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Associations Between the 2nd to 4th Digit Ratio and Autism Spectrum Disorder in Population-Based Samples of Boys and Girls: Findings from the Study to Explore Early Development / Laura A. SCHIEVE in Journal of Autism and Developmental Disorders, 48-7 (July 2018)
[article]
Titre : Associations Between the 2nd to 4th Digit Ratio and Autism Spectrum Disorder in Population-Based Samples of Boys and Girls: Findings from the Study to Explore Early Development Type de document : Texte imprimé et/ou numérique Auteurs : Laura A. SCHIEVE, Auteur ; L. TIAN, Auteur ; N. DOWLING, Auteur ; Lisa A. CROEN, Auteur ; J. HOOVER-FONG, Auteur ; A. ALEXANDER, Auteur ; S. K. SHAPIRA, Auteur Article en page(s) : p.2379-2395 Langues : Anglais (eng) Mots-clés : Autism spectrum disorder Estradiol Fetal development Testosterone Index. décimale : PER Périodiques Résumé : The ratio of the index (2nd) finger to ring (4th) finger lengths (2D:4D) is a proxy for fetal testosterone and estradiol. Studies suggesting 2D:4D is inversely associated with autism spectrum disorder (ASD) in males were limited by lack of confounder and subgroup assessments. Studies of females are sparse. We examined associations between ASD and 2D:4D among children in the Study to Explore Early Development; we considered case subgroups and numerous potential demographic and maternal-perinatal health confounders. We observed a modest inverse association between ASD and right-hand 2D:4D in males; subgroup analyses indicated associations were limited to ASD cases with birth defects/genetic syndromes or dysmorphic features. We observed a positive association between ASD and left-hand 2D:4D in females, overall and within most case subgroups. En ligne : http://dx.doi.org/10.1007/s10803-018-3495-z Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=367
in Journal of Autism and Developmental Disorders > 48-7 (July 2018) . - p.2379-2395[article] Associations Between the 2nd to 4th Digit Ratio and Autism Spectrum Disorder in Population-Based Samples of Boys and Girls: Findings from the Study to Explore Early Development [Texte imprimé et/ou numérique] / Laura A. SCHIEVE, Auteur ; L. TIAN, Auteur ; N. DOWLING, Auteur ; Lisa A. CROEN, Auteur ; J. HOOVER-FONG, Auteur ; A. ALEXANDER, Auteur ; S. K. SHAPIRA, Auteur . - p.2379-2395.
Langues : Anglais (eng)
in Journal of Autism and Developmental Disorders > 48-7 (July 2018) . - p.2379-2395
Mots-clés : Autism spectrum disorder Estradiol Fetal development Testosterone Index. décimale : PER Périodiques Résumé : The ratio of the index (2nd) finger to ring (4th) finger lengths (2D:4D) is a proxy for fetal testosterone and estradiol. Studies suggesting 2D:4D is inversely associated with autism spectrum disorder (ASD) in males were limited by lack of confounder and subgroup assessments. Studies of females are sparse. We examined associations between ASD and 2D:4D among children in the Study to Explore Early Development; we considered case subgroups and numerous potential demographic and maternal-perinatal health confounders. We observed a modest inverse association between ASD and right-hand 2D:4D in males; subgroup analyses indicated associations were limited to ASD cases with birth defects/genetic syndromes or dysmorphic features. We observed a positive association between ASD and left-hand 2D:4D in females, overall and within most case subgroups. En ligne : http://dx.doi.org/10.1007/s10803-018-3495-z Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=367 Maternal steroid levels and the autistic traits of the mother and infant / A. TSOMPANIDIS in Molecular Autism, 12 (2021)
[article]
Titre : Maternal steroid levels and the autistic traits of the mother and infant Type de document : Texte imprimé et/ou numérique Auteurs : A. TSOMPANIDIS, Auteur ; E. AYDIN, Auteur ; E. PADAIGAIT?, Auteur ; G. RICHARDS, Auteur ; Carrie ALLISON, Auteur ; G. HACKETT, Auteur ; T. AUSTIN, Auteur ; R. HOLT, Auteur ; Simon BARON-COHEN, Auteur Article en page(s) : 51 p. Langues : Anglais (eng) Mots-clés : Autism Autistic Traits Estradiol Interaction Pregnancy Prenatal Sex Index. décimale : PER Périodiques Résumé : BACKGROUND: Prenatal sex steroids have been associated with autism in several clinical and epidemiological studies. It is unclear how this relates to the autistic traits of the mother and how early this can be detected during pregnancy and postnatal development. METHODS: Maternal serum was collected from pregnant women (n?=?122) before or during their first ultrasound appointment [mean?=?12.7 (SD?