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Role of MeCP2, DNA methylation, and HDACs in regulating synapse function / E. T. KAVALALI in Journal of Neurodevelopmental Disorders, 3-3 (September 2011)
[article]
Titre : Role of MeCP2, DNA methylation, and HDACs in regulating synapse function Type de document : Texte imprimé et/ou numérique Auteurs : E. T. KAVALALI, Auteur ; E. D. NELSON, Auteur ; L. M. MONTEGGIA, Auteur Article en page(s) : p.250-6 Langues : Anglais (eng) Index. décimale : PER Périodiques Résumé : Over the past several years there has been intense effort to delineate the role of epigenetic factors, including methyl-CpG-binding protein 2, histone deacetylases, and DNA methyltransferases, in synaptic function. Studies from our group as well as others have shown that these key epigenetic mechanisms are critical regulators of synapse formation, maturation, as well as function. Although most studies have identified selective deficits in excitatory neurotransmission, the latest work has also uncovered deficits in inhibitory neurotransmission as well. Despite the rapid pace of advances, the exact synaptic mechanisms and gene targets that mediate these effects on neurotransmission remain unclear. Nevertheless, these findings not only open new avenues for understanding neuronal circuit abnormalities associated with neurodevelopmental disorders but also elucidate potential targets for addressing the pathophysiology of several intractable neuropsychiatric disorders. En ligne : http://dx.doi.org/10.1007/s11689-011-9078-3 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=343
in Journal of Neurodevelopmental Disorders > 3-3 (September 2011) . - p.250-6[article] Role of MeCP2, DNA methylation, and HDACs in regulating synapse function [Texte imprimé et/ou numérique] / E. T. KAVALALI, Auteur ; E. D. NELSON, Auteur ; L. M. MONTEGGIA, Auteur . - p.250-6.
Langues : Anglais (eng)
in Journal of Neurodevelopmental Disorders > 3-3 (September 2011) . - p.250-6
Index. décimale : PER Périodiques Résumé : Over the past several years there has been intense effort to delineate the role of epigenetic factors, including methyl-CpG-binding protein 2, histone deacetylases, and DNA methyltransferases, in synaptic function. Studies from our group as well as others have shown that these key epigenetic mechanisms are critical regulators of synapse formation, maturation, as well as function. Although most studies have identified selective deficits in excitatory neurotransmission, the latest work has also uncovered deficits in inhibitory neurotransmission as well. Despite the rapid pace of advances, the exact synaptic mechanisms and gene targets that mediate these effects on neurotransmission remain unclear. Nevertheless, these findings not only open new avenues for understanding neuronal circuit abnormalities associated with neurodevelopmental disorders but also elucidate potential targets for addressing the pathophysiology of several intractable neuropsychiatric disorders. En ligne : http://dx.doi.org/10.1007/s11689-011-9078-3 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=343 Role of miR-146a in neural stem cell differentiation and neural lineage determination: relevance for neurodevelopmental disorders / L. S. NGUYEN in Molecular Autism, 9 (2018)
[article]
Titre : Role of miR-146a in neural stem cell differentiation and neural lineage determination: relevance for neurodevelopmental disorders Type de document : Texte imprimé et/ou numérique Auteurs : L. S. NGUYEN, Auteur ; J. FREGEAC, Auteur ; C. BOLE-FEYSOT, Auteur ; N. CAGNARD, Auteur ; A. IYER, Auteur ; J. ANINK, Auteur ; E. ARONICA, Auteur ; O. ALIBEU, Auteur ; P. NITSCHKE, Auteur ; L. COLLEAUX, Auteur Article en page(s) : 38p. Langues : Anglais (eng) Mots-clés : Autism Spectrum Disorder/genetics/metabolism Cell Line Cell Lineage Child Female Humans Male MicroRNAs/genetics/metabolism Neural Stem Cells/cytology/metabolism Neurogenesis Temporal Lobe/cytology/metabolism Up-Regulation Autism spectrum disorders Human neural stem cell Transcriptome microRNA Index. décimale : PER Périodiques Résumé : Background: MicroRNAs (miRNAs) are small, non-coding RNAs that regulate gene expression at the post-transcriptional level. miRNAs have emerged as important modulators of brain development and neuronal function