auteur ; Amy E. MARGOLIS, Auteur . - p.1253-1265.
Langues : Anglais (eng)
in Journal of Child Psychology and Psychiatry > 61-11 (November 2020) . - p.1253-1265
Mots-clés : Attention deficit hyperactivity disorder adversity child behavior checklist child development toxicants Index. décimale : PER Périodiques Résumé : BACKGROUND: Risk for childhood psychopathology is complex and multifactorial, implicating direct and interacting effects of familial and environmental factors. The role of environmental neurotoxicants in psychiatric risk is of growing concern, including polycyclic aromatic hydrocarbons (PAH), common in air pollution. Prenatal PAH exposure is linked to adverse physical, behavioral, and cognitive outcomes as well as increasing psychiatric risk. It is unclear whether environmental exposures, like PAH, magnify the effects of exposure to early life stress (ELS), a critical risk factor for psychopathology. The current work aimed to test potential interactions between prenatal PAH exposure and psychosocial/socioeconomic stress on psychiatric symptoms in school-age children. METHODS: Data were from the Columbia Center for Children's Environmental Health Mothers and Newborns longitudinal birth cohort study. Prenatal PAH exposure was ascertained though air monitoring during pregnancy and maternal PAH-DNA adducts at delivery. Mothers reported on ELS (child age 5) and on child psychiatric symptoms across childhood (child age 5, 7, 9, and 11) using the Child Behavior Checklist (CBCL). RESULTS: Significant prenatal airborne PAH × ELS interactions (FDR-corrected) predicted CBCL Attention (? = 0.22, t(307) = 3.47, p < .001, p(fdr ) = .003) and Thought Problems T-scores (? = 0.21, t(307) = 3.29, p = .001, p(fdr ) = .004) at age 11 (n = 319). Relative to those with lower exposure, children with higher prenatal PAH exposure exhibited stronger positive associations between ELS and CBCL Attention and Thought Problem T-scores. This interaction was also significant examining convergent ADHD measures (Conners, DuPaul) and examining maternal PAH-DNA adducts (? = 0.29, t(261) = 2.48, p = .01; n = 273). A three-way interaction with assessment wave indicated that the PAH × ELS interaction on Attention Problems was stronger later in development (? = 0.03, t(1,601) = 2.19, p = .03; n = 477). CONCLUSIONS: Prenatal exposure to PAH, a common neurotoxicant in air pollution, may magnify or sustain the effects of early life psychosocial/socioeconomic stress on psychiatric outcomes later in child development. This work highlights the critical role of air pollution exposure on child mental health. En ligne : http://dx.doi.org/10.1111/jcpp.13189 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=434