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Auteur Sven BÖLTE |
Documents disponibles écrits par cet auteur (66)
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Is There an Epidemic of ASC / Sven BÖLTE
Titre : Is There an Epidemic of ASC Type de document : Texte imprimé et/ou numérique Auteurs : Sven BÖLTE, Auteur Année de publication : 2011 Importance : p.64-66 Langues : Anglais (eng) Index. décimale : AUT-B AUT-B - L'Autisme - Ouvrages généraux et scientifiques Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=138 Is There an Epidemic of ASC [Texte imprimé et/ou numérique] / Sven BÖLTE, Auteur . - 2011 . - p.64-66.
Langues : Anglais (eng)
Index. décimale : AUT-B AUT-B - L'Autisme - Ouvrages généraux et scientifiques Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=138 Exemplaires
Code-barres Cote Support Localisation Section Disponibilité aucun exemplaire Larger pupil dilation to nonsocial sounds in infants with subsequent autism diagnosis / Maja RUDLING in Journal of Child Psychology and Psychiatry, 63-7 (July 2022)
[article]
Titre : Larger pupil dilation to nonsocial sounds in infants with subsequent autism diagnosis Type de document : Texte imprimé et/ou numérique Auteurs : Maja RUDLING, Auteur ; Pär NYSTRÖM, Auteur ; Sven BÖLTE, Auteur ; Terje FALCK-YTTER, Auteur Article en page(s) : p.793-801 Langues : Anglais (eng) Mots-clés : Attention/physiology Auditory Perception/physiology Autism Spectrum Disorder/diagnosis Autistic Disorder Female Humans Infant Pupil/physiology Autism spectrum disorder auditory attention infancy pupil dilation Index. décimale : PER Périodiques Résumé : BACKGROUND: Studies of infants with an elevated likelihood of autism spectrum disorder can identify basic developmental processes that are associated with subsequently emerging clinical symptoms. Atypical responsiveness to sounds in infancy is such a potential early marker of autism. Here, we used pupillometry to quantify reactivity to social and nonsocial sounds in infants with a subsequent diagnosis. Previous research suggest that pupil dilation reflects attentional alerting, and link it to the locus coeruleus norepinephrine system. METHODS: We measured pupil dilation responses to child-directed speech and the sound of running water; sounds infants often hear in their everyday life. The final sample consisted of 99 ten-month-old infants (52 girls), of whom 68 had an elevated likelihood of autism and 31 were typically developing low-likelihood infants. At follow-up (36?months of age), 18 children in the elevated-likelihood group were diagnosed with autism. RESULTS: Compared to infants without diagnosis, the infants who were subsequently diagnosed with autism had larger pupil dilation when listening to nonsocial sounds, while reactivity to speech was strikingly similar between groups. In the total sample, more pupil dilation to the nonsocial sound was associated with higher levels of autistic symptoms. We also found that on a trial-by-trial basis, across all conditions and groups, more pupil dilation was associated with making fewer gaze shifts. CONCLUSIONS: This study did not find evidence of atypical pupillary reactivity to child-directed speech early in life in autism. Instead, the results suggest that certain nonsocial sounds elicit atypically strong alerting responses in infants with a subsequent autism diagnosis. These findings may have important theoretical and clinical implications. En ligne : http://dx.doi.org/10.1111/jcpp.13520 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=477
in Journal of Child Psychology and Psychiatry > 63-7 (July 2022) . - p.793-801[article] Larger pupil dilation to nonsocial sounds in infants with subsequent autism diagnosis [Texte imprimé et/ou numérique] / Maja RUDLING, Auteur ; Pär NYSTRÖM, Auteur ; Sven BÖLTE, Auteur ; Terje FALCK-YTTER, Auteur . - p.793-801.