and are implicated in several neurological diseases. Previous studies found miR-146a upregulation is the most common miRNA deregulation event in neurodevelopmental disorders such as autism spectrum disorder (ASD), epilepsy, and intellectual disability (ID). Yet, how miR-146a upregulation affects the developing fetal brain remains unclear. Methods: We analyzed the expression of miR-146a in the temporal lobe of ASD children using Taqman assay. To assess the role of miR-146a in early brain development, we generated and characterized stably induced H9 human neural stem cell (H9 hNSC) overexpressing miR-146a using various cell and molecular biology techniques. Results: We first showed that miR-146a upregulation occurs early during childhood in the ASD brain. In H9 hNSC, miR-146a overexpression enhances neurite outgrowth and branching and favors differentiation into neuronal like cells. Expression analyses revealed that 10% of the transcriptome was deregulated and organized into two modules critical for cell cycle control and neuronal differentiation. Twenty known or predicted targets of miR-146a were significantly deregulated in the modules, acting as potential drivers. The two modules also display distinct transcription profiles during human brain development, affecting regions relevant for ASD including the neocortex, amygdala, and hippocampus. Cell type analyses indicate markers for pyramidal, and interneurons are highly enriched in the deregulated gene list. Up to 40% of known markers of newly defined neuronal lineages were deregulated, suggesting that miR-146a could participate also in the acquisition of neuronal identities. Conclusion: Our results demonstrate the dynamic roles of miR-146a in early neuronal development and provide new insight into the molecular events that link miR-146a overexpression to impaired neurodevelopment. This, in turn, may yield new therapeutic targets and strategies. En ligne : https://dx.doi.org/10.1186/s13229-018-0219-3 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=371
in Molecular Autism > 9 (2018) . - 38p.[article] Role of miR-146a in neural stem cell differentiation and neural lineage determination: relevance for neurodevelopmental disorders [Texte imprimé et/ou numérique] / L. S. NGUYEN, Auteur ; J. FREGEAC, Auteur ; C. BOLE-FEYSOT, Auteur ; N. CAGNARD, Auteur ; A. IYER, Auteur ; J. ANINK, Auteur ; E. ARONICA, Auteur ; O. ALIBEU, Auteur ; P. NITSCHKE, Auteur ; L. COLLEAUX, Auteur . - 38p.
Langues : Anglais (eng)
in Molecular Autism > 9 (2018) . - 38p.
Mots-clés : Autism Spectrum Disorder/genetics/metabolism Cell Line Cell Lineage Child Female Humans Male MicroRNAs/genetics/metabolism Neural Stem Cells/cytology/metabolism Neurogenesis Temporal Lobe/cytology/metabolism Up-Regulation Autism spectrum disorders Human neural stem cell Transcriptome microRNA Index. décimale : PER Périodiques Résumé : Background: MicroRNAs (miRNAs) are small, non-coding RNAs that regulate gene expression at the post-transcriptional level. miRNAs have emerged as important modulators of brain development and neuronal function and are implicated in several neurological diseases. Previous studies found miR-146a upregulation is the most common miRNA deregulation event in neurodevelopmental disorders such as autism spectrum disorder (ASD), epilepsy, and intellectual disability (ID). Yet, how miR-146a upregulation affects the developing fetal brain remains unclear. Methods: We analyzed the expression of miR-146a in the temporal lobe of ASD children using Taqman assay. To assess the role of miR-146a in early brain development, we generated and characterized stably induced H9 human neural stem cell (H9 hNSC) overexpressing miR-146a using various cell and molecular biology techniques. Results: We first showed that miR-146a upregulation occurs early during childhood in the ASD brain. In H9 hNSC, miR-146a overexpression enhances neurite outgrowth and branching and favors differentiation into neuronal like cells. Expression analyses revealed that 10% of the transcriptome was deregulated and organized into two modules critical for cell cycle control and neuronal differentiation. Twenty known or predicted targets of miR-146a were significantly deregulated in the modules, acting as potential drivers. The two modules also display distinct