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Auteur Mary COUSSONS-READ |
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Increases in maternal depressive symptoms during pregnancy and infant cortisol reactivity: Mediation by placental corticotropin-releasing hormone / Jennifer A. SOMERS ; Isabel F. RAMOS ; Kharah M. ROSS ; Mary COUSSONS-READ ; Christine DUNKEL SCHETTER in Development and Psychopathology, 35-4 (October 2023)
[article]
Titre : Increases in maternal depressive symptoms during pregnancy and infant cortisol reactivity: Mediation by placental corticotropin-releasing hormone Type de document : Texte imprimé et/ou numérique Auteurs : Jennifer A. SOMERS, Auteur ; Isabel F. RAMOS, Auteur ; Kharah M. ROSS, Auteur ; Mary COUSSONS-READ, Auteur ; Christine DUNKEL SCHETTER, Auteur Article en page(s) : p.1997-2010 Langues : Anglais (eng) Mots-clés : depressive symptoms HPA axis infancy placental corticotropin-releasing hormone pregnancy Index. décimale : PER Périodiques Résumé : Background:Maternal depressive symptoms in pregnancy may affect offspring health through prenatal programming of the hypothalamic-pituitary-adrenal (HPA) axis. The biological mechanisms that explain the associations between maternal prenatal depressive symptoms and offspring HPA axis regulation are not yet clear. This pre-registered investigation examines whether patterns of maternal depressive symptoms in pregnancy are associated with infant cortisol reactivity and whether this association is mediated by changes in placental corticotropin-releasing hormone (pCRH).Method:A sample of 174 pregnant women completed assessments in early, mid, and late pregnancy that included standardized measures of depressive symptoms and blood samples for pCRH. Infant cortisol reactivity was assessed at 1 and 6 months of age.Results:Greater increases in maternal depressive symptoms in pregnancy were associated with higher cortisol infant cortisol reactivity at 1 and 6 months. Greater increases in maternal depressive symptoms in pregnancy were associated with greater increases in pCRH from early to late pregnancy which in turn were associated with higher infant cortisol reactivity.Conclusions:Increases in maternal depressive symptoms and pCRH over pregnancy may contribute to higher infant cortisol reactivity. These findings help to elucidate the prenatal biopsychosocial processes contributing to offspring HPA axis regulation early in development. En ligne : https://dx.doi.org/10.1017/S0954579422000621 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=515
in Development and Psychopathology > 35-4 (October 2023) . - p.1997-2010[article] Increases in maternal depressive symptoms during pregnancy and infant cortisol reactivity: Mediation by placental corticotropin-releasing hormone [Texte imprimé et/ou numérique] / Jennifer A. SOMERS, Auteur ; Isabel F. RAMOS, Auteur ; Kharah M. ROSS, Auteur ; Mary COUSSONS-READ, Auteur ; Christine DUNKEL SCHETTER, Auteur . - p.1997-2010.
Langues : Anglais (eng)
in Development and Psychopathology > 35-4 (October 2023) . - p.1997-2010
Mots-clés : depressive symptoms HPA axis infancy placental corticotropin-releasing hormone pregnancy Index. décimale : PER Périodiques Résumé : Background:Maternal depressive symptoms in pregnancy may affect offspring health through prenatal programming of the hypothalamic-pituitary-adrenal (HPA) axis. The biological mechanisms that explain the associations between maternal prenatal depressive symptoms and offspring HPA axis regulation are not yet clear. This pre-registered investigation examines whether patterns of maternal depressive symptoms in pregnancy are associated with infant cortisol reactivity and whether this association is mediated by changes in placental corticotropin-releasing hormone (pCRH).Method:A sample of 174 pregnant women completed assessments in early, mid, and late pregnancy that included standardized measures of depressive symptoms and blood samples for pCRH. Infant cortisol reactivity was assessed at 1 and 6 months of age.Results:Greater increases in maternal depressive symptoms in pregnancy were associated with higher cortisol infant cortisol reactivity at 1 and 6 months. Greater increases in maternal depressive symptoms in pregnancy were associated with greater increases in pCRH from early to late pregnancy which in turn were associated with higher infant cortisol reactivity.Conclusions:Increases in maternal depressive symptoms and pCRH over pregnancy may contribute to higher infant cortisol reactivity. These findings help to elucidate the prenatal biopsychosocial processes contributing to offspring HPA axis regulation early in development. En ligne : https://dx.doi.org/10.1017/S0954579422000621 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=515