Langues : Anglais (eng)
in Journal of Child Psychology and Psychiatry > 63-7 (July 2022) . - p.793-801
Mots-clés : Attention/physiology Auditory Perception/physiology Autism Spectrum Disorder/diagnosis Autistic Disorder Female Humans Infant Pupil/physiology Autism spectrum disorder auditory attention infancy pupil dilation Index. décimale : PER Périodiques Résumé : BACKGROUND: Studies of infants with an elevated likelihood of autism spectrum disorder can identify basic developmental processes that are associated with subsequently emerging clinical symptoms. Atypical responsiveness to sounds in infancy is such a potential early marker of autism. Here, we used pupillometry to quantify reactivity to social and nonsocial sounds in infants with a subsequent diagnosis. Previous research suggest that pupil dilation reflects attentional alerting, and link it to the locus coeruleus norepinephrine system. METHODS: We measured pupil dilation responses to child-directed speech and the sound of running water; sounds infants often hear in their everyday life. The final sample consisted of 99 ten-month-old infants (52 girls), of whom 68 had an elevated likelihood of autism and 31 were typically developing low-likelihood infants. At follow-up (36?months of age), 18 children in the elevated-likelihood group were diagnosed with autism. RESULTS: Compared to infants without diagnosis, the infants who were subsequently diagnosed with autism had larger pupil dilation when listening to nonsocial sounds, while reactivity to speech was strikingly similar between groups. In the total sample, more pupil dilation to the nonsocial sound was associated with higher levels of autistic symptoms. We also found that on a trial-by-trial basis, across all conditions and groups, more pupil dilation was associated with making fewer gaze shifts. CONCLUSIONS: This study did not find evidence of atypical pupillary reactivity to child-directed speech early in life in autism. Instead, the results suggest that certain nonsocial sounds elicit atypically strong alerting responses in infants with a subsequent autism diagnosis. These findings may have important theoretical and clinical implications. En ligne : http://dx.doi.org/10.1111/jcpp.13520 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=477 Local and Global Visual Processing in 3-Year-Olds With and Without Autism / E. NILSSON JOBS in Journal of Autism and Developmental Disorders, 48-6 (June 2018)
[article]
Titre : Local and Global Visual Processing in 3-Year-Olds With and Without Autism Type de document : Texte imprimé et/ou numérique Auteurs : E. NILSSON JOBS, Auteur ; T. FALCK-YTTER, Auteur ; Sven BÖLTE, Auteur Article en page(s) : p.2249-2257 Langues : Anglais (eng) Mots-clés : Autism Child development Cognition Local processing Neurodevelopmental disorder Visual perception Index. décimale : PER Périodiques Résumé : Research on visual local and global perception in Autism Spectrum Disorder (ASD) is incomplete in young children. We investigated 35 three-year-old siblings of children with ASD, either diagnosed (n = 12) or not diagnosed (n = 23) with ASD as well as 14 controls with typical development and with no family history of ASD. Data from the local tasks Children's Embedded Figures Test, Hidden Pictures, Figure-Ground and the global tasks Closure and Fragmented Picture Test were collected. Enhanced performance on the local task Hidden Pictures differentiated children with ASD from the other groups. Implications of these results are discussed. En ligne : http://dx.doi.org/10.1007/s10803-018-3470-8 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=362
in Journal of Autism and Developmental Disorders > 48-6 (June 2018) . - p.2249-2257[article] Local and Global Visual Processing in 3-Year-Olds With and Without Autism [Texte imprimé et/ou numérique] / E. NILSSON JOBS, Auteur ; T. FALCK-YTTER, Auteur ; Sven BÖLTE, Auteur . - p.2249-2257.
Langues : Anglais (eng)
in Journal of Autism and Developmental Disorders > 48-6 (June 2018) . - p.2249-2257