transcription profiles during human brain development, affecting regions relevant for ASD including the neocortex, amygdala, and hippocampus. Cell type analyses indicate markers for pyramidal, and interneurons are highly enriched in the deregulated gene list. Up to 40% of known markers of newly defined neuronal lineages were deregulated, suggesting that miR-146a could participate also in the acquisition of neuronal identities. Conclusion: Our results demonstrate the dynamic roles of miR-146a in early neuronal development and provide new insight into the molecular events that link miR-146a overexpression to impaired neurodevelopment. This, in turn, may yield new therapeutic targets and strategies. En ligne : https://dx.doi.org/10.1186/s13229-018-0219-3 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=371 Role of Parent Affective Behaviors and Child Negativity in Behavioral Functioning for Young Children With Developmental Delays / Kristin M. RISPOLI in Focus on Autism and Other Developmental Disabilities, 34-1 (March 2019)
[article]
Titre : Role of Parent Affective Behaviors and Child Negativity in Behavioral Functioning for Young Children With Developmental Delays Type de document : Texte imprimé et/ou numérique Auteurs : Kristin M. RISPOLI, Auteur Article en page(s) : p.20-28 Langues : Anglais (eng) Index. décimale : PER Périodiques Résumé : This study examined individual and interactive effects of child negativity and parental affective behaviors when children were 4 years of age on externalizing issues exhibited by children at 5 years of age using a subsample of children with developmental delays drawn from a nationally representative data set (N = 450). Hierarchical multiple regression analyses were used to address research questions. Results indicated that negativity displayed by parents when children were 4 years of age was associated with more externalizing issues when children reached age 5. Interactions between parent and child affective behaviors did not significantly explain additional variance in the model, though there was a trend in which parent and child negativity interacted to predict children?s 5-year externalizing issues. Findings suggest interventions targeting emotional regulation in preschool-age children with developmental delays should target child and parent affective expression, and equip parents with skills to manage negative emotion. En ligne : https://doi.org/10.1177/1088357618800262 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=383
in Focus on Autism and Other Developmental Disabilities > 34-1 (March 2019) . - p.20-28[article] Role of Parent Affective Behaviors and Child Negativity in Behavioral Functioning for Young Children With Developmental Delays [Texte imprimé et/ou numérique] / Kristin M. RISPOLI, Auteur . - p.20-28.
Langues : Anglais (eng)
in Focus on Autism and Other Developmental Disabilities > 34-1 (March 2019) . - p.20-28
Index. décimale : PER Périodiques Résumé : This study examined individual and interactive effects of child negativity and parental affective behaviors when children were 4 years of age on externalizing issues exhibited by children at 5 years of age using a subsample of children with developmental delays drawn from a nationally representative data set (N = 450). Hierarchical multiple regression analyses were used to address research questions. Results indicated that negativity displayed by parents when children were 4 years of age was associated with more externalizing issues when children reached age 5. Interactions between parent and child affective behaviors did not significantly explain additional variance in the model, though there was a trend in which parent and child negativity interacted to predict children?s 5-year externalizing issues. Findings suggest interventions targeting emotional regulation in preschool-age children with developmental delays should target child and parent affective expression, and equip parents with skills to manage negative emotion. En ligne : https://doi.org/10.1177/1088357618800262 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=383 Role of parental occupation in autism spectrum disorder diagnosis and severity / Aisha S. DICKERSON in Research in Autism Spectrum Disorders, 8-9 (September 2014)
[article]
