Centre d'Information et de documentation du CRA Rhône-Alpes
CRA
Informations pratiques
-
Adresse
Centre d'information et de documentation
du CRA Rhône-Alpes
Centre Hospitalier le Vinatier
bât 211
95, Bd Pinel
69678 Bron CedexHoraires
Lundi au Vendredi
9h00-12h00 13h30-16h00Contact
Tél: +33(0)4 37 91 54 65
Mail
Fax: +33(0)4 37 91 54 37
-
Détail de l'auteur
Auteur G. HACKETT |
Documents disponibles écrits par cet auteur (1)
Faire une suggestion Affiner la recherche
Maternal steroid levels and the autistic traits of the mother and infant / A. TSOMPANIDIS in Molecular Autism, 12 (2021)
[article]
Titre : Maternal steroid levels and the autistic traits of the mother and infant Type de document : Texte imprimé et/ou numérique Auteurs : A. TSOMPANIDIS, Auteur ; E. AYDIN, Auteur ; E. PADAIGAIT?, Auteur ; G. RICHARDS, Auteur ; Carrie ALLISON, Auteur ; G. HACKETT, Auteur ; T. AUSTIN, Auteur ; R. HOLT, Auteur ; Simon BARON-COHEN, Auteur Article en page(s) : 51 p. Langues : Anglais (eng) Mots-clés : Autism Autistic Traits Estradiol Interaction Pregnancy Prenatal Sex Index. décimale : PER Périodiques Résumé : BACKGROUND: Prenatal sex steroids have been associated with autism in several clinical and epidemiological studies. It is unclear how this relates to the autistic traits of the mother and how early this can be detected during pregnancy and postnatal development. METHODS: Maternal serum was collected from pregnant women (n?=?122) before or during their first ultrasound appointment [mean?=?12.7 (SD?=?0.7) weeks]. Concentrations of the following were measured via immunoassays: testosterone, estradiol, dehydroepiandrosterone sulphate, progesterone; and sex hormone-binding globulin which was used to compute the free fractions of estradiol (FEI) and testosterone (FTI). Standardised human choriogonadotropin (hCG) and pregnancy-associated plasma protein A (PAPP-A) values were obtained from clinical records corresponding to the same serum samples. Mothers completed the Autism Spectrum Quotient (AQ) and for their infants, the Quantitative Checklist for Autism in Toddlers (Q-CHAT) when the infants were between 18 and 20 months old. RESULTS: FEI was positively associated with maternal autistic traits in univariate (n?=?108, Pearson's r?=?0.22, p?=?0.019) and multiple regression models (semipartial r?=?0.19, p?=?0.048) controlling for maternal age and a diagnosis of PCOS. Maternal estradiol levels significantly interacted with fetal sex in predicting infant Q-CHAT scores, with a positive relationship in males but not females (n?=?100, interaction term: semipartial r?=?0.23, p?=?0.036) after controlling for maternal AQ and other covariates. The opposite was found for standardised hCG values and Q-CHAT scores, with a positive association in females but not in males (n?=?151, interaction term: r?=?-0.25, p?=?0.005). LIMITATIONS: Sample size of this cohort was small, with potential ascertainment bias given elective recruitment. Clinical covariates were controlled in multiple regression models, but additional research is needed to confirm the statistically significant findings in larger cohorts. CONCLUSION: Maternal steroid factors during pregnancy are associated with autistic traits in mothers and their infants. En ligne : http://dx.doi.org/10.1186/s13229-021-00453-7 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=459
in Molecular Autism > 12 (2021) . - 51 p.[article] Maternal steroid levels and the autistic traits of the mother and infant [Texte imprimé et/ou numérique] / A. TSOMPANIDIS, Auteur ; E. AYDIN, Auteur ; E. PADAIGAIT?, Auteur ; G. RICHARDS, Auteur ; Carrie ALLISON, Auteur ; G. HACKETT, Auteur ; T. AUSTIN, Auteur ; R. HOLT, Auteur ; Simon BARON-COHEN, Auteur . - 51 p.
Langues : Anglais (eng)
in Molecular Autism > 12 (2021) . - 51 p.
Mots-clés : Autism Autistic Traits Estradiol Interaction Pregnancy Prenatal Sex Index. décimale : PER Périodiques Résumé : BACKGROUND: Prenatal sex steroids have been associated with autism in several clinical and epidemiological studies. It is unclear how this relates to the autistic traits of the mother and how early this can be detected during pregnancy and postnatal development. METHODS: Maternal serum was collected from pregnant women (n?=?122) before or during their first ultrasound appointment [mean?=?12.7 (SD?=?0.7) weeks]. Concentrations of the following were measured via immunoassays: testosterone, estradiol, dehydroepiandrosterone sulphate, progesterone; and sex hormone-binding globulin which was used to compute the free fractions of estradiol (FEI) and testosterone (FTI). Standardised human choriogonadotropin (hCG) and pregnancy-associated plasma protein A (PAPP-A) values were obtained from clinical records corresponding to the same serum samples. Mothers completed the Autism Spectrum Quotient (AQ) and for their infants, the Quantitative Checklist for Autism in Toddlers (Q-CHAT) when the infants were between 18 and 20 months old. RESULTS: FEI was positively associated with maternal autistic traits in univariate (n?=?108, Pearson's r?=?0.22, p?=?0.019) and multiple regression models (semipartial r?=?0.19, p?=?0.048) controlling for maternal age and a diagnosis of PCOS. Maternal estradiol levels significantly interacted with fetal sex in predicting infant Q-CHAT scores, with a positive relationship in males but not females (n?=?100, interaction term: semipartial r?=?0.23, p?=?0.036) after controlling for maternal AQ and other covariates. The opposite was found for standardised hCG values and Q-CHAT scores, with a positive association in females but not in males (n?=?151, interaction term: r?=?-0.25, p?=?0.005). LIMITATIONS: Sample size of this cohort was small, with potential ascertainment bias given elective recruitment. Clinical covariates were controlled in multiple regression models, but additional research is needed to confirm the statistically significant findings in larger cohorts. CONCLUSION: Maternal steroid factors during pregnancy are associated with autistic traits in mothers and their infants. En ligne : http://dx.doi.org/10.1186/s13229-021-00453-7 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=459