Mots-clés : Autism Child development Cognition Local processing Neurodevelopmental disorder Visual perception Index. décimale : PER Périodiques Résumé : Research on visual local and global perception in Autism Spectrum Disorder (ASD) is incomplete in young children. We investigated 35 three-year-old siblings of children with ASD, either diagnosed (n = 12) or not diagnosed (n = 23) with ASD as well as 14 controls with typical development and with no family history of ASD. Data from the local tasks Children's Embedded Figures Test, Hidden Pictures, Figure-Ground and the global tasks Closure and Fragmented Picture Test were collected. Enhanced performance on the local task Hidden Pictures differentiated children with ASD from the other groups. Implications of these results are discussed. En ligne : http://dx.doi.org/10.1007/s10803-018-3470-8 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=362 Maternal blood folate status during early pregnancy and occurrence of autism spectrum disorder in offspring: a study of 62 serum biomarkers / Olga EGOROVA in Molecular Autism, 11 (2020)
[article]
Titre : Maternal blood folate status during early pregnancy and occurrence of autism spectrum disorder in offspring: a study of 62 serum biomarkers Type de document : Texte imprimé et/ou numérique Auteurs : Olga EGOROVA, Auteur ; Robin MYTE, Auteur ; Jörn SCHNEEDE, Auteur ; Bruno HAGGLOF, Auteur ; Sven BÖLTE, Auteur ; Erik DOMELLÖF, Auteur ; Barbro IVARS A'ROCH, Auteur ; Fredrik ELGH, Auteur ; Per Magne UELAND, Auteur ; Sven-Arne SILFVERDAL, Auteur Article en page(s) : 7 p. Langues : Anglais (eng) Mots-clés : Autism Folate Inflammation One-carbon metabolism Pregnancy Vitamin A Vitamin B Vitamin D that he has in the last 5 years acted as an author, consultant, or lecturer for Shire, Medice, Roche, Eli Lilly, Prima Psychiatry, GLGroup, System Analytic, Kompetento, Expo Medica, and Prophase. He receives royalties for text books and diagnostic tools from Huber/Hogrefe, Kohlhammer and UTB. Erik Domellöf is supported by a grant from the Knut and Alice Wallenberg Foundation (KAW 2015.0192). There are no other financial disclosures or conflicts of interest. Index. décimale : PER Périodiques Résumé : BACKGROUND: Autism spectrum disorder (ASD) evolves from an interplay between genetic and environmental factors during prenatal development. Since identifying maternal biomarkers associated with ASD risk in offspring during early pregnancy might result in new strategies for intervention, we investigated maternal metabolic biomarkers in relation to occurrence of ASD in offspring using both univariate logistic regression and multivariate network analysis. METHODS: Serum samples from 100 women with an offspring diagnosed with ASD and 100 matched control women with typically developing offspring were collected at week 14 of pregnancy. Concentrations of 62 metabolic biomarkers were determined, including amino acids, vitamins (A, B, D, E, and K), and biomarkers related to folate (vitamin B(9)) metabolism, lifestyle factors, as well as C-reactive protein (CRP), the kynurenine-tryptophan ratio (KTR), and neopterin as markers of inflammation and immune activation. RESULTS: We found weak evidence for a positive association between higher maternal serum concentrations of folate and increased occurrence of ASD (OR per 1 SD increase: 1.70, 95% CI 1.22-2.37, FDR adjusted P = 0.07). Multivariate network analysis confirmed expected internal biochemical relations between the biomarkers. Neither inflammation markers nor vitamin D(3) levels, all hypothesized to be involved in ASD etiology, displayed associations with ASD occurrence in the offspring. CONCLUSIONS: Our findings suggest that high maternal serum folate status during early pregnancy may be associated with the occurrence of ASD in offspring. No inference about physiological mechanisms behind this observation can be made at the present time because blood folate levels may have complex relations with nutritional intake, the cellular folate status and status of other B-vitamins. Therefore, further investigations, which may clarify the potential role and mechanisms of maternal blood folate status in ASD risk and the interplay with other potential risk factors, in larger materials are warranted. En ligne : http://dx.doi.org/10.1186/s13229-020-0315-z Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=427
in Molecular Autism > 11 (2020) . - 7 p.[article] Maternal blood folate status during early pregnancy and occurrence of autism spectrum disorder in offspring: a study of 62 serum biomarkers [Texte imprimé et/ou numérique] / Olga EGOROVA, Auteur ; Robin MYTE, Auteur ; Jörn SCHNEEDE, Auteur ; Bruno HAGGLOF, Auteur ; Sven BÖLTE, Auteur ; Erik DOMELLÖF, Auteur ; Barbro IVARS A'ROCH, Auteur ; Fredrik ELGH, Auteur ; Per Magne UELAND, Auteur ; Sven-Arne SILFVERDAL, Auteur . - 7 p.
Langues : Anglais (eng)
in Molecular Autism > 11 (2020) . - 7 p.