Titre : Role of parental occupation in autism spectrum disorder diagnosis and severity Type de document : Texte imprimé et/ou numérique Auteurs : Aisha S. DICKERSON, Auteur ; Deborah A. PEARSON, Auteur ; Katherine A. LOVELAND, Auteur ; Mohammad H. RAHBAR, Auteur ; Pauline A. FILIPEK, Auteur Article en page(s) : p.997-1007 Langues : Anglais (eng) Mots-clés : Autism Diagnosis Severity Risk Occupation Parents Index. décimale : PER Périodiques Résumé : Abstract Some have suggested that parents of children with autism spectrum disorder (ASD) may present with less recognizable autistic-like phenotypic characteristics, leading them to highly systemizing occupations. Using secondary analysis of data from two previous studies of children with ASD, we tested associations between parental occupations and ASD diagnosis and the association of parental occupational characteristics on ASD severity. We found that fathers in healthcare (P lt; 0.01) and finance (P = 0.03) were more likely to have children with ASD. Additionally, joint effects of parental technical occupations were associated with communication (P lt; 0.01) and social impairment (P = 0.04). These results support that a “broader phenotype” and possible assortative mating in adults with autistic-like characteristics might contribute to intergenerational transmission and having offspring with greater ASD severity. En ligne : http://dx.doi.org/10.1016/j.rasd.2014.05.007 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=238
in Research in Autism Spectrum Disorders > 8-9 (September 2014) . - p.997-1007[article] Role of parental occupation in autism spectrum disorder diagnosis and severity [Texte imprimé et/ou numérique] / Aisha S. DICKERSON, Auteur ; Deborah A. PEARSON, Auteur ; Katherine A. LOVELAND, Auteur ; Mohammad H. RAHBAR, Auteur ; Pauline A. FILIPEK, Auteur . - p.997-1007.
Langues : Anglais (eng)
in Research in Autism Spectrum Disorders > 8-9 (September 2014) . - p.997-1007
Mots-clés : Autism Diagnosis Severity Risk Occupation Parents Index. décimale : PER Périodiques Résumé : Abstract Some have suggested that parents of children with autism spectrum disorder (ASD) may present with less recognizable autistic-like phenotypic characteristics, leading them to highly systemizing occupations. Using secondary analysis of data from two previous studies of children with ASD, we tested associations between parental occupations and ASD diagnosis and the association of parental occupational characteristics on ASD severity. We found that fathers in healthcare (P lt; 0.01) and finance (P = 0.03) were more likely to have children with ASD. Additionally, joint effects of parental technical occupations were associated with communication (P lt; 0.01) and social impairment (P = 0.04). These results support that a “broader phenotype” and possible assortative mating in adults with autistic-like characteristics might contribute to intergenerational transmission and having offspring with greater ASD severity. En ligne : http://dx.doi.org/10.1016/j.rasd.2014.05.007 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=238 Role of sex chromosome in the determination and. differentiation of sex in mammals / Paul E. POLANI in Developmental Medicine & Child Neurology, 21-2 (April 1979)
[article]
Titre : Role of sex chromosome in the determination and. differentiation of sex in mammals Type de document : Texte imprimé et/ou numérique Auteurs : Paul E. POLANI, Auteur Année de publication : 1979 Article en page(s) : p.249-263 Langues : Anglais (eng) Index. décimale : PER Périodiques Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=489
in Developmental Medicine & Child Neurology > 21-2 (April 1979) . - p.249-263[article] Role of sex chromosome in the determination and. differentiation of sex in mammals [Texte imprimé et/ou numérique] / Paul E. POLANI, Auteur . - 1979 . - p.249-263.
Langues : Anglais (eng)
in Developmental Medicine & Child Neurology > 21-2 (April 1979) . - p.249-263
Index. décimale : PER Périodiques Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=489 Role of temperament in early adolescent pure and co-occurring internalizing and externalizing problems using a bifactor model: Moderation by parenting and gender / Frances L. WANG in Development and Psychopathology, 28-4 pt2 (November 2016)
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