=?0.7) weeks]. Concentrations of the following were measured via immunoassays: testosterone, estradiol, dehydroepiandrosterone sulphate, progesterone; and sex hormone-binding globulin which was used to compute the free fractions of estradiol (FEI) and testosterone (FTI). Standardised human choriogonadotropin (hCG) and pregnancy-associated plasma protein A (PAPP-A) values were obtained from clinical records corresponding to the same serum samples. Mothers completed the Autism Spectrum Quotient (AQ) and for their infants, the Quantitative Checklist for Autism in Toddlers (Q-CHAT) when the infants were between 18 and 20 months old. RESULTS: FEI was positively associated with maternal autistic traits in univariate (n?=?108, Pearson's r?=?0.22, p?=?0.019) and multiple regression models (semipartial r?=?0.19, p?=?0.048) controlling for maternal age and a diagnosis of PCOS. Maternal estradiol levels significantly interacted with fetal sex in predicting infant Q-CHAT scores, with a positive relationship in males but not females (n?=?100, interaction term: semipartial r?=?0.23, p?=?0.036) after controlling for maternal AQ and other covariates. The opposite was found for standardised hCG values and Q-CHAT scores, with a positive association in females but not in males (n?=?151, interaction term: r?=?-0.25, p?=?0.005). LIMITATIONS: Sample size of this cohort was small, with potential ascertainment bias given elective recruitment. Clinical covariates were controlled in multiple regression models, but additional research is needed to confirm the statistically significant findings in larger cohorts. CONCLUSION: Maternal steroid factors during pregnancy are associated with autistic traits in mothers and their infants. En ligne : http://dx.doi.org/10.1186/s13229-021-00453-7 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=459
in Molecular Autism > 12 (2021) . - 51 p.[article] Maternal steroid levels and the autistic traits of the mother and infant [Texte imprimé et/ou numérique] / A. TSOMPANIDIS, Auteur ; E. AYDIN, Auteur ; E. PADAIGAIT?, Auteur ; G. RICHARDS, Auteur ; Carrie ALLISON, Auteur ; G. HACKETT, Auteur ; T. AUSTIN, Auteur ; R. HOLT, Auteur ; Simon BARON-COHEN, Auteur . - 51 p.
Langues : Anglais (eng)
in Molecular Autism > 12 (2021) . - 51 p.
Mots-clés : Autism Autistic Traits Estradiol Interaction Pregnancy Prenatal Sex Index. décimale : PER Périodiques Résumé : BACKGROUND: Prenatal sex steroids have been associated with autism in several clinical and epidemiological studies. It is unclear how this relates to the autistic traits of the mother and how early this can be detected during pregnancy and postnatal development. METHODS: Maternal serum was collected from pregnant women (n?=?122) before or during their first ultrasound appointment [mean?=?12.7 (SD?=?0.7) weeks]. Concentrations of the following were measured via immunoassays: testosterone, estradiol, dehydroepiandrosterone sulphate, progesterone; and sex hormone-binding globulin which was used to compute the free fractions of estradiol (FEI) and testosterone (FTI). Standardised human choriogonadotropin (hCG) and pregnancy-associated plasma protein A (PAPP-A) values were obtained from clinical records corresponding to the same serum samples. Mothers completed the Autism Spectrum Quotient (AQ) and for their infants, the Quantitative Checklist for Autism in Toddlers (Q-CHAT) when the infants were between 18 and 20 months old. RESULTS: FEI was positively associated with maternal autistic traits in univariate (n?=?108, Pearson's r?=?0.22, p?=?0.019) and multiple regression models (semipartial r?=?0.19, p?=?0.048) controlling for maternal age and a diagnosis of PCOS. Maternal estradiol levels significantly interacted with fetal sex in predicting infant Q-CHAT scores, with a positive relationship in males but not females (n?=?100, interaction term: semipartial r?=?0.23, p?=?0.036) after controlling for maternal AQ and other covariates. The opposite was found for standardised hCG values and Q-CHAT scores, with a positive association in females but not in males (n?=?151, interaction term: r?=?-0.25, p?=?0.005). LIMITATIONS: Sample size of this cohort was small, with potential ascertainment bias given elective recruitment. Clinical covariates were controlled in multiple regression models, but additional research is needed to confirm the statistically significant findings in larger cohorts. CONCLUSION: Maternal steroid factors during pregnancy are associated with autistic traits in mothers and their infants. En ligne : http://dx.doi.org/10.1186/s13229-021-00453-7 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=459