Mots-clés : Autism Folate Inflammation One-carbon metabolism Pregnancy Vitamin A Vitamin B Vitamin D that he has in the last 5 years acted as an author, consultant, or lecturer for Shire, Medice, Roche, Eli Lilly, Prima Psychiatry, GLGroup, System Analytic, Kompetento, Expo Medica, and Prophase. He receives royalties for text books and diagnostic tools from Huber/Hogrefe, Kohlhammer and UTB. Erik Domellöf is supported by a grant from the Knut and Alice Wallenberg Foundation (KAW 2015.0192). There are no other financial disclosures or conflicts of interest. Index. décimale : PER Périodiques Résumé : BACKGROUND: Autism spectrum disorder (ASD) evolves from an interplay between genetic and environmental factors during prenatal development. Since identifying maternal biomarkers associated with ASD risk in offspring during early pregnancy might result in new strategies for intervention, we investigated maternal metabolic biomarkers in relation to occurrence of ASD in offspring using both univariate logistic regression and multivariate network analysis. METHODS: Serum samples from 100 women with an offspring diagnosed with ASD and 100 matched control women with typically developing offspring were collected at week 14 of pregnancy. Concentrations of 62 metabolic biomarkers were determined, including amino acids, vitamins (A, B, D, E, and K), and biomarkers related to folate (vitamin B(9)) metabolism, lifestyle factors, as well as C-reactive protein (CRP), the kynurenine-tryptophan ratio (KTR), and neopterin as markers of inflammation and immune activation. RESULTS: We found weak evidence for a positive association between higher maternal serum concentrations of folate and increased occurrence of ASD (OR per 1 SD increase: 1.70, 95% CI 1.22-2.37, FDR adjusted P = 0.07). Multivariate network analysis confirmed expected internal biochemical relations between the biomarkers. Neither inflammation markers nor vitamin D(3) levels, all hypothesized to be involved in ASD etiology, displayed associations with ASD occurrence in the offspring. CONCLUSIONS: Our findings suggest that high maternal serum folate status during early pregnancy may be associated with the occurrence of ASD in offspring. No inference about physiological mechanisms behind this observation can be made at the present time because blood folate levels may have complex relations with nutritional intake, the cellular folate status and status of other B-vitamins. Therefore, further investigations, which may clarify the potential role and mechanisms of maternal blood folate status in ASD risk and the interplay with other potential risk factors, in larger materials are warranted. En ligne : http://dx.doi.org/10.1186/s13229-020-0315-z Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=427 Mindfulness-based stress reduction for autistic adults: A feasibility study in an outpatient context / Anne-Kristina LUOTO ; Anna BACKMAN ; Carina ERIKSDOTTER ; Nitya JAYARAM-LINDSTRÖM ; Sven BÖLTE ; Tatja HIRVIKOSKI in Autism, 28-2 (February 2024)
[article]
Titre : Mindfulness-based stress reduction for autistic adults: A feasibility study in an outpatient context Type de document : Texte imprimé et/ou numérique Auteurs : Anne-Kristina LUOTO, Auteur ; Anna BACKMAN, Auteur ; Carina ERIKSDOTTER, Auteur ; Nitya JAYARAM-LINDSTRÖM, Auteur ; Sven BÖLTE, Auteur ; Tatja HIRVIKOSKI, Auteur Article en page(s) : p.403?414 Mots-clés : adults autism intervention mindfulness stress Index. décimale : PER Périodiques Résumé : Autistic adults report high stress and impaired ability to cope with stressors. Mindfulness-based stress reduction targets individual?s own resources to regulate stress responses. An open feasibility study was conducted in an outpatient context, recruiting autistic adults without intellectual disability. The intervention, guided by trained mindfulness-based stress reduction teachers, followed the contents of the standard manual while adapting the delivery to autistic adults? needs. The total sample comprised of N?=?50 participants; N?=?43 (86%) attended at least one session, and N?=?34 of these (79%) completed the intervention. Participants found mindfulness-based stress reduction logical, likely to lead to improvement and recommendable to autistic peers. No serious adverse events were reported. Measures of preliminary effectiveness indicated reduced symptoms of stress (p?0.001; d?=?0.51) and improved stress-coping skills (p?=?0.017; d?=?0.43) from pre- to post-intervention, as well as a reduction in symptoms of anxiety and depression. No changes were observed in mindful attention awareness, life satisfaction, or acceptance of the autism diagnosis. The data suggest that mindfulness-based stress reduction is a feasible and acceptable intervention for autistic adults in an outpatient setting. Further investigation in randomized clinical trials is warranted (Clinical Trials, clinicaltrials.gov, registration no. NCT05244265). Lay abstract Autistic adults report high stress levels and difficulties dealing with everyday stressors. Mindfulness-based stress reduction groups aim to help regulate stress responses. We asked 50 autistic adults, without intellectual disability, to participate in a study of mindfulness-based stress reduction. The group program was made accessible through clear group leader communication and good program predictability, as well as reduced exposure to disturbing sensory stimuli. The mindfulness and yoga based exercises from the original mindfulness-based stress reduction program were included. The participants were positive and would even recommend an autistic friend to participate in a mindfulness-based stress reduction group. They reported that mindfulness-based stress reduction could lower symptoms of stress and improved stress coping. We still need to investigate these effects further in larger studies. The findings of this work show that mindfulness-based stress reduction groups can be adapted for autistic adults and that the participants overall were positive to the intervention and the group format. En ligne : https://dx.doi.org/10.1177/13623613231172809 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=519
in Autism > 28-2 (February 2024) . - p.403?414[article] Mindfulness-based stress reduction for autistic adults: A feasibility study in an outpatient context [Texte imprimé et/ou numérique] / Anne-Kristina LUOTO, Auteur ; Anna BACKMAN, Auteur ; Carina ERIKSDOTTER, Auteur ; Nitya JAYARAM-LINDSTRÖM, Auteur ; Sven BÖLTE, Auteur ; Tatja HIRVIKOSKI, Auteur . - p.403?414.
in Autism > 28-2 (February 2024) . - p.403?414
Mots-clés : adults autism intervention mindfulness stress Index. décimale : PER Périodiques Résumé : Autistic adults report high stress and impaired ability to cope with stressors. Mindfulness-based stress reduction targets individual?s own resources to regulate stress responses. An open feasibility study was conducted in an outpatient context, recruiting autistic adults without intellectual disability. The intervention, guided by trained mindfulness-based stress reduction teachers, followed the contents of the standard manual while adapting the delivery to autistic adults? needs. The total sample comprised of N?=?50 participants; N?=?43 (86%) attended at least one session, and N?=?34 of these (79%) completed the intervention. Participants found mindfulness-based stress reduction logical, likely to lead to improvement and recommendable to autistic peers. No serious adverse events were reported. Measures of preliminary effectiveness indicated reduced symptoms of stress (p?0.001; d?=?0.51) and improved stress-coping skills (p?=?0.017; d?=?0.43) from pre- to post-intervention, as well as a reduction in symptoms of anxiety and depression. No changes were observed in mindful attention awareness, life satisfaction, or acceptance of the autism diagnosis. The data suggest that mindfulness-based stress reduction is a feasible and acceptable intervention for autistic adults in an outpatient setting. Further investigation in randomized clinical trials is warranted (Clinical Trials, clinicaltrials.gov, registration no. NCT05244265). Lay abstract Autistic adults report high stress levels and difficulties dealing with everyday stressors. Mindfulness-based stress reduction groups aim to help regulate stress responses. We asked 50 autistic adults, without intellectual disability, to participate in a study of mindfulness-based stress reduction. The group program was made accessible through clear group leader communication and good program predictability, as well as reduced exposure to disturbing sensory stimuli. The mindfulness and yoga based exercises from the original mindfulness-based stress reduction program were included. The participants were positive and would even recommend an autistic friend to participate in a mindfulness-based stress reduction group. They reported that mindfulness-based stress reduction could lower symptoms of stress and improved stress coping. We still need to investigate these effects further in larger studies. The findings of this work show that mindfulness-based stress reduction groups can be adapted for autistic adults and that the participants overall were positive to the intervention and the group format. En ligne : https://dx.doi.org/10.1177/13623613231172809 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=519 A more holistic approach to autism using the International Classification of Functioning: The why, what, and how of functioning / Sven BÖLTE in Autism, 27-1 (January 2023)
PermalinkMotor atypicalities in infancy are associated with general developmental level at 2 years, but not autistic symptoms / Sheila ACHERMANN in Autism, 24-7 (October 2020)
PermalinkMulti-informant International Perspectives on the Facilitators and Barriers to Employment for Autistic Adults / Melissa H. BLACK in Autism Research, 13-7 (July 2020)
PermalinkA multi-perspective study of Perceived Inclusive Education for students with Neurodevelopmental Disorders / Emma LEIFLER in Journal of Autism and Developmental Disorders, 54-4 (April 2024)
PermalinkMultimodal brain imaging in autism spectrum disorder and the promise of twin research / Katell MEVEL in Autism, 19-5 (July 2015)
PermalinkNeurological disorders in autism: A systematic review and meta-analysis / Pei-Yin PAN in Autism, 25-3 (April 2021)
PermalinkPermalinkNew Interview and Observation Measures of the Broader Autism Phenotype: Description of Strategy and Reliability Findings for the Interview Measures / Jeremy R. PARR in Autism Research, 8-5 (October 2015)
PermalinkNew Interview and Observation Measures of the Broader Autism Phenotype: Impressions of Interviewee Measure / A. PICKLES in Journal of Autism and Developmental Disorders, 43-9 (September 2013)
PermalinkNonshared environmental factors in the aetiology of autism and other neurodevelopmental conditions: a monozygotic co-twin control study / J. ISAKSSON in Molecular Autism, 13 (2022)
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